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The map label for this gene is carA [H]

Identifier: 78358685

GI number: 78358685

Start: 3609169

End: 3610296

Strand: Reverse

Name: carA [H]

Synonym: Dde_3646

Alternate gene names: 78358685

Gene position: 3610296-3609169 (Counterclockwise)

Preceding gene: 78358686

Following gene: 78358684

Centisome position: 96.78

GC content: 59.57

Gene sequence:

>1128_bases
ATGAGAGCGCTGCTGGCCCTTGAAGACGGCTTCGTACTGGAAGGCCGTTCCTTTACCGGCCCCGGAGAGACGGGTGGTGA
GGTGATTTTCAACACCGGCATGACCGGCTATCAGGAAGTGCTGACGGATCCTTCGTATGCGGGGCAGATGGTCTGCATGA
CCTATCCGCTTATCGGCAACTACGGAGTGACCCGCGAAGACGTGGAATCCGGCAAGGTGCACGTTGAGGCGTTCATTGTT
AAGGAATGCTGCAAGGTGCCCTCCAACTGGCGTTCCGTGGCGTCGCTTCCCGATTATCTCAAGCGTAACGGTATTATGGG
CATCGAAGGCATAGACACCCGCGCCCTTACCCGTCATCTGCGCATGCACGGAGCCATGCGGGGCATTATCTCCACTGCGG
AGACCGATCCCGCGGCGCTGGTGCAGCGGGCAAAAGACCTGCCGTCCATGGAAGGCCAGAATCTGGTTGTGCGCGTGGCA
CCCGAAAGCCCTTACCGCTGGGACGGCGAACGCCCTCAGAAAGTGACTCTGCAGGACGGGGTGTACGCATGGCCGGGCAA
GGGGCCGCGTGTGGTGGTCTATGACTTCGGCATCAAATGGAATATTCTGCGCCTGCTTGCCGCAGAAGGACTGGACCTGC
TTGTGGTGCCGCCTTCTTTTACCGCGCAGGACGTGCAGCGTTGCGGTGCCGAGGCCGTGTTCCTTTCCAACGGTCCCGGA
GACCCGGCAACGCTGAAGGCTGAAATAGCCGAAATCGCAAAACTGACCGACATGATGCCCGTGGCCGGCATCTGTCTGGG
GCATCAGCTGCTCGGGCATGCGCTGGGCGGTACCACGCGCAAGCTTAAATTCGGGCACCACGGCTGCAACAGCCCGGTGA
AGGACCTGACAACGGGGCGCATAGAAGTCTCTTCGCAAAACCACGGGTTCTGTGTAGAGTTGGATGCAGTTCCCGATGTG
CGTGTGACCCATGTGAACCTGAATGACAATACGCTTGAGGGTTTCGAGCATACCGTCAAACCGGTCATTTCGGTGCAGCA
CCACCCCGAAGCCAGCCCGGGACCCAACGACAGCCACTACTTCTTCGGCAGGTTCCGCAAACTGCTGCGCGAACATCTGG
GAAAGTAG

Upstream 100 bases:

>100_bases
ATATACCCATACGGGTGGTGGAAACGGCATACCGGACGCACGGTGTGGACCGCCCCGGGGATATCGACGTAATTATCAAC
ATGATACGGGAGAACGAAGG

Downstream 100 bases:

>100_bases
CCGTGCCGACCGGAGAAAAGAATGTCTGCTGAACTGACCAGAGCGCGGAAACAGCTTACGCAGGTGCGTTCGCTGCTGCG
GCAGGGCAAGGTTATGCCCG

Product: carbamoyl phosphate synthase small subunit

Products: NA

Alternate protein names: Carbamoyl-phosphate synthetase glutamine chain [H]

Number of amino acids: Translated: 375; Mature: 375

Protein sequence:

>375_residues
MRALLALEDGFVLEGRSFTGPGETGGEVIFNTGMTGYQEVLTDPSYAGQMVCMTYPLIGNYGVTREDVESGKVHVEAFIV
KECCKVPSNWRSVASLPDYLKRNGIMGIEGIDTRALTRHLRMHGAMRGIISTAETDPAALVQRAKDLPSMEGQNLVVRVA
PESPYRWDGERPQKVTLQDGVYAWPGKGPRVVVYDFGIKWNILRLLAAEGLDLLVVPPSFTAQDVQRCGAEAVFLSNGPG
DPATLKAEIAEIAKLTDMMPVAGICLGHQLLGHALGGTTRKLKFGHHGCNSPVKDLTTGRIEVSSQNHGFCVELDAVPDV
RVTHVNLNDNTLEGFEHTVKPVISVQHHPEASPGPNDSHYFFGRFRKLLREHLGK

Sequences:

>Translated_375_residues
MRALLALEDGFVLEGRSFTGPGETGGEVIFNTGMTGYQEVLTDPSYAGQMVCMTYPLIGNYGVTREDVESGKVHVEAFIV
KECCKVPSNWRSVASLPDYLKRNGIMGIEGIDTRALTRHLRMHGAMRGIISTAETDPAALVQRAKDLPSMEGQNLVVRVA
PESPYRWDGERPQKVTLQDGVYAWPGKGPRVVVYDFGIKWNILRLLAAEGLDLLVVPPSFTAQDVQRCGAEAVFLSNGPG
DPATLKAEIAEIAKLTDMMPVAGICLGHQLLGHALGGTTRKLKFGHHGCNSPVKDLTTGRIEVSSQNHGFCVELDAVPDV
RVTHVNLNDNTLEGFEHTVKPVISVQHHPEASPGPNDSHYFFGRFRKLLREHLGK
>Mature_375_residues
MRALLALEDGFVLEGRSFTGPGETGGEVIFNTGMTGYQEVLTDPSYAGQMVCMTYPLIGNYGVTREDVESGKVHVEAFIV
KECCKVPSNWRSVASLPDYLKRNGIMGIEGIDTRALTRHLRMHGAMRGIISTAETDPAALVQRAKDLPSMEGQNLVVRVA
PESPYRWDGERPQKVTLQDGVYAWPGKGPRVVVYDFGIKWNILRLLAAEGLDLLVVPPSFTAQDVQRCGAEAVFLSNGPG
DPATLKAEIAEIAKLTDMMPVAGICLGHQLLGHALGGTTRKLKFGHHGCNSPVKDLTTGRIEVSSQNHGFCVELDAVPDV
RVTHVNLNDNTLEGFEHTVKPVISVQHHPEASPGPNDSHYFFGRFRKLLREHLGK

Specific function: Arginine biosynthesis. Pyrimidine biosynthesis; first step. [C]

COG id: COG0505

COG function: function code EF; Carbamoylphosphate synthase small subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutamine amidotransferase type-1 domain [H]

Homologues:

Organism=Homo sapiens, GI18105007, Length=384, Percent_Identity=39.0625, Blast_Score=262, Evalue=5e-70,
Organism=Homo sapiens, GI21361331, Length=382, Percent_Identity=32.4607329842932, Blast_Score=198, Evalue=5e-51,
Organism=Homo sapiens, GI169790915, Length=382, Percent_Identity=32.4607329842932, Blast_Score=198, Evalue=7e-51,
Organism=Escherichia coli, GI1786215, Length=383, Percent_Identity=44.1253263707572, Blast_Score=312, Evalue=3e-86,
Organism=Caenorhabditis elegans, GI193204318, Length=390, Percent_Identity=36.9230769230769, Blast_Score=231, Evalue=3e-61,
Organism=Saccharomyces cerevisiae, GI6322331, Length=392, Percent_Identity=37.2448979591837, Blast_Score=250, Evalue=3e-67,
Organism=Saccharomyces cerevisiae, GI6324878, Length=382, Percent_Identity=38.2198952879581, Blast_Score=249, Evalue=7e-67,
Organism=Drosophila melanogaster, GI45555749, Length=390, Percent_Identity=41.025641025641, Blast_Score=251, Evalue=5e-67,
Organism=Drosophila melanogaster, GI24642586, Length=390, Percent_Identity=41.025641025641, Blast_Score=251, Evalue=7e-67,

Paralogues:

None

Copy number: 620 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2599 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR006274
- InterPro:   IPR002474
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991 [H]

Pfam domain/function: PF00988 CPSase_sm_chain; PF00117 GATase [H]

EC number: =6.3.5.5 [H]

Molecular weight: Translated: 40960; Mature: 40960

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALLALEDGFVLEGRSFTGPGETGGEVIFNTGMTGYQEVLTDPSYAGQMVCMTYPLIGN
CCEEEEECCCEEEECCCCCCCCCCCCCEEEECCCCHHHHHHCCCCCCCEEEEEEECCCCC
YGVTREDVESGKVHVEAFIVKECCKVPSNWRSVASLPDYLKRNGIMGIEGIDTRALTRHL
CCCCHHHHCCCCEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
RMHGAMRGIISTAETDPAALVQRAKDLPSMEGQNLVVRVAPESPYRWDGERPQKVTLQDG
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCC
VYAWPGKGPRVVVYDFGIKWNILRLLAAEGLDLLVVPPSFTAQDVQRCGAEAVFLSNGPG
EEECCCCCCEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCEEEEECCCC
DPATLKAEIAEIAKLTDMMPVAGICLGHQLLGHALGGTTRKLKFGHHGCNSPVKDLTTGR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCCCE
IEVSSQNHGFCVELDAVPDVRVTHVNLNDNTLEGFEHTVKPVISVQHHPEASPGPNDSHY
EEECCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCH
FFGRFRKLLREHLGK
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MRALLALEDGFVLEGRSFTGPGETGGEVIFNTGMTGYQEVLTDPSYAGQMVCMTYPLIGN
CCEEEEECCCEEEECCCCCCCCCCCCCEEEECCCCHHHHHHCCCCCCCEEEEEEECCCCC
YGVTREDVESGKVHVEAFIVKECCKVPSNWRSVASLPDYLKRNGIMGIEGIDTRALTRHL
CCCCHHHHCCCCEEEEHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
RMHGAMRGIISTAETDPAALVQRAKDLPSMEGQNLVVRVAPESPYRWDGERPQKVTLQDG
HHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCCCCCCCEEEECCC
VYAWPGKGPRVVVYDFGIKWNILRLLAAEGLDLLVVPPSFTAQDVQRCGAEAVFLSNGPG
EEECCCCCCEEEEEECCCCHHHHHHHHHCCCEEEEECCCCCHHHHHHCCCCEEEEECCCC
DPATLKAEIAEIAKLTDMMPVAGICLGHQLLGHALGGTTRKLKFGHHGCNSPVKDLTTGR
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCCCE
IEVSSQNHGFCVELDAVPDVRVTHVNLNDNTLEGFEHTVKPVISVQHHPEASPGPNDSHY
EEECCCCCCEEEEECCCCCEEEEEEECCCCHHHHHHHHHHHHHEECCCCCCCCCCCCCCH
FFGRFRKLLREHLGK
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA