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The map label for this gene is rpfC [H]

Identifier: 78357811

GI number: 78357811

Start: 2769649

End: 2771970

Strand: Direct

Name: rpfC [H]

Synonym: Dde_2769

Alternate gene names: 78357811

Gene position: 2769649-2771970 (Clockwise)

Preceding gene: 78357810

Following gene: 78357814

Centisome position: 74.25

GC content: 58.23

Gene sequence:

>2322_bases
ATGAACCGAACCCCTCTCAAACGCAGATTCACCGTCACCCTCATGCTGTTCACCCTGCTGTGCTGTGCTCTGTACACTGT
GACGGCAAGCAGTTTCATGCATTATCACAATGCCCAGATAACCTCCCGCACCGAGCGGCTGCTGCATGCTCTTGTGCTCC
AGCGCGAAAATGATCTGGCAAATCAGATTTTTGTTGGACACATCCGCGCGCTGCGCAGCACCGCTGCCGACCTGCAGGAA
ACTGACGATGTTTATTCCATCACCGTGTACGACAAATCAGGTAAACCGCTCATACATACCCGCCCCGAACGCCCGCTGCC
TCTCACCGGTGCCGAGATGGCCATCCTTGCACAGGGCGATGTGGATGCGCGCGGAACAGAAAACGGTGTCCCGCTGCTTT
ATCATACTTCGGCACTTATGGTCATAGGCGAACTACAGGGATTTGTAACCGTAGCCTACGACCTGTCGCATGTACGGCGC
GACACCATACTGCTGTCGGCCATGCTTACAATCCTGCTGCTGGGCACAGTGATTGCCGCGGGCATGGTGTGCAGTCATTT
CATTACGCAGCACATACGCCGGCCGCTCACAGCCCTGCGCGATGCCATGCACCGGGCACGCAGCGGCGAACTGCAGCACC
GCGCCCCCATCGAAGCACAGGACGAAGTGGGCCGGCTGGCGGAATCATTCAACGCCATGGTAGCCACACTGCAACGCAAC
GAATCGTCGCTGCGGCACGCCCAGACCATATACAAAGATATCTTTGAAAACGCGCTGGAAGGTATTTTCCAGATCACAGG
CCGCGGTTATCTGATTAACGCCAACCCCGCCCTTGCACGCATGCTGGGATATTCTTCAGTAATGGAGCTGCTGGCCGAAC
GCGGCACAACCCCGCTTAAATCGCTGGTCAACAGACGCGATCTGGCCCGCATGCTGCGGATGCTGCGCGCAAAGGGAGCA
GTGGACGGGTACGAAACCCGGGTCTACACCAAAGGCGGCGGTATCACGTGGATATCTGTTTCGGCGCGCACCATTGCAAA
AGAAGAAACCGGCCAGCCGGAATCATTCCGCTACGAAGGGTTTGTCAAAGACATCACCGAACACAGACGCCTGCGCGAAC
TGGAACAGACCCGCACCGCCATGATAGAAGCCGACAAGGCAAAGAGTGATTTTCTGGCGCACATGAGCCACGAAATACGC
ACCCCTATGAACTCGGTACTGGGCATGGCCGAGCAGATGCTGCGCACGCCGCTTTCGGCAGAACAGAAAGAATGCATGGA
TGTGCTGAAAAATTCCGGTGAATCGCTGCTGCACCTGATAAACGACATACTGGATCTTACACGGGTGGAAGGCGGCCAGC
TGGCACTGGCCAGTGCGCCTTTTACCGTGCATGCCGTGGTATACGGCGTGCGTGACATGCTCTCGCTGCAGGCCCGTCAG
AAAAACATTCTGCTGGCCGCGACCATTGCTCCCGATGTGCGCAAAAACCATATGGGCGATGCCCAGCGTCTGCAGCAGAT
ACTGGTGAACCTGCTGGGCAACGCGGTCAAGTTTACCGACAACGGTGAAGTTTCACTGCATGTCAGCCGTGCTCCCGATG
CCGTGCACGACGGAGATCTGCTCTTCACGGTCCGGGACACAGGCATAGGCATAACCCCTGCCGAACAGAGCAGACTTTTT
CAAAAATTTTCGCAGGCTTCCACAGCCATCCACAGCCGCTACGGCGGTTCGGGGCTCGGGCTTGCCATATCCAGACACCT
TGTGGACCTTATGGGCGGAACCATAAGACTGGAAAGCGAACCCGGGGTGGGGACAACCGTCACCTTTACCGCCCGCTTTG
CAGCCGTGCCGGAAGAAACAGCACGGACCGGCCATGAGGCGGAACAGCCGGATACCGCCGGCGACGACGCAACCGCGCTG
CCAGCCCTGACCGTGCTGCTGGCCGAAGACACCCCCAGCAACAGGGCCGTGGTGCGCATGATGCTGCAGGACACCCCCTG
CACCGTCATTGAAGCAGAAGACGGACAGCAGGCACTGCACCTCTTCGGGCAATACGATATCGATGTTGTGCTCATGGACA
TCAACATGCCTGTGATGGACGGCATGGAAGCCACACGGCAACTGCGCAGGCAGGAACACGGAAGCGGCAGACGCACACCG
GTCATAGCGCTGACAGCCAATGCCTTTCAACAGGACATCATCAGATACAGGCAGGCAGGCTGCGACGGCCATCTGGTAAA
ACCCGTCACACGCAAAGCACTGCTGACTGCGTTGCAGAGCTGTGCGGGCGGCGGTGCCACGCATTCCGGTTCCGGCGCCT
AA

Upstream 100 bases:

>100_bases
CCGACGGTGCACCGCCCCCCGGACCTGTTCATATCCTGCAGCTGCGCAACGGTTCGGCCCGGCCGGTACAGACTGTCACG
CTTTCCCCGCGGGAGGCTCA

Downstream 100 bases:

>100_bases
CGGTCAGCCTGTACGCCCCGGGCACCGGCCGGAGGCGCAACCAGCCAGACGCGCACCGGCAGTGCACCCCCTCCCACGGC
AACCGCAGCAGCTGTCCGGC

Product: multi-sensor hybrid histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 773; Mature: 773

Protein sequence:

>773_residues
MNRTPLKRRFTVTLMLFTLLCCALYTVTASSFMHYHNAQITSRTERLLHALVLQRENDLANQIFVGHIRALRSTAADLQE
TDDVYSITVYDKSGKPLIHTRPERPLPLTGAEMAILAQGDVDARGTENGVPLLYHTSALMVIGELQGFVTVAYDLSHVRR
DTILLSAMLTILLLGTVIAAGMVCSHFITQHIRRPLTALRDAMHRARSGELQHRAPIEAQDEVGRLAESFNAMVATLQRN
ESSLRHAQTIYKDIFENALEGIFQITGRGYLINANPALARMLGYSSVMELLAERGTTPLKSLVNRRDLARMLRMLRAKGA
VDGYETRVYTKGGGITWISVSARTIAKEETGQPESFRYEGFVKDITEHRRLRELEQTRTAMIEADKAKSDFLAHMSHEIR
TPMNSVLGMAEQMLRTPLSAEQKECMDVLKNSGESLLHLINDILDLTRVEGGQLALASAPFTVHAVVYGVRDMLSLQARQ
KNILLAATIAPDVRKNHMGDAQRLQQILVNLLGNAVKFTDNGEVSLHVSRAPDAVHDGDLLFTVRDTGIGITPAEQSRLF
QKFSQASTAIHSRYGGSGLGLAISRHLVDLMGGTIRLESEPGVGTTVTFTARFAAVPEETARTGHEAEQPDTAGDDATAL
PALTVLLAEDTPSNRAVVRMMLQDTPCTVIEAEDGQQALHLFGQYDIDVVLMDINMPVMDGMEATRQLRRQEHGSGRRTP
VIALTANAFQQDIIRYRQAGCDGHLVKPVTRKALLTALQSCAGGGATHSGSGA

Sequences:

>Translated_773_residues
MNRTPLKRRFTVTLMLFTLLCCALYTVTASSFMHYHNAQITSRTERLLHALVLQRENDLANQIFVGHIRALRSTAADLQE
TDDVYSITVYDKSGKPLIHTRPERPLPLTGAEMAILAQGDVDARGTENGVPLLYHTSALMVIGELQGFVTVAYDLSHVRR
DTILLSAMLTILLLGTVIAAGMVCSHFITQHIRRPLTALRDAMHRARSGELQHRAPIEAQDEVGRLAESFNAMVATLQRN
ESSLRHAQTIYKDIFENALEGIFQITGRGYLINANPALARMLGYSSVMELLAERGTTPLKSLVNRRDLARMLRMLRAKGA
VDGYETRVYTKGGGITWISVSARTIAKEETGQPESFRYEGFVKDITEHRRLRELEQTRTAMIEADKAKSDFLAHMSHEIR
TPMNSVLGMAEQMLRTPLSAEQKECMDVLKNSGESLLHLINDILDLTRVEGGQLALASAPFTVHAVVYGVRDMLSLQARQ
KNILLAATIAPDVRKNHMGDAQRLQQILVNLLGNAVKFTDNGEVSLHVSRAPDAVHDGDLLFTVRDTGIGITPAEQSRLF
QKFSQASTAIHSRYGGSGLGLAISRHLVDLMGGTIRLESEPGVGTTVTFTARFAAVPEETARTGHEAEQPDTAGDDATAL
PALTVLLAEDTPSNRAVVRMMLQDTPCTVIEAEDGQQALHLFGQYDIDVVLMDINMPVMDGMEATRQLRRQEHGSGRRTP
VIALTANAFQQDIIRYRQAGCDGHLVKPVTRKALLTALQSCAGGGATHSGSGA
>Mature_773_residues
MNRTPLKRRFTVTLMLFTLLCCALYTVTASSFMHYHNAQITSRTERLLHALVLQRENDLANQIFVGHIRALRSTAADLQE
TDDVYSITVYDKSGKPLIHTRPERPLPLTGAEMAILAQGDVDARGTENGVPLLYHTSALMVIGELQGFVTVAYDLSHVRR
DTILLSAMLTILLLGTVIAAGMVCSHFITQHIRRPLTALRDAMHRARSGELQHRAPIEAQDEVGRLAESFNAMVATLQRN
ESSLRHAQTIYKDIFENALEGIFQITGRGYLINANPALARMLGYSSVMELLAERGTTPLKSLVNRRDLARMLRMLRAKGA
VDGYETRVYTKGGGITWISVSARTIAKEETGQPESFRYEGFVKDITEHRRLRELEQTRTAMIEADKAKSDFLAHMSHEIR
TPMNSVLGMAEQMLRTPLSAEQKECMDVLKNSGESLLHLINDILDLTRVEGGQLALASAPFTVHAVVYGVRDMLSLQARQ
KNILLAATIAPDVRKNHMGDAQRLQQILVNLLGNAVKFTDNGEVSLHVSRAPDAVHDGDLLFTVRDTGIGITPAEQSRLF
QKFSQASTAIHSRYGGSGLGLAISRHLVDLMGGTIRLESEPGVGTTVTFTARFAAVPEETARTGHEAEQPDTAGDDATAL
PALTVLLAEDTPSNRAVVRMMLQDTPCTVIEAEDGQQALHLFGQYDIDVVLMDINMPVMDGMEATRQLRRQEHGSGRRTP
VIALTANAFQQDIIRYRQAGCDGHLVKPVTRKALLTALQSCAGGGATHSGSGA

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI48994928, Length=399, Percent_Identity=35.3383458646617, Blast_Score=213, Evalue=3e-56,
Organism=Escherichia coli, GI1788713, Length=399, Percent_Identity=37.0927318295739, Blast_Score=210, Evalue=3e-55,
Organism=Escherichia coli, GI1789149, Length=237, Percent_Identity=42.1940928270042, Blast_Score=196, Evalue=5e-51,
Organism=Escherichia coli, GI87081816, Length=396, Percent_Identity=32.8282828282828, Blast_Score=178, Evalue=1e-45,
Organism=Escherichia coli, GI145693157, Length=252, Percent_Identity=39.2857142857143, Blast_Score=158, Evalue=1e-39,
Organism=Escherichia coli, GI1786600, Length=354, Percent_Identity=25.4237288135593, Blast_Score=96, Evalue=1e-20,
Organism=Escherichia coli, GI1786912, Length=252, Percent_Identity=29.7619047619048, Blast_Score=86, Evalue=9e-18,
Organism=Escherichia coli, GI87082128, Length=237, Percent_Identity=31.2236286919831, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1788393, Length=237, Percent_Identity=25.7383966244726, Blast_Score=79, Evalue=1e-15,
Organism=Escherichia coli, GI1788549, Length=474, Percent_Identity=24.6835443037975, Blast_Score=78, Evalue=3e-15,
Organism=Escherichia coli, GI1790436, Length=242, Percent_Identity=28.099173553719, Blast_Score=76, Evalue=7e-15,
Organism=Escherichia coli, GI1790346, Length=230, Percent_Identity=28.2608695652174, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1786783, Length=216, Percent_Identity=29.6296296296296, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI1788521, Length=127, Percent_Identity=35.4330708661417, Blast_Score=71, Evalue=3e-13,
Organism=Escherichia coli, GI1790300, Length=223, Percent_Identity=26.457399103139, Blast_Score=65, Evalue=2e-11,
Organism=Escherichia coli, GI1788191, Length=113, Percent_Identity=37.1681415929204, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=153, Percent_Identity=33.3333333333333, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6322044, Length=67, Percent_Identity=49.2537313432836, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 84876; Mature: 84876

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: PS50885 HAMP ; PS50112 PAS ; PS50113 PAC ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRTPLKRRFTVTLMLFTLLCCALYTVTASSFMHYHNAQITSRTERLLHALVLQRENDLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHH
NQIFVGHIRALRSTAADLQETDDVYSITVYDKSGKPLIHTRPERPLPLTGAEMAILAQGD
HHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEECCCCCCCCCCCCCEEEEECCC
VDARGTENGVPLLYHTSALMVIGELQGFVTVAYDLSHVRRDTILLSAMLTILLLGTVIAA
CCCCCCCCCCCEEEEHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMVCSHFITQHIRRPLTALRDAMHRARSGELQHRAPIEAQDEVGRLAESFNAMVATLQRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
ESSLRHAQTIYKDIFENALEGIFQITGRGYLINANPALARMLGYSSVMELLAERGTTPLK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCHHH
SLVNRRDLARMLRMLRAKGAVDGYETRVYTKGGGITWISVSARTIAKEETGQPESFRYEG
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEECHHHHHHHCCCCCCCEEHHH
FVKDITEHRRLRELEQTRTAMIEADKAKSDFLAHMSHEIRTPMNSVLGMAEQMLRTPLSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCC
EQKECMDVLKNSGESLLHLINDILDLTRVEGGQLALASAPFTVHAVVYGVRDMLSLQARQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
KNILLAATIAPDVRKNHMGDAQRLQQILVNLLGNAVKFTDNGEVSLHVSRAPDAVHDGDL
CCEEEEEECCCHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCCCCCCE
LFTVRDTGIGITPAEQSRLFQKFSQASTAIHSRYGGSGLGLAISRHLVDLMGGTIRLESE
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECC
PGVGTTVTFTARFAAVPEETARTGHEAEQPDTAGDDATALPALTVLLAEDTPSNRAVVRM
CCCCEEEEEEEHHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHEEEEECCCCCCHHHHHH
MLQDTPCTVIEAEDGQQALHLFGQYDIDVVLMDINMPVMDGMEATRQLRRQEHGSGRRTP
HHCCCCCEEEECCCCHHHHHHHCCCCEEEEEEECCCCHHCCHHHHHHHHHHHCCCCCCCE
VIALTANAFQQDIIRYRQAGCDGHLVKPVTRKALLTALQSCAGGGATHSGSGA
EEEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure
MNRTPLKRRFTVTLMLFTLLCCALYTVTASSFMHYHNAQITSRTERLLHALVLQRENDLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHH
NQIFVGHIRALRSTAADLQETDDVYSITVYDKSGKPLIHTRPERPLPLTGAEMAILAQGD
HHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCEECCCCCCCCCCCCCEEEEECCC
VDARGTENGVPLLYHTSALMVIGELQGFVTVAYDLSHVRRDTILLSAMLTILLLGTVIAA
CCCCCCCCCCCEEEEHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GMVCSHFITQHIRRPLTALRDAMHRARSGELQHRAPIEAQDEVGRLAESFNAMVATLQRN
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHC
ESSLRHAQTIYKDIFENALEGIFQITGRGYLINANPALARMLGYSSVMELLAERGTTPLK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHCCCCHHH
SLVNRRDLARMLRMLRAKGAVDGYETRVYTKGGGITWISVSARTIAKEETGQPESFRYEG
HHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEECHHHHHHHCCCCCCCEEHHH
FVKDITEHRRLRELEQTRTAMIEADKAKSDFLAHMSHEIRTPMNSVLGMAEQMLRTPLSA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCC
EQKECMDVLKNSGESLLHLINDILDLTRVEGGQLALASAPFTVHAVVYGVRDMLSLQARQ
HHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHH
KNILLAATIAPDVRKNHMGDAQRLQQILVNLLGNAVKFTDNGEVSLHVSRAPDAVHDGDL
CCEEEEEECCCHHHHCCCCHHHHHHHHHHHHHCCCEEEECCCEEEEEEECCCCCCCCCCE
LFTVRDTGIGITPAEQSRLFQKFSQASTAIHSRYGGSGLGLAISRHLVDLMGGTIRLESE
EEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCEEEEECC
PGVGTTVTFTARFAAVPEETARTGHEAEQPDTAGDDATALPALTVLLAEDTPSNRAVVRM
CCCCEEEEEEEHHHCCCHHHHHCCCCCCCCCCCCCCCHHHHHHEEEEECCCCCCHHHHHH
MLQDTPCTVIEAEDGQQALHLFGQYDIDVVLMDINMPVMDGMEATRQLRRQEHGSGRRTP
HHCCCCCEEEECCCCHHHHHHHCCCCEEEEEEECCCCHHCCHHHHHHHHHHHCCCCCCCE
VIALTANAFQQDIIRYRQAGCDGHLVKPVTRKALLTALQSCAGGGATHSGSGA
EEEEEHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]