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The map label for this gene is atoC [H]

Identifier: 78358080

GI number: 78358080

Start: 3030732

End: 3032168

Strand: Direct

Name: atoC [H]

Synonym: Dde_3040

Alternate gene names: 78358080

Gene position: 3030732-3032168 (Clockwise)

Preceding gene: 78358077

Following gene: 78358081

Centisome position: 81.25

GC content: 58.59

Gene sequence:

>1437_bases
ATGCAGCACTATCTTGTGGCCACAGACAATCAGCCTGCAGCCAAGGCCATCACACGCAGTTTTTCCTCTCAGGCGGAACT
GACTGTGGTGCACAGTCCTCAGGAACTTCATGCCGCACTGGGCAGACGCATTCCCGATGTTCTTTTCGCCGATGTTTCAT
GGCTGGACCGTTCGCCGGAGCGCACTCTGGACACCATACGCACCGCGCTGCGCGCACTGTGGGCCATAGCGCCCAATCTG
GAAGTCATCGTGCTGGCCGGACAGGAAAACATACGCGAAGCCGTCAAATCGGTCCGGGCCGGTGCGGACAACTATCTGAC
GTACCCCGTTTCGGCAGAAGAAGCCGCCTATGTGCTTGAGAGCCTGCGCGAATCCCGCATGATGCAGACAGAGCTTGAGT
ATCTGCGCTCGTCGGCCGACGGCAAAACGCGTATTCCGCTGGAACAGGTGCACAGTACGGTCATGCAGACTGTGTTCGAC
AAAGTGCGGCGGGTGGCCGCGACAGACACAACCATACTGCTGCAGGGCGAAACCGGCACGGGCAAGGGGGTGCTGGCAAA
GCTCATCCACGCCCGCAGCAACCGGTCCAAAGGTCCCTTCATGGGCGTGCACTGCGGTGCCATTCCCGAAACGCTGGTGG
AAAGCGAACTGTTCGGCCATGAAAAAGGCGCCTTTACCGGAGCCAGCAAGCGCAAGCCCGGGCGCTTTGAGGTGGCCGCC
AAGGGAACCATATTTCTGGACGAAATAGGCACCATATCACTGCCGACACAGGTGCGGCTGCTGCAGGTGCTGCAGGACAA
AGTGTTCCAGCGGGTGGGCGGCGTGAACGACATTCCCATGGAAGCCCGCATTGTGGCCGCCAGCAACGTTGATCTGGAAG
AACTGGTAAAAAAAGGACAGTTCCGTGCCGACCTGCTGTTCCGGCTCAACGTTTTTCCCATCAGAGTGCCCGCCCTGCGC
GAGCGGCGCGAAGATATCCCCCTGCTGGCCGAGACTTTTCTGCAACGGCTGCGGCAGCGGCAGATGAAAAAAATTCAGGG
CATCCACCCCGAAGTGCTGACAGCTTTTCAGAACTACGCATGGCCCGGTAACATACGCGAACTGGAAAACCTGATGGAAC
GGGCCTATATTCTGGAAACCTCCCACATGCTCTCGCCCGATAACTTTCCGCAGGACCTGTTTGCAGGCGGCGCCCCGCTG
GCCAACGTCTCGCTGGACCTTTCACTGCCTCTTGCCGCTGTGCGCAATCAGGCCAAAGAACAGGCCCAGCGCCGCTACAT
TGAAGAGCTGATAGCCGAATGCAGGGGCAGAATAAACCTGACAGCGGAACGCGCGGGCATAACCACCCGCCAGCTGAGAA
AACTGCTCACCCGCTACGGCATCGACAAATCCGTGTACAAGCAGTCCAAAAGCGGAACTTCAGGTACCCAAAAATAA

Upstream 100 bases:

>100_bases
GGCACCCCCCTTGCAAAACACCTGTAAAAAGCGCATTGGTTGAAAAATTTTCCGGGCATGCCCGCTTCACCTGCAACCCC
CGCCCCCGGCGCCGCTTTTT

Downstream 100 bases:

>100_bases
AAAACGGAACCGGACGTTCCGTTCTGTGATTCCGGCCTGTCACAAGGCCGGAACGCAACTGCCCGCCTGTTTTTCGCATT
GCGCGCCTGCGCAACCGGAA

Product: two component Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 478; Mature: 478

Protein sequence:

>478_residues
MQHYLVATDNQPAAKAITRSFSSQAELTVVHSPQELHAALGRRIPDVLFADVSWLDRSPERTLDTIRTALRALWAIAPNL
EVIVLAGQENIREAVKSVRAGADNYLTYPVSAEEAAYVLESLRESRMMQTELEYLRSSADGKTRIPLEQVHSTVMQTVFD
KVRRVAATDTTILLQGETGTGKGVLAKLIHARSNRSKGPFMGVHCGAIPETLVESELFGHEKGAFTGASKRKPGRFEVAA
KGTIFLDEIGTISLPTQVRLLQVLQDKVFQRVGGVNDIPMEARIVAASNVDLEELVKKGQFRADLLFRLNVFPIRVPALR
ERREDIPLLAETFLQRLRQRQMKKIQGIHPEVLTAFQNYAWPGNIRELENLMERAYILETSHMLSPDNFPQDLFAGGAPL
ANVSLDLSLPLAAVRNQAKEQAQRRYIEELIAECRGRINLTAERAGITTRQLRKLLTRYGIDKSVYKQSKSGTSGTQK

Sequences:

>Translated_478_residues
MQHYLVATDNQPAAKAITRSFSSQAELTVVHSPQELHAALGRRIPDVLFADVSWLDRSPERTLDTIRTALRALWAIAPNL
EVIVLAGQENIREAVKSVRAGADNYLTYPVSAEEAAYVLESLRESRMMQTELEYLRSSADGKTRIPLEQVHSTVMQTVFD
KVRRVAATDTTILLQGETGTGKGVLAKLIHARSNRSKGPFMGVHCGAIPETLVESELFGHEKGAFTGASKRKPGRFEVAA
KGTIFLDEIGTISLPTQVRLLQVLQDKVFQRVGGVNDIPMEARIVAASNVDLEELVKKGQFRADLLFRLNVFPIRVPALR
ERREDIPLLAETFLQRLRQRQMKKIQGIHPEVLTAFQNYAWPGNIRELENLMERAYILETSHMLSPDNFPQDLFAGGAPL
ANVSLDLSLPLAAVRNQAKEQAQRRYIEELIAECRGRINLTAERAGITTRQLRKLLTRYGIDKSVYKQSKSGTSGTQK
>Mature_478_residues
MQHYLVATDNQPAAKAITRSFSSQAELTVVHSPQELHAALGRRIPDVLFADVSWLDRSPERTLDTIRTALRALWAIAPNL
EVIVLAGQENIREAVKSVRAGADNYLTYPVSAEEAAYVLESLRESRMMQTELEYLRSSADGKTRIPLEQVHSTVMQTVFD
KVRRVAATDTTILLQGETGTGKGVLAKLIHARSNRSKGPFMGVHCGAIPETLVESELFGHEKGAFTGASKRKPGRFEVAA
KGTIFLDEIGTISLPTQVRLLQVLQDKVFQRVGGVNDIPMEARIVAASNVDLEELVKKGQFRADLLFRLNVFPIRVPALR
ERREDIPLLAETFLQRLRQRQMKKIQGIHPEVLTAFQNYAWPGNIRELENLMERAYILETSHMLSPDNFPQDLFAGGAPL
ANVSLDLSLPLAAVRNQAKEQAQRRYIEELIAECRGRINLTAERAGITTRQLRKLLTRYGIDKSVYKQSKSGTSGTQK

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=437, Percent_Identity=36.1556064073227, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1790437, Length=414, Percent_Identity=38.6473429951691, Blast_Score=266, Evalue=3e-72,
Organism=Escherichia coli, GI1790299, Length=367, Percent_Identity=38.6920980926431, Blast_Score=244, Evalue=8e-66,
Organism=Escherichia coli, GI1788905, Length=393, Percent_Identity=34.0966921119593, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI87082117, Length=227, Percent_Identity=50.2202643171806, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI1789087, Length=320, Percent_Identity=41.875, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI87082152, Length=232, Percent_Identity=48.2758620689655, Blast_Score=210, Evalue=2e-55,
Organism=Escherichia coli, GI87081872, Length=309, Percent_Identity=39.8058252427184, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1789233, Length=311, Percent_Identity=36.6559485530547, Blast_Score=202, Evalue=5e-53,
Organism=Escherichia coli, GI1786524, Length=255, Percent_Identity=42.3529411764706, Blast_Score=192, Evalue=3e-50,
Organism=Escherichia coli, GI1787583, Length=242, Percent_Identity=38.4297520661157, Blast_Score=171, Evalue=1e-43,
Organism=Escherichia coli, GI87081858, Length=308, Percent_Identity=29.2207792207792, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1789828, Length=367, Percent_Identity=29.1553133514986, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53356; Mature: 53356

Theoretical pI: Translated: 9.87; Mature: 9.87

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHYLVATDNQPAAKAITRSFSSQAELTVVHSPQELHAALGRRIPDVLFADVSWLDRSPE
CCCEEEECCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHCCCHHHHHHHHHHHCCCHH
RTLDTIRTALRALWAIAPNLEVIVLAGQENIREAVKSVRAGADNYLTYPVSAEEAAYVLE
HHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHH
SLRESRMMQTELEYLRSSADGKTRIPLEQVHSTVMQTVFDKVRRVAATDTTILLQGETGT
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GKGVLAKLIHARSNRSKGPFMGVHCGAIPETLVESELFGHEKGAFTGASKRKPGRFEVAA
CHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEE
KGTIFLDEIGTISLPTQVRLLQVLQDKVFQRVGGVNDIPMEARIVAASNVDLEELVKKGQ
CCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHCCC
FRADLLFRLNVFPIRVPALRERREDIPLLAETFLQRLRQRQMKKIQGIHPEVLTAFQNYA
CHHHHEEEECCEEEECHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
WPGNIRELENLMERAYILETSHMLSPDNFPQDLFAGGAPLANVSLDLSLPLAAVRNQAKE
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCEEEEECCCCHHHHHHHHHH
QAQRRYIEELIAECRGRINLTAERAGITTRQLRKLLTRYGIDKSVYKQSKSGTSGTQK
HHHHHHHHHHHHHHCCCEEEEHHHHCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MQHYLVATDNQPAAKAITRSFSSQAELTVVHSPQELHAALGRRIPDVLFADVSWLDRSPE
CCCEEEECCCCHHHHHHHHHHCCCCCEEEEECCHHHHHHHHCCCHHHHHHHHHHHCCCHH
RTLDTIRTALRALWAIAPNLEVIVLAGQENIREAVKSVRAGADNYLTYPVSAEEAAYVLE
HHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHH
SLRESRMMQTELEYLRSSADGKTRIPLEQVHSTVMQTVFDKVRRVAATDTTILLQGETGT
HHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GKGVLAKLIHARSNRSKGPFMGVHCGAIPETLVESELFGHEKGAFTGASKRKPGRFEVAA
CHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEE
KGTIFLDEIGTISLPTQVRLLQVLQDKVFQRVGGVNDIPMEARIVAASNVDLEELVKKGQ
CCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHCCC
FRADLLFRLNVFPIRVPALRERREDIPLLAETFLQRLRQRQMKKIQGIHPEVLTAFQNYA
CHHHHEEEECCEEEECHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
WPGNIRELENLMERAYILETSHMLSPDNFPQDLFAGGAPLANVSLDLSLPLAAVRNQAKE
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCCCCCEEEEECCCCHHHHHHHHHH
QAQRRYIEELIAECRGRINLTAERAGITTRQLRKLLTRYGIDKSVYKQSKSGTSGTQK
HHHHHHHHHHHHHHCCCEEEEHHHHCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]