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The map label for this gene is hflC [H]

Identifier: 78357987

GI number: 78357987

Start: 2926563

End: 2927411

Strand: Direct

Name: hflC [H]

Synonym: Dde_2947

Alternate gene names: 78357987

Gene position: 2926563-2927411 (Clockwise)

Preceding gene: 78357986

Following gene: 78357988

Centisome position: 78.46

GC content: 55.71

Gene sequence:

>849_bases
ATGAGCAAGAAAACCGTTCCGGCACTGCTCGCGGCCCTTATTGTCATAGTGGCTGCCGTGCAGTCTTTGTACACCGTGCA
CCAGACAGAAAAAGCCATAGTGCTGCAGCTGGGTGAACCGGTAGGCGAAGTGATGGGACCGGGCCTGCATGTAAAGATGC
CGTTCATCCAGAACATCATCTATCTTGACGCCCGGATACTGGAATATGATGCCAATCCGGCAGAAGTGCTGACCAGCGAC
AAAAAAGCGCTGCTGCTTGACAATTACGCCCGCTGGCGCATTACCGACCCGCTGCTGTTCTACCGTACCGTGCGCACCAT
ACGCAGTGCGCAGGCACGTCTTGACGATATAGTCTATTCGCAGATGCGAGTCTTTCTGGGTCGCTATCCGCTGAGCGAAG
TCATTTCGTCCAAACGCTCCGTAATCATGGAAGAAGTGACCAAACGGTCTTCGGAACTGCTGAAGGATTACGGCATGGAA
GTGGTGGATGTGCGCATAAAACGCGCTGACCTGCCGCCGGAAAACCAGCGGGCCATTTTCGGCCGCATGCGGGCCGAACG
CGAACGTCAGGCCAAGCAGTACCGGTCCGAAGGGCAGGAAGAAGCCACCAAAATACGGTCGCTGGCCGACCGCGAGCGTG
CCGTCATGCTGGCCGAAGCACGGCGCTCCGCCGAAGTTATCAAAGGCGATGGCGAAGCGGAAGCCACACGCGTATATGCC
GCAGCGCTGCAGCAGGCGCCGGAATTCTACGCATTCAAGCGCAGTCTGGAAGCATATGAAAAAAGCCTGAAAGGCAAAAC
GCGTATCATCATGTCTTCTGACGAAGACTTCTTCAACTATCTGCAGTAA

Upstream 100 bases:

>100_bases
ATCTTGAAAAAATTATTCTGAGCGGTAAAGCGGGCGGCGTGGTGCCGTATCTGCCGCTGGACAAGCTGGACGCGGACCGC
GCCAGAAAGGGAGCGCAGCA

Downstream 100 bases:

>100_bases
TACGTCCCCACGTCACATGTTACACTTGTGTCACTCGACACAAGTGTAACATGTGACACTTTTTTCAGGCCATCTGCCTA
GCCTATACGCAAAAAACTTC

Product: HflC protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 282; Mature: 281

Protein sequence:

>282_residues
MSKKTVPALLAALIVIVAAVQSLYTVHQTEKAIVLQLGEPVGEVMGPGLHVKMPFIQNIIYLDARILEYDANPAEVLTSD
KKALLLDNYARWRITDPLLFYRTVRTIRSAQARLDDIVYSQMRVFLGRYPLSEVISSKRSVIMEEVTKRSSELLKDYGME
VVDVRIKRADLPPENQRAIFGRMRAERERQAKQYRSEGQEEATKIRSLADRERAVMLAEARRSAEVIKGDGEAEATRVYA
AALQQAPEFYAFKRSLEAYEKSLKGKTRIIMSSDEDFFNYLQ

Sequences:

>Translated_282_residues
MSKKTVPALLAALIVIVAAVQSLYTVHQTEKAIVLQLGEPVGEVMGPGLHVKMPFIQNIIYLDARILEYDANPAEVLTSD
KKALLLDNYARWRITDPLLFYRTVRTIRSAQARLDDIVYSQMRVFLGRYPLSEVISSKRSVIMEEVTKRSSELLKDYGME
VVDVRIKRADLPPENQRAIFGRMRAERERQAKQYRSEGQEEATKIRSLADRERAVMLAEARRSAEVIKGDGEAEATRVYA
AALQQAPEFYAFKRSLEAYEKSLKGKTRIIMSSDEDFFNYLQ
>Mature_281_residues
SKKTVPALLAALIVIVAAVQSLYTVHQTEKAIVLQLGEPVGEVMGPGLHVKMPFIQNIIYLDARILEYDANPAEVLTSDK
KALLLDNYARWRITDPLLFYRTVRTIRSAQARLDDIVYSQMRVFLGRYPLSEVISSKRSVIMEEVTKRSSELLKDYGMEV
VDVRIKRADLPPENQRAIFGRMRAERERQAKQYRSEGQEEATKIRSLADRERAVMLAEARRSAEVIKGDGEAEATRVYAA
ALQQAPEFYAFKRSLEAYEKSLKGKTRIIMSSDEDFFNYLQ

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790617, Length=309, Percent_Identity=35.2750809061489, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1790616, Length=258, Percent_Identity=24.4186046511628, Blast_Score=72, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193209764, Length=191, Percent_Identity=26.1780104712042, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17569493, Length=191, Percent_Identity=26.1780104712042, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17569499, Length=195, Percent_Identity=28.7179487179487, Blast_Score=65, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17569497, Length=159, Percent_Identity=27.6729559748428, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010200
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7 [H]

EC number: 3.4.-.-

Molecular weight: Translated: 32185; Mature: 32053

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKTVPALLAALIVIVAAVQSLYTVHQTEKAIVLQLGEPVGEVMGPGLHVKMPFIQNII
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCHHHHHHCCCCEEECHHHHHHH
YLDARILEYDANPAEVLTSDKKALLLDNYARWRITDPLLFYRTVRTIRSAQARLDDIVYS
HHHHHHEECCCCHHHHHHCCCCEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHH
QMRVFLGRYPLSEVISSKRSVIMEEVTKRSSELLKDYGMEVVDVRIKRADLPPENQRAIF
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCHHHHH
GRMRAERERQAKQYRSEGQEEATKIRSLADRERAVMLAEARRSAEVIKGDGEAEATRVYA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AALQQAPEFYAFKRSLEAYEKSLKGKTRIIMSSDEDFFNYLQ
HHHHHCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHCC
>Mature Secondary Structure 
SKKTVPALLAALIVIVAAVQSLYTVHQTEKAIVLQLGEPVGEVMGPGLHVKMPFIQNII
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEECCCHHHHHHCCCCEEECHHHHHHH
YLDARILEYDANPAEVLTSDKKALLLDNYARWRITDPLLFYRTVRTIRSAQARLDDIVYS
HHHHHHEECCCCHHHHHHCCCCEEECCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHH
QMRVFLGRYPLSEVISSKRSVIMEEVTKRSSELLKDYGMEVVDVRIKRADLPPENQRAIF
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHCCCCCCCHHHHH
GRMRAERERQAKQYRSEGQEEATKIRSLADRERAVMLAEARRSAEVIKGDGEAEATRVYA
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
AALQQAPEFYAFKRSLEAYEKSLKGKTRIIMSSDEDFFNYLQ
HHHHHCHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10993077 [H]