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The map label for this gene is trxA [H]

Identifier: 78484472

GI number: 78484472

Start: 159935

End: 160261

Strand: Reverse

Name: trxA [H]

Synonym: Tcr_0127

Alternate gene names: 78484472

Gene position: 160261-159935 (Counterclockwise)

Preceding gene: 78484478

Following gene: 78484471

Centisome position: 6.6

GC content: 41.9

Gene sequence:

>327_bases
ATGAGTGACAACATGATCGCGACATCAGACGCAAATTTTGACAGTGAAGTACTACAATCAGACGTTCCAGTATTAGTAGA
TTTTTGGGCTGAGTGGTGTGGACCTTGTAAAATGATTGCCCCGATCCTGGATGAAGTTGCAGGCGAATATGCTGGCAAAA
TTAAAGTGGCTAAGCTAAACATTGATGAAAACCCAGCCACACCACCAAAATATGGTGTCAGAGGCATCCCAACATTAGTG
CTGTTTAAAAATGGTGAAGTTGATGCCACCCAAGTCGGTGCGTTATCAAAATCACAATTATGTGCTTTCTTAGACGGAAA
CCTATAA

Upstream 100 bases:

>100_bases
CTCGATTCTGGCTTCTTCCCATGCGACTCCCCTCCAACTTATTCGGGTATTCGTGTAGGCGTTAGGGCGAGAGAAACAAA
TTTTAAGGAGTTACTACCTA

Downstream 100 bases:

>100_bases
TCCTCCGTCCCAAAAGTATGGTGCGTCCTTTCCAAAGGACGCCATTAATCTAAATCATCCAACTCATTTCTCGAAACAAT
CTCCAAACCCAATTCAATTA

Product: thioredoxin

Products: NA

Alternate protein names: Trx [H]

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MSDNMIATSDANFDSEVLQSDVPVLVDFWAEWCGPCKMIAPILDEVAGEYAGKIKVAKLNIDENPATPPKYGVRGIPTLV
LFKNGEVDATQVGALSKSQLCAFLDGNL

Sequences:

>Translated_108_residues
MSDNMIATSDANFDSEVLQSDVPVLVDFWAEWCGPCKMIAPILDEVAGEYAGKIKVAKLNIDENPATPPKYGVRGIPTLV
LFKNGEVDATQVGALSKSQLCAFLDGNL
>Mature_107_residues
SDNMIATSDANFDSEVLQSDVPVLVDFWAEWCGPCKMIAPILDEVAGEYAGKIKVAKLNIDENPATPPKYGVRGIPTLVL
FKNGEVDATQVGALSKSQLCAFLDGNL

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=93, Percent_Identity=40.8602150537634, Blast_Score=82, Evalue=9e-17,
Organism=Homo sapiens, GI5031973, Length=103, Percent_Identity=33.0097087378641, Blast_Score=68, Evalue=1e-12,
Organism=Homo sapiens, GI21361657, Length=85, Percent_Identity=37.6470588235294, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI20070125, Length=87, Percent_Identity=36.7816091954023, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=72.2222222222222, Blast_Score=168, Evalue=6e-44,
Organism=Escherichia coli, GI1788936, Length=93, Percent_Identity=40.8602150537634, Blast_Score=92, Evalue=1e-20,
Organism=Escherichia coli, GI87081747, Length=105, Percent_Identity=35.2380952380952, Blast_Score=68, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=94, Percent_Identity=41.4893617021277, Blast_Score=85, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI71998175, Length=91, Percent_Identity=39.5604395604396, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17554386, Length=88, Percent_Identity=40.9090909090909, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17556044, Length=86, Percent_Identity=34.8837209302326, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI115532378, Length=71, Percent_Identity=43.6619718309859, Blast_Score=68, Evalue=9e-13,
Organism=Caenorhabditis elegans, GI115532380, Length=71, Percent_Identity=43.6619718309859, Blast_Score=67, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17544108, Length=71, Percent_Identity=43.6619718309859, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17569137, Length=88, Percent_Identity=39.7727272727273, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI32566189, Length=88, Percent_Identity=39.7727272727273, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193209454, Length=88, Percent_Identity=39.7727272727273, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17549970, Length=80, Percent_Identity=35, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=84, Percent_Identity=46.4285714285714, Blast_Score=72, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6321648, Length=86, Percent_Identity=40.6976744186046, Blast_Score=70, Evalue=8e-14,
Organism=Drosophila melanogaster, GI24639826, Length=80, Percent_Identity=46.25, Blast_Score=82, Evalue=8e-17,
Organism=Drosophila melanogaster, GI28573567, Length=97, Percent_Identity=38.1443298969072, Blast_Score=80, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21358065, Length=96, Percent_Identity=39.5833333333333, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24664269, Length=61, Percent_Identity=45.9016393442623, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI19921434, Length=88, Percent_Identity=39.7727272727273, Blast_Score=69, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17648013, Length=62, Percent_Identity=43.5483870967742, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583090, Length=62, Percent_Identity=43.5483870967742, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24639068, Length=93, Percent_Identity=32.258064516129, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 11588; Mature: 11457

Theoretical pI: Translated: 4.07; Mature: 4.07

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNMIATSDANFDSEVLQSDVPVLVDFWAEWCGPCKMIAPILDEVAGEYAGKIKVAKLN
CCCCEECCCCCCCCHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEEEE
IDENPATPPKYGVRGIPTLVLFKNGEVDATQVGALSKSQLCAFLDGNL
CCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHCCCCHHHEEEEECCCC
>Mature Secondary Structure 
SDNMIATSDANFDSEVLQSDVPVLVDFWAEWCGPCKMIAPILDEVAGEYAGKIKVAKLN
CCCEECCCCCCCCHHHHHCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHCCEEEEEEEE
IDENPATPPKYGVRGIPTLVLFKNGEVDATQVGALSKSQLCAFLDGNL
CCCCCCCCCCCCCCCCCEEEEEECCCCCHHHHCCCCHHHEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10224002; 10984043 [H]