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The map label for this gene is mutL [H]

Identifier: 78358503

GI number: 78358503

Start: 3423304

End: 3425382

Strand: Direct

Name: mutL [H]

Synonym: Dde_3464

Alternate gene names: 78358503

Gene position: 3423304-3425382 (Clockwise)

Preceding gene: 78358502

Following gene: 78358504

Centisome position: 91.77

GC content: 64.21

Gene sequence:

>2079_bases
ATGACGCAAGATAACACTCCGCAGCGCAAACGCATACAGCTGCTGCCCGACGCCCTGCGCAACCAGATAGCCGCGGGCGA
AGTGGTGGAACGCCCTTCCAGCGTGGTCAAGGAACTGGTGGAAAACAGTCTGGACGCCGGTGCACGCACGGTGGAAGTGG
CCATTGAAGACGGCGGACGCAGCCTGATAACCGTACGCGACGACGGCGACGGCATAGACGCGGCCGAACTGGAACTGGCC
GTGACCAGACACGCCACCAGCAAAGTCACCACGTTTGACGAACTGATGCGCATAGCCAGTTACGGCTTCCGCGGAGAGGC
ACTGCCCAGCATAGCCTCGGTATCAGATTTCCGCATGACCTCAGCGCCTGCTCAGCGCACGGCGGCTGATACCGCACCGG
AAGCCAGCTGCATCCATGTGCGGCACGGCAGCATCATTTCGCACGGGCCGGCAGCGCTGTCCAGAGGCACACTGGTGGAA
GTGCGCGACCTGTTCATGAACGTTCCGGCACGGCTTAAATTTCTTAAAACCACAGCCACGGAAAGCAAACGCTGTCAGGA
ACTGTTCTGCAGGCTGGCGCTGGCACGCCCCGACGCGGGGTTTTCACTTTCCAGCGGCGGGCGCGAGGTGTTCCGCTTTC
CTGCCGGTCAGACGTGGCGCGAACGCCTTGCGGTGCTGTGGCCGCCCAGCATCACGGAATCAATGGTGGAAGTACCGCCT
TTGTGCAGCCGCGCCCACGACGGTACAGTACCCGACGTGCAGGTACGCGGACTGTGCGGCGACCCCCGCCAGTCGCAGCC
GCGGGCGGACAAGATGCTGTTTTACGTCAACGGCAGAGCGGTTACCGACAAATTGCTCATGCGTGCCGTGCGCGATGCCT
ATTCCGGCAGAATGCTGGGGCGCGAGTATCCGCAGGTGCTGCTGTTCATCGAACTGGACCCCGAAATGGTCGATGTGAAC
GTGCATCCCGCCAAAAGCGAAGTGCGCTTCCGCGAAGAACGGCATGTCTTCAGTGCCGTGCGCCGCGCGGTTGAAGCCGC
CCTGCAGCAGCTGAGCGCCACAGGGACACCGGACAGTCCGGATACCGCGGGCGTTGCAGACATACCCGGACATGCAGCTT
CCGGCGCAGCCGGTCTGCGTCTGACACCGGACAGCCCTGCCACCCCAAGGGCAGCCGCCCGTCCGCTGGGATTCTGGGGA
GAGGCAGACGCAGCACCCATTGTACCCAGAGCGCCGCGTGACCATGAGGACGACGAGGTGACGCTGCGTCATATGCCGCA
GCCGTCCTCTGCCGACGGCAGAACAGACCGCACGGAGCATACGGACAGTGCGGAAGCACCGGACGCGCACCTGCCTCACC
GTGACGACGGGGTGCGCATTGACTTCATGGCAGGCGGCCCTTCGCGGGCGGCAGGACACACGGACGCCGCAGTTGCGGAA
CAGCCGGACGCGGAATACGGCCATGCAGCCCCGCACAGCACCCCGCAGCCGGCCGGTGCCCCCGCGGACCCCGCACACGG
GGGTGTCACCGTGGGCGAATACACCTATCTCGGCCAGATTGCGGACACGTATCTGGTTGTCAGGCGCAAAGGCAGCACCC
TGCTGCTGCTCGACCAGCATGCCGTGCATGAGCGCGTGCTGTACGAACGCATCCGCCGCGATGCCACGCAGGGGCAGACG
CAGCTGCTGGCCTTTCCTGCGGAAATGCCCCTGCATAACGCAGAAGCGGAACGTCTTGCCTCGGTGTGGGAAAAGCTGGC
AGCCATGGGGTTTGCGCTGGAAACGCACGGGCCTTCGCTGCGCATCCGGGGCATACCGTCCACCCTGGACCAGCGCGGGG
CCACGGAATTTCTGCGTGAAGTGCTGGCAGACAGAAAGGGCAGACTGCCCGATATGTGGGTGATGATGTCGTGCCGCTCC
GCCATCAAGGCGGGGCAGCGGCTTACTCCTGACGAGGCTGCGGGCCTTATTGCCCAATGGCTTGAAGTGCCCGATAGAGA
ATTCTGCCCCCACGGGCGGCCCGCGGTGCTGCGCTTCACCCCCGCCGATCTGGAAAAAATGTTCAAACGCACAGGGTGA

Upstream 100 bases:

>100_bases
ATACGGGCGCACCGTGTCAGCCGCGTTACGCGCCGCACTTTACCCGCGCGCCCGTTTATGGCTAGATGGGCAGTGCACGA
GACTATGAGGACACATATCC

Downstream 100 bases:

>100_bases
GCCGGAGACGGCGCACCGGCAGGCCGGAACATTCCGGCCTTTTTTTGCGTCTTATTTTTCCGCAGGGTGGACGCAGCTCG
CGCTCCGTCGTAAACTGGGC

Product: DNA mismatch repair protein MutL

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 692; Mature: 691

Protein sequence:

>692_residues
MTQDNTPQRKRIQLLPDALRNQIAAGEVVERPSSVVKELVENSLDAGARTVEVAIEDGGRSLITVRDDGDGIDAAELELA
VTRHATSKVTTFDELMRIASYGFRGEALPSIASVSDFRMTSAPAQRTAADTAPEASCIHVRHGSIISHGPAALSRGTLVE
VRDLFMNVPARLKFLKTTATESKRCQELFCRLALARPDAGFSLSSGGREVFRFPAGQTWRERLAVLWPPSITESMVEVPP
LCSRAHDGTVPDVQVRGLCGDPRQSQPRADKMLFYVNGRAVTDKLLMRAVRDAYSGRMLGREYPQVLLFIELDPEMVDVN
VHPAKSEVRFREERHVFSAVRRAVEAALQQLSATGTPDSPDTAGVADIPGHAASGAAGLRLTPDSPATPRAAARPLGFWG
EADAAPIVPRAPRDHEDDEVTLRHMPQPSSADGRTDRTEHTDSAEAPDAHLPHRDDGVRIDFMAGGPSRAAGHTDAAVAE
QPDAEYGHAAPHSTPQPAGAPADPAHGGVTVGEYTYLGQIADTYLVVRRKGSTLLLLDQHAVHERVLYERIRRDATQGQT
QLLAFPAEMPLHNAEAERLASVWEKLAAMGFALETHGPSLRIRGIPSTLDQRGATEFLREVLADRKGRLPDMWVMMSCRS
AIKAGQRLTPDEAAGLIAQWLEVPDREFCPHGRPAVLRFTPADLEKMFKRTG

Sequences:

>Translated_692_residues
MTQDNTPQRKRIQLLPDALRNQIAAGEVVERPSSVVKELVENSLDAGARTVEVAIEDGGRSLITVRDDGDGIDAAELELA
VTRHATSKVTTFDELMRIASYGFRGEALPSIASVSDFRMTSAPAQRTAADTAPEASCIHVRHGSIISHGPAALSRGTLVE
VRDLFMNVPARLKFLKTTATESKRCQELFCRLALARPDAGFSLSSGGREVFRFPAGQTWRERLAVLWPPSITESMVEVPP
LCSRAHDGTVPDVQVRGLCGDPRQSQPRADKMLFYVNGRAVTDKLLMRAVRDAYSGRMLGREYPQVLLFIELDPEMVDVN
VHPAKSEVRFREERHVFSAVRRAVEAALQQLSATGTPDSPDTAGVADIPGHAASGAAGLRLTPDSPATPRAAARPLGFWG
EADAAPIVPRAPRDHEDDEVTLRHMPQPSSADGRTDRTEHTDSAEAPDAHLPHRDDGVRIDFMAGGPSRAAGHTDAAVAE
QPDAEYGHAAPHSTPQPAGAPADPAHGGVTVGEYTYLGQIADTYLVVRRKGSTLLLLDQHAVHERVLYERIRRDATQGQT
QLLAFPAEMPLHNAEAERLASVWEKLAAMGFALETHGPSLRIRGIPSTLDQRGATEFLREVLADRKGRLPDMWVMMSCRS
AIKAGQRLTPDEAAGLIAQWLEVPDREFCPHGRPAVLRFTPADLEKMFKRTG
>Mature_691_residues
TQDNTPQRKRIQLLPDALRNQIAAGEVVERPSSVVKELVENSLDAGARTVEVAIEDGGRSLITVRDDGDGIDAAELELAV
TRHATSKVTTFDELMRIASYGFRGEALPSIASVSDFRMTSAPAQRTAADTAPEASCIHVRHGSIISHGPAALSRGTLVEV
RDLFMNVPARLKFLKTTATESKRCQELFCRLALARPDAGFSLSSGGREVFRFPAGQTWRERLAVLWPPSITESMVEVPPL
CSRAHDGTVPDVQVRGLCGDPRQSQPRADKMLFYVNGRAVTDKLLMRAVRDAYSGRMLGREYPQVLLFIELDPEMVDVNV
HPAKSEVRFREERHVFSAVRRAVEAALQQLSATGTPDSPDTAGVADIPGHAASGAAGLRLTPDSPATPRAAARPLGFWGE
ADAAPIVPRAPRDHEDDEVTLRHMPQPSSADGRTDRTEHTDSAEAPDAHLPHRDDGVRIDFMAGGPSRAAGHTDAAVAEQ
PDAEYGHAAPHSTPQPAGAPADPAHGGVTVGEYTYLGQIADTYLVVRRKGSTLLLLDQHAVHERVLYERIRRDATQGQTQ
LLAFPAEMPLHNAEAERLASVWEKLAAMGFALETHGPSLRIRGIPSTLDQRGATEFLREVLADRKGRLPDMWVMMSCRSA
IKAGQRLTPDEAAGLIAQWLEVPDREFCPHGRPAVLRFTPADLEKMFKRTG

Specific function: This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-bindi

COG id: COG0323

COG function: function code L; DNA mismatch repair enzyme (predicted ATPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA mismatch repair mutL/hexB family [H]

Homologues:

Organism=Homo sapiens, GI4557757, Length=341, Percent_Identity=30.791788856305, Blast_Score=172, Evalue=9e-43,
Organism=Homo sapiens, GI4505911, Length=374, Percent_Identity=29.9465240641711, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI189458898, Length=385, Percent_Identity=29.6103896103896, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI310128478, Length=343, Percent_Identity=30.6122448979592, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI4505913, Length=343, Percent_Identity=30.6122448979592, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI189458896, Length=363, Percent_Identity=29.4765840220386, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI310128480, Length=316, Percent_Identity=27.5316455696203, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI263191589, Length=247, Percent_Identity=26.3157894736842, Blast_Score=81, Evalue=3e-15,
Organism=Escherichia coli, GI1790612, Length=405, Percent_Identity=41.7283950617284, Blast_Score=256, Evalue=3e-69,
Organism=Caenorhabditis elegans, GI71991825, Length=328, Percent_Identity=33.2317073170732, Blast_Score=164, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI17562796, Length=359, Percent_Identity=25.9052924791086, Blast_Score=126, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6323819, Length=355, Percent_Identity=30.9859154929577, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6324247, Length=363, Percent_Identity=28.099173553719, Blast_Score=124, Evalue=7e-29,
Organism=Saccharomyces cerevisiae, GI6325093, Length=153, Percent_Identity=32.6797385620915, Blast_Score=80, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323063, Length=365, Percent_Identity=24.3835616438356, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17136968, Length=364, Percent_Identity=31.3186813186813, Blast_Score=186, Evalue=4e-47,
Organism=Drosophila melanogaster, GI17136970, Length=360, Percent_Identity=27.7777777777778, Blast_Score=105, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002099
- InterPro:   IPR013507
- InterPro:   IPR014762
- InterPro:   IPR020667
- InterPro:   IPR014763
- InterPro:   IPR014790
- InterPro:   IPR020568
- InterPro:   IPR014721 [H]

Pfam domain/function: PF01119 DNA_mis_repair; PF02518 HATPase_c; PF08676 MutL_C [H]

EC number: NA

Molecular weight: Translated: 75345; Mature: 75214

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS00058 DNA_MISMATCH_REPAIR_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQDNTPQRKRIQLLPDALRNQIAAGEVVERPSSVVKELVENSLDAGARTVEVAIEDGGR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEEEEECCCC
SLITVRDDGDGIDAAELELAVTRHATSKVTTFDELMRIASYGFRGEALPSIASVSDFRMT
EEEEEECCCCCCCHHHEEEEEHHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHC
SAPAQRTAADTAPEASCIHVRHGSIISHGPAALSRGTLVEVRDLFMNVPARLKFLKTTAT
CCCHHHHHCCCCCCCCEEEEECCCEECCCCHHHCCCCHHHHHHHHHCCCHHHEEHHHHHH
ESKRCQELFCRLALARPDAGFSLSSGGREVFRFPAGQTWRERLAVLWPPSITESMVEVPP
HHHHHHHHHHHHHHCCCCCCCEECCCCCEEEECCCCCCHHHCEEEECCCHHHHHHHHCCC
LCSRAHDGTVPDVQVRGLCGDPRQSQPRADKMLFYVNGRAVTDKLLMRAVRDAYSGRMLG
HHHCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCC
REYPQVLLFIELDPEMVDVNVHPAKSEVRFREERHVFSAVRRAVEAALQQLSATGTPDSP
CCCCEEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DTAGVADIPGHAASGAAGLRLTPDSPATPRAAARPLGFWGEADAAPIVPRAPRDHEDDEV
CCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TLRHMPQPSSADGRTDRTEHTDSAEAPDAHLPHRDDGVRIDFMAGGPSRAAGHTDAAVAE
CEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHCC
QPDAEYGHAAPHSTPQPAGAPADPAHGGVTVGEYTYLGQIADTYLVVRRKGSTLLLLDQH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHEEEEEEECCCEEEEECHH
AVHERVLYERIRRDATQGQTQLLAFPAEMPLHNAEAERLASVWEKLAAMGFALETHGPSL
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCEEEECCCCEE
RIRGIPSTLDQRGATEFLREVLADRKGRLPDMWVMMSCRSAIKAGQRLTPDEAAGLIAQW
EEECCCHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LEVPDREFCPHGRPAVLRFTPADLEKMFKRTG
HHCCCHHCCCCCCCEEEEECHHHHHHHHHHCC
>Mature Secondary Structure 
TQDNTPQRKRIQLLPDALRNQIAAGEVVERPSSVVKELVENSLDAGARTVEVAIEDGGR
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCEEEEEEEECCCC
SLITVRDDGDGIDAAELELAVTRHATSKVTTFDELMRIASYGFRGEALPSIASVSDFRMT
EEEEEECCCCCCCHHHEEEEEHHHCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHC
SAPAQRTAADTAPEASCIHVRHGSIISHGPAALSRGTLVEVRDLFMNVPARLKFLKTTAT
CCCHHHHHCCCCCCCCEEEEECCCEECCCCHHHCCCCHHHHHHHHHCCCHHHEEHHHHHH
ESKRCQELFCRLALARPDAGFSLSSGGREVFRFPAGQTWRERLAVLWPPSITESMVEVPP
HHHHHHHHHHHHHHCCCCCCCEECCCCCEEEECCCCCCHHHCEEEECCCHHHHHHHHCCC
LCSRAHDGTVPDVQVRGLCGDPRQSQPRADKMLFYVNGRAVTDKLLMRAVRDAYSGRMLG
HHHCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHCCCCCC
REYPQVLLFIELDPEMVDVNVHPAKSEVRFREERHVFSAVRRAVEAALQQLSATGTPDSP
CCCCEEEEEEEECCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
DTAGVADIPGHAASGAAGLRLTPDSPATPRAAARPLGFWGEADAAPIVPRAPRDHEDDEV
CCCCCCCCCCCCCCCCCCEEECCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TLRHMPQPSSADGRTDRTEHTDSAEAPDAHLPHRDDGVRIDFMAGGPSRAAGHTDAAVAE
CEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCCHHCC
QPDAEYGHAAPHSTPQPAGAPADPAHGGVTVGEYTYLGQIADTYLVVRRKGSTLLLLDQH
CCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHEEEEEEECCCEEEEECHH
AVHERVLYERIRRDATQGQTQLLAFPAEMPLHNAEAERLASVWEKLAAMGFALETHGPSL
HHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCEEEECCCCEE
RIRGIPSTLDQRGATEFLREVLADRKGRLPDMWVMMSCRSAIKAGQRLTPDEAAGLIAQW
EEECCCHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
LEVPDREFCPHGRPAVLRFTPADLEKMFKRTG
HHCCCHHCCCCCCCEEEEECHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA