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The map label for this gene is fdhA [H]

Identifier: 78358551

GI number: 78358551

Start: 3471863

End: 3472429

Strand: Direct

Name: fdhA [H]

Synonym: Dde_3512

Alternate gene names: 78358551

Gene position: 3471863-3472429 (Clockwise)

Preceding gene: 78358550

Following gene: 78358552

Centisome position: 93.07

GC content: 57.85

Gene sequence:

>567_bases
ATGAATTGCACCCGGCGAGGATTCCTGAAGCTGGCCGGAGCGGGCGCAGCCTGTATTTCTCTGGCACAGCTCGGCTTCAG
TCTGAAAGAGGCGCGCGCCTTTGCCGCGTCGCTGAAGATTGAAGGGGCGAAGGAAGTCATCACCGTCTGTCCGTTCTGTT
CCGTCAGCTGCCACATCATCGCGTATGTGAAAAACGGCAAGCTGATCAGCACGGAAGGTGATCCGGATTATCCCATCAAC
GAAGGTTCGCTGTGCGCCAAGGGCGCCGCGCTGCTGACCATGTCGACCAGTCATCACAGACTGCTCAAACCCAAATACCG
CGCACCCTTCAGCGACAAGTGGGAAGAAAAAGACTGGGGCTGGACGCTGGAGCAGATAGCCCGCCGCGTCAAGGATACCC
GCGACAAGGAAATCATACTCGAAAACAACAAGGGCCAGCGGGTCAACCGTCTGGAATCCATGTTCCTGCTGGGCACATCC
CATGCGGACAACGAAGAGTGCGCCCTTGTGCACCAAGCAATGCGAGGCCTCGGTGTCGTCCATATGGACCACCAGGCACG
TATCTGA

Upstream 100 bases:

>100_bases
CTTTTTATTGACCAAACATTTCCTGACGTGGCATCCGTTGCATAGGATGCGGCGTGCACCTGCGCCGCGGCATTAGCAAC
CGAAAAAGGAGGCCGAGGAC

Downstream 100 bases:

>100_bases
CACAGCGCAACTGTAGCGGCTCTGGGAGAGTCGTTCGGACGCGGTGCGATGACCAACCATTGGATCGACATCAAGAATGC
CGATGCAATTCTTATTATGG

Product: formate dehydrogenase subunit alpha

Products: NA

Alternate protein names: FDH subunit alpha; Formate dehydrogenase large subunit [H]

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MNCTRRGFLKLAGAGAACISLAQLGFSLKEARAFAASLKIEGAKEVITVCPFCSVSCHIIAYVKNGKLISTEGDPDYPIN
EGSLCAKGAALLTMSTSHHRLLKPKYRAPFSDKWEEKDWGWTLEQIARRVKDTRDKEIILENNKGQRVNRLESMFLLGTS
HADNEECALVHQAMRGLGVVHMDHQARI

Sequences:

>Translated_188_residues
MNCTRRGFLKLAGAGAACISLAQLGFSLKEARAFAASLKIEGAKEVITVCPFCSVSCHIIAYVKNGKLISTEGDPDYPIN
EGSLCAKGAALLTMSTSHHRLLKPKYRAPFSDKWEEKDWGWTLEQIARRVKDTRDKEIILENNKGQRVNRLESMFLLGTS
HADNEECALVHQAMRGLGVVHMDHQARI
>Mature_188_residues
MNCTRRGFLKLAGAGAACISLAQLGFSLKEARAFAASLKIEGAKEVITVCPFCSVSCHIIAYVKNGKLISTEGDPDYPIN
EGSLCAKGAALLTMSTSHHRLLKPKYRAPFSDKWEEKDWGWTLEQIARRVKDTRDKEIILENNKGQRVNRLESMFLLGTS
HADNEECALVHQAMRGLGVVHMDHQARI

Specific function: Alpha chain of the formate dehydrogenase (FDH) catalyze the reversible two-electron oxidation of formate to carbon dioxide. FDH loses activity in the presence of air, but this activity can be restored. The alpha subunit of formate dehydrogenase forms the

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868719, Length=195, Percent_Identity=40.5128205128205, Blast_Score=146, Evalue=7e-37,
Organism=Escherichia coli, GI3868720, Length=195, Percent_Identity=38.4615384615385, Blast_Score=137, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006443
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 20841; Mature: 20841

Theoretical pI: Translated: 8.69; Mature: 8.69

Prosite motif: PS00551 MOLYBDOPTERIN_PROK_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNCTRRGFLKLAGAGAACISLAQLGFSLKEARAFAASLKIEGAKEVITVCPFCSVSCHII
CCCCCCCCEEECCCCHHHHHHHHHCCHHHHHHHHHHHEEECCCHHHHHHCCCCCCEEEEE
AYVKNGKLISTEGDPDYPINEGSLCAKGAALLTMSTSHHRLLKPKYRAPFSDKWEEKDWG
EEEECCEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCHHCCCCCCCCCCCCCCCCCCC
WTLEQIARRVKDTRDKEIILENNKGQRVNRLESMFLLGTSHADNEECALVHQAMRGLGVV
CCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCEE
HMDHQARI
EECCCCCC
>Mature Secondary Structure
MNCTRRGFLKLAGAGAACISLAQLGFSLKEARAFAASLKIEGAKEVITVCPFCSVSCHII
CCCCCCCCEEECCCCHHHHHHHHHCCHHHHHHHHHHHEEECCCHHHHHHCCCCCCEEEEE
AYVKNGKLISTEGDPDYPINEGSLCAKGAALLTMSTSHHRLLKPKYRAPFSDKWEEKDWG
EEEECCEEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCHHCCCCCCCCCCCCCCCCCCC
WTLEQIARRVKDTRDKEIILENNKGQRVNRLESMFLLGTSHADNEECALVHQAMRGLGVV
CCHHHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHEEECCCCCCHHHHHHHHHHHHCCEE
HMDHQARI
EECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA