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The map label for this gene is atoC [H]

Identifier: 78357992

GI number: 78357992

Start: 2932725

End: 2934176

Strand: Direct

Name: atoC [H]

Synonym: Dde_2952

Alternate gene names: 78357992

Gene position: 2932725-2934176 (Clockwise)

Preceding gene: 78357991

Following gene: 78357995

Centisome position: 78.62

GC content: 60.06

Gene sequence:

>1452_bases
ATGCGCATAATGATAATAGATGACAACACCAACAGTCTGCAAAGCCTCAGTGTGGTGCTGAGCGATCTGGGGCACGACCC
AGACGCGTTCAGCAGCCCCGTTGATGCGCTGCGGCAGGCCCGTCAGCAGTATTACCCGCTGGTCATCACCGACATACGCA
TGCCGGAAATGGACGGGCTGAGTCTGCTGACAGAACTGAAGGCACACCCTGCCACCGGCAGCAGCGATGTGGTGCTCATC
ACCGGCCACGGCGACATGCACACCGCCGTCGAAGCCCTGCGCAAAGGCGCCTACGATTATCTGGCAAAGCCCATCAATGC
GCGCGAACTGGCAGCCGTGGTCGAACGCAGCGCCGAACATCAGGCCCTGCTGCTGGAAAATAAAGACCTCAGACAAAATC
TGGACGCCCGTGTGGACAAGGTGACCGGCACCCTGAAGGCCGACCTTGAAAAAGTGCGCAGCCGTCTGAAGCGCGTTGTA
GGCATAGGCAATGTGGTGGCTCAGGCACCCGCCATGCGCCGGGCCATGGATGAAGCGAGAATCTTTCACCGCGACCCCAC
CGTGCCGGTGCTGCTGGAAGGCGAAACAGGCACAGGCAAGGAAGTGCTGGCAAGACTCATCCATTACGGTGACACAGGCA
CGGAAACCCCGTTTGTGGCCATCAACTGCGCCGCCATTCCCCACGACCTGTTCGAAGCCGAACTATTCGGACACGAGGAA
GGCGCCTACACCGGCAGCCGCTCCGGCGGTTCGCCGGGCAAGCTGGAAGCAGCCGACACAGGCACACTGTTTCTGGACGA
GGTGGCCGACCTGCCGCTGCAACTGCAGCCCAAGCTGCTGCGTGTGCTGGAAGAACACACATTCTACCGTGTGGGCGGCG
TAAAAAAACGTACTTTCAAAGCCCGTGTCATATGCGCGGCCAACCAGAATCTGGCACAACTTGTGGAGCAGGGAGCCTTC
CGGCGCGACCTGTATCACCGGCTCACCGTGGGACACATCACCCTGCCGCCGCTTCGCAGCCGCCCCGAAGACATTCCGCT
GCTGGCTGAAATGTTTCTGCTGCGCGAAGCCTCGCGCAAAAAAAAGCTTTTCCGCGAAATAGCGCCCGAAGCGCTGGCCA
TGCTGCAACAGCACCGCTGGCCGGGTAATGTGCGCGAACTGGAAAACGCCATAGAACGGGCAGTGCTCATCAACGACGGG
CACCTGCTGCAGCCGCGGCATCTGCGTTTTCTGCAGGAGCATACACCGCAGGAAGCCCCCTGCACCTCTGCTGCATGCAC
CTGTGCGCTGACTCCGGAAGCGCTGACCTTGCCCGAAGGCGGTCTTGACCTGGAAGGGCTGATTACACAGATAATGCGCA
AGGCCGTGGACAAATTTGACGGCAACAAAAGCAAGGCTGCTGCCTATCTGGGCATTTCACGCTTTGCACTGCACAGGCGC
CTGCAGAAATAG

Upstream 100 bases:

>100_bases
TTCATAGAAACGTGGGGCGGGTCGGTGCACGCCGGCGACAGACCGCCGCCGGAGCGGGGAGCCCGCTTTGTCATACTGCT
GCAACCCGCCGGAGACTGTC

Downstream 100 bases:

>100_bases
CGCGCCTGCGCACACCCGTGCGATAGCGCACGTGCATTTGCGCACACTCCCCCGTTGCATGGGAGAAACCAAAATCGCCA
CAAAGAATAACTTACTGTAA

Product: two component Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 483; Mature: 483

Protein sequence:

>483_residues
MRIMIIDDNTNSLQSLSVVLSDLGHDPDAFSSPVDALRQARQQYYPLVITDIRMPEMDGLSLLTELKAHPATGSSDVVLI
TGHGDMHTAVEALRKGAYDYLAKPINARELAAVVERSAEHQALLLENKDLRQNLDARVDKVTGTLKADLEKVRSRLKRVV
GIGNVVAQAPAMRRAMDEARIFHRDPTVPVLLEGETGTGKEVLARLIHYGDTGTETPFVAINCAAIPHDLFEAELFGHEE
GAYTGSRSGGSPGKLEAADTGTLFLDEVADLPLQLQPKLLRVLEEHTFYRVGGVKKRTFKARVICAANQNLAQLVEQGAF
RRDLYHRLTVGHITLPPLRSRPEDIPLLAEMFLLREASRKKKLFREIAPEALAMLQQHRWPGNVRELENAIERAVLINDG
HLLQPRHLRFLQEHTPQEAPCTSAACTCALTPEALTLPEGGLDLEGLITQIMRKAVDKFDGNKSKAAAYLGISRFALHRR
LQK

Sequences:

>Translated_483_residues
MRIMIIDDNTNSLQSLSVVLSDLGHDPDAFSSPVDALRQARQQYYPLVITDIRMPEMDGLSLLTELKAHPATGSSDVVLI
TGHGDMHTAVEALRKGAYDYLAKPINARELAAVVERSAEHQALLLENKDLRQNLDARVDKVTGTLKADLEKVRSRLKRVV
GIGNVVAQAPAMRRAMDEARIFHRDPTVPVLLEGETGTGKEVLARLIHYGDTGTETPFVAINCAAIPHDLFEAELFGHEE
GAYTGSRSGGSPGKLEAADTGTLFLDEVADLPLQLQPKLLRVLEEHTFYRVGGVKKRTFKARVICAANQNLAQLVEQGAF
RRDLYHRLTVGHITLPPLRSRPEDIPLLAEMFLLREASRKKKLFREIAPEALAMLQQHRWPGNVRELENAIERAVLINDG
HLLQPRHLRFLQEHTPQEAPCTSAACTCALTPEALTLPEGGLDLEGLITQIMRKAVDKFDGNKSKAAAYLGISRFALHRR
LQK
>Mature_483_residues
MRIMIIDDNTNSLQSLSVVLSDLGHDPDAFSSPVDALRQARQQYYPLVITDIRMPEMDGLSLLTELKAHPATGSSDVVLI
TGHGDMHTAVEALRKGAYDYLAKPINARELAAVVERSAEHQALLLENKDLRQNLDARVDKVTGTLKADLEKVRSRLKRVV
GIGNVVAQAPAMRRAMDEARIFHRDPTVPVLLEGETGTGKEVLARLIHYGDTGTETPFVAINCAAIPHDLFEAELFGHEE
GAYTGSRSGGSPGKLEAADTGTLFLDEVADLPLQLQPKLLRVLEEHTFYRVGGVKKRTFKARVICAANQNLAQLVEQGAF
RRDLYHRLTVGHITLPPLRSRPEDIPLLAEMFLLREASRKKKLFREIAPEALAMLQQHRWPGNVRELENAIERAVLINDG
HLLQPRHLRFLQEHTPQEAPCTSAACTCALTPEALTLPEGGLDLEGLITQIMRKAVDKFDGNKSKAAAYLGISRFALHRR
LQK

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=488, Percent_Identity=37.7049180327869, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1790437, Length=486, Percent_Identity=36.4197530864198, Blast_Score=286, Evalue=3e-78,
Organism=Escherichia coli, GI1790299, Length=504, Percent_Identity=37.3015873015873, Blast_Score=273, Evalue=1e-74,
Organism=Escherichia coli, GI87082117, Length=343, Percent_Identity=43.4402332361516, Blast_Score=246, Evalue=3e-66,
Organism=Escherichia coli, GI1788905, Length=482, Percent_Identity=32.3651452282158, Blast_Score=234, Evalue=9e-63,
Organism=Escherichia coli, GI1789233, Length=331, Percent_Identity=41.0876132930514, Blast_Score=229, Evalue=4e-61,
Organism=Escherichia coli, GI1789087, Length=323, Percent_Identity=42.7244582043344, Blast_Score=223, Evalue=3e-59,
Organism=Escherichia coli, GI1786524, Length=370, Percent_Identity=38.6486486486486, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI87081872, Length=307, Percent_Identity=37.785016286645, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI1787583, Length=328, Percent_Identity=35.3658536585366, Blast_Score=184, Evalue=9e-48,
Organism=Escherichia coli, GI87082152, Length=304, Percent_Identity=38.8157894736842, Blast_Score=183, Evalue=3e-47,
Organism=Escherichia coli, GI1789828, Length=237, Percent_Identity=35.4430379746835, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI87081858, Length=321, Percent_Identity=31.4641744548287, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI87082012, Length=136, Percent_Identity=35.2941176470588, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 53503; Mature: 53503

Theoretical pI: Translated: 7.30; Mature: 7.30

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIMIIDDNTNSLQSLSVVLSDLGHDPDAFSSPVDALRQARQQYYPLVITDIRMPEMDGL
CEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCHH
SLLTELKAHPATGSSDVVLITGHGDMHTAVEALRKGAYDYLAKPINARELAAVVERSAEH
HHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHCCCC
QALLLENKDLRQNLDARVDKVTGTLKADLEKVRSRLKRVVGIGNVVAQAPAMRRAMDEAR
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
IFHRDPTVPVLLEGETGTGKEVLARLIHYGDTGTETPFVAINCAAIPHDLFEAELFGHEE
HHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCC
GAYTGSRSGGSPGKLEAADTGTLFLDEVADLPLQLQPKLLRVLEEHTFYRVGGVKKRTFK
CCCCCCCCCCCCCCEECCCCCCEEHHHHHCCCCCCCHHHHHHHHHHCEEEECCCEEEEEE
ARVICAANQNLAQLVEQGAFRRDLYHRLTVGHITLPPLRSRPEDIPLLAEMFLLREASRK
EEEEEECCCHHHHHHHCCHHHHHHHHHHEECCEECCCCCCCCCCCHHHHHHHHHHHHHHH
KKLFREIAPEALAMLQQHRWPGNVRELENAIERAVLINDGHLLQPRHLRFLQEHTPQEAP
HHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHEEEECCCCEECHHHHHHHHHCCCCCCC
CTSAACTCALTPEALTLPEGGLDLEGLITQIMRKAVDKFDGNKSKAAAYLGISRFALHRR
CCCHHEEEEECCCCEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LQK
HCC
>Mature Secondary Structure
MRIMIIDDNTNSLQSLSVVLSDLGHDPDAFSSPVDALRQARQQYYPLVITDIRMPEMDGL
CEEEEEECCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCCCHH
SLLTELKAHPATGSSDVVLITGHGDMHTAVEALRKGAYDYLAKPINARELAAVVERSAEH
HHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHCCHHHHHCCCCHHHHHHHHHHCCCC
QALLLENKDLRQNLDARVDKVTGTLKADLEKVRSRLKRVVGIGNVVAQAPAMRRAMDEAR
CEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHH
IFHRDPTVPVLLEGETGTGKEVLARLIHYGDTGTETPFVAINCAAIPHDLFEAELFGHEE
HHCCCCCCEEEEECCCCCHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHCCCC
GAYTGSRSGGSPGKLEAADTGTLFLDEVADLPLQLQPKLLRVLEEHTFYRVGGVKKRTFK
CCCCCCCCCCCCCCEECCCCCCEEHHHHHCCCCCCCHHHHHHHHHHCEEEECCCEEEEEE
ARVICAANQNLAQLVEQGAFRRDLYHRLTVGHITLPPLRSRPEDIPLLAEMFLLREASRK
EEEEEECCCHHHHHHHCCHHHHHHHHHHEECCEECCCCCCCCCCCHHHHHHHHHHHHHHH
KKLFREIAPEALAMLQQHRWPGNVRELENAIERAVLINDGHLLQPRHLRFLQEHTPQEAP
HHHHHHHCHHHHHHHHHCCCCCCHHHHHHHHHHEEEECCCCEECHHHHHHHHHCCCCCCC
CTSAACTCALTPEALTLPEGGLDLEGLITQIMRKAVDKFDGNKSKAAAYLGISRFALHRR
CCCHHEEEEECCCCEECCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LQK
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]