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The map label for this gene is degP [C]

Identifier: 78358459

GI number: 78358459

Start: 3383048

End: 3384199

Strand: Direct

Name: degP [C]

Synonym: Dde_3420

Alternate gene names: 78358459

Gene position: 3383048-3384199 (Clockwise)

Preceding gene: 78358458

Following gene: 78358470

Centisome position: 90.69

GC content: 65.45

Gene sequence:

>1152_bases
ATGGCCTACCCCGACCCGTACGCGCGCCCGCCACAGGACCACTTTATCCGTCGCTGGCTCTTCATCACCGCCTGCATTGC
CGCGCTCATGCTGCTGTGGCAGTTTCTGCCCGCCATCGAGGCCTGGTTCAGTCCGCGCGAGGCGGCAGAACGCACCGTGA
CGGCGCGTGGCGATCTGGCGGCGGACGAGAAGGCCACCATCGAACTGTTCGAAAAATCGCGCGCCTCGGTGGTGTATATC
ACCACCGCACAGCTGGTACGAGACGTCTGGACGCGCAATGTCTTCTCCGTGCCGCGCGGCACCGGCTCGGGCTTCATCTG
GGACGACGCCGGCCACGTTGTCACCAACTTCCACGTCATCCAGGGGGCGTCCGAAGCCTCCGTCAAACTCGCCGACGGCC
GCGACTACCAAGCCGCGCTGGTGGGGGCAAGCCCCGCGCACGACATCGCTGTGCTCAAGATCGGCGTCGGTTTCAAGCGC
CCGCCTGCCGTGCCGATCGGCACCAGCGCCGACCTCAAGGTGGGTCAAAAGGTCTTTGCCATCGGCAACCCCTTCGGCCT
GGACTGGACGCTCACCGCCGGTATCGTCTCCGCGCTCGACCGCTCGTTACCCGGAGAAGCGGGCGGCCCGGCCATCGATC
ACCTGATCCAGACCGACGCCGCCATCAACCCTGGCAACTCCGGTGGGCCGCTGCTCGATTCGGCAGGAAGGCTCATCGGC
ATCAACACGGCGATCTATAGCCCCTCCGGCGCCTCGGCCGGGATTGGTTTCGCCGTGCCGGTGGACACCGTCATGCGCGT
AGTCCCGCAACTCATCAAGACCGGTAAGTACATCCGTCCGGCGCTGGGCATTCAGGTGGACGAACAGCTCAATCAGCGCC
TGCTGGCGCTGACTGGAAGCAAGGGCGTGTTCGTGCTGCGTGTTACCCCTGGTTCGGCAGCGCACAAGGCCGGCCTCGCG
GGTGTCGAAGTCACGCCGCAAGGCATCGTGCCCGGCGACCGCATCATCGGTGTTGATGGCAAGGCGACGGACAATGTGGC
TAAGCTGCTCGCGCGGCTAGACGACAGGAAGGTCGGCGATGTGGTGGTCTTGTCAGTGGAACGGGCCGGCAAAACGCGCG
AAGTGCGTGTGGAGCTGCAACCGGGGATTTGA

Upstream 100 bases:

>100_bases
CGAGATCCATTCCTTGCCGGAATCCGCTGTGACGCTGCGCCCCCCGCGCTGGCGCCCGAGCGGGCTATGGCGCTGATTGT
CTATCAACAGGAGACTTCTC

Downstream 100 bases:

>100_bases
CTGAATCGACCCGGTCTATCAGGCGGCGCGGAGCAGGCAAGTGGCCTCAGCCTCCCGCCGCGTGACAAGCCCCGGCAGCA
CCCTGCCGCCGCCATAGACC

Product: DegP2 peptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MAYPDPYARPPQDHFIRRWLFITACIAALMLLWQFLPAIEAWFSPREAAERTVTARGDLAADEKATIELFEKSRASVVYI
TTAQLVRDVWTRNVFSVPRGTGSGFIWDDAGHVVTNFHVIQGASEASVKLADGRDYQAALVGASPAHDIAVLKIGVGFKR
PPAVPIGTSADLKVGQKVFAIGNPFGLDWTLTAGIVSALDRSLPGEAGGPAIDHLIQTDAAINPGNSGGPLLDSAGRLIG
INTAIYSPSGASAGIGFAVPVDTVMRVVPQLIKTGKYIRPALGIQVDEQLNQRLLALTGSKGVFVLRVTPGSAAHKAGLA
GVEVTPQGIVPGDRIIGVDGKATDNVAKLLARLDDRKVGDVVVLSVERAGKTREVRVELQPGI

Sequences:

>Translated_383_residues
MAYPDPYARPPQDHFIRRWLFITACIAALMLLWQFLPAIEAWFSPREAAERTVTARGDLAADEKATIELFEKSRASVVYI
TTAQLVRDVWTRNVFSVPRGTGSGFIWDDAGHVVTNFHVIQGASEASVKLADGRDYQAALVGASPAHDIAVLKIGVGFKR
PPAVPIGTSADLKVGQKVFAIGNPFGLDWTLTAGIVSALDRSLPGEAGGPAIDHLIQTDAAINPGNSGGPLLDSAGRLIG
INTAIYSPSGASAGIGFAVPVDTVMRVVPQLIKTGKYIRPALGIQVDEQLNQRLLALTGSKGVFVLRVTPGSAAHKAGLA
GVEVTPQGIVPGDRIIGVDGKATDNVAKLLARLDDRKVGDVVVLSVERAGKTREVRVELQPGI
>Mature_382_residues
AYPDPYARPPQDHFIRRWLFITACIAALMLLWQFLPAIEAWFSPREAAERTVTARGDLAADEKATIELFEKSRASVVYIT
TAQLVRDVWTRNVFSVPRGTGSGFIWDDAGHVVTNFHVIQGASEASVKLADGRDYQAALVGASPAHDIAVLKIGVGFKRP
PAVPIGTSADLKVGQKVFAIGNPFGLDWTLTAGIVSALDRSLPGEAGGPAIDHLIQTDAAINPGNSGGPLLDSAGRLIGI
NTAIYSPSGASAGIGFAVPVDTVMRVVPQLIKTGKYIRPALGIQVDEQLNQRLLALTGSKGVFVLRVTPGSAAHKAGLAG
VEVTPQGIVPGDRIIGVDGKATDNVAKLLARLDDRKVGDVVVLSVERAGKTREVRVELQPGI

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=304, Percent_Identity=35.8552631578947, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI7019477, Length=301, Percent_Identity=33.8870431893688, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI4506141, Length=310, Percent_Identity=32.9032258064516, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI24308541, Length=303, Percent_Identity=31.6831683168317, Blast_Score=112, Evalue=7e-25,
Organism=Escherichia coli, GI1786356, Length=284, Percent_Identity=43.3098591549296, Blast_Score=187, Evalue=1e-48,
Organism=Escherichia coli, GI1789629, Length=287, Percent_Identity=41.8118466898955, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1789630, Length=290, Percent_Identity=36.551724137931, Blast_Score=140, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24646839, Length=314, Percent_Identity=32.1656050955414, Blast_Score=117, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 40496; Mature: 40365

Theoretical pI: Translated: 8.94; Mature: 8.94

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYPDPYARPPQDHFIRRWLFITACIAALMLLWQFLPAIEAWFSPREAAERTVTARGDLA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEECCCCCC
ADEKATIELFEKSRASVVYITTAQLVRDVWTRNVFSVPRGTGSGFIWDDAGHVVTNFHVI
CCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCEECCCCCCCEEEECCCCCEEEEEEEE
QGASEASVKLADGRDYQAALVGASPAHDIAVLKIGVGFKRPPAVPIGTSADLKVGQKVFA
ECCCCCEEEEECCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEE
IGNPFGLDWTLTAGIVSALDRSLPGEAGGPAIDHLIQTDAAINPGNSGGPLLDSAGRLIG
ECCCCCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHCCCCEEE
INTAIYSPSGASAGIGFAVPVDTVMRVVPQLIKTGKYIRPALGIQVDEQLNQRLLALTGS
EEEEEECCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCHHCCCEEHHHHCCEEEEEECC
KGVFVLRVTPGSAAHKAGLAGVEVTPQGIVPGDRIIGVDGKATDNVAKLLARLDDRKVGD
CCEEEEEECCCCHHHHCCCCCCEECCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCC
VVVLSVERAGKTREVRVELQPGI
EEEEEECCCCCCEEEEEEECCCC
>Mature Secondary Structure 
AYPDPYARPPQDHFIRRWLFITACIAALMLLWQFLPAIEAWFSPREAAERTVTARGDLA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEECCCCCC
ADEKATIELFEKSRASVVYITTAQLVRDVWTRNVFSVPRGTGSGFIWDDAGHVVTNFHVI
CCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCEECCCCCCCEEEECCCCCEEEEEEEE
QGASEASVKLADGRDYQAALVGASPAHDIAVLKIGVGFKRPPAVPIGTSADLKVGQKVFA
ECCCCCEEEEECCCCCEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCEEEE
IGNPFGLDWTLTAGIVSALDRSLPGEAGGPAIDHLIQTDAAINPGNSGGPLLDSAGRLIG
ECCCCCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHCCCCEEE
INTAIYSPSGASAGIGFAVPVDTVMRVVPQLIKTGKYIRPALGIQVDEQLNQRLLALTGS
EEEEEECCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCHHCCCEEHHHHCCEEEEEECC
KGVFVLRVTPGSAAHKAGLAGVEVTPQGIVPGDRIIGVDGKATDNVAKLLARLDDRKVGD
CCEEEEEECCCCHHHHCCCCCCEECCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCC
VVVLSVERAGKTREVRVELQPGI
EEEEEECCCCCCEEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]