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The map label for this gene is hisI

Identifier: 78484562

GI number: 78484562

Start: 256978

End: 257421

Strand: Reverse

Name: hisI

Synonym: Tcr_0217

Alternate gene names: 78484562

Gene position: 257421-256978 (Counterclockwise)

Preceding gene: 78484563

Following gene: 78484557

Centisome position: 10.6

GC content: 44.37

Gene sequence:

>444_bases
ATGTCACAACAACTCACATTCAAACAACTGGAAAAAGCGCAACAAGGCGATTCGTTTGACTGGGAAGCCGTTAAGAAACA
AGTCAAATATGATGATAATGGTCTGATTCCAGCCATTGCGCAGCAATTCGACAGCAAAGAAGTCTTAATGATGGCTTGGA
TGAATGAAGCTGCGTTGCAAGAAACCTTGGAAACCGGACGTGTCTGTTACTGGTCACGTTCACGTCAGTCTTACTGGCGT
AAAGGGGAAGAATCCGGGCAAATTCAGCTTTTAAAAGACTTACGTTTTGACTGTGACGGCGATGCGATTCTACTGTTGGT
GGATCAAACAGGTCCAGCCTGCCATACCGGACGTAAAAGCTGTTTTTACACCGCCATTCATGACCATCAGGCCAAAATCT
TAACCAACCCGATTATTGACCCTGAAGCGTTGTACAAAAAATAA

Upstream 100 bases:

>100_bases
AGATTAAAAAACCTGAGCCGGTGAAAGATGAAATTTCGAACAACCCATTTGCGCAGGCTTTTGCCGCCGCCAAACGTAAG
TCGAAATAACACGAGTCCTT

Downstream 100 bases:

>100_bases
CCATTTTCTGAATCAAAAAAATGGCCAGGCCTGGTCATTTTTCATTAATGTTCAAACGCTTAATCTTCCAGCTTGACCTC
AAATAATTCGCGCATCACCA

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 147; Mature: 146

Protein sequence:

>147_residues
MSQQLTFKQLEKAQQGDSFDWEAVKKQVKYDDNGLIPAIAQQFDSKEVLMMAWMNEAALQETLETGRVCYWSRSRQSYWR
KGEESGQIQLLKDLRFDCDGDAILLLVDQTGPACHTGRKSCFYTAIHDHQAKILTNPIIDPEALYKK

Sequences:

>Translated_147_residues
MSQQLTFKQLEKAQQGDSFDWEAVKKQVKYDDNGLIPAIAQQFDSKEVLMMAWMNEAALQETLETGRVCYWSRSRQSYWR
KGEESGQIQLLKDLRFDCDGDAILLLVDQTGPACHTGRKSCFYTAIHDHQAKILTNPIIDPEALYKK
>Mature_146_residues
SQQLTFKQLEKAQQGDSFDWEAVKKQVKYDDNGLIPAIAQQFDSKEVLMMAWMNEAALQETLETGRVCYWSRSRQSYWRK
GEESGQIQLLKDLRFDCDGDAILLLVDQTGPACHTGRKSCFYTAIHDHQAKILTNPIIDPEALYKK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=114, Percent_Identity=42.1052631578947, Blast_Score=101, Evalue=3e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_THICR (Q31J60)

Other databases:

- EMBL:   CP000109
- RefSeq:   YP_390487.1
- ProteinModelPortal:   Q31J60
- SMR:   Q31J60
- STRING:   Q31J60
- GeneID:   3761656
- GenomeReviews:   CP000109_GR
- KEGG:   tcx:Tcr_0217
- NMPDR:   fig|317025.3.peg.403
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   TQYVHEV
- PhylomeDB:   Q31J60
- BioCyc:   TCRU317025:TCR_0217-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 16905; Mature: 16774

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQQLTFKQLEKAQQGDSFDWEAVKKQVKYDDNGLIPAIAQQFDSKEVLMMAWMNEAALQ
CCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCEEHHHHHHHHHHH
ETLETGRVCYWSRSRQSYWRKGEESGQIQLLKDLRFDCDGDAILLLVDQTGPACHTGRKS
HHHHCCCEEEEECCHHHHHHCCCCCCCEEEHHHCCCCCCCCEEEEEECCCCCCCCCCCCC
CFYTAIHDHQAKILTNPIIDPEALYKK
EEEEEECCCCHHHHCCCCCCHHHHHCC
>Mature Secondary Structure 
SQQLTFKQLEKAQQGDSFDWEAVKKQVKYDDNGLIPAIAQQFDSKEVLMMAWMNEAALQ
CCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCHHHHHHCCCCCEEHHHHHHHHHHH
ETLETGRVCYWSRSRQSYWRKGEESGQIQLLKDLRFDCDGDAILLLVDQTGPACHTGRKS
HHHHCCCEEEEECCHHHHHHCCCCCCCEEEHHHCCCCCCCCEEEEEECCCCCCCCCCCCC
CFYTAIHDHQAKILTNPIIDPEALYKK
EEEEEECCCCHHHHCCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA