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The map label for this gene is fmt

Identifier: 78484537

GI number: 78484537

Start: 226371

End: 227309

Strand: Reverse

Name: fmt

Synonym: Tcr_0192

Alternate gene names: 78484537

Gene position: 227309-226371 (Counterclockwise)

Preceding gene: 78484538

Following gene: 78484536

Centisome position: 9.36

GC content: 52.5

Gene sequence:

>939_bases
ATGACGCAGCCTCTTAGAATTATCTTCGCCGGTACCCCTGACTTTTCCGTGCCCCCCCTTAAAACCTTGATTGACTCCGA
GCATGAGGTAGTGGCGGTTTACACGCAACCCGACCGCCCGGCCGGGCGTGGACGAAAACTCACGGCCAGTCCCGTGAAAC
AGACCGCGTTAGAGCACGACATTCCCGTTTACCAACCGGTGTCACTCAAAACACCTGAAGCGCAGGCGGAATTAGAAGCG
CTTCAAGCGGACGTGATGATTGTGGTGGCGTATGGCTTAATACTTCCAAAAGCTGTTTTAGACATGCCTAAGTATGGCTG
TTTGAACATTCATGCTTCGATCCTACCTCGCTGGCGAGGCGCGGCACCGATTCAGCGCGCGATTCAAATGGGCGATGCGG
AAACCGGCGTGACCATTATGCAAATGGATGTTGGGTTGGATACCGGGGACATGCTCACCATCTTGAAAACCCCCATCAAG
CCGGAAGACACCGCACAAACCTTGCATGACCGTTTAAGCGCGCTCGGATGTGACGCGATGATGACGACATTGAGCAACTT
ACAGACCGACCAGCTGTCTCCTGTGAAACAGGATGAACGCCAAGTCACCTATGCTGAAAAACTCAATAAAGCCGAAGCCG
AACTTGACTGGCAGGCATCCGCACAGACTTTAGCTCGACAAGTACAAGCGTTTAACCCTTGGCCGGTTGCGTTTACACAA
TACCAGGGTCAGCCTTTGCGTATCTGGCAGGCCGAAGTCGGTCATGCTTCAACCCAAAAATCGCCAGGCCTGGTCATTTC
TGTCAGCAAAACAGGGATGGAAGTCGCCACTGGAAAAGGGTCATTACTAATTAAGCAGGTACAACCGTCGGGCAAAAAAG
CCATGCCTGCTTATGACTTTGCGCAAGCTCGCCAGCTGACTGGCCAAACATTAGGATAA

Upstream 100 bases:

>100_bases
ATCATTTAAACGGCAAATTGTTTATTGACCATCTCTCTGGCTTAAAGCGGACCCGTGCAATTCAAAAATTTAAAAAAGAA
ATGGCAGAACAAGCAAACTC

Downstream 100 bases:

>100_bases
TACATGGCCGTTAACAGTCGCTATATCGCTTTGAAAATTTGTTTAACCGTCATTGAGCATGGACGCTCTTTAAGCCAATC
TTTAGCAGAAGGCCTGGCAC

Product: methionyl-tRNA formyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTQPLRIIFAGTPDFSVPPLKTLIDSEHEVVAVYTQPDRPAGRGRKLTASPVKQTALEHDIPVYQPVSLKTPEAQAELEA
LQADVMIVVAYGLILPKAVLDMPKYGCLNIHASILPRWRGAAPIQRAIQMGDAETGVTIMQMDVGLDTGDMLTILKTPIK
PEDTAQTLHDRLSALGCDAMMTTLSNLQTDQLSPVKQDERQVTYAEKLNKAEAELDWQASAQTLARQVQAFNPWPVAFTQ
YQGQPLRIWQAEVGHASTQKSPGLVISVSKTGMEVATGKGSLLIKQVQPSGKKAMPAYDFAQARQLTGQTLG

Sequences:

>Translated_312_residues
MTQPLRIIFAGTPDFSVPPLKTLIDSEHEVVAVYTQPDRPAGRGRKLTASPVKQTALEHDIPVYQPVSLKTPEAQAELEA
LQADVMIVVAYGLILPKAVLDMPKYGCLNIHASILPRWRGAAPIQRAIQMGDAETGVTIMQMDVGLDTGDMLTILKTPIK
PEDTAQTLHDRLSALGCDAMMTTLSNLQTDQLSPVKQDERQVTYAEKLNKAEAELDWQASAQTLARQVQAFNPWPVAFTQ
YQGQPLRIWQAEVGHASTQKSPGLVISVSKTGMEVATGKGSLLIKQVQPSGKKAMPAYDFAQARQLTGQTLG
>Mature_311_residues
TQPLRIIFAGTPDFSVPPLKTLIDSEHEVVAVYTQPDRPAGRGRKLTASPVKQTALEHDIPVYQPVSLKTPEAQAELEAL
QADVMIVVAYGLILPKAVLDMPKYGCLNIHASILPRWRGAAPIQRAIQMGDAETGVTIMQMDVGLDTGDMLTILKTPIKP
EDTAQTLHDRLSALGCDAMMTTLSNLQTDQLSPVKQDERQVTYAEKLNKAEAELDWQASAQTLARQVQAFNPWPVAFTQY
QGQPLRIWQAEVGHASTQKSPGLVISVSKTGMEVATGKGSLLIKQVQPSGKKAMPAYDFAQARQLTGQTLG

Specific function: Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by:(I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-

COG id: COG0223

COG function: function code J; Methionyl-tRNA formyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fmt family

Homologues:

Organism=Homo sapiens, GI238814322, Length=327, Percent_Identity=27.5229357798165, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI164663775, Length=223, Percent_Identity=32.7354260089686, Blast_Score=108, Evalue=6e-24,
Organism=Homo sapiens, GI21614513, Length=297, Percent_Identity=26.5993265993266, Blast_Score=100, Evalue=1e-21,
Organism=Escherichia coli, GI1789683, Length=305, Percent_Identity=57.3770491803279, Blast_Score=363, Evalue=1e-102,
Organism=Escherichia coli, GI1788589, Length=307, Percent_Identity=29.9674267100977, Blast_Score=135, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI133930964, Length=324, Percent_Identity=25.6172839506173, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45550868, Length=316, Percent_Identity=29.4303797468354, Blast_Score=124, Evalue=8e-29,
Organism=Drosophila melanogaster, GI28571984, Length=236, Percent_Identity=31.3559322033898, Blast_Score=114, Evalue=7e-26,
Organism=Drosophila melanogaster, GI24585660, Length=245, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: 400 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): FMT_THICR (Q31J85)

Other databases:

- EMBL:   CP000109
- RefSeq:   YP_390462.1
- HSSP:   P77398
- ProteinModelPortal:   Q31J85
- SMR:   Q31J85
- STRING:   Q31J85
- GeneID:   3762248
- GenomeReviews:   CP000109_GR
- KEGG:   tcx:Tcr_0192
- NMPDR:   fig|317025.3.peg.165
- eggNOG:   COG0223
- HOGENOM:   HBG571560
- OMA:   IMQMDEG
- PhylomeDB:   Q31J85
- ProtClustDB:   CLSK2464853
- BioCyc:   TCRU317025:TCR_0192-MONOMER
- HAMAP:   MF_00182
- InterPro:   IPR005794
- InterPro:   IPR005793
- InterPro:   IPR002376
- InterPro:   IPR011034
- InterPro:   IPR001555
- InterPro:   IPR015518
- Gene3D:   G3DSA:3.10.25.10
- Gene3D:   G3DSA:3.40.50.170
- PANTHER:   PTHR11138
- TIGRFAMs:   TIGR00460

Pfam domain/function: PF02911 Formyl_trans_C; PF00551 Formyl_trans_N; SSF50486 FMT_C_like; SSF53328 formyl_transf

EC number: =2.1.2.9

Molecular weight: Translated: 33963; Mature: 33831

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: PS00373 GART

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQPLRIIFAGTPDFSVPPLKTLIDSEHEVVAVYTQPDRPAGRGRKLTASPVKQTALEHD
CCCCEEEEEECCCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCCCEECCHHHHHHHHCC
IPVYQPVSLKTPEAQAELEALQADVMIVVAYGLILPKAVLDMPKYGCLNIHASILPRWRG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCCCC
AAPIQRAIQMGDAETGVTIMQMDVGLDTGDMLTILKTPIKPEDTAQTLHDRLSALGCDAM
CHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEHEEECCCCCCHHHHHHHHHHHHHCHHHH
MTTLSNLQTDQLSPVKQDERQVTYAEKLNKAEAELDWQASAQTLARQVQAFNPWPVAFTQ
HHHHHHCCCCCCCCCCHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEE
YQGQPLRIWQAEVGHASTQKSPGLVISVSKTGMEVATGKGSLLIKQVQPSGKKAMPAYDF
CCCCCEEEEEECCCCCCCCCCCCEEEEEECCCEEEECCCCCEEEEEECCCCCCCCCCHHH
AQARQLTGQTLG
HHHHHHCCCCCC
>Mature Secondary Structure 
TQPLRIIFAGTPDFSVPPLKTLIDSEHEVVAVYTQPDRPAGRGRKLTASPVKQTALEHD
CCCEEEEEECCCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCCCCEECCHHHHHHHHCC
IPVYQPVSLKTPEAQAELEALQADVMIVVAYGLILPKAVLDMPKYGCLNIHASILPRWRG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHCCCCCC
AAPIQRAIQMGDAETGVTIMQMDVGLDTGDMLTILKTPIKPEDTAQTLHDRLSALGCDAM
CHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEHEEECCCCCCHHHHHHHHHHHHHCHHHH
MTTLSNLQTDQLSPVKQDERQVTYAEKLNKAEAELDWQASAQTLARQVQAFNPWPVAFTQ
HHHHHHCCCCCCCCCCHHHHHHHHHHHHCHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEE
YQGQPLRIWQAEVGHASTQKSPGLVISVSKTGMEVATGKGSLLIKQVQPSGKKAMPAYDF
CCCCCEEEEEECCCCCCCCCCCCEEEEEECCCEEEECCCCCEEEEEECCCCCCCCCCHHH
AQARQLTGQTLG
HHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA