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The map label for this gene is argH

Identifier: 78484455

GI number: 78484455

Start: 140246

End: 141634

Strand: Reverse

Name: argH

Synonym: Tcr_0110

Alternate gene names: 78484455

Gene position: 141634-140246 (Counterclockwise)

Preceding gene: 78484456

Following gene: 78484452

Centisome position: 5.83

GC content: 45.0

Gene sequence:

>1389_bases
ATGAGCAATCAACACAATCAAGAAAAACTTTCCAGCGCACGTTTCAGCGAAGCAACTGATGCGTTTGTAGAAGAATTTAC
TGCATCTATTCAGTTTGATAAACGCATGTATCGTCAAGATATCCAAGGGTCTGTTGCCCATGCCAAAATGTTACATAAAG
TCGGCATATTGGACAAACAAGAATTAAAAGACATTATTGACGGCTTGGAAAAAGTTCAATCCGACATTGAGGCCGGAAAA
ATGAACTGGTCCATTAAGCAAGAAGATATTCACATGAATATCGAAGCAAAACTGACTGAACTGATTGGCATTACCGGTAA
AAAGCTGCATACCGGGCGTTCTCGTAATGATCAAGTAGCGACCGATATCCGCTTGTATTTACGTGATGAAATTGATGCCA
TCCTGCCGGAAATGGCCCGTCTGCAACATGGCATTTTATTATTGGCCGAAAAAGAAGCCGAGACCATTATGCCTGGCTTC
ACCCATCTTCAGACAGCGCAGCCCGTCACCTTTGGTCACCATATGATGGCTTGGTTTGAAATGATCAAACGCGACGTAGA
ACGCTTGGAAGATTGCCGTAAACGAGTCAATACCATGCCATTAGGCTCTGCGGCTTTGGCTGGAACAACCTACCCTATCC
AACGAGAATACACTGCGGAATTACTGCAGTTTGATCGCATCTCGGAAAACTCTTTAGACGGCGTTTCAGATCGAGATTTT
GCCATTGAGTTTACCGCATTTGCGGCAACCTTTTTAATGCATCTGTCTCGTTTTTCAGAAGAGTTGGTGCTTTGGTCATC
CGCACAGTTTAACTTTATTGATTTACCGGATCGTTTCTGCACCGGTTCGTCGATCATGCCACAAAAGAAAAACCCGGATG
TTCCTGAACTGGTACGTGGTAAAACTGGCCGTGTTTATGGCCACCTGATGAGTTTGTTGACGTTAATGAAATCACAACCA
TTGGCGTACAACAAAGATAATCAGGAAGATAAGGAACCGTTGTTTGATACGGTGGATACCGTCAAAGGAAGTTTGCGAGC
GTTTGCAGACATGGTGCCAGCGATCATTGTGAACCGTGAAGCGACTTATGCGGCCGCAAAACAAGGTTTTTCCACTGCGA
CCGATTTAGCGGATTACTTAGTCAACAAAGGACTGCCTTTCCGTGATGCGCATGAAGTCGTTGGACTGGCGGTCGCACAT
GGCATTCAAACAGGGCAGGACTTGTCTGAAATGCCTTTAGAAACGCTGCAAGCTTTCCACAGTAGCATAACCGATGATGT
GTTTGAGGTTCTAACGCTAGAAGGATCGGTTTCGGCACGCGATCATTTAGGCGGTACAGCCCCAAAACAAGTCAAAGCAG
CGATTAAACGTGCAAAAGATCGTTTATAG

Upstream 100 bases:

>100_bases
AGAGTTGAAATCTCTTGCCTAAAAAACACGCTAAGCCCTTATAATAGACACATTATTCAATTCATTCTGGACGCAAGTCC
GTTTAATAAAAAGACCGTTT

Downstream 100 bases:

>100_bases
TGGACTATTGATATAGTTCGTTTTCCATAAAAAAACCGCCAGGCCTGGCGGTTTTTTTATCTCTATCGAAATCTGATTAC
GCCACTTAAGCGACTTCTTC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MSNQHNQEKLSSARFSEATDAFVEEFTASIQFDKRMYRQDIQGSVAHAKMLHKVGILDKQELKDIIDGLEKVQSDIEAGK
MNWSIKQEDIHMNIEAKLTELIGITGKKLHTGRSRNDQVATDIRLYLRDEIDAILPEMARLQHGILLLAEKEAETIMPGF
THLQTAQPVTFGHHMMAWFEMIKRDVERLEDCRKRVNTMPLGSAALAGTTYPIQREYTAELLQFDRISENSLDGVSDRDF
AIEFTAFAATFLMHLSRFSEELVLWSSAQFNFIDLPDRFCTGSSIMPQKKNPDVPELVRGKTGRVYGHLMSLLTLMKSQP
LAYNKDNQEDKEPLFDTVDTVKGSLRAFADMVPAIIVNREATYAAAKQGFSTATDLADYLVNKGLPFRDAHEVVGLAVAH
GIQTGQDLSEMPLETLQAFHSSITDDVFEVLTLEGSVSARDHLGGTAPKQVKAAIKRAKDRL

Sequences:

>Translated_462_residues
MSNQHNQEKLSSARFSEATDAFVEEFTASIQFDKRMYRQDIQGSVAHAKMLHKVGILDKQELKDIIDGLEKVQSDIEAGK
MNWSIKQEDIHMNIEAKLTELIGITGKKLHTGRSRNDQVATDIRLYLRDEIDAILPEMARLQHGILLLAEKEAETIMPGF
THLQTAQPVTFGHHMMAWFEMIKRDVERLEDCRKRVNTMPLGSAALAGTTYPIQREYTAELLQFDRISENSLDGVSDRDF
AIEFTAFAATFLMHLSRFSEELVLWSSAQFNFIDLPDRFCTGSSIMPQKKNPDVPELVRGKTGRVYGHLMSLLTLMKSQP
LAYNKDNQEDKEPLFDTVDTVKGSLRAFADMVPAIIVNREATYAAAKQGFSTATDLADYLVNKGLPFRDAHEVVGLAVAH
GIQTGQDLSEMPLETLQAFHSSITDDVFEVLTLEGSVSARDHLGGTAPKQVKAAIKRAKDRL
>Mature_461_residues
SNQHNQEKLSSARFSEATDAFVEEFTASIQFDKRMYRQDIQGSVAHAKMLHKVGILDKQELKDIIDGLEKVQSDIEAGKM
NWSIKQEDIHMNIEAKLTELIGITGKKLHTGRSRNDQVATDIRLYLRDEIDAILPEMARLQHGILLLAEKEAETIMPGFT
HLQTAQPVTFGHHMMAWFEMIKRDVERLEDCRKRVNTMPLGSAALAGTTYPIQREYTAELLQFDRISENSLDGVSDRDFA
IEFTAFAATFLMHLSRFSEELVLWSSAQFNFIDLPDRFCTGSSIMPQKKNPDVPELVRGKTGRVYGHLMSLLTLMKSQPL
AYNKDNQEDKEPLFDTVDTVKGSLRAFADMVPAIIVNREATYAAAKQGFSTATDLADYLVNKGLPFRDAHEVVGLAVAHG
IQTGQDLSEMPLETLQAFHSSITDDVFEVLTLEGSVSARDHLGGTAPKQVKAAIKRAKDRL

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=451, Percent_Identity=41.6851441241685, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI68303542, Length=451, Percent_Identity=41.6851441241685, Blast_Score=355, Evalue=4e-98,
Organism=Homo sapiens, GI68303547, Length=451, Percent_Identity=39.689578713969, Blast_Score=328, Evalue=7e-90,
Organism=Homo sapiens, GI68303549, Length=451, Percent_Identity=39.0243902439024, Blast_Score=317, Evalue=1e-86,
Organism=Escherichia coli, GI1790398, Length=454, Percent_Identity=46.2555066079295, Blast_Score=411, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6321806, Length=459, Percent_Identity=42.483660130719, Blast_Score=360, Evalue=1e-100,
Organism=Drosophila melanogaster, GI221473854, Length=455, Percent_Identity=36.9230769230769, Blast_Score=313, Evalue=2e-85,
Organism=Drosophila melanogaster, GI78706858, Length=455, Percent_Identity=36.9230769230769, Blast_Score=313, Evalue=2e-85,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_THICR (Q31JG7)

Other databases:

- EMBL:   CP000109
- RefSeq:   YP_390380.1
- ProteinModelPortal:   Q31JG7
- SMR:   Q31JG7
- STRING:   Q31JG7
- GeneID:   3762518
- GenomeReviews:   CP000109_GR
- KEGG:   tcx:Tcr_0110
- NMPDR:   fig|317025.3.peg.64
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- PhylomeDB:   Q31JG7
- ProtClustDB:   PRK00855
- BioCyc:   TCRU317025:TCR_0110-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51818; Mature: 51686

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNQHNQEKLSSARFSEATDAFVEEFTASIQFDKRMYRQDIQGSVAHAKMLHKVGILDKQ
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHH
ELKDIIDGLEKVQSDIEAGKMNWSIKQEDIHMNIEAKLTELIGITGKKLHTGRSRNDQVA
HHHHHHHHHHHHHHHHHHCCCCCEEECCCEEECHHHHHHHHHCCCCCCCCCCCCCCCHHH
TDIRLYLRDEIDAILPEMARLQHGILLLAEKEAETIMPGFTHLQTAQPVTFGHHMMAWFE
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHCCCHHHHCCCCCCHHHHHHHHHHH
MIKRDVERLEDCRKRVNTMPLGSAALAGTTYPIQREYTAELLQFDRISENSLDGVSDRDF
HHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
AIEFTAFAATFLMHLSRFSEELVLWSSAQFNFIDLPDRFCTGSSIMPQKKNPDVPELVRG
EEHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEECCHHHCCCCCCCCCCCCCCCHHHHCC
KTGRVYGHLMSLLTLMKSQPLAYNKDNQEDKEPLFDTVDTVKGSLRAFADMVPAIIVNRE
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ATYAAAKQGFSTATDLADYLVNKGLPFRDAHEVVGLAVAHGIQTGQDLSEMPLETLQAFH
HHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHH
SSITDDVFEVLTLEGSVSARDHLGGTAPKQVKAAIKRAKDRL
HHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SNQHNQEKLSSARFSEATDAFVEEFTASIQFDKRMYRQDIQGSVAHAKMLHKVGILDKQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHH
ELKDIIDGLEKVQSDIEAGKMNWSIKQEDIHMNIEAKLTELIGITGKKLHTGRSRNDQVA
HHHHHHHHHHHHHHHHHHCCCCCEEECCCEEECHHHHHHHHHCCCCCCCCCCCCCCCHHH
TDIRLYLRDEIDAILPEMARLQHGILLLAEKEAETIMPGFTHLQTAQPVTFGHHMMAWFE
HHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCHHHHCCCHHHHCCCCCCHHHHHHHHHHH
MIKRDVERLEDCRKRVNTMPLGSAALAGTTYPIQREYTAELLQFDRISENSLDGVSDRDF
HHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCC
AIEFTAFAATFLMHLSRFSEELVLWSSAQFNFIDLPDRFCTGSSIMPQKKNPDVPELVRG
EEHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEECCHHHCCCCCCCCCCCCCCCHHHHCC
KTGRVYGHLMSLLTLMKSQPLAYNKDNQEDKEPLFDTVDTVKGSLRAFADMVPAIIVNRE
CCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ATYAAAKQGFSTATDLADYLVNKGLPFRDAHEVVGLAVAHGIQTGQDLSEMPLETLQAFH
HHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHH
SSITDDVFEVLTLEGSVSARDHLGGTAPKQVKAAIKRAKDRL
HHHHHHHHHHHHCCCCCCHHHHCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA