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The map label for this gene is hflK [H]

Identifier: 78357986

GI number: 78357986

Start: 2925487

End: 2926566

Strand: Direct

Name: hflK [H]

Synonym: Dde_2946

Alternate gene names: 78357986

Gene position: 2925487-2926566 (Clockwise)

Preceding gene: 78357975

Following gene: 78357987

Centisome position: 78.43

GC content: 56.02

Gene sequence:

>1080_bases
ATGAACTGGGACTGGGAAAAACTGCAAGAAAAACGGCAGAGGCAGTCGGGTGGAACACCGCCCGGCAACTGGGGCCCCAA
GGACCCCGGCTCCGATCCGCTCGGAGACGGAATCAAAAAGCTGCGTGAGTTCCGCTTTCCCGTAGGTAAGCTTGCTCTGG
CACTGCTGGTGCTGCTGTGGCTTTTTTCGGGCGTCTTCATCGTGGAACCGGACGAGGTCGGTGTTGTATTGCGTTTCGGC
GAATACAACAGAACCGTCCAGCCCGGCCCTCACTATCACATGCCCTTCCCCATGGAAACAGCGTACACCCCCAAGGTGTC
GCAGGTGCGCCGCGTGGAAGTGGGCTTCAGAAGCTCCGAGGGTTTCTCTCAGGGGCAGCTGCGTCCGGTGAAGGAAGAGT
CTCTGATGCTCACGGGCGACGAAAACATCGTCGACGTGCAGTTCATCGTGCAATACCAGATAAAAGACCCTGTGGCCTTT
CTGTTCAATGTCTCGCAGCAGGCTTGGACAGTGAAAAGCGCCGCCGAAGCCGCCATGCGTGAGGTCATAGGCTACAATGC
CATCGACTCTGCCCTGACGGGCGGTAAACTGGACATACAGAACAAGTCGCGTGACCTGCTGCAGGGCATTCTTGATAACT
ACAACGCCGGTGTGCATGTGGTTGCCGTGCAGATGCAGGATGTGCACCCCCCCAAAGAAGTCATAGATGCCTTCAAGGAT
GTGGCAAGCGCACGCGAAGACAGAAGCCGCATAATCAACGAAGCCGAAGCCTATCAGAATGAAATTCTGCCGCGTGCACG
CGGTCTTGCCGCCGAAATAATCAACCAGGCGGAGGCATACAAGGAAACCAGAATCCGTGATGCCAAGGGTGAATCGGCGC
GCTTTGTCAACGTGCTTGCCGAATACAACAAAGCCAAGGATATCACACGCAAGCGCATGTATCTGGAAACAATGGAAACC
ATTCTTTCCAACCCTGATCTTGAAAAAATTATTCTGAGCGGTAAAGCGGGCGGCGTGGTGCCGTATCTGCCGCTGGACAA
GCTGGACGCGGACCGCGCCAGAAAGGGAGCGCAGCAATGA

Upstream 100 bases:

>100_bases
TCTCCGTTAGGTGCGACAGTTTCGTCCGCGTTGCGACATTCCTAAACTTTATGGCTATCCCACTTGACCGCCCCTCGCAA
CTGCCCTATTTTTCGGTATT

Downstream 100 bases:

>100_bases
GCAAGAAAACCGTTCCGGCACTGCTCGCGGCCCTTATTGTCATAGTGGCTGCCGTGCAGTCTTTGTACACCGTGCACCAG
ACAGAAAAAGCCATAGTGCT

Product: HflK protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MNWDWEKLQEKRQRQSGGTPPGNWGPKDPGSDPLGDGIKKLREFRFPVGKLALALLVLLWLFSGVFIVEPDEVGVVLRFG
EYNRTVQPGPHYHMPFPMETAYTPKVSQVRRVEVGFRSSEGFSQGQLRPVKEESLMLTGDENIVDVQFIVQYQIKDPVAF
LFNVSQQAWTVKSAAEAAMREVIGYNAIDSALTGGKLDIQNKSRDLLQGILDNYNAGVHVVAVQMQDVHPPKEVIDAFKD
VASAREDRSRIINEAEAYQNEILPRARGLAAEIINQAEAYKETRIRDAKGESARFVNVLAEYNKAKDITRKRMYLETMET
ILSNPDLEKIILSGKAGGVVPYLPLDKLDADRARKGAQQ

Sequences:

>Translated_359_residues
MNWDWEKLQEKRQRQSGGTPPGNWGPKDPGSDPLGDGIKKLREFRFPVGKLALALLVLLWLFSGVFIVEPDEVGVVLRFG
EYNRTVQPGPHYHMPFPMETAYTPKVSQVRRVEVGFRSSEGFSQGQLRPVKEESLMLTGDENIVDVQFIVQYQIKDPVAF
LFNVSQQAWTVKSAAEAAMREVIGYNAIDSALTGGKLDIQNKSRDLLQGILDNYNAGVHVVAVQMQDVHPPKEVIDAFKD
VASAREDRSRIINEAEAYQNEILPRARGLAAEIINQAEAYKETRIRDAKGESARFVNVLAEYNKAKDITRKRMYLETMET
ILSNPDLEKIILSGKAGGVVPYLPLDKLDADRARKGAQQ
>Mature_359_residues
MNWDWEKLQEKRQRQSGGTPPGNWGPKDPGSDPLGDGIKKLREFRFPVGKLALALLVLLWLFSGVFIVEPDEVGVVLRFG
EYNRTVQPGPHYHMPFPMETAYTPKVSQVRRVEVGFRSSEGFSQGQLRPVKEESLMLTGDENIVDVQFIVQYQIKDPVAF
LFNVSQQAWTVKSAAEAAMREVIGYNAIDSALTGGKLDIQNKSRDLLQGILDNYNAGVHVVAVQMQDVHPPKEVIDAFKD
VASAREDRSRIINEAEAYQNEILPRARGLAAEIINQAEAYKETRIRDAKGESARFVNVLAEYNKAKDITRKRMYLETMET
ILSNPDLEKIILSGKAGGVVPYLPLDKLDADRARKGAQQ

Specific function: HflC and HflK could encode or regulate a protease [H]

COG id: COG0330

COG function: function code O; Membrane protease subunits, stomatin/prohibitin homologs

Gene ontology:

Cell location: Membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the band 7/mec-2 family. HflK subfamily [H]

Homologues:

Organism=Escherichia coli, GI1790616, Length=286, Percent_Identity=36.3636363636364, Blast_Score=182, Evalue=2e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001107
- InterPro:   IPR010201
- InterPro:   IPR020980
- InterPro:   IPR001972 [H]

Pfam domain/function: PF01145 Band_7; PF12221 HflK_N [H]

EC number: NA

Molecular weight: Translated: 40254; Mature: 40254

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWDWEKLQEKRQRQSGGTPPGNWGPKDPGSDPLGDGIKKLREFRFPVGKLALALLVLLW
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
LFSGVFIVEPDEVGVVLRFGEYNRTVQPGPHYHMPFPMETAYTPKVSQVRRVEVGFRSSE
HHCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCC
GFSQGQLRPVKEESLMLTGDENIVDVQFIVQYQIKDPVAFLFNVSQQAWTVKSAAEAAMR
CCCCCCCCCCCCCCEEEECCCCEEEEEEEEEEHHCCHHHHHHHCCHHHHHHHHHHHHHHH
EVIGYNAIDSALTGGKLDIQNKSRDLLQGILDNYNAGVHVVAVQMQDVHPPKEVIDAFKD
HHHCCHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHH
VASAREDRSRIINEAEAYQNEILPRARGLAAEIINQAEAYKETRIRDAKGESARFVNVLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
EYNKAKDITRKRMYLETMETILSNPDLEKIILSGKAGGVVPYLPLDKLDADRARKGAQQ
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEECCCCCCCCCCCCCCCCHHHHHCCCCC
>Mature Secondary Structure
MNWDWEKLQEKRQRQSGGTPPGNWGPKDPGSDPLGDGIKKLREFRFPVGKLALALLVLLW
CCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHH
LFSGVFIVEPDEVGVVLRFGEYNRTVQPGPHYHMPFPMETAYTPKVSQVRRVEVGFRSSE
HHCCEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCC
GFSQGQLRPVKEESLMLTGDENIVDVQFIVQYQIKDPVAFLFNVSQQAWTVKSAAEAAMR
CCCCCCCCCCCCCCEEEECCCCEEEEEEEEEEHHCCHHHHHHHCCHHHHHHHHHHHHHHH
EVIGYNAIDSALTGGKLDIQNKSRDLLQGILDNYNAGVHVVAVQMQDVHPPKEVIDAFKD
HHHCCHHHHHHCCCCEEEECCCHHHHHHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHH
VASAREDRSRIINEAEAYQNEILPRARGLAAEIINQAEAYKETRIRDAKGESARFVNVLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
EYNKAKDITRKRMYLETMETILSNPDLEKIILSGKAGGVVPYLPLDKLDADRARKGAQQ
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHEEECCCCCCCCCCCCCCCCHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]