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The map label for this gene is accC [H]

Identifier: 78484788

GI number: 78484788

Start: 495840

End: 497189

Strand: Reverse

Name: accC [H]

Synonym: Tcr_0443

Alternate gene names: 78484788

Gene position: 497189-495840 (Counterclockwise)

Preceding gene: 78484789

Following gene: 78484787

Centisome position: 20.48

GC content: 46.52

Gene sequence:

>1350_bases
ATGATTGAAAAAATTCTGATTGCCAACCGCGGAGAAATCGCACTACGCGTGCTAAGAGCCTGTAAAGAAATGGGCATCAA
AACGGTCGCAGTCCACTCCACAGCCGATGCTAACCTAAAACATGTCTTGCTAGCAGACGAATCTGTTTGCATTGGGCCTG
CACCGTCTTCTGAAAGTTACCTGAACATTCCGGCCATTATTTCAGCCGCTGAAATCACGGATGCCGAAGCCATCCACCCA
GGATATGGTTTTCTATCCGAAAATGCCGACTTTGCCGAGCGCGTTGAAGAAAGCGGTTTTATCTTTATGGGCCCAAAGGC
TGAAACAATCCGCATCATGGGTGACAAAGTGTCCGCTATCCGCGCAATGAAAGCGGCAGGTGTCCCGACCGTTCCAGGCT
CCGGCGGCCCATTAAGCGATGACGAAGAAGCCAATAAACAACTGGCTAAAGAAATTGGTTACCCAATTATCATCAAAGCT
TCCGGTGGCGGCGGCGGACGTGGTATGCGCGTCGTTCATACCGAATCAAACCTGATCAAATCAATTCAATTGACTAAGTC
AGAAGCCGGCAGCTTCTTTGGTAACCCAGAAGTTTATATGGAAAAATTCCTGGAAACACCTCGTCACATTGAAATTCAAG
TATTGGCGGATGGTCAGGGCAATGCCATTCATTTAGGTGAACGTGACTGCTCAATGCAGCGTCGCCACCAAAAAGTGGTT
GAAGAAGCCCCAGCACCAGGCATTACCGAAGAACAACGTAACCGTATCGGTCAAGCTTGTGTAAATGCCTGTCTTGAAAT
CGGCTATCGTGGTGCGGGAACCTTTGAGTTTTTATATGAAAACGGCGAGTTCTACTTCATCGAAATGAATACCCGCTTAC
AGGTTGAACACCCCGTTACTGAACAAGTCACCGGTGTCGATTTGGTTAAAGCACAAATTGAAGTTGCAATGGGGAAACCG
TTGAGCATTAAGCAAGAAGACATCATCATTCGTGGACACGCCATTGAGTGTCGTATCAATGCTGAAAACCCTTCTAAAAA
CTTCATTCCTTCTCCAGGCAAAATTGAACGTTTGCACTTGGCCGGCGGAATTGGTGTTCGTTGGGATTCTCATATTTATA
CAGGCTACCCAGTGCCACCTCATTACGATTCTATGATTGGTAAACTAATTTGTTATGGCCCAGATCGTACGTCAGCGATC
GCACGCATGGACACGGCTTTGGACGAACTGATTATTCAAGGAATCGAAACCAATATTCGCATGCAACGCGAAATCATGAA
TGACTTCGGGTTCTGTGAAGGTGAACAAAATATTCATTATTTAGAGCACCGCTTGGAACATCTCGTTTAG

Upstream 100 bases:

>100_bases
GCAGATGTTTCTGGAACCGTGAAGAAAATTCTTGCTCAGAACGCTGAACCTGTTGAGTTCGGTCAAGCTTTATTCATCAT
CGAATAATAGGATACCCTGC

Downstream 100 bases:

>100_bases
ACTCGAGTTTTCACACAAACCCACTGACATCAACCACGTTGAGCCTATAATGCAATTTATCGGCCACGTGGTTTTTACGT
TTAAAGGACCCATATGGCCT

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MIEKILIANRGEIALRVLRACKEMGIKTVAVHSTADANLKHVLLADESVCIGPAPSSESYLNIPAIISAAEITDAEAIHP
GYGFLSENADFAERVEESGFIFMGPKAETIRIMGDKVSAIRAMKAAGVPTVPGSGGPLSDDEEANKQLAKEIGYPIIIKA
SGGGGGRGMRVVHTESNLIKSIQLTKSEAGSFFGNPEVYMEKFLETPRHIEIQVLADGQGNAIHLGERDCSMQRRHQKVV
EEAPAPGITEEQRNRIGQACVNACLEIGYRGAGTFEFLYENGEFYFIEMNTRLQVEHPVTEQVTGVDLVKAQIEVAMGKP
LSIKQEDIIIRGHAIECRINAENPSKNFIPSPGKIERLHLAGGIGVRWDSHIYTGYPVPPHYDSMIGKLICYGPDRTSAI
ARMDTALDELIIQGIETNIRMQREIMNDFGFCEGEQNIHYLEHRLEHLV

Sequences:

>Translated_449_residues
MIEKILIANRGEIALRVLRACKEMGIKTVAVHSTADANLKHVLLADESVCIGPAPSSESYLNIPAIISAAEITDAEAIHP
GYGFLSENADFAERVEESGFIFMGPKAETIRIMGDKVSAIRAMKAAGVPTVPGSGGPLSDDEEANKQLAKEIGYPIIIKA
SGGGGGRGMRVVHTESNLIKSIQLTKSEAGSFFGNPEVYMEKFLETPRHIEIQVLADGQGNAIHLGERDCSMQRRHQKVV
EEAPAPGITEEQRNRIGQACVNACLEIGYRGAGTFEFLYENGEFYFIEMNTRLQVEHPVTEQVTGVDLVKAQIEVAMGKP
LSIKQEDIIIRGHAIECRINAENPSKNFIPSPGKIERLHLAGGIGVRWDSHIYTGYPVPPHYDSMIGKLICYGPDRTSAI
ARMDTALDELIIQGIETNIRMQREIMNDFGFCEGEQNIHYLEHRLEHLV
>Mature_449_residues
MIEKILIANRGEIALRVLRACKEMGIKTVAVHSTADANLKHVLLADESVCIGPAPSSESYLNIPAIISAAEITDAEAIHP
GYGFLSENADFAERVEESGFIFMGPKAETIRIMGDKVSAIRAMKAAGVPTVPGSGGPLSDDEEANKQLAKEIGYPIIIKA
SGGGGGRGMRVVHTESNLIKSIQLTKSEAGSFFGNPEVYMEKFLETPRHIEIQVLADGQGNAIHLGERDCSMQRRHQKVV
EEAPAPGITEEQRNRIGQACVNACLEIGYRGAGTFEFLYENGEFYFIEMNTRLQVEHPVTEQVTGVDLVKAQIEVAMGKP
LSIKQEDIIIRGHAIECRINAENPSKNFIPSPGKIERLHLAGGIGVRWDSHIYTGYPVPPHYDSMIGKLICYGPDRTSAI
ARMDTALDELIIQGIETNIRMQREIMNDFGFCEGEQNIHYLEHRLEHLV

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI65506442, Length=446, Percent_Identity=51.3452914798206, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI189095269, Length=446, Percent_Identity=51.3452914798206, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI295821183, Length=446, Percent_Identity=51.3452914798206, Blast_Score=431, Evalue=1e-121,
Organism=Homo sapiens, GI116805327, Length=443, Percent_Identity=47.8555304740406, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI106049528, Length=451, Percent_Identity=46.5631929046563, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI106049295, Length=451, Percent_Identity=46.5631929046563, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI106049292, Length=451, Percent_Identity=46.5631929046563, Blast_Score=394, Evalue=1e-110,
Organism=Homo sapiens, GI38679974, Length=474, Percent_Identity=34.3881856540084, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI38679971, Length=474, Percent_Identity=34.3881856540084, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI38679960, Length=474, Percent_Identity=34.3881856540084, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI38679977, Length=474, Percent_Identity=34.3881856540084, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI38679967, Length=474, Percent_Identity=34.3881856540084, Blast_Score=263, Evalue=2e-70,
Organism=Homo sapiens, GI134142062, Length=510, Percent_Identity=32.3529411764706, Blast_Score=248, Evalue=6e-66,
Organism=Escherichia coli, GI1789654, Length=445, Percent_Identity=74.1573033707865, Blast_Score=665, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=239, Percent_Identity=25.5230125523013, Blast_Score=80, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=47.1783295711061, Blast_Score=400, Evalue=1e-112,
Organism=Caenorhabditis elegans, GI71987519, Length=449, Percent_Identity=46.5478841870824, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17562816, Length=451, Percent_Identity=44.3458980044346, Blast_Score=361, Evalue=1e-100,
Organism=Caenorhabditis elegans, GI71997168, Length=513, Percent_Identity=30.4093567251462, Blast_Score=212, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71997163, Length=513, Percent_Identity=30.4093567251462, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI133931226, Length=495, Percent_Identity=29.6969696969697, Blast_Score=211, Evalue=6e-55,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=41.7607223476298, Blast_Score=358, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6319695, Length=447, Percent_Identity=45.8612975391499, Blast_Score=355, Evalue=1e-98,
Organism=Saccharomyces cerevisiae, GI6321376, Length=447, Percent_Identity=46.9798657718121, Blast_Score=346, Evalue=4e-96,
Organism=Saccharomyces cerevisiae, GI6324343, Length=515, Percent_Identity=32.4271844660194, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6323863, Length=437, Percent_Identity=33.8672768878719, Blast_Score=233, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24651757, Length=421, Percent_Identity=47.7434679334917, Blast_Score=395, Evalue=1e-110,
Organism=Drosophila melanogaster, GI281363050, Length=447, Percent_Identity=47.8747203579418, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652224, Length=447, Percent_Identity=47.8747203579418, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652222, Length=447, Percent_Identity=47.8747203579418, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652220, Length=447, Percent_Identity=47.8747203579418, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652218, Length=447, Percent_Identity=47.8747203579418, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652212, Length=447, Percent_Identity=47.8747203579418, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652210, Length=447, Percent_Identity=47.8747203579418, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652214, Length=447, Percent_Identity=47.8747203579418, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI19921944, Length=447, Percent_Identity=47.8747203579418, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24652216, Length=447, Percent_Identity=47.8747203579418, Blast_Score=392, Evalue=1e-109,
Organism=Drosophila melanogaster, GI24651759, Length=384, Percent_Identity=46.875, Blast_Score=354, Evalue=6e-98,
Organism=Drosophila melanogaster, GI161076407, Length=469, Percent_Identity=32.6226012793177, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24586460, Length=469, Percent_Identity=32.6226012793177, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI161076409, Length=469, Percent_Identity=32.6226012793177, Blast_Score=235, Evalue=4e-62,
Organism=Drosophila melanogaster, GI24586458, Length=469, Percent_Identity=32.6226012793177, Blast_Score=235, Evalue=5e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49315; Mature: 49315

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEKILIANRGEIALRVLRACKEMGIKTVAVHSTADANLKHVLLADESVCIGPAPSSESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCEEECCCCCCCCE
LNIPAIISAAEITDAEAIHPGYGFLSENADFAERVEESGFIFMGPKAETIRIMGDKVSAI
EECHHHEEEHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCHHHHH
RAMKAAGVPTVPGSGGPLSDDEEANKQLAKEIGYPIIIKASGGGGGRGMRVVHTESNLIK
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCHHHH
SIQLTKSEAGSFFGNPEVYMEKFLETPRHIEIQVLADGQGNAIHLGERDCSMQRRHQKVV
HHEEEHHHCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGITEEQRNRIGQACVNACLEIGYRGAGTFEFLYENGEFYFIEMNTRLQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCCH
EQVTGVDLVKAQIEVAMGKPLSIKQEDIIIRGHAIECRINAENPSKNFIPSPGKIERLHL
HHHCCHHHHHEEHHHCCCCCCCCCCCCEEEECEEEEEEEECCCCCCCCCCCCCCEEEEEE
AGGIGVRWDSHIYTGYPVPPHYDSMIGKLICYGPDRTSAIARMDTALDELIIQGIETNIR
ECCCCCEECCEEEECCCCCCCHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHH
MQREIMNDFGFCEGEQNIHYLEHRLEHLV
HHHHHHHHCCCCCCCCCHHHHHHHHHHCC
>Mature Secondary Structure
MIEKILIANRGEIALRVLRACKEMGIKTVAVHSTADANLKHVLLADESVCIGPAPSSESY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEEEECCCEEECCCCCCCCE
LNIPAIISAAEITDAEAIHPGYGFLSENADFAERVEESGFIFMGPKAETIRIMGDKVSAI
EECHHHEEEHHCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEECCCCCEEEEECCHHHHH
RAMKAAGVPTVPGSGGPLSDDEEANKQLAKEIGYPIIIKASGGGGGRGMRVVHTESNLIK
HHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECCCHHHH
SIQLTKSEAGSFFGNPEVYMEKFLETPRHIEIQVLADGQGNAIHLGERDCSMQRRHQKVV
HHEEEHHHCCCCCCCHHHHHHHHHCCCCEEEEEEEECCCCCEEEECCCCHHHHHHHHHHH
EEAPAPGITEEQRNRIGQACVNACLEIGYRGAGTFEFLYENGEFYFIEMNTRLQVEHPVT
HHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEEEEECCEEEECCCCH
EQVTGVDLVKAQIEVAMGKPLSIKQEDIIIRGHAIECRINAENPSKNFIPSPGKIERLHL
HHHCCHHHHHEEHHHCCCCCCCCCCCCEEEECEEEEEEEECCCCCCCCCCCCCCEEEEEE
AGGIGVRWDSHIYTGYPVPPHYDSMIGKLICYGPDRTSAIARMDTALDELIIQGIETNIR
ECCCCCEECCEEEECCCCCCCHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCHH
MQREIMNDFGFCEGEQNIHYLEHRLEHLV
HHHHHHHHCCCCCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]