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The map label for this gene is atoS [H]

Identifier: 78358757

GI number: 78358757

Start: 3677866

End: 3680346

Strand: Reverse

Name: atoS [H]

Synonym: Dde_3718

Alternate gene names: 78358757

Gene position: 3680346-3677866 (Counterclockwise)

Preceding gene: 78358758

Following gene: 78358756

Centisome position: 98.66

GC content: 56.75

Gene sequence:

>2481_bases
GTGCCAGAAAAGGCGCCTGATGGTACCATTTGGTACCGTATTGCGCCGGAAGAATTCCGGTGTGTGAATGTCTTGCACCG
GCGGGGCTTTTGTGGTTCTGCCGTGCGGATGTTCCGCGCAAATGCTGTGTGCGTGCGGCGCGCTGCGTGTTATTGCTGCG
CCGGCCACATGCAGGGGAATACCATGCATAAAAAGACATCCCCCCGCCGGTTCGGTCTGGTGTACCGCATCGTGCTGACC
ACGGGTGTGACGCTGCTTACAGGGCTTGTGGCGCTTTCCTGGTTTAACATGCGCTACCATCAGCGTCATGCCATGCGCGA
ATTTGCCGAAGGCGCGGACAGGCTGGGCAGTACCATTCTGCTGGGCACGCGCTATGCCATGATGACCAACGCCCGCCATG
AGCTTGATCAGATCATACGCGATCTGGCCCGTCAGCCCGACATCCATTCCATCCGTATTTACAATAAAGCCGGAGCCATC
ATGTTTTCCAGTCAGGCCGACGAGGTCGGACGGGTGACAAACATACGTGATGAAGCCTGCAATGTCTGCCACCACACCGA
GCCGCCGCTGACCCGGCTGGCTCTTTCTGAAAGCACCCGCCGCTTTACCGGTGCGGACGGAGAACCTCTGCTGGGCAGCC
TGCGGCCCATCATGAATGAAGAAGGCTGTTCCGGCGGGCCGTGCCATGTGCATTCTGCCGATAAACAGGTGCTCGGCGCA
CTGGACGTGGTGATGCGCCTTGGTCCTGCGCAGCTGGACTTTGCCCGTTTCCAGCAGGGGATGGTAGGTGCCACGGCAGT
GGTCTTTCTGCTTTCTGCTTCGGCCATTGTGCTGTTGCTGCGGCGGTTTATCACGCAACCTGTTTCGCGCCTGAAGGAAA
ACACCAGACGCATAGGCAGGGGCGAGCCGGTGCTGATAACGGATGCAGGCCAGCATGACGAGATAGGAGAGCTGGCCGGC
GCGGTGCAGTCCATGGCCGATGATATCCGCCAGAAGCAGGAAGAACTGTTGCGGCAGCGGCGGGAATATCAGGCGCTGTT
TGAGCAGGTGCCGTGCAGCATCACCGTGCAGGACAGAGAATACCGTCTGTTGCAGTTCAACAGGGAATTTGCAGAGCGCT
TTCACCCGTTGCCCGGTGCGTTCTGCTATCAGGCGTATAAAGGCCGCACAGACCCCTGTCCCAATTGTCCTGTGGAACGT
ACATTTGCCACGGGCAGGTCGCATTGCAGCGAAGAATACCGCACCAATCCGGATGGTTCCAGAACACACTGGCTTGTGCA
TACCTCTCCTGTTGTGGATGAAAACGGGCAGGTGACAGCAGCCATGGAAATGTCCATTGACGTTTCGGCGCTGAAAAAGG
CCGAAGACAGGCTGCGTCGCTCGGAACAGAAATATCACGCCATCTTCAATAACATTCCCAACGCCGTGTTTGTACTGGAT
GCGCAGACGCTTGATATTGTTGACTGCAACCATACCGTGGAAACCCTGTACGGTTATGAACGCAGCCAGCTGACCGGTAT
GTCGTTTCTTGACATGTTTCCCGAAGAGGAGCGCAGGCGGTACGCATCGCAGCTGAAAGCATTTACTGTACTTCCCCGGG
CCCGCAATCATCGCAAGGACGGCAGCATGTTGTATGTCGACATCATGCTGTCGCCCGCAGAATACCATGAGCGTACAGTG
CTGCTGGTGGCTGCCAGCGATGTGACCGAACGGCTGGAGACCGAACAGAAGCTGATTCAGGCCGGAAAAATGGCTACACT
GGGTGAGATGGCAACCGGCGTGGCACATGAACTGAACCAGCCGCTGACTGTCATTAAAACCGCGAGCAGTTTTATCATGC
GCAAAATACATCGCGGTGAACCAGTGGCACCCGATGTGCTGGAAACCATGGCGCGCGAAATAGACAGCCATGTGGACAGA
GCCAGCGGTATTATTAATCATATGCGGGACTTCGGCCGCCAGTCGGATATCACGCTGGAACCGGTAAATCTCAATGCTGT
TCTGCAGTCATCGTGCGAGTTTTTTGCCCGCCAGCTTTCTTTGCGGCAGATTGAAGTGGACTGGCAGCTGGCCGAAGTTC
TGCCGCCGGTCATGGCCATGCCTAACAGGCTTGAACAGGTGTTCACAAACATGCTGCTCAATGCGCGTGATGCCATTGAA
GAGCGTTCGGAGCGCGATCCTAATGCCCCGCGCCGTATCACCGTGCGCACAACGGTGGAAGACAGAGAGGTTGTGGTGCG
TGTGTGCGACACAGGCAAGGGGATTCCCCGTTCGCTGCTTAACAAGATATTCGAACCGTTTTTCACTACCAAAAGCGTGG
GCAAGGGAACGGGACTCGGTCTTTCCATCAGCTACGGGCTGGTGAAAGATTTCGGTGGTAGCATACAGGCGGCAAATATG
CCGGAAGGCGGCGCCTGTTTTATTCTGCGGTTTCCTTCCACCAGCTCTCTGCCCGCCGGGTCTGAGAGCGCTGCAACATA
A

Upstream 100 bases:

>100_bases
ACATTTGCCGAGCTTGTGGCCTACTCCGATCAGGGGGTGCGGTTCGGCGATTTCTGCCAGACCATCGAAGACGAGCACTG
CAGGCACGCCTCGGGCAGCC

Downstream 100 bases:

>100_bases
CATCTTTATCCCGCCTGCGCGGAGCGATGGAACAGTACCATGCCGGATCTGACAGCGGCAGCGGAGTCTGCACCTCTTTC
TGTCATGCTTGTAGATGATG

Product: multi-sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 826; Mature: 825

Protein sequence:

>826_residues
MPEKAPDGTIWYRIAPEEFRCVNVLHRRGFCGSAVRMFRANAVCVRRAACYCCAGHMQGNTMHKKTSPRRFGLVYRIVLT
TGVTLLTGLVALSWFNMRYHQRHAMREFAEGADRLGSTILLGTRYAMMTNARHELDQIIRDLARQPDIHSIRIYNKAGAI
MFSSQADEVGRVTNIRDEACNVCHHTEPPLTRLALSESTRRFTGADGEPLLGSLRPIMNEEGCSGGPCHVHSADKQVLGA
LDVVMRLGPAQLDFARFQQGMVGATAVVFLLSASAIVLLLRRFITQPVSRLKENTRRIGRGEPVLITDAGQHDEIGELAG
AVQSMADDIRQKQEELLRQRREYQALFEQVPCSITVQDREYRLLQFNREFAERFHPLPGAFCYQAYKGRTDPCPNCPVER
TFATGRSHCSEEYRTNPDGSRTHWLVHTSPVVDENGQVTAAMEMSIDVSALKKAEDRLRRSEQKYHAIFNNIPNAVFVLD
AQTLDIVDCNHTVETLYGYERSQLTGMSFLDMFPEEERRRYASQLKAFTVLPRARNHRKDGSMLYVDIMLSPAEYHERTV
LLVAASDVTERLETEQKLIQAGKMATLGEMATGVAHELNQPLTVIKTASSFIMRKIHRGEPVAPDVLETMAREIDSHVDR
ASGIINHMRDFGRQSDITLEPVNLNAVLQSSCEFFARQLSLRQIEVDWQLAEVLPPVMAMPNRLEQVFTNMLLNARDAIE
ERSERDPNAPRRITVRTTVEDREVVVRVCDTGKGIPRSLLNKIFEPFFTTKSVGKGTGLGLSISYGLVKDFGGSIQAANM
PEGGACFILRFPSTSSLPAGSESAAT

Sequences:

>Translated_826_residues
MPEKAPDGTIWYRIAPEEFRCVNVLHRRGFCGSAVRMFRANAVCVRRAACYCCAGHMQGNTMHKKTSPRRFGLVYRIVLT
TGVTLLTGLVALSWFNMRYHQRHAMREFAEGADRLGSTILLGTRYAMMTNARHELDQIIRDLARQPDIHSIRIYNKAGAI
MFSSQADEVGRVTNIRDEACNVCHHTEPPLTRLALSESTRRFTGADGEPLLGSLRPIMNEEGCSGGPCHVHSADKQVLGA
LDVVMRLGPAQLDFARFQQGMVGATAVVFLLSASAIVLLLRRFITQPVSRLKENTRRIGRGEPVLITDAGQHDEIGELAG
AVQSMADDIRQKQEELLRQRREYQALFEQVPCSITVQDREYRLLQFNREFAERFHPLPGAFCYQAYKGRTDPCPNCPVER
TFATGRSHCSEEYRTNPDGSRTHWLVHTSPVVDENGQVTAAMEMSIDVSALKKAEDRLRRSEQKYHAIFNNIPNAVFVLD
AQTLDIVDCNHTVETLYGYERSQLTGMSFLDMFPEEERRRYASQLKAFTVLPRARNHRKDGSMLYVDIMLSPAEYHERTV
LLVAASDVTERLETEQKLIQAGKMATLGEMATGVAHELNQPLTVIKTASSFIMRKIHRGEPVAPDVLETMAREIDSHVDR
ASGIINHMRDFGRQSDITLEPVNLNAVLQSSCEFFARQLSLRQIEVDWQLAEVLPPVMAMPNRLEQVFTNMLLNARDAIE
ERSERDPNAPRRITVRTTVEDREVVVRVCDTGKGIPRSLLNKIFEPFFTTKSVGKGTGLGLSISYGLVKDFGGSIQAANM
PEGGACFILRFPSTSSLPAGSESAAT
>Mature_825_residues
PEKAPDGTIWYRIAPEEFRCVNVLHRRGFCGSAVRMFRANAVCVRRAACYCCAGHMQGNTMHKKTSPRRFGLVYRIVLTT
GVTLLTGLVALSWFNMRYHQRHAMREFAEGADRLGSTILLGTRYAMMTNARHELDQIIRDLARQPDIHSIRIYNKAGAIM
FSSQADEVGRVTNIRDEACNVCHHTEPPLTRLALSESTRRFTGADGEPLLGSLRPIMNEEGCSGGPCHVHSADKQVLGAL
DVVMRLGPAQLDFARFQQGMVGATAVVFLLSASAIVLLLRRFITQPVSRLKENTRRIGRGEPVLITDAGQHDEIGELAGA
VQSMADDIRQKQEELLRQRREYQALFEQVPCSITVQDREYRLLQFNREFAERFHPLPGAFCYQAYKGRTDPCPNCPVERT
FATGRSHCSEEYRTNPDGSRTHWLVHTSPVVDENGQVTAAMEMSIDVSALKKAEDRLRRSEQKYHAIFNNIPNAVFVLDA
QTLDIVDCNHTVETLYGYERSQLTGMSFLDMFPEEERRRYASQLKAFTVLPRARNHRKDGSMLYVDIMLSPAEYHERTVL
LVAASDVTERLETEQKLIQAGKMATLGEMATGVAHELNQPLTVIKTASSFIMRKIHRGEPVAPDVLETMAREIDSHVDRA
SGIINHMRDFGRQSDITLEPVNLNAVLQSSCEFFARQLSLRQIEVDWQLAEVLPPVMAMPNRLEQVFTNMLLNARDAIEE
RSERDPNAPRRITVRTTVEDREVVVRVCDTGKGIPRSLLNKIFEPFFTTKSVGKGTGLGLSISYGLVKDFGGSIQAANMP
EGGACFILRFPSTSSLPAGSESAAT

Specific function: Member of the two-component regulatory system AtoS/AtoC; may activate AtoC by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PAS (PER-ARNT-SIM) domain [H]

Homologues:

Organism=Escherichia coli, GI1788549, Length=395, Percent_Identity=29.873417721519, Blast_Score=141, Evalue=2e-34,
Organism=Escherichia coli, GI1790436, Length=231, Percent_Identity=33.7662337662338, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI87081816, Length=176, Percent_Identity=31.8181818181818, Blast_Score=88, Evalue=2e-18,
Organism=Escherichia coli, GI1786912, Length=263, Percent_Identity=28.8973384030418, Blast_Score=79, Evalue=9e-16,
Organism=Escherichia coli, GI1790861, Length=224, Percent_Identity=29.4642857142857, Blast_Score=75, Evalue=2e-14,
Organism=Escherichia coli, GI1789149, Length=278, Percent_Identity=28.0575539568345, Blast_Score=67, Evalue=6e-12,
Organism=Escherichia coli, GI48994928, Length=393, Percent_Identity=22.9007633587786, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI87082128, Length=232, Percent_Identity=23.7068965517241, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788393, Length=227, Percent_Identity=24.2290748898678, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR000014
- InterPro:   IPR000700
- InterPro:   IPR013767
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF00989 PAS [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 92577; Mature: 92446

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEKAPDGTIWYRIAPEEFRCVNVLHRRGFCGSAVRMFRANAVCVRRAACYCCAGHMQGN
CCCCCCCCEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TMHKKTSPRRFGLVYRIVLTTGVTLLTGLVALSWFNMRYHQRHAMREFAEGADRLGSTIL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
LGTRYAMMTNARHELDQIIRDLARQPDIHSIRIYNKAGAIMFSSQADEVGRVTNIRDEAC
EECHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCHHHHHHCCCCHHHH
NVCHHTEPPLTRLALSESTRRFTGADGEPLLGSLRPIMNEEGCSGGPCHVHSADKQVLGA
HHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCEECCHHHHHHHH
LDVVMRLGPAQLDFARFQQGMVGATAVVFLLSASAIVLLLRRFITQPVSRLKENTRRIGR
HHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GEPVLITDAGQHDEIGELAGAVQSMADDIRQKQEELLRQRREYQALFEQVPCSITVQDRE
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
YRLLQFNREFAERFHPLPGAFCYQAYKGRTDPCPNCPVERTFATGRSHCSEEYRTNPDGS
HHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
RTHWLVHTSPVVDENGQVTAAMEMSIDVSALKKAEDRLRRSEQKYHAIFNNIPNAVFVLD
CEEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
AQTLDIVDCNHTVETLYGYERSQLTGMSFLDMFPEEERRRYASQLKAFTVLPRARNHRKD
CCEEEEEECCHHHHHHHCCCHHHHCCCHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCCC
GSMLYVDIMLSPAEYHERTVLLVAASDVTERLETEQKLIQAGKMATLGEMATGVAHELNQ
CCEEEEEEEECCHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
PLTVIKTASSFIMRKIHRGEPVAPDVLETMAREIDSHVDRASGIINHMRDFGRQSDITLE
CHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
PVNLNAVLQSSCEFFARQLSLRQIEVDWQLAEVLPPVMAMPNRLEQVFTNMLLNARDAIE
CCCHHHHHHHHHHHHHHHHHHHHEEECEEHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHH
ERSERDPNAPRRITVRTTVEDREVVVRVCDTGKGIPRSLLNKIFEPFFTTKSVGKGTGLG
HHHCCCCCCCCEEEEEEECCCCHHHEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
LSISYGLVKDFGGSIQAANMPEGGACFILRFPSTSSLPAGSESAAT
EEEEHHHHHHCCCCEEECCCCCCCEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure 
PEKAPDGTIWYRIAPEEFRCVNVLHRRGFCGSAVRMFRANAVCVRRAACYCCAGHMQGN
CCCCCCCEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TMHKKTSPRRFGLVYRIVLTTGVTLLTGLVALSWFNMRYHQRHAMREFAEGADRLGSTIL
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
LGTRYAMMTNARHELDQIIRDLARQPDIHSIRIYNKAGAIMFSSQADEVGRVTNIRDEAC
EECHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEECCCCEEECCCCHHHHHHCCCCHHHH
NVCHHTEPPLTRLALSESTRRFTGADGEPLLGSLRPIMNEEGCSGGPCHVHSADKQVLGA
HHHCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCEECCHHHHHHHH
LDVVMRLGPAQLDFARFQQGMVGATAVVFLLSASAIVLLLRRFITQPVSRLKENTRRIGR
HHHHHHCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
GEPVLITDAGQHDEIGELAGAVQSMADDIRQKQEELLRQRREYQALFEQVPCSITVQDRE
CCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCC
YRLLQFNREFAERFHPLPGAFCYQAYKGRTDPCPNCPVERTFATGRSHCSEEYRTNPDGS
HHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCC
RTHWLVHTSPVVDENGQVTAAMEMSIDVSALKKAEDRLRRSEQKYHAIFNNIPNAVFVLD
CEEEEEECCCCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEE
AQTLDIVDCNHTVETLYGYERSQLTGMSFLDMFPEEERRRYASQLKAFTVLPRARNHRKD
CCEEEEEECCHHHHHHHCCCHHHHCCCHHHHCCCHHHHHHHHHHHHHHHCCCCHHCCCCC
GSMLYVDIMLSPAEYHERTVLLVAASDVTERLETEQKLIQAGKMATLGEMATGVAHELNQ
CCEEEEEEEECCHHHCCCEEEEEECCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCC
PLTVIKTASSFIMRKIHRGEPVAPDVLETMAREIDSHVDRASGIINHMRDFGRQSDITLE
CHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEE
PVNLNAVLQSSCEFFARQLSLRQIEVDWQLAEVLPPVMAMPNRLEQVFTNMLLNARDAIE
CCCHHHHHHHHHHHHHHHHHHHHEEECEEHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHH
ERSERDPNAPRRITVRTTVEDREVVVRVCDTGKGIPRSLLNKIFEPFFTTKSVGKGTGLG
HHHCCCCCCCCEEEEEEECCCCHHHEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCC
LSISYGLVKDFGGSIQAANMPEGGACFILRFPSTSSLPAGSESAAT
EEEEHHHHHHCCCCEEECCCCCCCEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8346225; 9097040; 9278503 [H]