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The map label for this gene is nrdA [H]

Identifier: 78484808

GI number: 78484808

Start: 518204

End: 520486

Strand: Reverse

Name: nrdA [H]

Synonym: Tcr_0463

Alternate gene names: 78484808

Gene position: 520486-518204 (Counterclockwise)

Preceding gene: 78484823

Following gene: 78484804

Centisome position: 21.44

GC content: 43.23

Gene sequence:

>2283_bases
ATGTCTACAGAAACCATGAATGTTGCCAAGCGCAATGGCGAAACAGAGCCGCTCGATTTAGAAAAAATTCACCGCGTTAT
TACGTGGGCCGCCGAAGGTCTGGAAAATGTCTCCGTATCAGAAGTTGAATTGAGGTCTCATATCCAATTTTATGACGGCA
TGAAAACATCGGATATCCATGAGACGATTATCAAATCTGCAGCGGACTTAATTTCAGAAAGCGCACCCGACTATCAGCAC
CTTGCGGCGCGACTGGCTATTTTCCACTTACGCAAAAAAGCATTTGACCGCTTTACACCACCAACCTTATTTGAGCACGT
CAATAAAATGGTACGCAATCGCCTTTACGACCCTCAAATACAAGATGATTACACGAAAGCGGAATTTGATGAACTGGATA
ACTACATCCAACATGATCGTGATATGAATTTCAGCTATGCTGCGGTCAAGCAACTGGAAGGAAAGTATTTAGTACAGAAC
CGTGTTACTGGCAAGATCTATGAAAGCCCGCAATTTATTTATATGCTGATCCCTATGAGCTTGTTTGCGCATTATCCAAA
CGACGCCGAGCCCGGCAAAACACGATTGGATTATGTAAAGCGCTTTTACGATGCGGCCTCTAACTTTAAATTGTCTTTAC
CAACGCCAATTATGTCAGGGGTACGCACACCGACACGCCAATTCAGCTCTTGCGTTCTTATTGAATGCGGGGACTCATTA
GATTCGATCAATGCCACCTCTTCTTCTATTGTGAAATACGTTTCTCAAAGAGCAGGCATCGGTGTGAATGTTGGACAGAT
TCGTGCACTCGGAAGTGAAATCCGTGGCGGTGAAGCTTATCACACAGGCATGATTCCCTTTATCAAACACTTTCAAACCG
CGGTTAAATCGTGCTCTCAGGGCGGTGTACGCGGCGGTGCAGCAACACTCTTTTTCCCTATTTGGCACTTGGAAGTGGAA
TCTTTAATTGTTTTGAAGAACAACCGTGGGGTAGAAGAAAACCGAGCCCGTCATTTAGATTATGGGGTACAGGTTAATAA
GCTCATGTATCAACGCATGATTGAAGGTGGCAACATTACGCTATTCAGCCCCTCCGATGTTCCTGGACTTTATGATGCTT
TCTTTGAAGACCAAGAAGAATTTGAACGCTTATACAAAATCTACGAAGCCGATGACACCATTCGTAAAAAAACCATGAAA
GCCGTTGACCTGTTTACCCAGGTCGCTCAAGAACGTGCACAAACCGGCCGTATTTATATTCAAAATGTGGATCACTCCAA
CACTCATAGTTCATTTGATCCGAAAAAAGCACCGATTCATCAATCAAATCTCTGCTTGGAAATCACCCTTCCGACTCACC
CACTCAATTCAGTGGATGATCCAGAAGGTGAAATTGCCTTATGTACTTTATCGGCATTCAACTTAGGCGCATTGGAAGAC
CTTGATGAGTTGGACGAACTCTCGGATCTTATCGTTCGTGCTTTGGACAGCTTACTCGATTACCAAGACTACCCGGTTGA
AGCGGCTCGAAAAGCAAGCATGGGGCGCAGAACATTAGGCGTTGGAGTCACAAACCTGGCTTATTATTTGGCTAAAAACC
ATGTGAAGTACTCGGATGGTTCCGCCAACAACTTAGTTCACAAAGCATTTGAAGCCATTCAATATTACCTATTGAAGGCC
TCTTTAAACTTGTCAAAAGAGTACGGTAAATGTGACTTTTTTGAAGACACTAAATACGCTCAAGGCATTTTACCAATCGA
CACCTATAAAAAAGAATTGGATGAATTTTGCACTGAACCTTTGCATTACGACTGGGAAACACTTCGAAGCGAAATCCAGA
AGCATGGTTTAAGAAATTCAACCATGACAGCGTTAATGCCTTGCGAAACCTCTTCGCAAATCACCAATTCAACCAATGGA
ATTGAACCGCCACGTGGTTATGTTTCTGTTAAAGCGTCTAAGGATGGTATTTTGAAACAAGTGGTTCCAGGCTTTAAAGA
GTTTCGTGATCAATATGAGTTGCTTTGGCAAATTCCTGACAATAAAGGCTATTTACAGCTTGTCGGTATTATGCAGAAGT
TTGTGGATCAGGCTATCTCAGCAAACACAAACTATGACCCTGCTAAATTTGAAGACGGACGCGTCCCGATTAAACTGGTT
CTTCAAGATTTACTGTATGCCTATAAAGCGGGTTTAAAAACGCTTTATTACCACAACACTCGAGATGGTGCGGATGACTC
TCATGAAGACGATGGATGTGCAGGAGGTGCGTGTAAGCTCTAA

Upstream 100 bases:

>100_bases
GTATAAACACAAAAACAACCACACTATGTTAATCGCACTTATTCAAGTCCCACGACACGATACTCATTTAACCAACTGAA
ATAATTAAAGATTGCAAATT

Downstream 100 bases:

>100_bases
CGCTCAACGCACACACACATTTTCTTTATTAAAAAAGGCGCTATATGCGCCTTTTTTATTATCTGTACTCAAACCACAAC
AAGATCAAACAAACCCAGCT

Product: ribonucleotide-diphosphate reductase subunit alpha

Products: NA

Alternate protein names: Ribonucleotide reductase [H]

Number of amino acids: Translated: 760; Mature: 759

Protein sequence:

>760_residues
MSTETMNVAKRNGETEPLDLEKIHRVITWAAEGLENVSVSEVELRSHIQFYDGMKTSDIHETIIKSAADLISESAPDYQH
LAARLAIFHLRKKAFDRFTPPTLFEHVNKMVRNRLYDPQIQDDYTKAEFDELDNYIQHDRDMNFSYAAVKQLEGKYLVQN
RVTGKIYESPQFIYMLIPMSLFAHYPNDAEPGKTRLDYVKRFYDAASNFKLSLPTPIMSGVRTPTRQFSSCVLIECGDSL
DSINATSSSIVKYVSQRAGIGVNVGQIRALGSEIRGGEAYHTGMIPFIKHFQTAVKSCSQGGVRGGAATLFFPIWHLEVE
SLIVLKNNRGVEENRARHLDYGVQVNKLMYQRMIEGGNITLFSPSDVPGLYDAFFEDQEEFERLYKIYEADDTIRKKTMK
AVDLFTQVAQERAQTGRIYIQNVDHSNTHSSFDPKKAPIHQSNLCLEITLPTHPLNSVDDPEGEIALCTLSAFNLGALED
LDELDELSDLIVRALDSLLDYQDYPVEAARKASMGRRTLGVGVTNLAYYLAKNHVKYSDGSANNLVHKAFEAIQYYLLKA
SLNLSKEYGKCDFFEDTKYAQGILPIDTYKKELDEFCTEPLHYDWETLRSEIQKHGLRNSTMTALMPCETSSQITNSTNG
IEPPRGYVSVKASKDGILKQVVPGFKEFRDQYELLWQIPDNKGYLQLVGIMQKFVDQAISANTNYDPAKFEDGRVPIKLV
LQDLLYAYKAGLKTLYYHNTRDGADDSHEDDGCAGGACKL

Sequences:

>Translated_760_residues
MSTETMNVAKRNGETEPLDLEKIHRVITWAAEGLENVSVSEVELRSHIQFYDGMKTSDIHETIIKSAADLISESAPDYQH
LAARLAIFHLRKKAFDRFTPPTLFEHVNKMVRNRLYDPQIQDDYTKAEFDELDNYIQHDRDMNFSYAAVKQLEGKYLVQN
RVTGKIYESPQFIYMLIPMSLFAHYPNDAEPGKTRLDYVKRFYDAASNFKLSLPTPIMSGVRTPTRQFSSCVLIECGDSL
DSINATSSSIVKYVSQRAGIGVNVGQIRALGSEIRGGEAYHTGMIPFIKHFQTAVKSCSQGGVRGGAATLFFPIWHLEVE
SLIVLKNNRGVEENRARHLDYGVQVNKLMYQRMIEGGNITLFSPSDVPGLYDAFFEDQEEFERLYKIYEADDTIRKKTMK
AVDLFTQVAQERAQTGRIYIQNVDHSNTHSSFDPKKAPIHQSNLCLEITLPTHPLNSVDDPEGEIALCTLSAFNLGALED
LDELDELSDLIVRALDSLLDYQDYPVEAARKASMGRRTLGVGVTNLAYYLAKNHVKYSDGSANNLVHKAFEAIQYYLLKA
SLNLSKEYGKCDFFEDTKYAQGILPIDTYKKELDEFCTEPLHYDWETLRSEIQKHGLRNSTMTALMPCETSSQITNSTNG
IEPPRGYVSVKASKDGILKQVVPGFKEFRDQYELLWQIPDNKGYLQLVGIMQKFVDQAISANTNYDPAKFEDGRVPIKLV
LQDLLYAYKAGLKTLYYHNTRDGADDSHEDDGCAGGACKL
>Mature_759_residues
STETMNVAKRNGETEPLDLEKIHRVITWAAEGLENVSVSEVELRSHIQFYDGMKTSDIHETIIKSAADLISESAPDYQHL
AARLAIFHLRKKAFDRFTPPTLFEHVNKMVRNRLYDPQIQDDYTKAEFDELDNYIQHDRDMNFSYAAVKQLEGKYLVQNR
VTGKIYESPQFIYMLIPMSLFAHYPNDAEPGKTRLDYVKRFYDAASNFKLSLPTPIMSGVRTPTRQFSSCVLIECGDSLD
SINATSSSIVKYVSQRAGIGVNVGQIRALGSEIRGGEAYHTGMIPFIKHFQTAVKSCSQGGVRGGAATLFFPIWHLEVES
LIVLKNNRGVEENRARHLDYGVQVNKLMYQRMIEGGNITLFSPSDVPGLYDAFFEDQEEFERLYKIYEADDTIRKKTMKA
VDLFTQVAQERAQTGRIYIQNVDHSNTHSSFDPKKAPIHQSNLCLEITLPTHPLNSVDDPEGEIALCTLSAFNLGALEDL
DELDELSDLIVRALDSLLDYQDYPVEAARKASMGRRTLGVGVTNLAYYLAKNHVKYSDGSANNLVHKAFEAIQYYLLKAS
LNLSKEYGKCDFFEDTKYAQGILPIDTYKKELDEFCTEPLHYDWETLRSEIQKHGLRNSTMTALMPCETSSQITNSTNGI
EPPRGYVSVKASKDGILKQVVPGFKEFRDQYELLWQIPDNKGYLQLVGIMQKFVDQAISANTNYDPAKFEDGRVPIKLVL
QDLLYAYKAGLKTLYYHNTRDGADDSHEDDGCAGGACKL

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=788, Percent_Identity=28.2994923857868, Blast_Score=261, Evalue=2e-69,
Organism=Escherichia coli, GI2367133, Length=764, Percent_Identity=72.9057591623037, Blast_Score=1186, Evalue=0.0,
Organism=Escherichia coli, GI1789030, Length=584, Percent_Identity=25.6849315068493, Blast_Score=160, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI17555242, Length=784, Percent_Identity=28.3163265306122, Blast_Score=263, Evalue=2e-70,
Organism=Saccharomyces cerevisiae, GI6320914, Length=791, Percent_Identity=29.456384323641, Blast_Score=278, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6322123, Length=789, Percent_Identity=29.1508238276299, Blast_Score=276, Evalue=8e-75,
Organism=Drosophila melanogaster, GI17352481, Length=793, Percent_Identity=27.4905422446406, Blast_Score=268, Evalue=9e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013346
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 85938; Mature: 85807

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS51161 ATP_CONE ; PS00089 RIBORED_LARGE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTETMNVAKRNGETEPLDLEKIHRVITWAAEGLENVSVSEVELRSHIQFYDGMKTSDIH
CCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHH
ETIIKSAADLISESAPDYQHLAARLAIFHLRKKAFDRFTPPTLFEHVNKMVRNRLYDPQI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
QDDYTKAEFDELDNYIQHDRDMNFSYAAVKQLEGKYLVQNRVTGKIYESPQFIYMLIPMS
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEHHCCCCEEECCCCEEEHHHHHH
LFAHYPNDAEPGKTRLDYVKRFYDAASNFKLSLPTPIMSGVRTPTRQFSSCVLIECGDSL
HHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCHHHHCCCCCHHHHCCEEEEEECCCC
DSINATSSSIVKYVSQRAGIGVNVGQIRALGSEIRGGEAYHTGMIPFIKHFQTAVKSCSQ
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHC
GGVRGGAATLFFPIWHLEVESLIVLKNNRGVEENRARHLDYGVQVNKLMYQRMIEGGNIT
CCCCCCCCEEEHHHHHEEEEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEE
LFSPSDVPGLYDAFFEDQEEFERLYKIYEADDTIRKKTMKAVDLFTQVAQERAQTGRIYI
EECCCCCCHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
QNVDHSNTHSSFDPKKAPIHQSNLCLEITLPTHPLNSVDDPEGEIALCTLSAFNLGALED
EECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCHHH
LDELDELSDLIVRALDSLLDYQDYPVEAARKASMGRRTLGVGVTNLAYYLAKNHVKYSDG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHCCCHHHHHHHHHHCCEEECCC
SANNLVHKAFEAIQYYLLKASLNLSKEYGKCDFFEDTKYAQGILPIDTYKKELDEFCTEP
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCC
LHYDWETLRSEIQKHGLRNSTMTALMPCETSSQITNSTNGIEPPRGYVSVKASKDGILKQ
CCCCHHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCEEEECCCCCHHHH
VVPGFKEFRDQYELLWQIPDNKGYLQLVGIMQKFVDQAISANTNYDPAKFEDGRVPIKLV
HHCCHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LQDLLYAYKAGLKTLYYHNTRDGADDSHEDDGCAGGACKL
HHHHHHHHHHCCHHEEEECCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
STETMNVAKRNGETEPLDLEKIHRVITWAAEGLENVSVSEVELRSHIQFYDGMKTSDIH
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCHHHH
ETIIKSAADLISESAPDYQHLAARLAIFHLRKKAFDRFTPPTLFEHVNKMVRNRLYDPQI
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCC
QDDYTKAEFDELDNYIQHDRDMNFSYAAVKQLEGKYLVQNRVTGKIYESPQFIYMLIPMS
CCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEHHCCCCEEECCCCEEEHHHHHH
LFAHYPNDAEPGKTRLDYVKRFYDAASNFKLSLPTPIMSGVRTPTRQFSSCVLIECGDSL
HHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEECCCHHHHCCCCCHHHHCCEEEEEECCCC
DSINATSSSIVKYVSQRAGIGVNVGQIRALGSEIRGGEAYHTGMIPFIKHFQTAVKSCSQ
CCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHC
GGVRGGAATLFFPIWHLEVESLIVLKNNRGVEENRARHLDYGVQVNKLMYQRMIEGGNIT
CCCCCCCCEEEHHHHHEEEEEEEEEECCCCCCHHHHHHHHCCCHHHHHHHHHHHCCCCEE
LFSPSDVPGLYDAFFEDQEEFERLYKIYEADDTIRKKTMKAVDLFTQVAQERAQTGRIYI
EECCCCCCHHHHHHHCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCEEEE
QNVDHSNTHSSFDPKKAPIHQSNLCLEITLPTHPLNSVDDPEGEIALCTLSAFNLGALED
EECCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCCEEEEEECCCCCCCHHH
LDELDELSDLIVRALDSLLDYQDYPVEAARKASMGRRTLGVGVTNLAYYLAKNHVKYSDG
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCHHHCCCHHHHHHHHHHCCEEECCC
SANNLVHKAFEAIQYYLLKASLNLSKEYGKCDFFEDTKYAQGILPIDTYKKELDEFCTEP
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHCCCCCHHHHHHHHHHHHCCC
LHYDWETLRSEIQKHGLRNSTMTALMPCETSSQITNSTNGIEPPRGYVSVKASKDGILKQ
CCCCHHHHHHHHHHCCCCCCCCEEEECCCCCHHHCCCCCCCCCCCCCEEEECCCCCHHHH
VVPGFKEFRDQYELLWQIPDNKGYLQLVGIMQKFVDQAISANTNYDPAKFEDGRVPIKLV
HHCCHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHH
LQDLLYAYKAGLKTLYYHNTRDGADDSHEDDGCAGGACKL
HHHHHHHHHHCCHHEEEECCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]