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The map label for this gene is hom [H]

Identifier: 78357773

GI number: 78357773

Start: 2733697

End: 2734986

Strand: Direct

Name: hom [H]

Synonym: Dde_2731

Alternate gene names: 78357773

Gene position: 2733697-2734986 (Clockwise)

Preceding gene: 78357772

Following gene: 78357774

Centisome position: 73.28

GC content: 61.63

Gene sequence:

>1290_bases
GTGGCTAGCGACAAACGACTCGTGCTCGGCGTTGCCGGTTTCGGCACCGTGGGCACGGGCCTGACATCCATACTGGAAGA
AAACCGCGACTGGATCATCCAGCGCACCGGACGCGAGATTGTCGTAAAGACGGTGCTGGTGCGCGACGTGAACAAAAAAC
GCGCCGTCAAACTGCCCGAAGGGGCAGAGCTGACAGATGATCCTGCCCGGCTGGTGAACGATCCCGAAATCGACGTGCTG
GTGGAGCTTATGGGCGGCATAGAAGCCCCCAAGGCGCTCATCCTGCAGGCTCTCAACGCCGGCAAGCACGTTGTGACCGC
CAACAAGGCGCTGCTGGCCGAAGACGGTTTCGAACTATTCCGCGCGGCACAGCAGAACGGGGCGGGACTGTACTACGAAG
CCAGCGTCTGCGGCGGCATACCCATAGTCCAGACACTGCGGGAAAGTCTGGCCGGCAACCAGATGACCTCGCTGGTGGGC
ATTCTGAACGGAACGGCCAACTACATCCTTTCCGAGATGACCACCAACGGTCTGGACTTTGACACCGCGCTTTCGCAGGC
GCAGGAACTGGGCTTTGCCGAGGCCGACCCCACGCTGGACATCGAAGGCTTTGACGCCGCACACAAGCTGTGTCTGCTCA
TCAGACTGGCATTCGGCAGAGATTACCCCTTCAGCATGCTTCCGGTACAGGGTATTTCCGGCGTTGACCGTATGGATATC
GAGTTTGCACGCGAGTTCGGCTACCGTCTGAAGCTGCTGGGCGAAGTGCGCAACGTGGACGGCAGGCTGGAAGCAGGCGT
ATTTCCCATGCTGGTGCACCACACCTATCTTATCGCGCGGGTGGGCGGTGCCTACAATGCGGTACGGATGGAAGGCAACG
CCGTGGGACCGGTGTTTCTGCACGGTCTCGGCGCGGGTGCAACCCCCACGGGCAGCGCGGTGCTCAGCGACATCATGGCA
GTAGCCCGCGGCTGCGCCCCCAACAATACGGGGTTTGTCGAGCAGGTTCCGGCTCCCGCCGACATCATGCCGCCCGAAGA
AGCTGAAGCCTGCTACTATTTCCGCGTGATGGTCAGAGACCAGCCCGGCGTGCTGCGGGATCTGGCCGGTGCCATGGCAC
GGCAGGACATATCCATAGCGCAGGCAGTGCAGAAGGGGCAGGACCCCGGCGGTGTGCCCATCGTGTTTATGACGCACGAA
GCCAAAGCCAGAAACGTGGCGGCCGCGCTGGAAGACCTTAAAGGTGCCGGTCTGCTGCTGGCGGAGCCTGTCCATTACCG
GATTCTGTAA

Upstream 100 bases:

>100_bases
CACTTCGGCGACCACCACGTGCGGTTTGCCCTTATTGAAAATCCCCATCGCATCAAGCAGGCGATAAAGGGTATAAAACG
AGTACTATCAGGGAGCTCCT

Downstream 100 bases:

>100_bases
TGCGCCCGCTTATCGTGGCCGTTGCCGACGGCATGGGCGACCTGCCGTGTCCGGCATCGGGCGGTACCCCGCTGGAAACC
GCCGCCACACCTACCCTTGA

Product: homoserine dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 429; Mature: 428

Protein sequence:

>429_residues
MASDKRLVLGVAGFGTVGTGLTSILEENRDWIIQRTGREIVVKTVLVRDVNKKRAVKLPEGAELTDDPARLVNDPEIDVL
VELMGGIEAPKALILQALNAGKHVVTANKALLAEDGFELFRAAQQNGAGLYYEASVCGGIPIVQTLRESLAGNQMTSLVG
ILNGTANYILSEMTTNGLDFDTALSQAQELGFAEADPTLDIEGFDAAHKLCLLIRLAFGRDYPFSMLPVQGISGVDRMDI
EFAREFGYRLKLLGEVRNVDGRLEAGVFPMLVHHTYLIARVGGAYNAVRMEGNAVGPVFLHGLGAGATPTGSAVLSDIMA
VARGCAPNNTGFVEQVPAPADIMPPEEAEACYYFRVMVRDQPGVLRDLAGAMARQDISIAQAVQKGQDPGGVPIVFMTHE
AKARNVAAALEDLKGAGLLLAEPVHYRIL

Sequences:

>Translated_429_residues
MASDKRLVLGVAGFGTVGTGLTSILEENRDWIIQRTGREIVVKTVLVRDVNKKRAVKLPEGAELTDDPARLVNDPEIDVL
VELMGGIEAPKALILQALNAGKHVVTANKALLAEDGFELFRAAQQNGAGLYYEASVCGGIPIVQTLRESLAGNQMTSLVG
ILNGTANYILSEMTTNGLDFDTALSQAQELGFAEADPTLDIEGFDAAHKLCLLIRLAFGRDYPFSMLPVQGISGVDRMDI
EFAREFGYRLKLLGEVRNVDGRLEAGVFPMLVHHTYLIARVGGAYNAVRMEGNAVGPVFLHGLGAGATPTGSAVLSDIMA
VARGCAPNNTGFVEQVPAPADIMPPEEAEACYYFRVMVRDQPGVLRDLAGAMARQDISIAQAVQKGQDPGGVPIVFMTHE
AKARNVAAALEDLKGAGLLLAEPVHYRIL
>Mature_428_residues
ASDKRLVLGVAGFGTVGTGLTSILEENRDWIIQRTGREIVVKTVLVRDVNKKRAVKLPEGAELTDDPARLVNDPEIDVLV
ELMGGIEAPKALILQALNAGKHVVTANKALLAEDGFELFRAAQQNGAGLYYEASVCGGIPIVQTLRESLAGNQMTSLVGI
LNGTANYILSEMTTNGLDFDTALSQAQELGFAEADPTLDIEGFDAAHKLCLLIRLAFGRDYPFSMLPVQGISGVDRMDIE
FAREFGYRLKLLGEVRNVDGRLEAGVFPMLVHHTYLIARVGGAYNAVRMEGNAVGPVFLHGLGAGATPTGSAVLSDIMAV
ARGCAPNNTGFVEQVPAPADIMPPEEAEACYYFRVMVRDQPGVLRDLAGAMARQDISIAQAVQKGQDPGGVPIVFMTHEA
KARNVAAALEDLKGAGLLLAEPVHYRIL

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0460

COG function: function code E; Homoserine dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=249, Percent_Identity=26.9076305220884, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790376, Length=358, Percent_Identity=24.8603351955307, Blast_Score=72, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6322599, Length=157, Percent_Identity=31.2101910828025, Blast_Score=73, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR005106
- InterPro:   IPR016204
- InterPro:   IPR001342
- InterPro:   IPR019811
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01842 ACT; PF00742 Homoserine_dh; PF03447 NAD_binding_3 [H]

EC number: =1.1.1.3 [H]

Molecular weight: Translated: 45848; Mature: 45717

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS01042 HOMOSER_DHGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASDKRLVLGVAGFGTVGTGLTSILEENRDWIIQRTGREIVVKTVLVRDVNKKRAVKLPE
CCCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCHHHCEECCC
GAELTDDPARLVNDPEIDVLVELMGGIEAPKALILQALNAGKHVVTANKALLAEDGFELF
CCCCCCCHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHH
RAAQQNGAGLYYEASVCGGIPIVQTLRESLAGNQMTSLVGILNGTANYILSEMTTNGLDF
HHHHHCCCCEEEECHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHCCCCCH
DTALSQAQELGFAEADPTLDIEGFDAAHKLCLLIRLAFGRDYPFSMLPVQGISGVDRMDI
HHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHH
EFAREFGYRLKLLGEVRNVDGRLEAGVFPMLVHHTYLIARVGGAYNAVRMEGNAVGPVFL
HHHHHCCHHHEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHH
HGLGAGATPTGSAVLSDIMAVARGCAPNNTGFVEQVPAPADIMPPEEAEACYYFRVMVRD
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCCCEEEEEEEEEC
QPGVLRDLAGAMARQDISIAQAVQKGQDPGGVPIVFMTHEAKARNVAAALEDLKGAGLLL
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEE
AEPVHYRIL
ECCCEEECC
>Mature Secondary Structure 
ASDKRLVLGVAGFGTVGTGLTSILEENRDWIIQRTGREIVVKTVLVRDVNKKRAVKLPE
CCCCEEEEEECCCCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCCCHHHCEECCC
GAELTDDPARLVNDPEIDVLVELMGGIEAPKALILQALNAGKHVVTANKALLAEDGFELF
CCCCCCCHHHHCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCEEEECCCHHHHHHHHHHH
RAAQQNGAGLYYEASVCGGIPIVQTLRESLAGNQMTSLVGILNGTANYILSEMTTNGLDF
HHHHHCCCCEEEECHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHCCCCCH
DTALSQAQELGFAEADPTLDIEGFDAAHKLCLLIRLAFGRDYPFSMLPVQGISGVDRMDI
HHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHCCCCCCEECCCCCCCCCCHHHH
EFAREFGYRLKLLGEVRNVDGRLEAGVFPMLVHHTYLIARVGGAYNAVRMEGNAVGPVFL
HHHHHCCHHHEEHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHH
HGLGAGATPTGSAVLSDIMAVARGCAPNNTGFVEQVPAPADIMPPEEAEACYYFRVMVRD
CCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEECCCCCCCCCCCCCCCEEEEEEEEEC
QPGVLRDLAGAMARQDISIAQAVQKGQDPGGVPIVFMTHEAKARNVAAALEDLKGAGLLL
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEE
AEPVHYRIL
ECCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]