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The map label for this gene is galE [C]

Identifier: 78358725

GI number: 78358725

Start: 3646876

End: 3647799

Strand: Direct

Name: galE [C]

Synonym: Dde_3686

Alternate gene names: 78358725

Gene position: 3646876-3647799 (Clockwise)

Preceding gene: 78358724

Following gene: 78358726

Centisome position: 97.77

GC content: 57.79

Gene sequence:

>924_bases
ATGAAAATCACAGTATTCGGCGGTGCCGGTTTTCTCGGTTCGCATGTTTGCGACAAGCTGTCGGAAGCAGGCCACGAGGT
CACCATATTCGACATTGTCGCATCCCCGTGGCTGCGCGGCGACCAGACCATGATCACAGGCGACATTCTGGACGAAAACG
CCGTGCAGCGGGCAGTGGACGGGGCACAGGCCGTCTACAACTTTGCCGGTATAGCCGACATAGGCGAAGCCGGAGAACGC
CCCGTGGACACGGTGAAGTACAACATACTGGGCAACACCATTGTGCTGGACGCCTGCCGCAGGGCAGGAGTCCGTCGTTT
TGTCTTTGCCAGCTCGGTGTATGTGTACAGTCAGGCGGGCAGCTTTTACCGCTGCAGCAAACAAGCCAGCGAACTGTACA
TCGAAACCTACCAGCAACTGCACGGGCTTGATTACACCATACTGCGCTACGGCTCGCTGTACGGTCCCCGCGCCGACAAG
CGCAACGCCATATACCGTTTTGTGCGCGAAGCTCTGGAAACAGGACACATCACCTACTACGGCCGTCCCACGGCGCTGCG
CGAATACATCCATGTGGAAGATGCGGCGCGCTCCAGCGTGGAGATACTCAACCCCGAATATGCCAACCTGCACATCGTGC
TGACCGGACACCAGCCCATGCAGGTGGGAAATCTGCTTAAAATGATTGCCGAAATGCTGGGCAGGCCTGTCAGTTTTTCA
TTCAACGACAATCCCGCCAGCGGGCACTACGAAATTACACCGTACAATTTCAGTCCCCGCGTGGGCAGAAAAATGACCCC
TGTGCTGCATACCGACCTGGGACAGGGCGTGCTGCATACCATTGAAGAACTGCACAGGGAGCTGCACCCCGAAATGGATG
AGGTGCAGGGCGTGCTGGTGCACGACCCCGGAAGCGGCAGCTGA

Upstream 100 bases:

>100_bases
GCTTCATCGCTTACGGGCTTGATGCCGTCTTTCTGTGGAATGCCGCACAGAACCCTGCCGCGGCACCCCGCTGAACCTGC
AGCCGATAACGGAGTACGTC

Downstream 100 bases:

>100_bases
GCCTGCCCCTGAAAAGTTGTCCCTGAAAATTTATCCCTGATGATTTCTTTCTGATGATTTATTTCTGACAGCCCGCGGCT
GCCGCAGCGGCAGTACGCGG

Product: NAD-dependent epimerase/dehydratase family protein

Products: NA

Alternate protein names: Galactowaldenase; UDP-galactose 4-epimerase [H]

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MKITVFGGAGFLGSHVCDKLSEAGHEVTIFDIVASPWLRGDQTMITGDILDENAVQRAVDGAQAVYNFAGIADIGEAGER
PVDTVKYNILGNTIVLDACRRAGVRRFVFASSVYVYSQAGSFYRCSKQASELYIETYQQLHGLDYTILRYGSLYGPRADK
RNAIYRFVREALETGHITYYGRPTALREYIHVEDAARSSVEILNPEYANLHIVLTGHQPMQVGNLLKMIAEMLGRPVSFS
FNDNPASGHYEITPYNFSPRVGRKMTPVLHTDLGQGVLHTIEELHRELHPEMDEVQGVLVHDPGSGS

Sequences:

>Translated_307_residues
MKITVFGGAGFLGSHVCDKLSEAGHEVTIFDIVASPWLRGDQTMITGDILDENAVQRAVDGAQAVYNFAGIADIGEAGER
PVDTVKYNILGNTIVLDACRRAGVRRFVFASSVYVYSQAGSFYRCSKQASELYIETYQQLHGLDYTILRYGSLYGPRADK
RNAIYRFVREALETGHITYYGRPTALREYIHVEDAARSSVEILNPEYANLHIVLTGHQPMQVGNLLKMIAEMLGRPVSFS
FNDNPASGHYEITPYNFSPRVGRKMTPVLHTDLGQGVLHTIEELHRELHPEMDEVQGVLVHDPGSGS
>Mature_307_residues
MKITVFGGAGFLGSHVCDKLSEAGHEVTIFDIVASPWLRGDQTMITGDILDENAVQRAVDGAQAVYNFAGIADIGEAGER
PVDTVKYNILGNTIVLDACRRAGVRRFVFASSVYVYSQAGSFYRCSKQASELYIETYQQLHGLDYTILRYGSLYGPRADK
RNAIYRFVREALETGHITYYGRPTALREYIHVEDAARSSVEILNPEYANLHIVLTGHQPMQVGNLLKMIAEMLGRPVSFS
FNDNPASGHYEITPYNFSPRVGRKMTPVLHTDLGQGVLHTIEELHRELHPEMDEVQGVLVHDPGSGS

Specific function: Galactose metabolism; third step. [C]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=225, Percent_Identity=25.7777777777778, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI56237023, Length=253, Percent_Identity=28.4584980237154, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI56118217, Length=253, Percent_Identity=28.4584980237154, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI189083684, Length=253, Percent_Identity=28.4584980237154, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI1786974, Length=292, Percent_Identity=27.3972602739726, Blast_Score=73, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17539532, Length=319, Percent_Identity=22.884012539185, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17570557, Length=324, Percent_Identity=24.3827160493827, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21356223, Length=283, Percent_Identity=24.7349823321555, Blast_Score=68, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: =5.1.3.2 [H]

Molecular weight: Translated: 34082; Mature: 34082

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKITVFGGAGFLGSHVCDKLSEAGHEVTIFDIVASPWLRGDQTMITGDILDENAVQRAVD
CEEEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEECCHHCHHHHHHHHH
GAQAVYNFAGIADIGEAGERPVDTVKYNILGNTIVLDACRRAGVRRFVFASSVYVYSQAG
HHHHHHHHHCHHHHHHCCCCCCHHEEEEECCCHHHHHHHHHCCHHHHHHHHEEEEEECCC
SFYRCSKQASELYIETYQQLHGLDYTILRYGSLYGPRADKRNAIYRFVREALETGHITYY
CHHHHHHHHHHHHHHHHHHHHCCCEEEEHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEE
GRPTALREYIHVEDAARSSVEILNPEYANLHIVLTGHQPMQVGNLLKMIAEMLGRPVSFS
CCHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEE
FNDNPASGHYEITPYNFSPRVGRKMTPVLHTDLGQGVLHTIEELHRELHPEMDEVQGVLV
ECCCCCCCEEEEECCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCHHHCCEEEE
HDPGSGS
ECCCCCC
>Mature Secondary Structure
MKITVFGGAGFLGSHVCDKLSEAGHEVTIFDIVASPWLRGDQTMITGDILDENAVQRAVD
CEEEEEECCCHHHHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEECCHHCHHHHHHHHH
GAQAVYNFAGIADIGEAGERPVDTVKYNILGNTIVLDACRRAGVRRFVFASSVYVYSQAG
HHHHHHHHHCHHHHHHCCCCCCHHEEEEECCCHHHHHHHHHCCHHHHHHHHEEEEEECCC
SFYRCSKQASELYIETYQQLHGLDYTILRYGSLYGPRADKRNAIYRFVREALETGHITYY
CHHHHHHHHHHHHHHHHHHHHCCCEEEEHHCCCCCCCCCCHHHHHHHHHHHHHCCCEEEE
GRPTALREYIHVEDAARSSVEILNPEYANLHIVLTGHQPMQVGNLLKMIAEMLGRPVSFS
CCHHHHHHHHHHHHHHCCCEEECCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCCCEEEE
FNDNPASGHYEITPYNFSPRVGRKMTPVLHTDLGQGVLHTIEELHRELHPEMDEVQGVLV
ECCCCCCCEEEEECCCCCCCCCCCCCCHHHHHCCHHHHHHHHHHHHHHCCCHHHCCEEEE
HDPGSGS
ECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]