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The map label for this gene is algA [H]

Identifier: 78357971

GI number: 78357971

Start: 2911009

End: 2912451

Strand: Direct

Name: algA [H]

Synonym: Dde_2931

Alternate gene names: 78357971

Gene position: 2911009-2912451 (Clockwise)

Preceding gene: 78357970

Following gene: 78357972

Centisome position: 78.04

GC content: 58.7

Gene sequence:

>1443_bases
ATGAGTGAATCAGCCCCCTCTTCCGCCATGGAACGCTGCCACGCCGTCATTCTTGCAGGCGGTTCGGGCACGCGCCTGTG
GCCTCTTTCCCGCGCGCTGTTTCCCAAGCAGCTGCTGGCGCTGAACGGTGAGCTTACCCTGCTGCAGCAGACAGTGAAAC
GCGCTCTTGATATTTTTCCCCCGCAGCGCATCCATATAGTTACCAACGAAGAGCACGTTTTCGAGGTTCGCGCACAGGCA
AAAGCCCTGGATGCGGCGCTGGAAGACAATGTGCTGGCCGAACCCATGATACGCAACACCCTGCCGGCCCTCATGCTGGG
GCTTAACGCCGCCATGAAGCAGGATGCCGCCCCCCTGCTGGCGGTCTTTCCTTCAGATCATATGATCCACAACGCCGCCA
GCTGGCAGCGTGCCGTGCAGGCAGGGGCGGAACTGGCCGCACAGAACCACTTTGTGACGTTCGGCATACCTCCGGCACAT
CCGGAAACTGGTTACGGATACATTCATCGCGGCGCCCGCATAGCAGACGGCTGTTACGCCGTTGAGGGCTTTGTGGAAAA
GCCTCCCAGAGAAAAAGCCGAAGAATTTCTGCGCGGCGGTATGCATTTCTGGAACAGCGGCATGTTTGTGTTCAACGGCG
AAGACCTGATAGCCGCACTGGAAACCTACCAGCCTGCGCTTGCCGCGTGGTGGAACACCCGCACCGCCACGTCATTGCGT
CAGGGCTACAGTGCCATCCCCTCGCTTTCCATCGACTACGGCATTATGGAGCACGTTTCGCGCATCGCCGTGGTTGAAGC
GGACTTCGGATGGGACGATCTGGGAAGCTGGGAAGCCATTTTCCGGCTGGGAGAAAAAGATGAACAGGGCTGCGTTGTTC
AGGGCGACGCCATGGCCATTGACTGCGAAAACAGCCTGCTGCTGTCACGCGGGGGCAAGCTGGCGGCCATAGGGCTGAAA
GATGTCATTGCCGTGCAGACGCGGGACGCCACCCTGCTGTGCGCCAAAGACCAGGTGCAGCGCGTGCGCGAGGTTGTCTC
GCGCCTTAAGGCCGAAGGCAGCCCTCTGACGGAAGTGCACCTGACTGTGCACCGCCCGTGGGGCAGCTATACCGTGCTTG
AAGAAAACGCCGGCTACAAAATCAAACGCATTGCCGTACACCCCGGCGCGCGGCTGTCGCTGCAGCGCCATTATCATCGC
AGCGAACACTGGGTAGTCATTCAGGGAACGGCCCTTGTGCAGGTGGGGGACAAGGAAATGCTGCTTTCGCAGAACCAGTG
GGCCGAGATACCTGAAACCGCTGTTCACCGTCTGACCAACCCGGGACGCATCCCGTTGGAAATCATAGAAATACAGACAG
GGCCATATCTGGAAGAAGATGACATAGAACGCTTTGAAGACGTGTATGGCAGGCCCAAAGGAGGTAAGAACAAATCTAAT
TAA

Upstream 100 bases:

>100_bases
TGGAAGCGGTGCTGTCTCCCAAGGATGCGGAGCTGCCCCGCCTGTGCGATTTCGCCTCCCCTTTTGTCTATGTTCCCTGA
AACACAGGAGTACAGAAGCT

Downstream 100 bases:

>100_bases
ATCGTCATGTTGAAAAAACACATCCGGTAGTTCGTGAATTTTTTCACCTTGACACCCTTTTACCCTGTCGCGTACTAGTT
CAACGTGGCAAGTGTGGGCA

Product: mannose-1-phosphate guanylyltransferase

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 480; Mature: 479

Protein sequence:

>480_residues
MSESAPSSAMERCHAVILAGGSGTRLWPLSRALFPKQLLALNGELTLLQQTVKRALDIFPPQRIHIVTNEEHVFEVRAQA
KALDAALEDNVLAEPMIRNTLPALMLGLNAAMKQDAAPLLAVFPSDHMIHNAASWQRAVQAGAELAAQNHFVTFGIPPAH
PETGYGYIHRGARIADGCYAVEGFVEKPPREKAEEFLRGGMHFWNSGMFVFNGEDLIAALETYQPALAAWWNTRTATSLR
QGYSAIPSLSIDYGIMEHVSRIAVVEADFGWDDLGSWEAIFRLGEKDEQGCVVQGDAMAIDCENSLLLSRGGKLAAIGLK
DVIAVQTRDATLLCAKDQVQRVREVVSRLKAEGSPLTEVHLTVHRPWGSYTVLEENAGYKIKRIAVHPGARLSLQRHYHR
SEHWVVIQGTALVQVGDKEMLLSQNQWAEIPETAVHRLTNPGRIPLEIIEIQTGPYLEEDDIERFEDVYGRPKGGKNKSN

Sequences:

>Translated_480_residues
MSESAPSSAMERCHAVILAGGSGTRLWPLSRALFPKQLLALNGELTLLQQTVKRALDIFPPQRIHIVTNEEHVFEVRAQA
KALDAALEDNVLAEPMIRNTLPALMLGLNAAMKQDAAPLLAVFPSDHMIHNAASWQRAVQAGAELAAQNHFVTFGIPPAH
PETGYGYIHRGARIADGCYAVEGFVEKPPREKAEEFLRGGMHFWNSGMFVFNGEDLIAALETYQPALAAWWNTRTATSLR
QGYSAIPSLSIDYGIMEHVSRIAVVEADFGWDDLGSWEAIFRLGEKDEQGCVVQGDAMAIDCENSLLLSRGGKLAAIGLK
DVIAVQTRDATLLCAKDQVQRVREVVSRLKAEGSPLTEVHLTVHRPWGSYTVLEENAGYKIKRIAVHPGARLSLQRHYHR
SEHWVVIQGTALVQVGDKEMLLSQNQWAEIPETAVHRLTNPGRIPLEIIEIQTGPYLEEDDIERFEDVYGRPKGGKNKSN
>Mature_479_residues
SESAPSSAMERCHAVILAGGSGTRLWPLSRALFPKQLLALNGELTLLQQTVKRALDIFPPQRIHIVTNEEHVFEVRAQAK
ALDAALEDNVLAEPMIRNTLPALMLGLNAAMKQDAAPLLAVFPSDHMIHNAASWQRAVQAGAELAAQNHFVTFGIPPAHP
ETGYGYIHRGARIADGCYAVEGFVEKPPREKAEEFLRGGMHFWNSGMFVFNGEDLIAALETYQPALAAWWNTRTATSLRQ
GYSAIPSLSIDYGIMEHVSRIAVVEADFGWDDLGSWEAIFRLGEKDEQGCVVQGDAMAIDCENSLLLSRGGKLAAIGLKD
VIAVQTRDATLLCAKDQVQRVREVVSRLKAEGSPLTEVHLTVHRPWGSYTVLEENAGYKIKRIAVHPGARLSLQRHYHRS
EHWVVIQGTALVQVGDKEMLLSQNQWAEIPETAVHRLTNPGRIPLEIIEIQTGPYLEEDDIERFEDVYGRPKGGKNKSN

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=479, Percent_Identity=40.9185803757829, Blast_Score=355, Evalue=3e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 53080; Mature: 52949

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESAPSSAMERCHAVILAGGSGTRLWPLSRALFPKQLLALNGELTLLQQTVKRALDIFP
CCCCCCHHHHHHCEEEEEECCCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
PQRIHIVTNEEHVFEVRAQAKALDAALEDNVLAEPMIRNTLPALMLGLNAAMKQDAAPLL
CCEEEEEECCCCEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEE
AVFPSDHMIHNAASWQRAVQAGAELAAQNHFVTFGIPPAHPETGYGYIHRGARIADGCYA
EECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEECCCEECCCHHE
VEGFVEKPPREKAEEFLRGGMHFWNSGMFVFNGEDLIAALETYQPALAAWWNTRTATSLR
EHHHHCCCCHHHHHHHHHCCHHHHCCCEEEECCCHHHHHHHHCCCHHHHHHCCHHHHHHH
QGYSAIPSLSIDYGIMEHVSRIAVVEADFGWDDLGSWEAIFRLGEKDEQGCVVQGDAMAI
HHHHHCCCCCCCHHHHHHHHHEEEEEECCCCCCCCCHHHHHHCCCCCCCCCEEECCEEEE
DCENSLLLSRGGKLAAIGLKDVIAVQTRDATLLCAKDQVQRVREVVSRLKAEGSPLTEVH
ECCCCEEEECCCCEEEECCCCEEEEEECCCEEEECHHHHHHHHHHHHHHHCCCCCCEEEE
LTVHRPWGSYTVLEENAGYKIKRIAVHPGARLSLQRHYHRSEHWVVIQGTALVQVGDKEM
EEEECCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHCCCCCEEEEECCEEEEECCHHH
LLSQNQWAEIPETAVHRLTNPGRIPLEIIEIQTGPYLEEDDIERFEDVYGRPKGGKNKSN
HHCCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SESAPSSAMERCHAVILAGGSGTRLWPLSRALFPKQLLALNGELTLLQQTVKRALDIFP
CCCCCHHHHHHCEEEEEECCCCCEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCC
PQRIHIVTNEEHVFEVRAQAKALDAALEDNVLAEPMIRNTLPALMLGLNAAMKQDAAPLL
CCEEEEEECCCCEEHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCEE
AVFPSDHMIHNAASWQRAVQAGAELAAQNHFVTFGIPPAHPETGYGYIHRGARIADGCYA
EECCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCCCCEEECCCEECCCHHE
VEGFVEKPPREKAEEFLRGGMHFWNSGMFVFNGEDLIAALETYQPALAAWWNTRTATSLR
EHHHHCCCCHHHHHHHHHCCHHHHCCCEEEECCCHHHHHHHHCCCHHHHHHCCHHHHHHH
QGYSAIPSLSIDYGIMEHVSRIAVVEADFGWDDLGSWEAIFRLGEKDEQGCVVQGDAMAI
HHHHHCCCCCCCHHHHHHHHHEEEEEECCCCCCCCCHHHHHHCCCCCCCCCEEECCEEEE
DCENSLLLSRGGKLAAIGLKDVIAVQTRDATLLCAKDQVQRVREVVSRLKAEGSPLTEVH
ECCCCEEEECCCCEEEECCCCEEEEEECCCEEEECHHHHHHHHHHHHHHHCCCCCCEEEE
LTVHRPWGSYTVLEENAGYKIKRIAVHPGARLSLQRHYHRSEHWVVIQGTALVQVGDKEM
EEEECCCCCEEEEECCCCCEEEEEEECCCCCCHHHHHHCCCCCEEEEECCEEEEECCHHH
LLSQNQWAEIPETAVHRLTNPGRIPLEIIEIQTGPYLEEDDIERFEDVYGRPKGGKNKSN
HHCCCCCCCCCHHHHHHCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3089876; 10984043; 1846611 [H]