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The map label for this gene is folE2

Identifier: 78357997

GI number: 78357997

Start: 2937460

End: 2938230

Strand: Direct

Name: folE2

Synonym: Dde_2957

Alternate gene names: 78357997

Gene position: 2937460-2938230 (Clockwise)

Preceding gene: 78357996

Following gene: 78357998

Centisome position: 78.75

GC content: 56.81

Gene sequence:

>771_bases
ATGGAAGACGTACAGAACAGCCCTTCGCAGGTTCCTCTCGCCATTGACACCGTGGGTGTAAAAAGCCTGCATCTGCCGCT
CATTGTCAGCGACAGGGCCAACGGACACCAGCATACCGTGGCCGTGGTGGATATCGGGGTCGAGCTGCCGGCACGTTTCA
AGGGCACCCATATGAGCCGCTTTGTCGAAGCGCTGGCTCACTGGGACGAACACCTGAACTACCGTACCATCAAAAGCCTG
CTGGAAGATGTGAAAACGCGGCTGCAGGCCAGAAAAGCCCATGTGCATTTCCGTTTTCCCTACTTCATCGCCAAAAAAGC
ACCGGCAACCGGCAGCCCCGGGCTTGTAAGCTACAACTGCTGCCTTACGGGTGAACTGGCCGACGGCAGACCCGCCATGA
TGCTTGATGTGGAAGTGCCTGTCATGACGGTTTGCCCCTGCTCAAAAGCCATAAGCGACGAAGGCGCCCACAGCCAGCGT
GCACTGGTGCGCATCTCGCTGCGCATGAAGGAATTCTGCTGGCTGGAAGAATTCATCGAACTGGCGGAACGCTCCGCCTC
TTCGCCGGTGTATACGCTGCTTAAACGCGAAGATGAAAAGTTCGTCACCGAAGACGCATTCGCCCATCCCACTTTTGTGG
AAGACGTGGTGCGCGCTGCGGCCCAGCAGCTGGAAGCCCATCCCAGTGTGTCGTGGTTCCGGGTCGAGGTGGAAAGCATA
GAATCCATACACAACCACAGCGCATTCGCCCGTATTGAAAAACACAAATAG

Upstream 100 bases:

>100_bases
CCTCTGGTCCGGCAGCAGCTCCGGGCGCAAGGCCGGGGTTTTTGGTGTTTTTTCTTTTCGGCACGGCACGCAACACGCTA
ACAGACTAACCGGAAAAATT

Downstream 100 bases:

>100_bases
CCTGCCGCTGCCGGTACGCAGCACCGCACCGGCAGCAGACAGCGGCGCAGCACAACCATCAGGCGCAGTCACCGGCACAC
ACCGGCAGTCTGCGCCTTGT

Product: putative GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 256; Mature: 256

Protein sequence:

>256_residues
MEDVQNSPSQVPLAIDTVGVKSLHLPLIVSDRANGHQHTVAVVDIGVELPARFKGTHMSRFVEALAHWDEHLNYRTIKSL
LEDVKTRLQARKAHVHFRFPYFIAKKAPATGSPGLVSYNCCLTGELADGRPAMMLDVEVPVMTVCPCSKAISDEGAHSQR
ALVRISLRMKEFCWLEEFIELAERSASSPVYTLLKREDEKFVTEDAFAHPTFVEDVVRAAAQQLEAHPSVSWFRVEVESI
ESIHNHSAFARIEKHK

Sequences:

>Translated_256_residues
MEDVQNSPSQVPLAIDTVGVKSLHLPLIVSDRANGHQHTVAVVDIGVELPARFKGTHMSRFVEALAHWDEHLNYRTIKSL
LEDVKTRLQARKAHVHFRFPYFIAKKAPATGSPGLVSYNCCLTGELADGRPAMMLDVEVPVMTVCPCSKAISDEGAHSQR
ALVRISLRMKEFCWLEEFIELAERSASSPVYTLLKREDEKFVTEDAFAHPTFVEDVVRAAAQQLEAHPSVSWFRVEVESI
ESIHNHSAFARIEKHK
>Mature_256_residues
MEDVQNSPSQVPLAIDTVGVKSLHLPLIVSDRANGHQHTVAVVDIGVELPARFKGTHMSRFVEALAHWDEHLNYRTIKSL
LEDVKTRLQARKAHVHFRFPYFIAKKAPATGSPGLVSYNCCLTGELADGRPAMMLDVEVPVMTVCPCSKAISDEGAHSQR
ALVRISLRMKEFCWLEEFIELAERSASSPVYTLLKREDEKFVTEDAFAHPTFVEDVVRAAAQQLEAHPSVSWFRVEVESI
ESIHNHSAFARIEKHK

Specific function: Converts GTP to 7,8-dihydroneopterin triphosphate

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH4_DESDG (Q30X45)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_389446.1
- ProteinModelPortal:   Q30X45
- SMR:   Q30X45
- STRING:   Q30X45
- GeneID:   3757962
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2957
- NMPDR:   fig|207559.3.peg.2979
- eggNOG:   COG1469
- HOGENOM:   HBG626871
- OMA:   SLMDYEV
- ProtClustDB:   PRK13674
- BioCyc:   DDES207559:DDE_2957-MONOMER
- HAMAP:   MF_01527_B
- InterPro:   IPR022838
- InterPro:   IPR003801
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10

Pfam domain/function: PF02649 DUF198

EC number: =3.5.4.16

Molecular weight: Translated: 28749; Mature: 28749

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDVQNSPSQVPLAIDTVGVKSLHLPLIVSDRANGHQHTVAVVDIGVELPARFKGTHMSR
CCCCCCCCCCCCEEEEECCCCEEEEEEEEECCCCCCEEEEEEEEECCCCCCCCCCHHHHH
FVEALAHWDEHLNYRTIKSLLEDVKTRLQARKAHVHFRFPYFIAKKAPATGSPGLVSYNC
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEECCEEEEECCCCCCCCCEEEEEE
CLTGELADGRPAMMLDVEVPVMTVCPCSKAISDEGAHSQRALVRISLRMKEFCWLEEFIE
EEECCCCCCCCEEEEEECCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LAERSASSPVYTLLKREDEKFVTEDAFAHPTFVEDVVRAAAQQLEAHPSVSWFRVEVESI
HHHHCCCCCHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHH
ESIHNHSAFARIEKHK
HHHHCCHHHHHEECCC
>Mature Secondary Structure
MEDVQNSPSQVPLAIDTVGVKSLHLPLIVSDRANGHQHTVAVVDIGVELPARFKGTHMSR
CCCCCCCCCCCCEEEEECCCCEEEEEEEEECCCCCCEEEEEEEEECCCCCCCCCCHHHHH
FVEALAHWDEHLNYRTIKSLLEDVKTRLQARKAHVHFRFPYFIAKKAPATGSPGLVSYNC
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEEEEECCEEEEECCCCCCCCCEEEEEE
CLTGELADGRPAMMLDVEVPVMTVCPCSKAISDEGAHSQRALVRISLRMKEFCWLEEFIE
EEECCCCCCCCEEEEEECCCEEEECCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LAERSASSPVYTLLKREDEKFVTEDAFAHPTFVEDVVRAAAQQLEAHPSVSWFRVEVESI
HHHHCCCCCHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEHHHH
ESIHNHSAFARIEKHK
HHHHCCHHHHHEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA