Click here to switch to the map view.

The map label for this gene is accB [H]

Identifier: 78484789

GI number: 78484789

Start: 497203

End: 497658

Strand: Reverse

Name: accB [H]

Synonym: Tcr_0444

Alternate gene names: 78484789

Gene position: 497658-497203 (Counterclockwise)

Preceding gene: 78484790

Following gene: 78484788

Centisome position: 20.5

GC content: 47.59

Gene sequence:

>456_bases
ATGGATATTCGTTCAATTCGTAAATTGATTGAAATTGTAGAACAGTCTGACGTTGCTGAAATTGAAATTAAAGAAGGTGA
GCACAACATTCGCATCACTCGCAGCAAAGAGCCTGTCATGATGTCTGCGCCTGCGGCACCAGCACAAATGGCTTATGAAG
CAGCGCCATCTGCAGCCCCACAACCTGCGGCGGCCCCTGCAGAAGCTCCAGCCGCCGAAACAGGTCATACGGTTCCCTCA
CCAATGGTGGGCACATTTTACGCCTCACCTTCTCCGGATGCCGGTCCATTTGTAAGCGTGGGTGACCAAGTTTCAGCAGG
TGACACTCTTTGTATTATTGAAGCGATGAAAATCATGAACCCAATTGAAGCAGATGTTTCTGGAACCGTGAAGAAAATTC
TTGCTCAGAACGCTGAACCTGTTGAGTTCGGTCAAGCTTTATTCATCATCGAATAA

Upstream 100 bases:

>100_bases
CTAGGTCCAATCGGCTACCAGCTCGCACTGGCCGCCGCAGTTGAAAAACTGAAATAAAAAAATACATTTAAATAACGACT
ATTTAAGAGGAATAGAGAAC

Downstream 100 bases:

>100_bases
TAGGATACCCTGCATGATTGAAAAAATTCTGATTGCCAACCGCGGAGAAATCGCACTACGCGTGCTAAGAGCCTGTAAAG
AAATGGGCATCAAAACGGTC

Product: acetyl-CoA carboxylase, biotin carboxyl carrier protein

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP [H]

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MDIRSIRKLIEIVEQSDVAEIEIKEGEHNIRITRSKEPVMMSAPAAPAQMAYEAAPSAAPQPAAAPAEAPAAETGHTVPS
PMVGTFYASPSPDAGPFVSVGDQVSAGDTLCIIEAMKIMNPIEADVSGTVKKILAQNAEPVEFGQALFIIE

Sequences:

>Translated_151_residues
MDIRSIRKLIEIVEQSDVAEIEIKEGEHNIRITRSKEPVMMSAPAAPAQMAYEAAPSAAPQPAAAPAEAPAAETGHTVPS
PMVGTFYASPSPDAGPFVSVGDQVSAGDTLCIIEAMKIMNPIEADVSGTVKKILAQNAEPVEFGQALFIIE
>Mature_151_residues
MDIRSIRKLIEIVEQSDVAEIEIKEGEHNIRITRSKEPVMMSAPAAPAQMAYEAAPSAAPQPAAAPAEAPAAETGHTVPS
PMVGTFYASPSPDAGPFVSVGDQVSAGDTLCIIEAMKIMNPIEADVSGTVKKILAQNAEPVEFGQALFIIE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789653, Length=158, Percent_Identity=56.9620253164557, Blast_Score=163, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl [H]

EC number: NA

Molecular weight: Translated: 15856; Mature: 15856

Theoretical pI: Translated: 4.19; Mature: 4.19

Prosite motif: PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRSIRKLIEIVEQSDVAEIEIKEGEHNIRITRSKEPVMMSAPAAPAQMAYEAAPSAAP
CCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCEEEECCCCCHHHHHHCCCCCCC
QPAAAPAEAPAAETGHTVPSPMVGTFYASPSPDAGPFVSVGDQVSAGDTLCIIEAMKIMN
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHC
PIEADVSGTVKKILAQNAEPVEFGQALFIIE
CCCCCHHHHHHHHHHCCCCCCCCCCEEEEEC
>Mature Secondary Structure
MDIRSIRKLIEIVEQSDVAEIEIKEGEHNIRITRSKEPVMMSAPAAPAQMAYEAAPSAAP
CCHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCEEEECCCCCHHHHHHCCCCCCC
QPAAAPAEAPAAETGHTVPSPMVGTFYASPSPDAGPFVSVGDQVSAGDTLCIIEAMKIMN
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHC
PIEADVSGTVKKILAQNAEPVEFGQALFIIE
CCCCCHHHHHHHHHHCCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]