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The map label for this gene is cobT

Identifier: 78358815

GI number: 78358815

Start: 3720145

End: 3721221

Strand: Direct

Name: cobT

Synonym: Dde_3777

Alternate gene names: 78358815

Gene position: 3720145-3721221 (Clockwise)

Preceding gene: 78358807

Following gene: 78358816

Centisome position: 99.73

GC content: 59.33

Gene sequence:

>1077_bases
ATGTCACATTCCGTGGAATACATAATACAGCACATTCCCCCTGTTGATACTTCGCTTGCCGGTGCTGCACAGGCGCATCT
GGACAACCTGACAAAGCCGCGGGGCAGTCTGGGACGTCTGGAAGAACTGGCGCTCCGCCTTTACTGCATACAAGGCGGCG
ATACCCCGCTGGCAGCCGATCCGGCGCGCATTTACACCATTGCCGGTGATCATGGTGTAGCAGCCGAAGGCGTCAGCCCC
TTTCCGCAGGAGGTCACGCGGCAGATGGTGCTCAACTTTCTGAGCAACGGCGCAGGCATCAATGTACTGTGCAATACCGT
GGGCTGTGAACAGTTTGTTGTGGATGCCGGCAGCTGCGGAGGGGCCTACCCCGAACACCCCCGGCTGATACAGCGCAAAA
TTCATCCCGGAACAGCCAGTATCGCGCAGGGTCCGGCCATGACAGCCGAGCAATGCAGACAGGCCCTGCAACTGGGCATT
GATCTGGCCGGCATGGCCCGCGAGGCGGGTTGCCGCACCGTGGGTACAGGCGAGATGGGCATATCAAATACCACTCCTTC
CACAGCGCTTTACTGTGCCTACCTCGGGCTTGACCCTGCCGGCATCACCGGCCCCGGAGCGGGCATCACCCCGGACCTTG
TAAAACATAAGACAGATATTATCCGCAGAGCCCTTGCCGTCAACGCCGGTGCGGTACAGTCACAAAACGCCGTGGATATT
CTTGCCGCCCTAGGGGGCTACGAAATAGCGGCTCTGACGGGACTTATTCTCGGTGCCGCCTACCATCGCATGGCTGTTCT
GGTGGACGGATTCATTTCCACTGCCGCATGGACCGCCGCATGGAAGATATGCCCCGCTGTGAGCGATTACAGCTTTTTCA
GCCACGCATCTGCCGAAGCAGGCCACAAAACGGCGCTGCGTTCCATGGGTATTGAGCCTCTGCACGATCTCGGTCTGCGC
CTGGGAGAAGGCACCGGAGCTGCTCTCACCCTGTTCCTGCTGCGCTCCGCGGCGGCAATTTTCAACGATATGGCAACGTT
TTCCTCGGCAGGAGTCGCCACACAATCATCCTGTTGA

Upstream 100 bases:

>100_bases
CGCAGCAGCTGTTTTCATAGCATTTCCCTCTCCGCCATGCGGCTGTCTTGCCATTTCACCATGCCGATTGTAGGTATCAG
GATTCTTAAAGGAGTCTTTC

Downstream 100 bases:

>100_bases
GCAACCCTGTGGCCACTGATACCATCAGCCATGCCCCAACATCACACCACGGACGCCATGCACGATAATACACCCCTTCT
GCAGATAACAGACGTTTCGC

Product: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase

Products: NA

Alternate protein names: NN:DBI PRT; N(1)-alpha-phosphoribosyltransferase

Number of amino acids: Translated: 358; Mature: 357

Protein sequence:

>358_residues
MSHSVEYIIQHIPPVDTSLAGAAQAHLDNLTKPRGSLGRLEELALRLYCIQGGDTPLAADPARIYTIAGDHGVAAEGVSP
FPQEVTRQMVLNFLSNGAGINVLCNTVGCEQFVVDAGSCGGAYPEHPRLIQRKIHPGTASIAQGPAMTAEQCRQALQLGI
DLAGMAREAGCRTVGTGEMGISNTTPSTALYCAYLGLDPAGITGPGAGITPDLVKHKTDIIRRALAVNAGAVQSQNAVDI
LAALGGYEIAALTGLILGAAYHRMAVLVDGFISTAAWTAAWKICPAVSDYSFFSHASAEAGHKTALRSMGIEPLHDLGLR
LGEGTGAALTLFLLRSAAAIFNDMATFSSAGVATQSSC

Sequences:

>Translated_358_residues
MSHSVEYIIQHIPPVDTSLAGAAQAHLDNLTKPRGSLGRLEELALRLYCIQGGDTPLAADPARIYTIAGDHGVAAEGVSP
FPQEVTRQMVLNFLSNGAGINVLCNTVGCEQFVVDAGSCGGAYPEHPRLIQRKIHPGTASIAQGPAMTAEQCRQALQLGI
DLAGMAREAGCRTVGTGEMGISNTTPSTALYCAYLGLDPAGITGPGAGITPDLVKHKTDIIRRALAVNAGAVQSQNAVDI
LAALGGYEIAALTGLILGAAYHRMAVLVDGFISTAAWTAAWKICPAVSDYSFFSHASAEAGHKTALRSMGIEPLHDLGLR
LGEGTGAALTLFLLRSAAAIFNDMATFSSAGVATQSSC
>Mature_357_residues
SHSVEYIIQHIPPVDTSLAGAAQAHLDNLTKPRGSLGRLEELALRLYCIQGGDTPLAADPARIYTIAGDHGVAAEGVSPF
PQEVTRQMVLNFLSNGAGINVLCNTVGCEQFVVDAGSCGGAYPEHPRLIQRKIHPGTASIAQGPAMTAEQCRQALQLGID
LAGMAREAGCRTVGTGEMGISNTTPSTALYCAYLGLDPAGITGPGAGITPDLVKHKTDIIRRALAVNAGAVQSQNAVDIL
AALGGYEIAALTGLILGAAYHRMAVLVDGFISTAAWTAAWKICPAVSDYSFFSHASAEAGHKTALRSMGIEPLHDLGLRL
GEGTGAALTLFLLRSAAAIFNDMATFSSAGVATQSSC

Specific function: Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB)

COG id: COG2038

COG function: function code H; NaMN:DMB phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CobT family

Homologues:

Organism=Escherichia coli, GI1788300, Length=348, Percent_Identity=37.0689655172414, Blast_Score=215, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COBT_DESDG (Q30US7)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_390264.1
- ProteinModelPortal:   Q30US7
- SMR:   Q30US7
- STRING:   Q30US7
- GeneID:   3758765
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_3777
- NMPDR:   fig|207559.3.peg.2479
- eggNOG:   COG2038
- HOGENOM:   HBG634399
- OMA:   NEMATFS
- ProtClustDB:   CLSK706296
- BioCyc:   DDES207559:DDE_3777-MONOMER
- HAMAP:   MF_00230
- InterPro:   IPR003200
- InterPro:   IPR023195
- InterPro:   IPR017846
- Gene3D:   G3DSA:1.10.1610.10
- TIGRFAMs:   TIGR03160

Pfam domain/function: PF02277 DBI_PRT; SSF52733 NN:DBI_PRT

EC number: =2.4.2.21

Molecular weight: Translated: 37038; Mature: 36906

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: ACT_SITE 323-323

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSVEYIIQHIPPVDTSLAGAAQAHLDNLTKPRGSLGRLEELALRLYCIQGGDTPLAAD
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEEECCCCCCCCC
PARIYTIAGDHGVAAEGVSPFPQEVTRQMVLNFLSNGAGINVLCNTVGCEQFVVDAGSCG
CCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHEEECCCCC
GAYPEHPRLIQRKIHPGTASIAQGPAMTAEQCRQALQLGIDLAGMAREAGCRTVGTGEMG
CCCCCCHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCC
ISNTTPSTALYCAYLGLDPAGITGPGAGITPDLVKHKTDIIRRALAVNAGAVQSQNAVDI
CCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
LAALGGYEIAALTGLILGAAYHRMAVLVDGFISTAAWTAAWKICPAVSDYSFFSHASAEA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCC
GHKTALRSMGIEPLHDLGLRLGEGTGAALTLFLLRSAAAIFNDMATFSSAGVATQSSC
HHHHHHHHCCCCHHHHHHCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SHSVEYIIQHIPPVDTSLAGAAQAHLDNLTKPRGSLGRLEELALRLYCIQGGDTPLAAD
CCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHEEEEEECCCCCCCCC
PARIYTIAGDHGVAAEGVSPFPQEVTRQMVLNFLSNGAGINVLCNTVGCEQFVVDAGSCG
CCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHEEECCCCC
GAYPEHPRLIQRKIHPGTASIAQGPAMTAEQCRQALQLGIDLAGMAREAGCRTVGTGEMG
CCCCCCHHHHHHHCCCCCCHHHCCCCCCHHHHHHHHHHCCCHHHHHHHCCCCCCCCCCCC
ISNTTPSTALYCAYLGLDPAGITGPGAGITPDLVKHKTDIIRRALAVNAGAVQSQNAVDI
CCCCCCCCEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
LAALGGYEIAALTGLILGAAYHRMAVLVDGFISTAAWTAAWKICPAVSDYSFFSHASAEA
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCC
GHKTALRSMGIEPLHDLGLRLGEGTGAALTLFLLRSAAAIFNDMATFSSAGVATQSSC
HHHHHHHHCCCCHHHHHHCEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA