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The map label for this gene is proC [H]

Identifier: 78778777

GI number: 78778777

Start: 372101

End: 372913

Strand: Direct

Name: proC [H]

Synonym: PMT9312_0392

Alternate gene names: 78778777

Gene position: 372101-372913 (Clockwise)

Preceding gene: 78778776

Following gene: 78778782

Centisome position: 21.77

GC content: 29.03

Gene sequence:

>813_bases
GTGACTGATAAAATTGCGATTATTGGGTTTGGCAATATTGCAAATGCTATTATTACTCCTTTATTCGATAAGAATTTAAT
ACAGCCAGAGAGAGTTTATTGTGTTGTAAATTCAGAAAAGAGTTTAGAAAATATAAAAAAAAATTATAAATACAATATAA
ATGTTTATAAATCAGGTTCTAAAGAGTCAGAAATAATTTGGGATTGTCAATTTAAACTTCTTTCAATAAAACCCCAACAT
CTTAAAGATATAACTGAGGGAGATATTATAAAAAACAAGAACAATTTATTAGTATCAATTCTTGCAGGAGTTTCAATAAA
TAAACTTCATCAAAAATTTCCTAACCATAAATGCGTAAGGGTTGTTACAAATATCCCAATAACTGTTGGAAAGGGTTTAA
CAGGCATTGCTTGGGGTGAAAATCTTACAGAAGATCAGAAAGAATTTACAAAAAAATTGTTTGAAAATACTAGTAAGATT
TATGAATTTACTGAAGAATATCTTGATATTTTTTTAGCTTTAACCTCATCAGGGCCTGCAATTATTGCTTTAATTATAGA
ATCATTAAGTGATGGAGGGTTGAGTGGTGGATTACCAAAAATACTTTCAGAAGAACTTGTAATGGAAATGATAATAGGGA
CTATAAGTTTAATTAAAGAAAAAAAACTTACTACTTCAGAGCTTAAAAATTTAGTAACCTCTCCCGGTGGAACAACTATT
TCTGCTTTACGGGTTCTAGAAAAAAAAGGAGTAAGGTCAGCATTAATTGAATCGATTGTTTCAGCTAGTAATCGAAGTAA
AGAGTTTAGTTAG

Upstream 100 bases:

>100_bases
GTTTCTCCAAAGAATACACCGCAATATAGTGTAGAAAATAATACTGCTCCGGAACCAGCTTGGGGAAATTCTAAATTAAG
TGCTTTTTCATGATTAATCT

Downstream 100 bases:

>100_bases
GTTTTGAAATTATCTTTTAATTTTATATAAACTTTCTCAAGAGAATTTATATTTTTAGTAATTGTATATCTTTCAATTAT
TCGTTCTCTAGCTTTTTTCC

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MTDKIAIIGFGNIANAIITPLFDKNLIQPERVYCVVNSEKSLENIKKNYKYNINVYKSGSKESEIIWDCQFKLLSIKPQH
LKDITEGDIIKNKNNLLVSILAGVSINKLHQKFPNHKCVRVVTNIPITVGKGLTGIAWGENLTEDQKEFTKKLFENTSKI
YEFTEEYLDIFLALTSSGPAIIALIIESLSDGGLSGGLPKILSEELVMEMIIGTISLIKEKKLTTSELKNLVTSPGGTTI
SALRVLEKKGVRSALIESIVSASNRSKEFS

Sequences:

>Translated_270_residues
MTDKIAIIGFGNIANAIITPLFDKNLIQPERVYCVVNSEKSLENIKKNYKYNINVYKSGSKESEIIWDCQFKLLSIKPQH
LKDITEGDIIKNKNNLLVSILAGVSINKLHQKFPNHKCVRVVTNIPITVGKGLTGIAWGENLTEDQKEFTKKLFENTSKI
YEFTEEYLDIFLALTSSGPAIIALIIESLSDGGLSGGLPKILSEELVMEMIIGTISLIKEKKLTTSELKNLVTSPGGTTI
SALRVLEKKGVRSALIESIVSASNRSKEFS
>Mature_269_residues
TDKIAIIGFGNIANAIITPLFDKNLIQPERVYCVVNSEKSLENIKKNYKYNINVYKSGSKESEIIWDCQFKLLSIKPQHL
KDITEGDIIKNKNNLLVSILAGVSINKLHQKFPNHKCVRVVTNIPITVGKGLTGIAWGENLTEDQKEFTKKLFENTSKIY
EFTEEYLDIFLALTSSGPAIIALIIESLSDGGLSGGLPKILSEELVMEMIIGTISLIKEKKLTTSELKNLVTSPGGTTIS
ALRVLEKKGVRSALIESIVSASNRSKEFS

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=269, Percent_Identity=25.6505576208178, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI21361454, Length=272, Percent_Identity=27.9411764705882, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI24797097, Length=271, Percent_Identity=26.1992619926199, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI24797095, Length=271, Percent_Identity=26.1992619926199, Blast_Score=107, Evalue=2e-23,
Organism=Escherichia coli, GI1786585, Length=272, Percent_Identity=28.3088235294118, Blast_Score=120, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI17569021, Length=267, Percent_Identity=27.7153558052434, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17540664, Length=280, Percent_Identity=27.1428571428571, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320861, Length=293, Percent_Identity=29.0102389078498, Blast_Score=117, Evalue=1e-27,
Organism=Drosophila melanogaster, GI21358587, Length=268, Percent_Identity=25.7462686567164, Blast_Score=121, Evalue=6e-28,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=30.1775147928994, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24648116, Length=283, Percent_Identity=25.4416961130742, Blast_Score=94, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29860; Mature: 29729

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDKIAIIGFGNIANAIITPLFDKNLIQPERVYCVVNSEKSLENIKKNYKYNINVYKSGS
CCCCEEEEECCHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHCCEEEEEEEECCC
KESEIIWDCQFKLLSIKPQHLKDITEGDIIKNKNNLLVSILAGVSINKLHQKFPNHKCVR
CCCCEEEEEEEEEEECCHHHHHCCCCCCEEECCCCEEEEHHHCCCHHHHHHHCCCCCEEE
VVTNIPITVGKGLTGIAWGENLTEDQKEFTKKLFENTSKIYEFTEEYLDIFLALTSSGPA
EEECCCEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
IIALIIESLSDGGLSGGLPKILSEELVMEMIIGTISLIKEKKLTTSELKNLVTSPGGTTI
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHH
SALRVLEKKGVRSALIESIVSASNRSKEFS
HHHHHHHHCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TDKIAIIGFGNIANAIITPLFDKNLIQPERVYCVVNSEKSLENIKKNYKYNINVYKSGS
CCCEEEEECCHHHHHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHCCEEEEEEEECCC
KESEIIWDCQFKLLSIKPQHLKDITEGDIIKNKNNLLVSILAGVSINKLHQKFPNHKCVR
CCCCEEEEEEEEEEECCHHHHHCCCCCCEEECCCCEEEEHHHCCCHHHHHHHCCCCCEEE
VVTNIPITVGKGLTGIAWGENLTEDQKEFTKKLFENTSKIYEFTEEYLDIFLALTSSGPA
EEECCCEEECCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
IIALIIESLSDGGLSGGLPKILSEELVMEMIIGTISLIKEKKLTTSELKNLVTSPGGTTI
HHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHH
SALRVLEKKGVRSALIESIVSASNRSKEFS
HHHHHHHHCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]