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The map label for this gene is mrpE [H]

Identifier: 78484406

GI number: 78484406

Start: 71821

End: 72318

Strand: Reverse

Name: mrpE [H]

Synonym: Tcr_0060

Alternate gene names: 78484406

Gene position: 72318-71821 (Counterclockwise)

Preceding gene: 78484407

Following gene: 78484405

Centisome position: 2.98

GC content: 37.75

Gene sequence:

>498_bases
ATGAACATTAAAAAAATCTTACCTCATCCCATCTTAAGTTTATTTTTATGGGGAATTTGGTTATTACTGAACAACAATTT
TAGCGCAGGCCATATTGTGCTTGGGTTTATCCTGGCACTGATTATTCCGATGTTCACTTCCAGCTTCTGGCCGGAAAAAG
TGTGTTTAAAACACCCTATAACTTTGCTTAAATTTCTTGGCATCGTATTATGGGATATCTTGGTGGCGAATGTTACGGTC
GCTAAATTGATTTTAGGAAAAACGGCTCATCTTCAACCGGGCTTTTTAACCATTGAATTAGACATTACGCATCCTTTAGG
AATTAGTTTTTTGGCCAATACCATTTCATTAACGCCAGGCACCGTTTCATGTGATTTATCGGAAGATCGAAAGCAATTAC
TTGTTCACGCTTTGCATATAGAAAATGCGGCCGAAACCATAGAAGAAATAAAACAACGCTATGAGCGTCCATTAATGGAG
GTATTTCCATCATGTTAG

Upstream 100 bases:

>100_bases
CTATTACCTCAATGACCGATACCATTGCACAACAATTATTTGACTCGAATCATTACATTCATTCGGTTCTTAATACCCCT
GCTGTTGGAGAGGTGTCGCC

Downstream 100 bases:

>100_bases
AGATAGCCTTAGAACTCGCTTTTGTATTGGTTGCGCTGGCTTTGATTTTGAGCTTTTATCGATTGATTAAAGGGCCTTCT
ATTCCAGATCGAATTTTAGC

Product: cation antiporter

Products: NA

Alternate protein names: Mrp complex subunit E; Multiple resistance and pH homeostasis protein E [H]

Number of amino acids: Translated: 165; Mature: 165

Protein sequence:

>165_residues
MNIKKILPHPILSLFLWGIWLLLNNNFSAGHIVLGFILALIIPMFTSSFWPEKVCLKHPITLLKFLGIVLWDILVANVTV
AKLILGKTAHLQPGFLTIELDITHPLGISFLANTISLTPGTVSCDLSEDRKQLLVHALHIENAAETIEEIKQRYERPLME
VFPSC

Sequences:

>Translated_165_residues
MNIKKILPHPILSLFLWGIWLLLNNNFSAGHIVLGFILALIIPMFTSSFWPEKVCLKHPITLLKFLGIVLWDILVANVTV
AKLILGKTAHLQPGFLTIELDITHPLGISFLANTISLTPGTVSCDLSEDRKQLLVHALHIENAAETIEEIKQRYERPLME
VFPSC
>Mature_165_residues
MNIKKILPHPILSLFLWGIWLLLNNNFSAGHIVLGFILALIIPMFTSSFWPEKVCLKHPITLLKFLGIVLWDILVANVTV
AKLILGKTAHLQPGFLTIELDITHPLGISFLANTISLTPGTVSCDLSEDRKQLLVHALHIENAAETIEEIKQRYERPLME
VFPSC

Specific function: Mrp complex is a Na(+)/H(+) antiporter that is considered to be the major Na(+) excretion system in B.subtilis. Has a major role in Na(+) resistance and a minor role in Na(+)- and K(+)-dependent pH homeostasis as compared to TetB. MrpA may be the actual N

COG id: COG1863

COG function: function code P; Multisubunit Na+/H+ antiporter, MnhE subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002758 [H]

Pfam domain/function: PF01899 MNHE [H]

EC number: NA

Molecular weight: Translated: 18527; Mature: 18527

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKKILPHPILSLFLWGIWLLLNNNFSAGHIVLGFILALIIPMFTSSFWPEKVCLKHPI
CCCHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHH
TLLKFLGIVLWDILVANVTVAKLILGKTAHLQPGFLTIELDITHPLGISFLANTISLTPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCC
TVSCDLSEDRKQLLVHALHIENAAETIEEIKQRYERPLMEVFPSC
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCC
>Mature Secondary Structure
MNIKKILPHPILSLFLWGIWLLLNNNFSAGHIVLGFILALIIPMFTSSFWPEKVCLKHPI
CCCHHHCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHCHH
TLLKFLGIVLWDILVANVTVAKLILGKTAHLQPGFLTIELDITHPLGISFLANTISLTPG
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCCCC
TVSCDLSEDRKQLLVHALHIENAAETIEEIKQRYERPLMEVFPSC
EEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9384377; 10198001; 11356194 [H]