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The map label for this gene is gpmA

Identifier: 78358044

GI number: 78358044

Start: 2990103

End: 2990864

Strand: Direct

Name: gpmA

Synonym: Dde_3004

Alternate gene names: 78358044

Gene position: 2990103-2990864 (Clockwise)

Preceding gene: 78358043

Following gene: 78358045

Centisome position: 80.16

GC content: 62.2

Gene sequence:

>762_bases
ATGTACAAGCTGGTACTTGTCCGCCACGGACAAAGCACATGGAATCTGGAAAACCGGTTCACCGGCTGGACCGATGTGGA
TCTGACCCCGCTGGGCGAAACCGAAGCCCGCGAAGGCGCACGTCTGATAGCCGCAGCGGGCCTTACCTTTGACGAATGCC
ATACCTCGGTGCTCAAGCGGGCCATACGCACCCTGAACATCATACAGGAAGAGCTGGACCTGCTGTGGCTGCCTGTGCAC
CGCCACTGGCGGCTCAACGAGCGCCACTACGGCGCGCTGCAGGGACTGAATAAAAAAGAAATGTCGGAAAAATACGGCGA
GGAACAGGTATTCATCTGGCGGCGCAGCTTTGACACACCGCCCCCTGCCCTTACCGCCGACGACCCGCGCCACCCCGCGC
ATGACCGGCGGTACGCCTCGCTGACAGCCCGTCAGATGCCGCTGTGCGAAAGCCTTAAAGACACCGTGGCCAGAGTGCTG
CCATACTGGCACGAAACCCTTGCTCCGGCCATACAGGCCGGCCGCCGCCTGCTGGTGGCCGCACACGGCAACAGTCTGCG
GGCGCTCGTCATGCACCTTGACGGCATGTCGCCAGACGAAGTCACGGGGCTGAACATTCCCACCGGGCTGCCGCTGGTGT
ACGAACTGGACAGTAATCTTACACCGCTGCGGCGCGCGTATCTGGGTGATGCCGAAGCCGCCGAGGCAAAAGCCAGAGCC
GTTGCCGAACAGGCAAAGGCTGGAACAACGGAACGCCCGTGA

Upstream 100 bases:

>100_bases
CCTTGAACGCAGCTACCTGTACCGCAAACTGAAATCATACAACATTCAGACTCCGGAGTAGTGCACGCGGGTGCACCGCC
CGCCGGAAGCAGGAGGCAGC

Downstream 100 bases:

>100_bases
CGCAGAATCCGGTAAAACCCGTACACGGGTGGCGGCGCACGCTGCATGAAATCATCTTTGAGGCGGACACCCCTGCGGGC
CGCCTTTTTGATATTATACT

Product: phosphoglycerate mutase

Products: NA

Alternate protein names: BPG-dependent PGAM; PGAM; Phosphoglyceromutase; dPGM

Number of amino acids: Translated: 253; Mature: 253

Protein sequence:

>253_residues
MYKLVLVRHGQSTWNLENRFTGWTDVDLTPLGETEAREGARLIAAAGLTFDECHTSVLKRAIRTLNIIQEELDLLWLPVH
RHWRLNERHYGALQGLNKKEMSEKYGEEQVFIWRRSFDTPPPALTADDPRHPAHDRRYASLTARQMPLCESLKDTVARVL
PYWHETLAPAIQAGRRLLVAAHGNSLRALVMHLDGMSPDEVTGLNIPTGLPLVYELDSNLTPLRRAYLGDAEAAEAKARA
VAEQAKAGTTERP

Sequences:

>Translated_253_residues
MYKLVLVRHGQSTWNLENRFTGWTDVDLTPLGETEAREGARLIAAAGLTFDECHTSVLKRAIRTLNIIQEELDLLWLPVH
RHWRLNERHYGALQGLNKKEMSEKYGEEQVFIWRRSFDTPPPALTADDPRHPAHDRRYASLTARQMPLCESLKDTVARVL
PYWHETLAPAIQAGRRLLVAAHGNSLRALVMHLDGMSPDEVTGLNIPTGLPLVYELDSNLTPLRRAYLGDAEAAEAKARA
VAEQAKAGTTERP
>Mature_253_residues
MYKLVLVRHGQSTWNLENRFTGWTDVDLTPLGETEAREGARLIAAAGLTFDECHTSVLKRAIRTLNIIQEELDLLWLPVH
RHWRLNERHYGALQGLNKKEMSEKYGEEQVFIWRRSFDTPPPALTADDPRHPAHDRRYASLTARQMPLCESLKDTVARVL
PYWHETLAPAIQAGRRLLVAAHGNSLRALVMHLDGMSPDEVTGLNIPTGLPLVYELDSNLTPLRRAYLGDAEAAEAKARA
VAEQAKAGTTERP

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI50593010, Length=252, Percent_Identity=55.952380952381, Blast_Score=290, Evalue=7e-79,
Organism=Homo sapiens, GI4505753, Length=249, Percent_Identity=57.0281124497992, Blast_Score=287, Evalue=8e-78,
Organism=Homo sapiens, GI71274132, Length=249, Percent_Identity=54.6184738955823, Blast_Score=270, Evalue=9e-73,
Organism=Homo sapiens, GI4502445, Length=256, Percent_Identity=44.53125, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI40353764, Length=256, Percent_Identity=44.53125, Blast_Score=233, Evalue=1e-61,
Organism=Homo sapiens, GI310129614, Length=162, Percent_Identity=60.4938271604938, Blast_Score=192, Evalue=2e-49,
Organism=Escherichia coli, GI1786970, Length=245, Percent_Identity=60.4081632653061, Blast_Score=305, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6322697, Length=246, Percent_Identity=50.8130081300813, Blast_Score=241, Evalue=8e-65,
Organism=Saccharomyces cerevisiae, GI6324516, Length=293, Percent_Identity=31.0580204778157, Blast_Score=141, Evalue=1e-34,
Organism=Saccharomyces cerevisiae, GI6320183, Length=296, Percent_Identity=31.4189189189189, Blast_Score=129, Evalue=5e-31,
Organism=Drosophila melanogaster, GI24646216, Length=250, Percent_Identity=48, Blast_Score=238, Evalue=2e-63,
Organism=Drosophila melanogaster, GI85725270, Length=250, Percent_Identity=49.6, Blast_Score=237, Evalue=6e-63,
Organism=Drosophila melanogaster, GI85725272, Length=250, Percent_Identity=49.6, Blast_Score=237, Evalue=6e-63,
Organism=Drosophila melanogaster, GI24650981, Length=250, Percent_Identity=49.6, Blast_Score=237, Evalue=6e-63,
Organism=Drosophila melanogaster, GI28571815, Length=249, Percent_Identity=38.1526104417671, Blast_Score=164, Evalue=6e-41,
Organism=Drosophila melanogaster, GI28571817, Length=249, Percent_Identity=38.1526104417671, Blast_Score=164, Evalue=7e-41,
Organism=Drosophila melanogaster, GI24648979, Length=249, Percent_Identity=38.1526104417671, Blast_Score=164, Evalue=7e-41,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA_DESDG (Q30WZ8)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_389493.1
- ProteinModelPortal:   Q30WZ8
- SMR:   Q30WZ8
- STRING:   Q30WZ8
- GeneID:   3758802
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_3004
- NMPDR:   fig|207559.3.peg.3153
- eggNOG:   COG0588
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- BioCyc:   DDES207559:DDE_3004-MONOMER
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 28512; Mature: 28512

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYKLVLVRHGQSTWNLENRFTGWTDVDLTPLGETEAREGARLIAAAGLTFDECHTSVLKR
CEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHH
AIRTLNIIQEELDLLWLPVHRHWRLNERHYGALQGLNKKEMSEKYGEEQVFIWRRSFDTP
HHHHHHHHHHHHHEEEECCCCCEECCCCHHHHHCCCCHHHHHHHHCCCEEEEEEECCCCC
PPALTADDPRHPAHDRRYASLTARQMPLCESLKDTVARVLPYWHETLAPAIQAGRRLLVA
CCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
AHGNSLRALVMHLDGMSPDEVTGLNIPTGLPLVYELDSNLTPLRRAYLGDAEAAEAKARA
ECCCCCEEHEEHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCHHHHHHHHH
VAEQAKAGTTERP
HHHHHHCCCCCCC
>Mature Secondary Structure
MYKLVLVRHGQSTWNLENRFTGWTDVDLTPLGETEAREGARLIAAAGLTFDECHTSVLKR
CEEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCEEEEECCCCHHHHHHHHHHH
AIRTLNIIQEELDLLWLPVHRHWRLNERHYGALQGLNKKEMSEKYGEEQVFIWRRSFDTP
HHHHHHHHHHHHHEEEECCCCCEECCCCHHHHHCCCCHHHHHHHHCCCEEEEEEECCCCC
PPALTADDPRHPAHDRRYASLTARQMPLCESLKDTVARVLPYWHETLAPAIQAGRRLLVA
CCCCCCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEE
AHGNSLRALVMHLDGMSPDEVTGLNIPTGLPLVYELDSNLTPLRRAYLGDAEAAEAKARA
ECCCCCEEHEEHHCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHCCCCHHHHHHHHH
VAEQAKAGTTERP
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA