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The map label for this gene is pheS

Identifier: 78357677

GI number: 78357677

Start: 2652787

End: 2653827

Strand: Reverse

Name: pheS

Synonym: Dde_2635

Alternate gene names: 78357677

Gene position: 2653827-2652787 (Counterclockwise)

Preceding gene: 78357678

Following gene: 78357676

Centisome position: 71.14

GC content: 58.02

Gene sequence:

>1041_bases
ATGACCCTGGTCAATGAATTGGAGAGCCTGGTCCCGGACCTTGCCAAGGGCCTGGATCAGGCTTCTTCTTTAGAAATGCT
GGAAGAGCTGCGCATTGATTTTCTCGGCCGTAAAGGCCGCCTTGCGCAGATCATGGGCCGCCTGCCTGAACTCGCTCCCG
AGGAGCGTCCCGTGGTGGGCAAGACGGCTAACGCCGTCAAGGAATCACTCAATAACCTGTTCGACCGGCGCAAAACCGCG
CTGGAAGAAGAACGCGAAGCCGAAAAGCTGTCGCGTTTCGATCCTTCCATGCCCGGACGTATGCCCCGTGTCGGCTCGCT
GCACCCCGTGACGCAGGTGATGGACGAAATCTGTCAGGTCTTCAAAGGGCTTGGCTATGATATCGTCACCGGTCCCGAGG
TGGAGAACGACTACCACAACTTTGAAGCGCTCAACATGCCGCCGGAGCATCCCGCCCGCGACATGCAGGACACGCTGTAC
GTCACGGAAAATATCCTGCTGCGTACGCATACCTCGCCCCTGCAGGTGCGCACCATGAAAGAGCGCAAGCCCCCCGTGGC
CGCCATCGCTCCGGGCAAGGTGTACCGCCGCGATTCCGACCTTACGCATACGCCCATGTTTCATCAGATTGAAGGATTCA
TGGTCGACCGTAACGTCAGCATGGCCGATCTGCGGGGCACGCTTACCTCGTTTCTGCAGCAGGTGTTCGGCAAAGACACC
AGAGTGCGCTTCCGTCCCAGCTTTTTTCCCTTTACCGAGCCAAGTGCCGAGGTTGATATCTCGTGCTGCATGTGCGGGGG
CAAAGGCTATCATAAAGACGGTGCGCCCTGCCGCGTGTGCAAGACCACAGGCTGGGTGGAGATTCTGGGCTGCGGCATGA
TAGACCCCGAGGTCTTCAAATCCGTCGGCTATGATCCTGAAGTCTACTCCGGTTTTGCATTCGGTCTGGGTGTGGAGCGT
GTGACCATGCTCAAATACGGCATCGGCGATCTGCGTATGTTCTTTGAGAACGACGTGCGCTTTTTGCGGCAGTTTGCCTG
A

Upstream 100 bases:

>100_bases
TGCTGGCCGATCTCGCCGTTCGTGAAAAAGAGGACTTCGCCAAGCTGGCGGAACTCGTGAAGTCGAAACTCAGCTAGATA
CGAATCGGGACTCCATCCCT

Downstream 100 bases:

>100_bases
TGCGGTTGTGCCGCGCGGCCTGCGGGCCGGTGCGGATGACCTGTTGCGTATTTGCTGCGGGGCGCTGCATGTGCCCCGCT
GCGTGGCCTGCCGGATGCGC

Product: phenylalanyl-tRNA synthetase subunit alpha

Products: NA

Alternate protein names: Phenylalanine--tRNA ligase alpha chain; PheRS

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MTLVNELESLVPDLAKGLDQASSLEMLEELRIDFLGRKGRLAQIMGRLPELAPEERPVVGKTANAVKESLNNLFDRRKTA
LEEEREAEKLSRFDPSMPGRMPRVGSLHPVTQVMDEICQVFKGLGYDIVTGPEVENDYHNFEALNMPPEHPARDMQDTLY
VTENILLRTHTSPLQVRTMKERKPPVAAIAPGKVYRRDSDLTHTPMFHQIEGFMVDRNVSMADLRGTLTSFLQQVFGKDT
RVRFRPSFFPFTEPSAEVDISCCMCGGKGYHKDGAPCRVCKTTGWVEILGCGMIDPEVFKSVGYDPEVYSGFAFGLGVER
VTMLKYGIGDLRMFFENDVRFLRQFA

Sequences:

>Translated_346_residues
MTLVNELESLVPDLAKGLDQASSLEMLEELRIDFLGRKGRLAQIMGRLPELAPEERPVVGKTANAVKESLNNLFDRRKTA
LEEEREAEKLSRFDPSMPGRMPRVGSLHPVTQVMDEICQVFKGLGYDIVTGPEVENDYHNFEALNMPPEHPARDMQDTLY
VTENILLRTHTSPLQVRTMKERKPPVAAIAPGKVYRRDSDLTHTPMFHQIEGFMVDRNVSMADLRGTLTSFLQQVFGKDT
RVRFRPSFFPFTEPSAEVDISCCMCGGKGYHKDGAPCRVCKTTGWVEILGCGMIDPEVFKSVGYDPEVYSGFAFGLGVER
VTMLKYGIGDLRMFFENDVRFLRQFA
>Mature_345_residues
TLVNELESLVPDLAKGLDQASSLEMLEELRIDFLGRKGRLAQIMGRLPELAPEERPVVGKTANAVKESLNNLFDRRKTAL
EEEREAEKLSRFDPSMPGRMPRVGSLHPVTQVMDEICQVFKGLGYDIVTGPEVENDYHNFEALNMPPEHPARDMQDTLYV
TENILLRTHTSPLQVRTMKERKPPVAAIAPGKVYRRDSDLTHTPMFHQIEGFMVDRNVSMADLRGTLTSFLQQVFGKDTR
VRFRPSFFPFTEPSAEVDISCCMCGGKGYHKDGAPCRVCKTTGWVEILGCGMIDPEVFKSVGYDPEVYSGFAFGLGVERV
TMLKYGIGDLRMFFENDVRFLRQFA

