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The map label for this gene is pdxB

Identifier: 78484796

GI number: 78484796

Start: 505036

End: 506163

Strand: Reverse

Name: pdxB

Synonym: Tcr_0451

Alternate gene names: 78484796

Gene position: 506163-505036 (Counterclockwise)

Preceding gene: 78484801

Following gene: 78484795

Centisome position: 20.85

GC content: 43.71

Gene sequence:

>1128_bases
ATGACACCAAGCCGAACGTTAGTAATAGACGATGCCGTTCCTTATGCCAAAGAGCTGTTTTCTCATCTGGGAAACGTTAT
CTCTCTACCAGGAAAAGAAATCAACACAGAGCATCTTCAAAATGCAGATGCCTTGATTGTCCGTTCACGAACCCAAGTCA
ATTCGGCTTTATTGGAACACACGAACGTTTCCTTTGTTGGCAGCACTGTCGTGGGTTTAGACCATGTAGATCAACCCTAT
TTAAAAGAAAACGCCATTGAATTTTATTCAGCACAAGGATGCAATGCCAATTCTGTGTCTGAATATGTCATAACCAATCT
TGTTAATTTGGCGATTGAAAAAAAATTTACGTTATCCGAAAAAAGTTTGGCCATTATTGGTGTCGGCCACGTAGGTAAGC
TGGTGGAAAAGAAAGCCCGCGCTCTTGGCATGACCGTCTTACTCAATGACCCGCCTAGAGCTCGACAAGAAATGTCTGAC
GAGTTCATTGACTTAGACAACGCGCTTAAATCAGACATTATCACTGTACACACACCGCTTACAAAAACAGGCCAAGATGC
GACTTTTCACCTTCTATCCACTGACAAACTTAAAAAAATCCAACCACATCAAATTCTGATCAACGCCGCTCGCGGTGGGA
TTATTGATGAACAAGCCTGGATCAACACACCGACTGAAAGCAATATTATTGACTGCTGGGAAAATGAACCCAATATCAAT
CCTGACCTATACAATCAAGCAGACATTGCAACACCCCATATTGCCGGCCATGCTCTAGATGCCAAGATTGCAGGAAGCGA
AATGGTTTATCGAGCACTTTGTCAACATTGGCAAATCTCTCCTGATGACAGCTGGCGCCGGTTCTTACCCCCTCCACCGC
CACCAATATCGCTTTCATTGACAGGCAATCACCAGGAAGATATTCATAACGTATTACAACAATGCTACCGCCCGGAAGAG
GACGATGCCGCCATTAGAGCTAATAACATTGTAGTCACCCATAAAAAATATGAATACTACCGAAGACACTATCCTATTCA
CCGAGAGTGGCCTCAACACAGGGTCATTAAAACGCCCGACCCAACCTTCAATAACCTTCTGTATTCCCTTGGGTTTCAGC
TTATTTGA

Upstream 100 bases:

>100_bases
AAAAGGCTTGATACAATATAGTGTAATCAAGTCATTAACGACTTCAAACCATTTAATCGATTAAATGACTCTTTAATTTT
CTAATTTTAAACAGGTTCCC

Downstream 100 bases:

>100_bases
ACCCACGACAAATAAACATTTAATAAAAGAATTATATTAGTAAGTGATAATGTGTATAAAAGAAAGTTATCAGACCACAA
AAAAATTAATTTTTATTTTA

Product: D-isomer specific 2-hydroxyacid dehydrogenase, NAD-binding

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MTPSRTLVIDDAVPYAKELFSHLGNVISLPGKEINTEHLQNADALIVRSRTQVNSALLEHTNVSFVGSTVVGLDHVDQPY
LKENAIEFYSAQGCNANSVSEYVITNLVNLAIEKKFTLSEKSLAIIGVGHVGKLVEKKARALGMTVLLNDPPRARQEMSD
EFIDLDNALKSDIITVHTPLTKTGQDATFHLLSTDKLKKIQPHQILINAARGGIIDEQAWINTPTESNIIDCWENEPNIN
PDLYNQADIATPHIAGHALDAKIAGSEMVYRALCQHWQISPDDSWRRFLPPPPPPISLSLTGNHQEDIHNVLQQCYRPEE
DDAAIRANNIVVTHKKYEYYRRHYPIHREWPQHRVIKTPDPTFNNLLYSLGFQLI

Sequences:

>Translated_375_residues
MTPSRTLVIDDAVPYAKELFSHLGNVISLPGKEINTEHLQNADALIVRSRTQVNSALLEHTNVSFVGSTVVGLDHVDQPY
LKENAIEFYSAQGCNANSVSEYVITNLVNLAIEKKFTLSEKSLAIIGVGHVGKLVEKKARALGMTVLLNDPPRARQEMSD
EFIDLDNALKSDIITVHTPLTKTGQDATFHLLSTDKLKKIQPHQILINAARGGIIDEQAWINTPTESNIIDCWENEPNIN
PDLYNQADIATPHIAGHALDAKIAGSEMVYRALCQHWQISPDDSWRRFLPPPPPPISLSLTGNHQEDIHNVLQQCYRPEE
DDAAIRANNIVVTHKKYEYYRRHYPIHREWPQHRVIKTPDPTFNNLLYSLGFQLI
>Mature_374_residues
TPSRTLVIDDAVPYAKELFSHLGNVISLPGKEINTEHLQNADALIVRSRTQVNSALLEHTNVSFVGSTVVGLDHVDQPYL
KENAIEFYSAQGCNANSVSEYVITNLVNLAIEKKFTLSEKSLAIIGVGHVGKLVEKKARALGMTVLLNDPPRARQEMSDE
FIDLDNALKSDIITVHTPLTKTGQDATFHLLSTDKLKKIQPHQILINAARGGIIDEQAWINTPTESNIIDCWENEPNINP
DLYNQADIATPHIAGHALDAKIAGSEMVYRALCQHWQISPDDSWRRFLPPPPPPISLSLTGNHQEDIHNVLQQCYRPEED
DAAIRANNIVVTHKKYEYYRRHYPIHREWPQHRVIKTPDPTFNNLLYSLGFQLI

Specific function: Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. PdxB subfamily

Homologues:

Organism=Homo sapiens, GI23308577, Length=259, Percent_Identity=26.2548262548263, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788660, Length=378, Percent_Identity=37.3015873015873, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1787645, Length=207, Percent_Identity=25.1207729468599, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1789279, Length=259, Percent_Identity=25.4826254826255, Blast_Score=69, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=292, Percent_Identity=26.7123287671233, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6320925, Length=293, Percent_Identity=27.6450511945392, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6322116, Length=293, Percent_Identity=27.3037542662116, Blast_Score=83, Evalue=7e-17,
Organism=Saccharomyces cerevisiae, GI6324055, Length=159, Percent_Identity=26.4150943396226, Blast_Score=70, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19921140, Length=295, Percent_Identity=27.1186440677966, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXB_THICR (Q31IH6)

Other databases:

- EMBL:   CP000109
- RefSeq:   YP_390721.1
- ProteinModelPortal:   Q31IH6
- SMR:   Q31IH6
- STRING:   Q31IH6
- GeneID:   3761478
- GenomeReviews:   CP000109_GR
- KEGG:   tcx:Tcr_0451
- NMPDR:   fig|317025.3.peg.629
- eggNOG:   COG0111
- HOGENOM:   HBG289972
- OMA:   SAPGCNA
- PhylomeDB:   Q31IH6
- ProtClustDB:   CLSK842706
- BioCyc:   TCRU317025:TCR_0451-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01825
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR020921
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR10996:SF4

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C

EC number: =1.1.1.290

Molecular weight: Translated: 42174; Mature: 42043

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1; PS00670 D_2_HYDROXYACID_DH_2; PS00671 D_2_HYDROXYACID_DH_3

Important sites: ACT_SITE 211-211 ACT_SITE 236-236 ACT_SITE 253-253 BINDING 49-49 BINDING 150-150 BINDING 178-178 BINDING 231-231 BINDING 256-256

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSRTLVIDDAVPYAKELFSHLGNVISLPGKEINTEHLQNADALIVRSRTQVNSALLEH
CCCCCEEEEECCCHHHHHHHHHHCCEEECCCCCCCHHHHCCCCEEEEECHHHHHHHHHHH
TNVSFVGSTVVGLDHVDQPYLKENAIEFYSAQGCNANSVSEYVITNLVNLAIEKKFTLSE
CCCEEECCEEECCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCEEECC
KSLAIIGVGHVGKLVEKKARALGMTVLLNDPPRARQEMSDEFIDLDNALKSDIITVHTPL
CCEEEEECCHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHCEEEEECCC
TKTGQDATFHLLSTDKLKKIQPHQILINAARGGIIDEQAWINTPTESNIIDCWENEPNIN
CCCCCCCEEEEECCCCHHHCCCHHEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCC
PDLYNQADIATPHIAGHALDAKIAGSEMVYRALCQHWQISPDDSWRRFLPPPPPPISLSL
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEE
TGNHQEDIHNVLQQCYRPEEDDAAIRANNIVVTHKKYEYYRRHYPIHREWPQHRVIKTPD
CCCCHHHHHHHHHHHCCCCCCCCEEEECCEEEECHHHHHHHHCCCCCCCCCCCCCCCCCC
PTFNNLLYSLGFQLI
CCHHHHHHHHCCCCC
>Mature Secondary Structure 
TPSRTLVIDDAVPYAKELFSHLGNVISLPGKEINTEHLQNADALIVRSRTQVNSALLEH
CCCCEEEEECCCHHHHHHHHHHCCEEECCCCCCCHHHHCCCCEEEEECHHHHHHHHHHH
TNVSFVGSTVVGLDHVDQPYLKENAIEFYSAQGCNANSVSEYVITNLVNLAIEKKFTLSE
CCCEEECCEEECCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCEEECC
KSLAIIGVGHVGKLVEKKARALGMTVLLNDPPRARQEMSDEFIDLDNALKSDIITVHTPL
CCEEEEECCHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHCEEEEECCC
TKTGQDATFHLLSTDKLKKIQPHQILINAARGGIIDEQAWINTPTESNIIDCWENEPNIN
CCCCCCCEEEEECCCCHHHCCCHHEEEECCCCCCCCCCCCCCCCCCCCEEECCCCCCCCC
PDLYNQADIATPHIAGHALDAKIAGSEMVYRALCQHWQISPDDSWRRFLPPPPPPISLSL
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEE
TGNHQEDIHNVLQQCYRPEEDDAAIRANNIVVTHKKYEYYRRHYPIHREWPQHRVIKTPD
CCCCHHHHHHHHHHHCCCCCCCCEEEECCEEEECHHHHHHHHCCCCCCCCCCCCCCCCCC
PTFNNLLYSLGFQLI
CCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA