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The map label for this gene is fusA

Identifier: 78357783

GI number: 78357783

Start: 2743327

End: 2745387

Strand: Direct

Name: fusA

Synonym: Dde_2741

Alternate gene names: 78357783

Gene position: 2743327-2745387 (Clockwise)

Preceding gene: 78357778

Following gene: 78357784

Centisome position: 73.54

GC content: 57.54

Gene sequence:

>2061_bases
ATGTCCAGAGCGCTTGAAAATCAAAGAACCTATGCCCTGGTCGGCACCGGAGGCAGCGGCAAGACCTCGCTGGCGGAAAT
GCTTCTTTTCCAGTCCGGCGCGGTCAGCCGCATGGGAAAAATCGAGGACGGAACAAGCTGCCTTGATTACGAGCCGGAGG
AAGTGAAGCGGCGCGGCAGCATACAGCCCGCTTTTGCGACATTTTCATGGAACAAGAACCGGCACTTTCTTGCTGACATC
CCCGGCGATAACAACTTTATCGGCGACATCAACTACCTGCTGGCCGGCGTTGATGCCGCCGTTTTTGTTGTCGATGCCGT
GGACGGAGTACGCCCCCTGACACGTAAACTGTGGAACGCCGTGAAAAATGCCGGTCTGCCCGCCATGGTCTTCATCAACA
AGACCGACCGCGACAGAGCCGACTTCGACATGGCCTTTGCGGGATTGTCCGACATACTGGGTATCAAACCCGTTCTGCTC
TATTCTCCCGTGGGGCAGCAGGAAAACTTTCGCGGGGTGGCCGATGTGCTGGCAGGCAAGGCCCTGCTGTTCGGCGAAAA
CGGCAGCGTGACCGAAGCTGACATACCCGCGGACATGGCAGACGACATACAGGCCCTGCGCGAAACCATGGTGGAAAACA
TCGCGGAAAGCGATGAAGAGCTTATGGAAAAATACCTTGAAGAAGGTGAACTGACAGACGAAGAAATACACGCTGCCCTG
CGCAAAGGCGTACTGAAAGGCGAACTGATACCGGTTGCTGCCGGTTCGGCACTGGAAAACAAAGGCGGCGCGCAGGTGCT
CGACCTCATCCAGAGTCTTTTCCCCTCGCCGCTGGACCGCGCGGCATGGCTTGACGAAGAAGGCAACGAGCGCGTCTCCT
CTCCCGACGGGCCGGTGTCTGCATTTGTCATAAAAACGCTGGCCGACCCCTTTGCAGGGCAGCTCAGTATTCTGCGTATT
CTTTCCGGCACGCTGAAGCCCGACACCACGCTGTACAACCCCGCCAGAGAAGAAAACGAGCGTGTGGGCACACCGCTGTG
CCTGGTGGGCAAAGAGCAGACCCCCTGCAAGGAAGCTCTTGAACCCGGTGCCGTTATTGCCGTGGCCAAACTGAAAAACA
CCCGTACCGGCGACACACTGTGCGAAGAAAAAACACCCTTTGCGCTGGCGCGCCCGCATATGCCCCCCACTCTTATCACC
TATGCGCTGGCCCCGCAGGAAAAAGGCGATGAAGACAAAGTATACGCGGCCGTGCACAAACTGCTTGATGAAGACATAAC
CCTGCGTCTGAACAGAGACGAAGAAACCGGAGACATACTGCTTTCCGGCATGGGGCAGATGCACATAGAAACCGCCGTGG
AACGTGCGCGCCGCCGTTACAAGGCGGACATTGTGCTGAAAACGCCCAAGGTGCCCTACCGCGAAACCATCAAGGGCAAA
GCGCAGGTGCAGGGCAGACACAAGAAACAATCCGGCGGACGCGGGCAGTTCGGCGACTGCTGGGTGGAAATCAGCCCGCA
GGAGCGCGGAGCAGGGTACACCTTTGAAGACGCCATCGTGGGCGGTTCCATTCCCCGCCAGTATATACCCGCTGTGGATA
AAGGCGTTCAGGAGGCCGCCCACAGAGGCTATCTTGCCGGATATCCCATGGTGGACTTCAAGGTGCGTCTGTACGACGGG
TCGTACCACACGGTGGACTCTTCGGAAATGGCCTTTAAAATCGCAGGATCGCTTGCCTTTAAAAAAGCCATGGAATCATG
CCGCCCCGTACTGCTTGAACCCGTCATGCTGGTCAGCGTGTCTGTGCCGGATGAATACATGGGGGACATCATCGGCGACC
TTTCGAGCCGCCGCGGCAAAGTGCTTGGCTCCGACTCCACAGCCGGCATAACAGAAATCAAAGCGCACATCCCCATGAAT
GAAATCATGCGCTATGCCCCCGATCTGCGTTCCATGACCGGCGGACAGGGCGTGTTCACCATGGAATTCGATCATTACGA
AGAAGCTCCGCCCCATATCACCGAAAAGGTGGTGGCAGAAAGCCAGCAGGCAGCAGCCTGA

Upstream 100 bases:

>100_bases
TAGACTCGCAGCACCGGAAAAGGGCTGCACTGAGCAAAAGGACAAAACCCCTGCGCGCAGGGGCTATTCCCACGATACAC
ACGTTACAAGGGAGAGCTAC

Downstream 100 bases:

>100_bases
TCTGCATTGCCTCAACGACATCCACGCGGCCGCCTCCGGGCGGCCGCATGCATTGTATCGGGGTGTGATATCCCCTGCCG
CGACAGCCCCCGTGCAGCAC

Product: elongation factor G

Products: GDP; phosphate

Alternate protein names: EF-G [H]

Number of amino acids: Translated: 686; Mature: 685

Protein sequence:

>686_residues
MSRALENQRTYALVGTGGSGKTSLAEMLLFQSGAVSRMGKIEDGTSCLDYEPEEVKRRGSIQPAFATFSWNKNRHFLADI
PGDNNFIGDINYLLAGVDAAVFVVDAVDGVRPLTRKLWNAVKNAGLPAMVFINKTDRDRADFDMAFAGLSDILGIKPVLL
YSPVGQQENFRGVADVLAGKALLFGENGSVTEADIPADMADDIQALRETMVENIAESDEELMEKYLEEGELTDEEIHAAL
RKGVLKGELIPVAAGSALENKGGAQVLDLIQSLFPSPLDRAAWLDEEGNERVSSPDGPVSAFVIKTLADPFAGQLSILRI
LSGTLKPDTTLYNPAREENERVGTPLCLVGKEQTPCKEALEPGAVIAVAKLKNTRTGDTLCEEKTPFALARPHMPPTLIT
YALAPQEKGDEDKVYAAVHKLLDEDITLRLNRDEETGDILLSGMGQMHIETAVERARRRYKADIVLKTPKVPYRETIKGK
AQVQGRHKKQSGGRGQFGDCWVEISPQERGAGYTFEDAIVGGSIPRQYIPAVDKGVQEAAHRGYLAGYPMVDFKVRLYDG
SYHTVDSSEMAFKIAGSLAFKKAMESCRPVLLEPVMLVSVSVPDEYMGDIIGDLSSRRGKVLGSDSTAGITEIKAHIPMN
EIMRYAPDLRSMTGGQGVFTMEFDHYEEAPPHITEKVVAESQQAAA

Sequences:

>Translated_686_residues
MSRALENQRTYALVGTGGSGKTSLAEMLLFQSGAVSRMGKIEDGTSCLDYEPEEVKRRGSIQPAFATFSWNKNRHFLADI
PGDNNFIGDINYLLAGVDAAVFVVDAVDGVRPLTRKLWNAVKNAGLPAMVFINKTDRDRADFDMAFAGLSDILGIKPVLL
YSPVGQQENFRGVADVLAGKALLFGENGSVTEADIPADMADDIQALRETMVENIAESDEELMEKYLEEGELTDEEIHAAL
RKGVLKGELIPVAAGSALENKGGAQVLDLIQSLFPSPLDRAAWLDEEGNERVSSPDGPVSAFVIKTLADPFAGQLSILRI
LSGTLKPDTTLYNPAREENERVGTPLCLVGKEQTPCKEALEPGAVIAVAKLKNTRTGDTLCEEKTPFALARPHMPPTLIT
YALAPQEKGDEDKVYAAVHKLLDEDITLRLNRDEETGDILLSGMGQMHIETAVERARRRYKADIVLKTPKVPYRETIKGK
AQVQGRHKKQSGGRGQFGDCWVEISPQERGAGYTFEDAIVGGSIPRQYIPAVDKGVQEAAHRGYLAGYPMVDFKVRLYDG
SYHTVDSSEMAFKIAGSLAFKKAMESCRPVLLEPVMLVSVSVPDEYMGDIIGDLSSRRGKVLGSDSTAGITEIKAHIPMN
EIMRYAPDLRSMTGGQGVFTMEFDHYEEAPPHITEKVVAESQQAAA
>Mature_685_residues
SRALENQRTYALVGTGGSGKTSLAEMLLFQSGAVSRMGKIEDGTSCLDYEPEEVKRRGSIQPAFATFSWNKNRHFLADIP
GDNNFIGDINYLLAGVDAAVFVVDAVDGVRPLTRKLWNAVKNAGLPAMVFINKTDRDRADFDMAFAGLSDILGIKPVLLY
SPVGQQENFRGVADVLAGKALLFGENGSVTEADIPADMADDIQALRETMVENIAESDEELMEKYLEEGELTDEEIHAALR
KGVLKGELIPVAAGSALENKGGAQVLDLIQSLFPSPLDRAAWLDEEGNERVSSPDGPVSAFVIKTLADPFAGQLSILRIL
SGTLKPDTTLYNPAREENERVGTPLCLVGKEQTPCKEALEPGAVIAVAKLKNTRTGDTLCEEKTPFALARPHMPPTLITY
ALAPQEKGDEDKVYAAVHKLLDEDITLRLNRDEETGDILLSGMGQMHIETAVERARRRYKADIVLKTPKVPYRETIKGKA
QVQGRHKKQSGGRGQFGDCWVEISPQERGAGYTFEDAIVGGSIPRQYIPAVDKGVQEAAHRGYLAGYPMVDFKVRLYDGS
YHTVDSSEMAFKIAGSLAFKKAMESCRPVLLEPVMLVSVSVPDEYMGDIIGDLSSRRGKVLGSDSTAGITEIKAHIPMNE
IMRYAPDLRSMTGGQGVFTMEFDHYEEAPPHITEKVVAESQQAAA

Specific function: Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and

COG id: COG0480

COG function: function code J; Translation elongation factors (GTPases)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI18390331, Length=686, Percent_Identity=30.9037900874636, Blast_Score=330, Evalue=3e-90,
Organism=Homo sapiens, GI19923640, Length=707, Percent_Identity=27.5813295615276, Blast_Score=256, Evalue=4e-68,
Organism=Homo sapiens, GI25306287, Length=707, Percent_Identity=26.3083451202263, Blast_Score=225, Evalue=9e-59,
Organism=Homo sapiens, GI25306283, Length=386, Percent_Identity=30.8290155440415, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI4503483, Length=479, Percent_Identity=21.7118997912317, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1789738, Length=680, Percent_Identity=39.5588235294118, Blast_Score=483, Evalue=1e-137,
Organism=Escherichia coli, GI1790835, Length=473, Percent_Identity=22.8329809725159, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI48994988, Length=218, Percent_Identity=29.3577981651376, Blast_Score=72, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17533571, Length=700, Percent_Identity=29.8571428571429, Blast_Score=323, Evalue=2e-88,
Organism=Caenorhabditis elegans, GI17556745, Length=710, Percent_Identity=23.6619718309859, Blast_Score=179, Evalue=5e-45,
Organism=Caenorhabditis elegans, GI17506493, Length=144, Percent_Identity=31.9444444444444, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323098, Length=685, Percent_Identity=31.8248175182482, Blast_Score=338, Evalue=2e-93,
Organism=Saccharomyces cerevisiae, GI6322359, Length=780, Percent_Identity=24.4871794871795, Blast_Score=221, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24582462, Length=699, Percent_Identity=31.0443490701001, Blast_Score=354, Evalue=9e-98,
Organism=Drosophila melanogaster, GI221458488, Length=703, Percent_Identity=26.3157894736842, Blast_Score=212, Evalue=7e-55,
Organism=Drosophila melanogaster, GI24585711, Length=144, Percent_Identity=31.25, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24585713, Length=144, Percent_Identity=31.25, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24585709, Length=144, Percent_Identity=31.25, Blast_Score=70, Evalue=4e-12,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2520 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 20 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 7984 Molecules/Cell In: Growth Phase, Gl

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR005225
- InterPro:   IPR004540
- InterPro:   IPR000640
- InterPro:   IPR005517
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF00679 EFG_C; PF03764 EFG_IV; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: 3.6.5.3

Molecular weight: Translated: 74755; Mature: 74624

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRALENQRTYALVGTGGSGKTSLAEMLLFQSGAVSRMGKIEDGTSCLDYEPEEVKRRGS
CCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCHHHHHHCCC
IQPAFATFSWNKNRHFLADIPGDNNFIGDINYLLAGVDAAVFVVDAVDGVRPLTRKLWNA
CCCEEEEEEECCCCEEEEECCCCCCEECHHHHHHHHCCCEEEEEHHHCCCHHHHHHHHHH
VKNAGLPAMVFINKTDRDRADFDMAFAGLSDILGIKPVLLYSPVGQQENFRGVADVLAGK
HHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHCCC
ALLFGENGSVTEADIPADMADDIQALRETMVENIAESDEELMEKYLEEGELTDEEIHAAL
EEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHH
RKGVLKGELIPVAAGSALENKGGAQVLDLIQSLFPSPLDRAAWLDEEGNERVSSPDGPVS
HCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCHH
AFVIKTLADPFAGQLSILRILSGTLKPDTTLYNPAREENERVGTPLCLVGKEQTPCKEAL
HHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCCCCHHHHC
EPGAVIAVAKLKNTRTGDTLCEEKTPFALARPHMPPTLITYALAPQEKGDEDKVYAAVHK
CCCCEEEEEECCCCCCCCHHHCCCCCCEEECCCCCHHHEEEEECCCCCCCHHHHHHHHHH
LLDEDITLRLNRDEETGDILLSGMGQMHIETAVERARRRYKADIVLKTPKVPYRETIKGK
HHCCCEEEEECCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHCCCC
AQVQGRHKKQSGGRGQFGDCWVEISPQERGAGYTFEDAIVGGSIPRQYIPAVDKGVQEAA
HHHCCCHHCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHH
HRGYLAGYPMVDFKVRLYDGSYHTVDSSEMAFKIAGSLAFKKAMESCRPVLLEPVMLVSV
HCCCCCCCCEEEEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEE
SVPDEYMGDIIGDLSSRRGKVLGSDSTAGITEIKAHIPMNEIMRYAPDLRSMTGGQGVFT
ECCHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHCCCHHHHHHHCCCHHHCCCCCEEEE
MEFDHYEEAPPHITEKVVAESQQAAA
EECCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SRALENQRTYALVGTGGSGKTSLAEMLLFQSGAVSRMGKIEDGTSCLDYEPEEVKRRGS
CCCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCHHHHHHCCC
IQPAFATFSWNKNRHFLADIPGDNNFIGDINYLLAGVDAAVFVVDAVDGVRPLTRKLWNA
CCCEEEEEEECCCCEEEEECCCCCCEECHHHHHHHHCCCEEEEEHHHCCCHHHHHHHHHH
VKNAGLPAMVFINKTDRDRADFDMAFAGLSDILGIKPVLLYSPVGQQENFRGVADVLAGK
HHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHCCC
ALLFGENGSVTEADIPADMADDIQALRETMVENIAESDEELMEKYLEEGELTDEEIHAAL
EEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHH
RKGVLKGELIPVAAGSALENKGGAQVLDLIQSLFPSPLDRAAWLDEEGNERVSSPDGPVS
HCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCCCHH
AFVIKTLADPFAGQLSILRILSGTLKPDTTLYNPAREENERVGTPLCLVGKEQTPCKEAL
HHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHCCCCEEEECCCCCCHHHHC
EPGAVIAVAKLKNTRTGDTLCEEKTPFALARPHMPPTLITYALAPQEKGDEDKVYAAVHK
CCCCEEEEEECCCCCCCCHHHCCCCCCEEECCCCCHHHEEEEECCCCCCCHHHHHHHHHH
LLDEDITLRLNRDEETGDILLSGMGQMHIETAVERARRRYKADIVLKTPKVPYRETIKGK
HHCCCEEEEECCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHCCCC
AQVQGRHKKQSGGRGQFGDCWVEISPQERGAGYTFEDAIVGGSIPRQYIPAVDKGVQEAA
HHHCCCHHCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHHHH
HRGYLAGYPMVDFKVRLYDGSYHTVDSSEMAFKIAGSLAFKKAMESCRPVLLEPVMLVSV
HCCCCCCCCEEEEEEEEECCCEEECCCCHHHHHHHHHHHHHHHHHHCCHHHHCCEEEEEE
SVPDEYMGDIIGDLSSRRGKVLGSDSTAGITEIKAHIPMNEIMRYAPDLRSMTGGQGVFT
ECCHHHHHHHHHHHHHHCCCEECCCCCCCHHHHHHCCCHHHHHHHCCCHHHCCCCCEEEE
MEFDHYEEAPPHITEKVVAESQQAAA
EECCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GTP; H2O

Specific reaction: GTP + H2O = GDP + phosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA