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The map label for this gene is ddc [H]

Identifier: 78779267

GI number: 78779267

Start: 815067

End: 816452

Strand: Direct

Name: ddc [H]

Synonym: PMT9312_0883

Alternate gene names: 78779267

Gene position: 815067-816452 (Clockwise)

Preceding gene: 78779265

Following gene: 78779273

Centisome position: 47.69

GC content: 30.66

Gene sequence:

>1386_bases
ATGACTGAAGATTTAATTAATAAAAAAGATATATACTTCCCTTCGTATTTAGGGACTAACGATAACTTCATTACTCTCCT
CAATAGAGCAACTCAAATTCTTTGTGACTGGTTCTCTAATTCCGAGAAAGATGGTCCATTAACCTTTGATGAGAATTTCA
AGTGCTTTATGCCTGATGAGCTTGGTAATTCTACAGAAGATTTGTTTTCTGAGATTCAATCCCTTTTGAATAATTCATTT
AATCCCGTTCATCCGGGTTCTCTAGCTCATCTTGATCCCCCACCTTTGATTTTTTCTATTTTAGGAGATTTAATTGCTGC
TGGTTTAAATAATAATCTTCTTGCTTACGAGTTATCTCCAAGTGTTACTTTACTTGAGGAGTCATTATGCAAATGGTTTG
CTAAAAAAATAGGCTTTAATGATTCTTCAGGAGGCATAGCAGCTAGCGGAGGTACTTTAAGTAATTTGAATGCACTTATA
GCAGCTAGACATAATGCTGGATTAGGTTCAGATCCTAATTCTGTATTACTTGTAAGTGAAGATGCTCATTCTTCCTTCAT
TAAATGCACAAGAATTATGGGTCTTAATGATACAAATCTAGTAAAGATTAAAACTGACAATAAAGGTTGTATGGATATAG
ATAATCTAAAAAATTCCTTAGATCAATGTTTAATAAATAATAAAAAAATCTTTGCTATTGTTGCCACATTAGGAACAACT
GTAAGAGGAGCAATTGATCCTATTAAGGATATAAGTGATATATGCAAAGAAAGAAATATTTGGCTACATATCGATGGCTC
TATTGGTGGGATTTTTGGAGTAACTTCTATTCCAATAGAAGGTTTAAATAATATTAATCAGGCTAATTCCATAACAATAA
ATCCCCAAAAAATAATTGGCATTACAAAGACTTCCTCTCTGTTATTGGTATCAAACATGCGTACTTTGGAAAAGACCTTT
TCGACTGGACTTCCATACATATCATCTAAGGAAAACATTATAAACAGAGGAGAATTAGGTATTCAAGGTTCTAGACCTGC
AGAAGTTATAAAACTTTGGCTTGGATTAAGATCTTTAGGTTTAAAAGGAATGGAAGATATATTAAACTCATCAATTAATA
GAAAAGACTTTTTTATAAAAAATATTAATAAAAATAAGTTTGAAATATATTCAGGACCTCTACATATTATTTCTTTCTTA
CCAAAGGGACTTACTACAAAAGACACAAATTTCTGGACTCAAACTAAAGTTAATGAACTAATGAAAAATAATTTTATGCT
TTCTAGACCAAAATTTAAAGGTAAATATTATTTAAGAGTTGTCATGGGTAATTACAATACTAATGTATCTCATATTGAAG
AACTTTTGAAAATTCTACATGCTTAA

Upstream 100 bases:

>100_bases
CTTTCTTCCTCTATTTAGATCATTATTACTATTTCCATTTTCAAAAATATTCCTCATTTAACAATATTCAGAATAGACTT
ATTAATAGATATCTTATCTG

Downstream 100 bases:

>100_bases
CAATGAATTTCGGTAGACCAAAAATTATTGCAATAGTAACAGGTTTTATATCTATAGCCATTTGTATTGCTTACTTACTT
TTAATAACTATCTTTGATTT

Product: pyridoxal-dependent decarboxylase family protein

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MTEDLINKKDIYFPSYLGTNDNFITLLNRATQILCDWFSNSEKDGPLTFDENFKCFMPDELGNSTEDLFSEIQSLLNNSF
NPVHPGSLAHLDPPPLIFSILGDLIAAGLNNNLLAYELSPSVTLLEESLCKWFAKKIGFNDSSGGIAASGGTLSNLNALI
AARHNAGLGSDPNSVLLVSEDAHSSFIKCTRIMGLNDTNLVKIKTDNKGCMDIDNLKNSLDQCLINNKKIFAIVATLGTT
VRGAIDPIKDISDICKERNIWLHIDGSIGGIFGVTSIPIEGLNNINQANSITINPQKIIGITKTSSLLLVSNMRTLEKTF
STGLPYISSKENIINRGELGIQGSRPAEVIKLWLGLRSLGLKGMEDILNSSINRKDFFIKNINKNKFEIYSGPLHIISFL
PKGLTTKDTNFWTQTKVNELMKNNFMLSRPKFKGKYYLRVVMGNYNTNVSHIEELLKILHA

Sequences:

>Translated_461_residues
MTEDLINKKDIYFPSYLGTNDNFITLLNRATQILCDWFSNSEKDGPLTFDENFKCFMPDELGNSTEDLFSEIQSLLNNSF
NPVHPGSLAHLDPPPLIFSILGDLIAAGLNNNLLAYELSPSVTLLEESLCKWFAKKIGFNDSSGGIAASGGTLSNLNALI
AARHNAGLGSDPNSVLLVSEDAHSSFIKCTRIMGLNDTNLVKIKTDNKGCMDIDNLKNSLDQCLINNKKIFAIVATLGTT
VRGAIDPIKDISDICKERNIWLHIDGSIGGIFGVTSIPIEGLNNINQANSITINPQKIIGITKTSSLLLVSNMRTLEKTF
STGLPYISSKENIINRGELGIQGSRPAEVIKLWLGLRSLGLKGMEDILNSSINRKDFFIKNINKNKFEIYSGPLHIISFL
PKGLTTKDTNFWTQTKVNELMKNNFMLSRPKFKGKYYLRVVMGNYNTNVSHIEELLKILHA
>Mature_460_residues
TEDLINKKDIYFPSYLGTNDNFITLLNRATQILCDWFSNSEKDGPLTFDENFKCFMPDELGNSTEDLFSEIQSLLNNSFN
PVHPGSLAHLDPPPLIFSILGDLIAAGLNNNLLAYELSPSVTLLEESLCKWFAKKIGFNDSSGGIAASGGTLSNLNALIA
ARHNAGLGSDPNSVLLVSEDAHSSFIKCTRIMGLNDTNLVKIKTDNKGCMDIDNLKNSLDQCLINNKKIFAIVATLGTTV
RGAIDPIKDISDICKERNIWLHIDGSIGGIFGVTSIPIEGLNNINQANSITINPQKIIGITKTSSLLLVSNMRTLEKTFS
TGLPYISSKENIINRGELGIQGSRPAEVIKLWLGLRSLGLKGMEDILNSSINRKDFFIKNINKNKFEIYSGPLHIISFLP
KGLTTKDTNFWTQTKVNELMKNNFMLSRPKFKGKYYLRVVMGNYNTNVSHIEELLKILHA

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197383062, Length=409, Percent_Identity=26.6503667481663, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI58331246, Length=360, Percent_Identity=28.0555555555556, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI197276620, Length=364, Percent_Identity=28.021978021978, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI4503875, Length=364, Percent_Identity=28.021978021978, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI194294551, Length=410, Percent_Identity=24.8780487804878, Blast_Score=147, Evalue=2e-35,
Organism=Homo sapiens, GI92110055, Length=318, Percent_Identity=27.6729559748428, Blast_Score=99, Evalue=8e-21,
Organism=Homo sapiens, GI4503281, Length=419, Percent_Identity=22.1957040572792, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI132814448, Length=419, Percent_Identity=22.1957040572792, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17555682, Length=469, Percent_Identity=24.3070362473348, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71993058, Length=388, Percent_Identity=26.8041237113402, Blast_Score=150, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI71993062, Length=310, Percent_Identity=28.7096774193548, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17534819, Length=385, Percent_Identity=24.6753246753247, Blast_Score=92, Evalue=8e-19,
Organism=Caenorhabditis elegans, GI17534817, Length=385, Percent_Identity=24.6753246753247, Blast_Score=91, Evalue=9e-19,
Organism=Drosophila melanogaster, GI17136594, Length=373, Percent_Identity=29.2225201072386, Blast_Score=163, Evalue=2e-40,
Organism=Drosophila melanogaster, GI21356415, Length=301, Percent_Identity=28.2392026578073, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI24657193, Length=363, Percent_Identity=28.3746556473829, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24657185, Length=363, Percent_Identity=28.3746556473829, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI24657188, Length=363, Percent_Identity=28.3746556473829, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI28573972, Length=438, Percent_Identity=26.027397260274, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24652373, Length=380, Percent_Identity=24.4736842105263, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17136190, Length=381, Percent_Identity=23.3595800524934, Blast_Score=96, Evalue=5e-20,
Organism=Drosophila melanogaster, GI24585135, Length=377, Percent_Identity=23.0769230769231, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24586044, Length=391, Percent_Identity=23.0179028132992, Blast_Score=79, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 50980; Mature: 50849

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEDLINKKDIYFPSYLGTNDNFITLLNRATQILCDWFSNSEKDGPLTFDENFKCFMPDE
CCCHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCEEECCCCEEECCHH
LGNSTEDLFSEIQSLLNNSFNPVHPGSLAHLDPPPLIFSILGDLIAAGLNNNLLAYELSP
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCC
SVTLLEESLCKWFAKKIGFNDSSGGIAASGGTLSNLNALIAARHNAGLGSDPNSVLLVSE
CHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHCCEEEEEECCCCCCCCCCCEEEEEC
DAHSSFIKCTRIMGLNDTNLVKIKTDNKGCMDIDNLKNSLDQCLINNKKIFAIVATLGTT
CCCHHHHHHHHEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEEHHCCH
VRGAIDPIKDISDICKERNIWLHIDGSIGGIFGVTSIPIEGLNNINQANSITINPQKIIG
HHHHHCHHHHHHHHHHCCCEEEEECCCCCCEECCCCCCHHCCCCCCCCCEEEECHHHEEE
ITKTSSLLLVSNMRTLEKTFSTGLPYISSKENIINRGELGIQGSRPAEVIKLWLGLRSLG
EECCCCEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
LKGMEDILNSSINRKDFFIKNINKNKFEIYSGPLHIISFLPKGLTTKDTNFWTQTKVNEL
CCHHHHHHCCCCCCCEEEEECCCCCEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHH
MKNNFMLSRPKFKGKYYLRVVMGNYNTNVSHIEELLKILHA
HHCCEEEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
TEDLINKKDIYFPSYLGTNDNFITLLNRATQILCDWFSNSEKDGPLTFDENFKCFMPDE
CCHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHHHHCCCCCCCCEEECCCCEEECCHH
LGNSTEDLFSEIQSLLNNSFNPVHPGSLAHLDPPPLIFSILGDLIAAGLNNNLLAYELSP
CCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCC
SVTLLEESLCKWFAKKIGFNDSSGGIAASGGTLSNLNALIAARHNAGLGSDPNSVLLVSE
CHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCHHHCCEEEEEECCCCCCCCCCCEEEEEC
DAHSSFIKCTRIMGLNDTNLVKIKTDNKGCMDIDNLKNSLDQCLINNKKIFAIVATLGTT
CCCHHHHHHHHEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEEEEHHCCH
VRGAIDPIKDISDICKERNIWLHIDGSIGGIFGVTSIPIEGLNNINQANSITINPQKIIG
HHHHHCHHHHHHHHHHCCCEEEEECCCCCCEECCCCCCHHCCCCCCCCCEEEECHHHEEE
ITKTSSLLLVSNMRTLEKTFSTGLPYISSKENIINRGELGIQGSRPAEVIKLWLGLRSLG
EECCCCEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
LKGMEDILNSSINRKDFFIKNINKNKFEIYSGPLHIISFLPKGLTTKDTNFWTQTKVNEL
CCHHHHHHCCCCCCCEEEEECCCCCEEEEECCHHHHHHHCCCCCCCCCCCCCHHHHHHHH
MKNNFMLSRPKFKGKYYLRVVMGNYNTNVSHIEELLKILHA
HHCCEEEECCCCCCEEEEEEEEECCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8772175 [H]