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The map label for this gene is hdrA2 [H]

Identifier: 78358565

GI number: 78358565

Start: 3484792

End: 3486750

Strand: Direct

Name: hdrA2 [H]

Synonym: Dde_3526

Alternate gene names: 78358565

Gene position: 3484792-3486750 (Clockwise)

Preceding gene: 78358564

Following gene: 78358566

Centisome position: 93.42

GC content: 59.72

Gene sequence:

>1959_bases
ATGAACATAGGTGTTTTCGTCTGCCACTGCGGCAGCAACATTGCCGGCACCGTGGATACGGAAAAAGTGGCCGAGGCCGC
GCGCATGTATCCCGAAGTCCGCTTTGCCACCGATACAATGTACGCCTGTTCCGAACCGGGGCAGGAGGGCATCATATCCG
CCATCCGCGAACACGGGCTGGACGGCGTGGTGGTGGCGTCATGCACGCCGCGCATGCACGAAGCCACTTTCCGCCGCACG
CTGGAACGGGCTGGGCTGAACCGCTACATGTTCGAAATGGCAAACATCCGCGAACATGTTTCATGGATCGGCAAAGACAT
GGAAGCCAACACGTCCAAGGCCATGGACCTTGTACGCATCGCGGTGGAAAAACTGCGCCGCAACACCCCGCTGCATCCCC
GCAAATTTGACATAAACAAACGCGTCATGGTCATCGGCGGCGGCGTGGCCGGCATTCAGGCCGCACTGGACTGCGCCGAA
GGCGGGCTTGAGGTGGTGCTGGTGGAGCGCGAGCCCACCATCGGCGGCAAAATGGCCAAGCTGGACAAGACATTCCCCAC
CGTGGACTGTTCCAGCTGCATCCTCGGCCCCAAAATGGTGGACATTGCCCAGCACCCCAACATCACGCTGTACGCTCTTT
CAGAAGTGGAAAGCGTGAACGGGTTCGTGGGCAATTTCAGCGTGAACATACGCAGAAAGGCCGCCTATGTGGACTGGTCG
CTGTGCACCGGCTGCGGTGCCTGCGAAGAAAAATGCCCCGCGCGCAAAACGTATGACAAATTCAATGAAGGCATAGGCCG
CACCACGGCCATCAAGATAGCCTTTCCGCAGGCCATACCCAAAAAGGCCGTCATCACACCGGAAACATGCATCATGCTGA
CCAAAGGCAAGTGCGGAAACTGCGCCAAGGTCTGCCCCGCAGGGGCCATTCAGTTTGACCAGAAGGACAGCATTGTCACG
GAAGAAGTGGGAGCCATCATCGCCGCCACGGGGTATGACCTGTTCGACCACACCGCACTGGGGCAGTACGGCGGCGGACG
CTACGCCGATGTCATCACCTCGCTGCAGTATGAACGCATGCTCTCGGCATCCGGTCCCACGGGCGGACACGTCAAGCGGC
CGTCAGACGGCGCCGAACCGAAAAACATCGTCTTCATCCAGTGCGCCGGTTCGCGCGACAAGTCCATCGGCCGCCCCTAC
TGTTCGGGGTTCTGCTGCATGTATACGGCCAAACAGGCCATTCTGACAAAAGATCACATTCCCGACTCCCAGTCCTATGT
CTTTTACATGGACATCCGCTCACCGGGCAAAATGTACGACGAGTTCACCCGCCGCGCCATGGAGGAATACGGTGCCCGCT
ACATACGCGGCCGCGTTTCCGCCATCCAGCCCAGGGGCGGCAGATATCTGGTGAAGGGCGCGGACACGCTGCTGGGCAAT
CAGGTGGAAATCGAAGCCGACATGGTGGTGCTGGCCGTAGGTGTGGAATCGGCCAAGGGCGCCTCTGAACTGGCTGAAAA
ACTGCGCATCTCCTACGACAGCTACGGCTTTTTCATGGAAGGCCATCCCAAGCTGAAGCCCGTGGAAACCAACACCGCAG
GTGTGTATCTGGCCGGTTCCTGTCAGGGCCCCAAGGATATCCCCTCTTCCGTGGCACAGGGCGGCGCCGCCGCCAGCAAA
GTGCTCAGCCTGTTCTCCAGAGACAAGCTGGAAAGCGACCCGCAGGTTTCCGCCGTATCGCTGCTGCGATGCGTAGGATG
CGGCAAATGCAGGGAAACGTGTCCGTTCGGCGCCATCGAAATGACCGAATTCCGCGGCATGCCCAAAGCCTCCGTGGTGG
AAACCGTGTGTCAGGGATGCGGCATATGCGCCGTCACCTGCCCTCAGGGTGCCATTCAGCTGCAGCATTTCACAGACAAC
CAGATACTTGCCGAGGTCAACGCCCTATGCCGGTACTAG

Upstream 100 bases:

>100_bases
GGCTGGACAAGCTGTGCGTCAGCCCGGCAGGCGCCCTTGCCTGCATAACCCCCGCCGCGGGGCCGGACACCGCACCGGCG
CAACCACGGGAGGCCGGAGC

Downstream 100 bases:

>100_bases
AAGGAAAAGAACTGCGCATCATCGGATTTCTGTGCAACTGGTGCTCCTACGGCGGTGCCGACACCGCAGGCGTGGGACGG
TTTGCCCAGCCCACTGACCT

Product: heterodisulfide reductase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 652; Mature: 652

Protein sequence:

>652_residues
MNIGVFVCHCGSNIAGTVDTEKVAEAARMYPEVRFATDTMYACSEPGQEGIISAIREHGLDGVVVASCTPRMHEATFRRT
LERAGLNRYMFEMANIREHVSWIGKDMEANTSKAMDLVRIAVEKLRRNTPLHPRKFDINKRVMVIGGGVAGIQAALDCAE
GGLEVVLVEREPTIGGKMAKLDKTFPTVDCSSCILGPKMVDIAQHPNITLYALSEVESVNGFVGNFSVNIRRKAAYVDWS
LCTGCGACEEKCPARKTYDKFNEGIGRTTAIKIAFPQAIPKKAVITPETCIMLTKGKCGNCAKVCPAGAIQFDQKDSIVT
EEVGAIIAATGYDLFDHTALGQYGGGRYADVITSLQYERMLSASGPTGGHVKRPSDGAEPKNIVFIQCAGSRDKSIGRPY
CSGFCCMYTAKQAILTKDHIPDSQSYVFYMDIRSPGKMYDEFTRRAMEEYGARYIRGRVSAIQPRGGRYLVKGADTLLGN
QVEIEADMVVLAVGVESAKGASELAEKLRISYDSYGFFMEGHPKLKPVETNTAGVYLAGSCQGPKDIPSSVAQGGAAASK
VLSLFSRDKLESDPQVSAVSLLRCVGCGKCRETCPFGAIEMTEFRGMPKASVVETVCQGCGICAVTCPQGAIQLQHFTDN
QILAEVNALCRY

Sequences:

>Translated_652_residues
MNIGVFVCHCGSNIAGTVDTEKVAEAARMYPEVRFATDTMYACSEPGQEGIISAIREHGLDGVVVASCTPRMHEATFRRT
LERAGLNRYMFEMANIREHVSWIGKDMEANTSKAMDLVRIAVEKLRRNTPLHPRKFDINKRVMVIGGGVAGIQAALDCAE
GGLEVVLVEREPTIGGKMAKLDKTFPTVDCSSCILGPKMVDIAQHPNITLYALSEVESVNGFVGNFSVNIRRKAAYVDWS
LCTGCGACEEKCPARKTYDKFNEGIGRTTAIKIAFPQAIPKKAVITPETCIMLTKGKCGNCAKVCPAGAIQFDQKDSIVT
EEVGAIIAATGYDLFDHTALGQYGGGRYADVITSLQYERMLSASGPTGGHVKRPSDGAEPKNIVFIQCAGSRDKSIGRPY
CSGFCCMYTAKQAILTKDHIPDSQSYVFYMDIRSPGKMYDEFTRRAMEEYGARYIRGRVSAIQPRGGRYLVKGADTLLGN
QVEIEADMVVLAVGVESAKGASELAEKLRISYDSYGFFMEGHPKLKPVETNTAGVYLAGSCQGPKDIPSSVAQGGAAASK
VLSLFSRDKLESDPQVSAVSLLRCVGCGKCRETCPFGAIEMTEFRGMPKASVVETVCQGCGICAVTCPQGAIQLQHFTDN
QILAEVNALCRY
>Mature_652_residues
MNIGVFVCHCGSNIAGTVDTEKVAEAARMYPEVRFATDTMYACSEPGQEGIISAIREHGLDGVVVASCTPRMHEATFRRT
LERAGLNRYMFEMANIREHVSWIGKDMEANTSKAMDLVRIAVEKLRRNTPLHPRKFDINKRVMVIGGGVAGIQAALDCAE
GGLEVVLVEREPTIGGKMAKLDKTFPTVDCSSCILGPKMVDIAQHPNITLYALSEVESVNGFVGNFSVNIRRKAAYVDWS
LCTGCGACEEKCPARKTYDKFNEGIGRTTAIKIAFPQAIPKKAVITPETCIMLTKGKCGNCAKVCPAGAIQFDQKDSIVT
EEVGAIIAATGYDLFDHTALGQYGGGRYADVITSLQYERMLSASGPTGGHVKRPSDGAEPKNIVFIQCAGSRDKSIGRPY
CSGFCCMYTAKQAILTKDHIPDSQSYVFYMDIRSPGKMYDEFTRRAMEEYGARYIRGRVSAIQPRGGRYLVKGADTLLGN
QVEIEADMVVLAVGVESAKGASELAEKLRISYDSYGFFMEGHPKLKPVETNTAGVYLAGSCQGPKDIPSSVAQGGAAASK
VLSLFSRDKLESDPQVSAVSLLRCVGCGKCRETCPFGAIEMTEFRGMPKASVVETVCQGCGICAVTCPQGAIQLQHFTDN
QILAEVNALCRY

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR012285 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4 [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 70562; Mature: 70562

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
7.7 %Cys+Met (Translated Protein)
4.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
7.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGVFVCHCGSNIAGTVDTEKVAEAARMYPEVRFATDTMYACSEPGQEGIISAIREHGL
CCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCHHHCCCCCHHHHHHHHHHCCC
DGVVVASCTPRMHEATFRRTLERAGLNRYMFEMANIREHVSWIGKDMEANTSKAMDLVRI
CEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AVEKLRRNTPLHPRKFDINKRVMVIGGGVAGIQAALDCAEGGLEVVLVEREPTIGGKMAK
HHHHHHCCCCCCCCEECCCCEEEEEECCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHH
LDKTFPTVDCSSCILGPKMVDIAQHPNITLYALSEVESVNGFVGNFSVNIRRKAAYVDWS
HCCCCCCCCCHHHHCCCCHHHHHCCCCEEEEEECCHHHCCCEEEEEEEEEEEEEEEEEHH
LCTGCGACEEKCPARKTYDKFNEGIGRTTAIKIAFPQAIPKKAVITPETCIMLTKGKCGN
HHCCCCCHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCEECCCEEEEEECCCCCC
CAKVCPAGAIQFDQKDSIVTEEVGAIIAATGYDLFDHTALGQYGGGRYADVITSLQYERM
CHHHCCCCCEEECCCCCHHHHHHCEEEEECCCCHHHCCCCCCCCCCHHHHHHHHHHHHHH
LSASGPTGGHVKRPSDGAEPKNIVFIQCAGSRDKSIGRPYCSGFCCMYTAKQAILTKDHI
HHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCC
PDSQSYVFYMDIRSPGKMYDEFTRRAMEEYGARYIRGRVSAIQPRGGRYLVKGADTLLGN
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHEEECCCCCEEEEECCHHHCCC
QVEIEADMVVLAVGVESAKGASELAEKLRISYDSYGFFMEGHPKLKPVETNTAGVYLAGS
EEEEEECEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCEECCCCCCEEEEEC
CQGPKDIPSSVAQGGAAASKVLSLFSRDKLESDPQVSAVSLLRCVGCGKCRETCPFGAIE
CCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCEE
MTEFRGMPKASVVETVCQGCGICAVTCPQGAIQLQHFTDNQILAEVNALCRY
HHHHCCCCHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCHHHHHHHHHHCC
>Mature Secondary Structure
MNIGVFVCHCGSNIAGTVDTEKVAEAARMYPEVRFATDTMYACSEPGQEGIISAIREHGL
CCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCEEEECCCHHHCCCCCHHHHHHHHHHCCC
DGVVVASCTPRMHEATFRRTLERAGLNRYMFEMANIREHVSWIGKDMEANTSKAMDLVRI
CEEEEEECCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
AVEKLRRNTPLHPRKFDINKRVMVIGGGVAGIQAALDCAEGGLEVVLVEREPTIGGKMAK
HHHHHHCCCCCCCCEECCCCEEEEEECCHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHH
LDKTFPTVDCSSCILGPKMVDIAQHPNITLYALSEVESVNGFVGNFSVNIRRKAAYVDWS
HCCCCCCCCCHHHHCCCCHHHHHCCCCEEEEEECCHHHCCCEEEEEEEEEEEEEEEEEHH
LCTGCGACEEKCPARKTYDKFNEGIGRTTAIKIAFPQAIPKKAVITPETCIMLTKGKCGN
HHCCCCCHHHCCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCEECCCEEEEEECCCCCC
CAKVCPAGAIQFDQKDSIVTEEVGAIIAATGYDLFDHTALGQYGGGRYADVITSLQYERM
CHHHCCCCCEEECCCCCHHHHHHCEEEEECCCCHHHCCCCCCCCCCHHHHHHHHHHHHHH
LSASGPTGGHVKRPSDGAEPKNIVFIQCAGSRDKSIGRPYCSGFCCMYTAKQAILTKDHI
HHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCHHHCCCHHHHHHHHHHHHHCCC
PDSQSYVFYMDIRSPGKMYDEFTRRAMEEYGARYIRGRVSAIQPRGGRYLVKGADTLLGN
CCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCHHEEECCCCCEEEEECCHHHCCC
QVEIEADMVVLAVGVESAKGASELAEKLRISYDSYGFFMEGHPKLKPVETNTAGVYLAGS
EEEEEECEEEEEECCCCCCCHHHHHHHHHCCCCCCEEEEECCCCCCEECCCCCCEEEEEC
CQGPKDIPSSVAQGGAAASKVLSLFSRDKLESDPQVSAVSLLRCVGCGKCRETCPFGAIE
CCCCHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHCCCCCCEE
MTEFRGMPKASVVETVCQGCGICAVTCPQGAIQLQHFTDNQILAEVNALCRY
HHHHCCCCHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9063468; 11930014 [H]