Specific function: Unknown

COG id: COG0016

COG function: function code J; Phenylalanyl-tRNA synthetase alpha subunit

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha chain type 1 subfamily

Homologues:

Organism=Homo sapiens, GI4758340, Length=280, Percent_Identity=30.7142857142857, Blast_Score=125, Evalue=4e-29,
Organism=Homo sapiens, GI5729820, Length=248, Percent_Identity=30.6451612903226, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI1788007, Length=344, Percent_Identity=49.7093023255814, Blast_Score=355, Evalue=3e-99,
Organism=Caenorhabditis elegans, GI17508957, Length=296, Percent_Identity=29.3918918918919, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI32563657, Length=296, Percent_Identity=29.3918918918919, Blast_Score=134, Evalue=8e-32,
Organism=Caenorhabditis elegans, GI32566635, Length=257, Percent_Identity=31.9066147859922, Blast_Score=125, Evalue=4e-29,
Organism=Saccharomyces cerevisiae, GI6321087, Length=273, Percent_Identity=28.9377289377289, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6325304, Length=287, Percent_Identity=27.8745644599303, Blast_Score=108, Evalue=1e-24,
Organism=Drosophila melanogaster, GI18858079, Length=375, Percent_Identity=28, Blast_Score=123, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17137424, Length=310, Percent_Identity=26.7741935483871, Blast_Score=108, Evalue=7e-24,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYFA_DESDG (Q30Y15)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_389126.1
- ProteinModelPortal:   Q30Y15
- SMR:   Q30Y15
- STRING:   Q30Y15
- GeneID:   3757657
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2635
- NMPDR:   fig|207559.3.peg.2852
- eggNOG:   COG0016
- HOGENOM:   HBG284353
- OMA:   FRASYFP
- ProtClustDB:   PRK00488
- BioCyc:   DDES207559:DDE_2635-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00281
- InterPro:   IPR006195
- InterPro:   IPR004529
- InterPro:   IPR004188
- InterPro:   IPR022911
- InterPro:   IPR002319
- InterPro:   IPR010978
- PANTHER:   PTHR11538
- TIGRFAMs:   TIGR00468

Pfam domain/function: PF02912 Phe_tRNA-synt_N; PF01409 tRNA-synt_2d; SSF46589 tRNA_binding_arm

EC number: =6.1.1.20

Molecular weight: Translated: 39095; Mature: 38964

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
6.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLVNELESLVPDLAKGLDQASSLEMLEELRIDFLGRKGRLAQIMGRLPELAPEERPVVG
CCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCC
KTANAVKESLNNLFDRRKTALEEEREAEKLSRFDPSMPGRMPRVGSLHPVTQVMDEICQV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FKGLGYDIVTGPEVENDYHNFEALNMPPEHPARDMQDTLYVTENILLRTHTSPLQVRTMK
HHCCCCEEECCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHEEEEECCCCHHHHHHH
ERKPPVAAIAPGKVYRRDSDLTHTPMFHQIEGFMVDRNVSMADLRGTLTSFLQQVFGKDT
HCCCCEEEECCCHHEECCCCCCCCCHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCCC
RVRFRPSFFPFTEPSAEVDISCCMCGGKGYHKDGAPCRVCKTTGWVEILGCGMIDPEVFK
EEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEECCCCCCCEEECCCCCHHHHH
SVGYDPEVYSGFAFGLGVERVTMLKYGIGDLRMFFENDVRFLRQFA
HCCCCCHHHCCHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TLVNELESLVPDLAKGLDQASSLEMLEELRIDFLGRKGRLAQIMGRLPELAPEERPVVG
CHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCC
KTANAVKESLNNLFDRRKTALEEEREAEKLSRFDPSMPGRMPRVGSLHPVTQVMDEICQV
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHH
FKGLGYDIVTGPEVENDYHNFEALNMPPEHPARDMQDTLYVTENILLRTHTSPLQVRTMK
HHCCCCEEECCCCCCCCCCCCEECCCCCCCCCHHHHHHHHHHHHEEEEECCCCHHHHHHH
ERKPPVAAIAPGKVYRRDSDLTHTPMFHQIEGFMVDRNVSMADLRGTLTSFLQQVFGKDT
HCCCCEEEECCCHHEECCCCCCCCCHHHHHCCEEEECCCCHHHHHHHHHHHHHHHHCCCC
RVRFRPSFFPFTEPSAEVDISCCMCGGKGYHKDGAPCRVCKTTGWVEILGCGMIDPEVFK
EEEECCCCCCCCCCCCCEEEEEEEECCCCCCCCCCCEEEECCCCCCCEEECCCCCHHHHH
SVGYDPEVYSGFAFGLGVERVTMLKYGIGDLRMFFENDVRFLRQFA
HCCCCCHHHCCHHHHCCHHHHHHHHHCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA