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The map label for this gene is fdhA [H]

Identifier: 78358552

GI number: 78358552

Start: 3472478

End: 3474904

Strand: Direct

Name: fdhA [H]

Synonym: Dde_3513

Alternate gene names: 78358552

Gene position: 3472478-3474904 (Clockwise)

Preceding gene: 78358551

Following gene: 78358553

Centisome position: 93.09

GC content: 59.74

Gene sequence:

>2427_bases
ATGACCAACCATTGGATCGACATCAAGAATGCCGATGCAATTCTTATTATGGGCAGCAATGCTGCCGAACACCACCCCAT
CTCGTTCAAATGGGTGCTGCAGGCCAAAGACAAGGGCGCCGTGGTAATGCACGTCGATCCCAAGTTTTCGCGCACATCCG
CACGCGCGGACTTTCATGTACCGCTGCGTTCGGGCACCGACATCGCCTTTATGGGCGGGATGATACACTACATTCTGGAA
ACGGAAAGCTACTTCCGGCAGTACGTGCTTGATTATACCAACGCATCGTTCATCGTGGGCGAATCGTACGGGTTCAAGGA
CGGACTGTTCAGCGGGTACGATATACACACCCGCAGCTACGACCGCAGCAAGTGGAACTTTGAAACCGACGCGCAGGGCA
CGCCCAAACGCGACCCCTCGCTCAAGCACCCGCGCTGCGTCTTCCGCCTGATGCAGGAACATTATTCACGCTATACGCTG
GACAATGTTTCATCTGTAACCGGTGTGACAAAGGAAAACCTGCTGAAGGTCTACAAAGCCTTTGCCGCCACCGGCAAACC
GGACAAAGCAGGCACCATGATGTACGCCCTCGGCTGGACACAGCACACGGTGGGCGTGCAGAACATCCGCAGCGCCGCCA
TTGTGCAGCTGCTGCTGGGCAACATAGGTGTGGCGGGCGGCGGCATCAACGCCCTGCGCGGCGAACCCAACGTGCAGGGT
TCCACCGACCACTGCCTGCTCTATCACATCATTCCGGGCTACATGACCATGCCCATGGCCGACTGGCAGACCTATGCCGA
TTACAACAAGGCCAACACGCCTGTTTCCGCAGACCCGCAGAGCGCCAACTGGTGGCAGCACAAGCCCAAGTACCTGACCA
GCCTGCTCAAGGCATGGTTCGGCGATGCGGCCACGGCGGAAAACGGCTACTGCTACGGGCTGCTGCCCAAAATAGAAAAA
GGCGCCGACCACTCCTACATGTTCCTGTTTGACAGGATGTACAGCGGCAAGATCACAGGCGGCTTCATCATCGGGCTGAA
CCCCATGAACAGCGTGCCCAACACCAACAAGGTCCGCAAGGCGCTGGACAACCTCGACTGGCTGGTCACCGCGGAACTGC
ACCATTCCGAAACCACGGATAACTGGCGCAGACCCGGTGTAGACCCGGCAACTGTCAAAACCGAGGTGTTTCTGCTGCCT
TCCGCCCACCGTGTTGAAAAGGCAGGCTCGGTGAGCAACAGCGGGCGCTGGCTTGTGTGGCACCACAAGGCCGTGGAACC
CGAAGGCGAAGCCCGCAGCTTCGGCGACATGTTCGTACCGCTTATAAACGTGGTACGCGACCTGTACCGCAAAGAAGGCG
GCACCATGCCTGAAGCCGTGCTTAACCTCGACTGGCCGCAGCAGTACGACCCCGAGGAATGGGCACGCCGCATCAACGGG
TTCTTCCTCAAGGACACCACGGTAAACGGCAAAGAGTACAAAAAAGGGCAGCTGGTGCCCTCCTTCACGGCGCTTGCCGA
TGACGGCAGCACCTCTTCGCTCAACTGGCTGTACTCGGGCAGCTACACGGAAGAAGACGGCAACAAGGCTCAGCGGCGGG
ACCCCTCGCAGACCCCCATGCAGGCCGCCATCGGCCTGTACCCCAAGTGGTCGTGGTGCTGGCCTGTCAACCGCCGTATT
CTGTACAACCGTGCGTCCGTGGACGCTCAGGGCAAACCGTGGAACCCTGCCAAGGCTGTCATCAGCTGGAACGGCAAAAA
ATGGGAAGGCGATGTCCCCGACGGCGGCTGGCCGCCCATGGCCACCGGCAAGGGCAGACATCCGTTCATCATGAGCAAGC
ACGGCTTCGGCCAGCTGTACGGCACCGGCCGCATGGACGGGCCGTTCTCGGAACACTACGAGCCGGTGGAAACCCCCATC
GACGCGCATCCGTTCTCCAAACAGCTGAGCAGCCCCGTGTACAAGTTCGTTTCGAGCGACATGGATAAACTGGCCAGACC
GGCCGACCCGCGCTTCCCCTATGTGCTGACCACCTACAACGTGACGGAACACTGGTGCGGCGGCGGCGAAACCCGTAACG
TGCCCAACCTGCTTGAGGCCGAACCGCAGCTGTATGTGGAATTAAGCCCCGAGCTGGCAGAAGAAAAAGGCATCGCCAAC
GGCGACGGAGTGATTCTGGAAAGTGCCCGCGGAAGGGTAGAGGCTATCGCCATGGTGACGGTGCGCATACGCCCCTTCAC
CGTTCAGGGAAAAACGGTACACCTTGTGGGGATGCCGTTCTGCTTCGGCTGGACGACACCCGGCACGGGCGACTCGACCA
ACAGGCTTACGCCTTCGGTCGGCGACCCCAACACATCCATACCGGAATACAAGGCCAGCTGCGTCAATATACGCAAGGCC
GACACCCTGACCGAAATCGACCGATAG

Upstream 100 bases:

>100_bases
AGCAATGCGAGGCCTCGGTGTCGTCCATATGGACCACCAGGCACGTATCTGACACAGCGCAACTGTAGCGGCTCTGGGAG
AGTCGTTCGGACGCGGTGCG

Downstream 100 bases:

>100_bases
CCATACGGCGGACGGCCGCTTCATGTGGCCGCCCCGCCAAGGAGTCATGACATGTCAAAAGCCATATTCATAGACACCAC
CCGCTGCACGGCGTGCCGCG

Product: formate dehydrogenase subunit alpha

Products: NA

Alternate protein names: FDH subunit alpha; Formate dehydrogenase large subunit [H]

Number of amino acids: Translated: 808; Mature: 807

Protein sequence:

>808_residues
MTNHWIDIKNADAILIMGSNAAEHHPISFKWVLQAKDKGAVVMHVDPKFSRTSARADFHVPLRSGTDIAFMGGMIHYILE
TESYFRQYVLDYTNASFIVGESYGFKDGLFSGYDIHTRSYDRSKWNFETDAQGTPKRDPSLKHPRCVFRLMQEHYSRYTL
DNVSSVTGVTKENLLKVYKAFAATGKPDKAGTMMYALGWTQHTVGVQNIRSAAIVQLLLGNIGVAGGGINALRGEPNVQG
STDHCLLYHIIPGYMTMPMADWQTYADYNKANTPVSADPQSANWWQHKPKYLTSLLKAWFGDAATAENGYCYGLLPKIEK
GADHSYMFLFDRMYSGKITGGFIIGLNPMNSVPNTNKVRKALDNLDWLVTAELHHSETTDNWRRPGVDPATVKTEVFLLP
SAHRVEKAGSVSNSGRWLVWHHKAVEPEGEARSFGDMFVPLINVVRDLYRKEGGTMPEAVLNLDWPQQYDPEEWARRING
FFLKDTTVNGKEYKKGQLVPSFTALADDGSTSSLNWLYSGSYTEEDGNKAQRRDPSQTPMQAAIGLYPKWSWCWPVNRRI
LYNRASVDAQGKPWNPAKAVISWNGKKWEGDVPDGGWPPMATGKGRHPFIMSKHGFGQLYGTGRMDGPFSEHYEPVETPI
DAHPFSKQLSSPVYKFVSSDMDKLARPADPRFPYVLTTYNVTEHWCGGGETRNVPNLLEAEPQLYVELSPELAEEKGIAN
GDGVILESARGRVEAIAMVTVRIRPFTVQGKTVHLVGMPFCFGWTTPGTGDSTNRLTPSVGDPNTSIPEYKASCVNIRKA
DTLTEIDR

Sequences:

>Translated_808_residues
MTNHWIDIKNADAILIMGSNAAEHHPISFKWVLQAKDKGAVVMHVDPKFSRTSARADFHVPLRSGTDIAFMGGMIHYILE
TESYFRQYVLDYTNASFIVGESYGFKDGLFSGYDIHTRSYDRSKWNFETDAQGTPKRDPSLKHPRCVFRLMQEHYSRYTL
DNVSSVTGVTKENLLKVYKAFAATGKPDKAGTMMYALGWTQHTVGVQNIRSAAIVQLLLGNIGVAGGGINALRGEPNVQG
STDHCLLYHIIPGYMTMPMADWQTYADYNKANTPVSADPQSANWWQHKPKYLTSLLKAWFGDAATAENGYCYGLLPKIEK
GADHSYMFLFDRMYSGKITGGFIIGLNPMNSVPNTNKVRKALDNLDWLVTAELHHSETTDNWRRPGVDPATVKTEVFLLP
SAHRVEKAGSVSNSGRWLVWHHKAVEPEGEARSFGDMFVPLINVVRDLYRKEGGTMPEAVLNLDWPQQYDPEEWARRING
FFLKDTTVNGKEYKKGQLVPSFTALADDGSTSSLNWLYSGSYTEEDGNKAQRRDPSQTPMQAAIGLYPKWSWCWPVNRRI
LYNRASVDAQGKPWNPAKAVISWNGKKWEGDVPDGGWPPMATGKGRHPFIMSKHGFGQLYGTGRMDGPFSEHYEPVETPI
DAHPFSKQLSSPVYKFVSSDMDKLARPADPRFPYVLTTYNVTEHWCGGGETRNVPNLLEAEPQLYVELSPELAEEKGIAN
GDGVILESARGRVEAIAMVTVRIRPFTVQGKTVHLVGMPFCFGWTTPGTGDSTNRLTPSVGDPNTSIPEYKASCVNIRKA
DTLTEIDR
>Mature_807_residues
TNHWIDIKNADAILIMGSNAAEHHPISFKWVLQAKDKGAVVMHVDPKFSRTSARADFHVPLRSGTDIAFMGGMIHYILET
ESYFRQYVLDYTNASFIVGESYGFKDGLFSGYDIHTRSYDRSKWNFETDAQGTPKRDPSLKHPRCVFRLMQEHYSRYTLD
NVSSVTGVTKENLLKVYKAFAATGKPDKAGTMMYALGWTQHTVGVQNIRSAAIVQLLLGNIGVAGGGINALRGEPNVQGS
TDHCLLYHIIPGYMTMPMADWQTYADYNKANTPVSADPQSANWWQHKPKYLTSLLKAWFGDAATAENGYCYGLLPKIEKG
ADHSYMFLFDRMYSGKITGGFIIGLNPMNSVPNTNKVRKALDNLDWLVTAELHHSETTDNWRRPGVDPATVKTEVFLLPS
AHRVEKAGSVSNSGRWLVWHHKAVEPEGEARSFGDMFVPLINVVRDLYRKEGGTMPEAVLNLDWPQQYDPEEWARRINGF
FLKDTTVNGKEYKKGQLVPSFTALADDGSTSSLNWLYSGSYTEEDGNKAQRRDPSQTPMQAAIGLYPKWSWCWPVNRRIL
YNRASVDAQGKPWNPAKAVISWNGKKWEGDVPDGGWPPMATGKGRHPFIMSKHGFGQLYGTGRMDGPFSEHYEPVETPID
AHPFSKQLSSPVYKFVSSDMDKLARPADPRFPYVLTTYNVTEHWCGGGETRNVPNLLEAEPQLYVELSPELAEEKGIANG
DGVILESARGRVEAIAMVTVRIRPFTVQGKTVHLVGMPFCFGWTTPGTGDSTNRLTPSVGDPNTSIPEYKASCVNIRKAD
TLTEIDR

Specific function: Alpha chain of the formate dehydrogenase (FDH) catalyze the reversible two-electron oxidation of formate to carbon dioxide. FDH loses activity in the presence of air, but this activity can be restored. The alpha subunit of formate dehydrogenase forms the

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868719, Length=817, Percent_Identity=45.5324357405141, Blast_Score=709, Evalue=0.0,
Organism=Escherichia coli, GI3868720, Length=815, Percent_Identity=45.0306748466258, Blast_Score=691, Evalue=0.0,
Organism=Escherichia coli, GI3868721, Length=428, Percent_Identity=23.1308411214953, Blast_Score=121, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006443
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 90338; Mature: 90207

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNHWIDIKNADAILIMGSNAAEHHPISFKWVLQAKDKGAVVMHVDPKFSRTSARADFHV
CCCCEEEECCCCEEEEECCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCEEEE
PLRSGTDIAFMGGMIHYILETESYFRQYVLDYTNASFIVGESYGFKDGLFSGYDIHTRSY
ECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECCC
DRSKWNFETDAQGTPKRDPSLKHPRCVFRLMQEHYSRYTLDNVSSVTGVTKENLLKVYKA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHH
FAATGKPDKAGTMMYALGWTQHTVGVQNIRSAAIVQLLLGNIGVAGGGINALRGEPNVQG
HHCCCCCCCCCEEEEEECCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
STDHCLLYHIIPGYMTMPMADWQTYADYNKANTPVSADPQSANWWQHKPKYLTSLLKAWF
CCCCEEEEEECCCCEECCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
GDAATAENGYCYGLLPKIEKGADHSYMFLFDRMYSGKITGGFIIGLNPMNSVPNTNKVRK
CCCCCCCCCEEEEECCCCCCCCCCCEEEEEEHHHCCCCCCEEEEEECCCCCCCCHHHHHH
ALDNLDWLVTAELHHSETTDNWRRPGVDPATVKTEVFLLPSAHRVEKAGSVSNSGRWLVW
HHCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHCCCCCCCCCEEEE
HHKAVEPEGEARSFGDMFVPLINVVRDLYRKEGGTMPEAVLNLDWPQQYDPEEWARRING
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEECCCCCCCCHHHHHHHHCC
FFLKDTTVNGKEYKKGQLVPSFTALADDGSTSSLNWLYSGSYTEEDGNKAQRRDPSQTPM
EEEEEEECCCCCCCCCCCCCCHHEECCCCCCCCEEEEEECCCCCCCCCHHHCCCCCCCCH
QAAIGLYPKWSWCWPVNRRILYNRASVDAQGKPWNPAKAVISWNGKKWEGDVPDGGWPPM
HHHHCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCEECCCCCCCCCCCC
ATGKGRHPFIMSKHGFGQLYGTGRMDGPFSEHYEPVETPIDAHPFSKQLSSPVYKFVSSD
CCCCCCCCEEEECCCCEEEEECCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MDKLARPADPRFPYVLTTYNVTEHWCGGGETRNVPNLLEAEPQLYVELSPELAEEKGIAN
HHHHCCCCCCCCCEEEEEECCHHHHCCCCCCCCCCHHHCCCCEEEEEECHHHHHHCCCCC
GDGVILESARGRVEAIAMVTVRIRPFTVQGKTVHLVGMPFCFGWTTPGTGDSTNRLTPSV
CCCEEEECCCCCEEEEEEEEEEEEEEEECCCEEEEEECCEEECCCCCCCCCCCCCCCCCC
GDPNTSIPEYKASCVNIRKADTLTEIDR
CCCCCCCCCHHHHHEEECCCCCHHHCCC
>Mature Secondary Structure 
TNHWIDIKNADAILIMGSNAAEHHPISFKWVLQAKDKGAVVMHVDPKFSRTSARADFHV
CCCEEEECCCCEEEEECCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCCCCCCEEEE
PLRSGTDIAFMGGMIHYILETESYFRQYVLDYTNASFIVGESYGFKDGLFSGYDIHTRSY
ECCCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCEEEEECCC
DRSKWNFETDAQGTPKRDPSLKHPRCVFRLMQEHYSRYTLDNVSSVTGVTKENLLKVYKA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHCCCCHHHHHHHHHH
FAATGKPDKAGTMMYALGWTQHTVGVQNIRSAAIVQLLLGNIGVAGGGINALRGEPNVQG
HHCCCCCCCCCEEEEEECCCHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
STDHCLLYHIIPGYMTMPMADWQTYADYNKANTPVSADPQSANWWQHKPKYLTSLLKAWF
CCCCEEEEEECCCCEECCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHC
GDAATAENGYCYGLLPKIEKGADHSYMFLFDRMYSGKITGGFIIGLNPMNSVPNTNKVRK
CCCCCCCCCEEEEECCCCCCCCCCCEEEEEEHHHCCCCCCEEEEEECCCCCCCCHHHHHH
ALDNLDWLVTAELHHSETTDNWRRPGVDPATVKTEVFLLPSAHRVEKAGSVSNSGRWLVW
HHCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEECCCHHHHHHCCCCCCCCCEEEE
HHKAVEPEGEARSFGDMFVPLINVVRDLYRKEGGTMPEAVLNLDWPQQYDPEEWARRING
ECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEECCCCCCCCHHHHHHHHCC
FFLKDTTVNGKEYKKGQLVPSFTALADDGSTSSLNWLYSGSYTEEDGNKAQRRDPSQTPM
EEEEEEECCCCCCCCCCCCCCHHEECCCCCCCCEEEEEECCCCCCCCCHHHCCCCCCCCH
QAAIGLYPKWSWCWPVNRRILYNRASVDAQGKPWNPAKAVISWNGKKWEGDVPDGGWPPM
HHHHCCCCCCEEECCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCEECCCCCCCCCCCC
ATGKGRHPFIMSKHGFGQLYGTGRMDGPFSEHYEPVETPIDAHPFSKQLSSPVYKFVSSD
CCCCCCCCEEEECCCCEEEEECCCCCCCHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHH
MDKLARPADPRFPYVLTTYNVTEHWCGGGETRNVPNLLEAEPQLYVELSPELAEEKGIAN
HHHHCCCCCCCCCEEEEEECCHHHHCCCCCCCCCCHHHCCCCEEEEEECHHHHHHCCCCC
GDGVILESARGRVEAIAMVTVRIRPFTVQGKTVHLVGMPFCFGWTTPGTGDSTNRLTPSV
CCCEEEECCCCCEEEEEEEEEEEEEEEECCCEEEEEECCEEECCCCCCCCCCCCCCCCCC
GDPNTSIPEYKASCVNIRKADTLTEIDR
CCCCCCCCCHHHHHEEECCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA