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The map label for this gene is uup [H]

Identifier: 78357520

GI number: 78357520

Start: 2496722

End: 2498659

Strand: Reverse

Name: uup [H]

Synonym: Dde_2477

Alternate gene names: 78357520

Gene position: 2498659-2496722 (Counterclockwise)

Preceding gene: 78357522

Following gene: 78357519

Centisome position: 66.98

GC content: 59.91

Gene sequence:

>1938_bases
ATGGCGCTTATCAGCGTACGCGATGTTTCATTGAATCTTTACGGCCCGCAACTGCTCGATCAGGTGACTGTGCAGATAGA
GCAGGGCGAACGGGTTTGTCTTATGGGGCGCAACGGACAGGGCAAGTCCACCTTTCTCAAGCTGCTTGCCGGTGTGATGC
AGCCTGACTCGGGGCAGATCGTGCGCGGACAGGGGGTGCGTACGGCCTTTCTGGCACAGGACGTGCCGCAGGATATCACA
GGCGATGTCTATTCCGTGGTATGCGGGGGGCTGGGCGAAGAAGGCAGGGCGCTGGCCGCATTTCACGGGGCCATGCGCCA
GACCGGAACCGCGGACGACGACGGCATGGTTTCTGCCGCTCAGGCCGCGGTGGATGCTGCCTCCGGCTGGGAGCGGCATG
GCGACATCATGAGCGCGCTCAACCATCTTCAGCTTGATCCGTATGCCGATTTTTCGTGTCTTTCTGGCGGGATGAAACGC
CGTGCCATGCTGGCACGCGCACTGGTCAGCGATCCGGACCTGCTGCTGCTGGACGAACCCACAAACCATCTGGACATCAG
TTCCATAGCATGGCTTGAAGATTTTCTGCTGCGCAGGGCCAGAGCGCTTGTGTTTGTGACACACGACAGAGCCTTTCTGC
GCAGGGTGGCAAAACGCATCATCGAGCTGGACAGGGGCCGCATGGCCGACTGGAGCTGTGATTATGACACCTTTCTGGAG
CGCAAACAGGCCCAGCTGGAAATAGAGGAAAAGGAATGGGCCAACTTTGATAAAAAGCTGGCGCAGGAAGAAGTGTGGAT
CCGGCAGGGCATAAAGGCCCGGCGTACCAGAAACATGGGGCGTGTACGCGCACTGCAGGCCATGCGGGACGAGAGGAGAA
AGCGCCGCGAGCGGCAGGGCACCGTGACCATGCAGATGCAGGAGGCTGAACGCAGCGGCAAGCTGGTTATCGAGGCTGAC
GGTATATCCTACACCTGGCCCGACGCTCCGGCAGGCACGGCGCCGGTCATCCGCGATGCCTCGGTGCTGGTTACCAGAGG
CGACAAAGTGGGCATCATCGGCCCCAACGGAGCGGGTAAGACAACGCTGCTGCGGCTGCTGCTGGGCGATCTGAAGCCGG
ACTGCGGCAGCATCCGGCACGGCACCAGACTGGAAATCGCCTATTTTGACCAGCTGCGCAATGTTCTGGATGATGAGGCC
AGCGTACGCGAAAGCGTGGCAGGCGGTAACGACACCCTGGAGATCAACGGCGTGCGCAAGCACGTTGTGGGGTATCTGAA
AGAATTTCTTTTTGAACCGGAGCGGACCATGCTGCCGGTAAAAGTGCTTTCGGGTGGCGAGCGCAACAGGTTGCTGCTGG
CCAGATTGTTTGCGCGTCCTTCCAACCTGCTGGTGATGGACGAACCCACCAACGATCTGGACATGGAAACGCTGGAGCTG
CTGGAGGAACTGCTGGGTGAATATTCGGGTACCGTGCTCATTGTCAGCCACGACAGAGCTTTTCTGAACAATGTGGTGAC
CTCTACGCTGGCATTCGAGGGCGGCGGGTGCGTGAATGAATATGTGGGCGGCTACGATGACTGGCTGCGCCAGCGCCCGC
AGCCGGTGCAGGAAGAAAAGCCTGCAGCCTCCCGGCAGTCCAGAACGGAGCGGCAGCAGGAAAAACCGCGCAAGCTGACG
TTTAATGAACAGCGCGAACTGAAACAGCTGGAAGAAGAACTGCAGGAACTGCCGCTCCGCATGGAAGCGCTGGAAAAAGA
GCAGGCGGCGGCGGAAGCCGAACTGTCAGACCCTGCATTGTATACCGGCAATCCAGAGCGCTTTGCCGTGCTTTCCGCAA
GGCTGCCCGCCATTGAAGAAGAACTCATGGAACTGCTGACCCGCTGGGAAGAGACGGAACAGCGTGCCGCCGACCTGCGC
GGCATGCCCGGTCAGTAA

Upstream 100 bases:

>100_bases
ATGTGCGGCAAGCGTTAGCAACGCTGCACAGGCAGGTACGCTTGCCCCGGAGGGCCGCACGCGCTACAACCTGCCCGCGC
ATGCCGCGCAAGGAGATAGT

Downstream 100 bases:

>100_bases
CGGTTCTGCTGCGCGGGCGGCACGGGCAGGAGCATAGTTCTGACATCCACCCGTGCGCGCATGCGCCATGGCGCATTGCC
ATCTGCTTTTGTATCAAAAA

Product: ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 645; Mature: 644

Protein sequence:

>645_residues
MALISVRDVSLNLYGPQLLDQVTVQIEQGERVCLMGRNGQGKSTFLKLLAGVMQPDSGQIVRGQGVRTAFLAQDVPQDIT
GDVYSVVCGGLGEEGRALAAFHGAMRQTGTADDDGMVSAAQAAVDAASGWERHGDIMSALNHLQLDPYADFSCLSGGMKR
RAMLARALVSDPDLLLLDEPTNHLDISSIAWLEDFLLRRARALVFVTHDRAFLRRVAKRIIELDRGRMADWSCDYDTFLE
RKQAQLEIEEKEWANFDKKLAQEEVWIRQGIKARRTRNMGRVRALQAMRDERRKRRERQGTVTMQMQEAERSGKLVIEAD
GISYTWPDAPAGTAPVIRDASVLVTRGDKVGIIGPNGAGKTTLLRLLLGDLKPDCGSIRHGTRLEIAYFDQLRNVLDDEA
SVRESVAGGNDTLEINGVRKHVVGYLKEFLFEPERTMLPVKVLSGGERNRLLLARLFARPSNLLVMDEPTNDLDMETLEL
LEELLGEYSGTVLIVSHDRAFLNNVVTSTLAFEGGGCVNEYVGGYDDWLRQRPQPVQEEKPAASRQSRTERQQEKPRKLT
FNEQRELKQLEEELQELPLRMEALEKEQAAAEAELSDPALYTGNPERFAVLSARLPAIEEELMELLTRWEETEQRAADLR
GMPGQ

Sequences:

>Translated_645_residues
MALISVRDVSLNLYGPQLLDQVTVQIEQGERVCLMGRNGQGKSTFLKLLAGVMQPDSGQIVRGQGVRTAFLAQDVPQDIT
GDVYSVVCGGLGEEGRALAAFHGAMRQTGTADDDGMVSAAQAAVDAASGWERHGDIMSALNHLQLDPYADFSCLSGGMKR
RAMLARALVSDPDLLLLDEPTNHLDISSIAWLEDFLLRRARALVFVTHDRAFLRRVAKRIIELDRGRMADWSCDYDTFLE
RKQAQLEIEEKEWANFDKKLAQEEVWIRQGIKARRTRNMGRVRALQAMRDERRKRRERQGTVTMQMQEAERSGKLVIEAD
GISYTWPDAPAGTAPVIRDASVLVTRGDKVGIIGPNGAGKTTLLRLLLGDLKPDCGSIRHGTRLEIAYFDQLRNVLDDEA
SVRESVAGGNDTLEINGVRKHVVGYLKEFLFEPERTMLPVKVLSGGERNRLLLARLFARPSNLLVMDEPTNDLDMETLEL
LEELLGEYSGTVLIVSHDRAFLNNVVTSTLAFEGGGCVNEYVGGYDDWLRQRPQPVQEEKPAASRQSRTERQQEKPRKLT
FNEQRELKQLEEELQELPLRMEALEKEQAAAEAELSDPALYTGNPERFAVLSARLPAIEEELMELLTRWEETEQRAADLR
GMPGQ
>Mature_644_residues
ALISVRDVSLNLYGPQLLDQVTVQIEQGERVCLMGRNGQGKSTFLKLLAGVMQPDSGQIVRGQGVRTAFLAQDVPQDITG
DVYSVVCGGLGEEGRALAAFHGAMRQTGTADDDGMVSAAQAAVDAASGWERHGDIMSALNHLQLDPYADFSCLSGGMKRR
AMLARALVSDPDLLLLDEPTNHLDISSIAWLEDFLLRRARALVFVTHDRAFLRRVAKRIIELDRGRMADWSCDYDTFLER
KQAQLEIEEKEWANFDKKLAQEEVWIRQGIKARRTRNMGRVRALQAMRDERRKRRERQGTVTMQMQEAERSGKLVIEADG
ISYTWPDAPAGTAPVIRDASVLVTRGDKVGIIGPNGAGKTTLLRLLLGDLKPDCGSIRHGTRLEIAYFDQLRNVLDDEAS
VRESVAGGNDTLEINGVRKHVVGYLKEFLFEPERTMLPVKVLSGGERNRLLLARLFARPSNLLVMDEPTNDLDMETLELL
EELLGEYSGTVLIVSHDRAFLNNVVTSTLAFEGGGCVNEYVGGYDDWLRQRPQPVQEEKPAASRQSRTERQQEKPRKLTF
NEQRELKQLEEELQELPLRMEALEKEQAAAEAELSDPALYTGNPERFAVLSARLPAIEEELMELLTRWEETEQRAADLRG
MPGQ

Specific function: Unknown

COG id: COG0488

COG function: function code R; ATPase components of ABC transporters with duplicated ATPase domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ABC transporter domains [H]

Homologues:

Organism=Homo sapiens, GI148612853, Length=532, Percent_Identity=31.9548872180451, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI69354671, Length=555, Percent_Identity=29.3693693693694, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI10947135, Length=555, Percent_Identity=29.3693693693694, Blast_Score=168, Evalue=2e-41,
Organism=Homo sapiens, GI10947137, Length=527, Percent_Identity=27.134724857685, Blast_Score=160, Evalue=4e-39,
Organism=Homo sapiens, GI27881506, Length=527, Percent_Identity=27.134724857685, Blast_Score=160, Evalue=5e-39,
Organism=Homo sapiens, GI171184400, Length=253, Percent_Identity=26.8774703557312, Blast_Score=68, Evalue=2e-11,
Organism=Escherichia coli, GI1787182, Length=641, Percent_Identity=46.801872074883, Blast_Score=530, Evalue=1e-151,
Organism=Escherichia coli, GI2367384, Length=519, Percent_Identity=34.6820809248555, Blast_Score=285, Evalue=7e-78,
Organism=Escherichia coli, GI1787041, Length=535, Percent_Identity=30.0934579439252, Blast_Score=242, Evalue=5e-65,
Organism=Escherichia coli, GI1789751, Length=639, Percent_Identity=29.5774647887324, Blast_Score=223, Evalue=4e-59,
Organism=Escherichia coli, GI1786253, Length=205, Percent_Identity=31.219512195122, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789032, Length=213, Percent_Identity=29.1079812206573, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789890, Length=250, Percent_Identity=26.4, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87081834, Length=209, Percent_Identity=29.1866028708134, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1788506, Length=227, Percent_Identity=26.8722466960352, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17559834, Length=555, Percent_Identity=26.1261261261261, Blast_Score=188, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17555318, Length=529, Percent_Identity=27.2211720226843, Blast_Score=168, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI17553372, Length=552, Percent_Identity=28.9855072463768, Blast_Score=155, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17558664, Length=304, Percent_Identity=26.3157894736842, Blast_Score=72, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17565938, Length=227, Percent_Identity=29.9559471365639, Blast_Score=71, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17543740, Length=235, Percent_Identity=25.9574468085106, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI17569145, Length=323, Percent_Identity=25.077399380805, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17533971, Length=209, Percent_Identity=27.2727272727273, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320874, Length=535, Percent_Identity=27.8504672897196, Blast_Score=170, Evalue=6e-43,
Organism=Saccharomyces cerevisiae, GI6321121, Length=563, Percent_Identity=27.886323268206, Blast_Score=168, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6325030, Length=391, Percent_Identity=27.8772378516624, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6323278, Length=385, Percent_Identity=24.6753246753247, Blast_Score=110, Evalue=7e-25,
Organism=Saccharomyces cerevisiae, GI6324314, Length=386, Percent_Identity=23.8341968911917, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24666836, Length=539, Percent_Identity=29.3135435992579, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24642252, Length=572, Percent_Identity=29.1958041958042, Blast_Score=191, Evalue=2e-48,
Organism=Drosophila melanogaster, GI18859989, Length=572, Percent_Identity=29.1958041958042, Blast_Score=191, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24641342, Length=545, Percent_Identity=28.0733944954128, Blast_Score=190, Evalue=3e-48,
Organism=Drosophila melanogaster, GI116007184, Length=166, Percent_Identity=31.9277108433735, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI221500365, Length=166, Percent_Identity=31.9277108433735, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI24659289, Length=219, Percent_Identity=29.6803652968037, Blast_Score=66, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593 [H]

Pfam domain/function: PF00005 ABC_tran [H]

EC number: NA

Molecular weight: Translated: 72193; Mature: 72062

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALISVRDVSLNLYGPQLLDQVTVQIEQGERVCLMGRNGQGKSTFLKLLAGVMQPDSGQI
CCEEEEEEEEEEECCHHHHHHHHHEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCE
VRGQGVRTAFLAQDVPQDITGDVYSVVCGGLGEEGRALAAFHGAMRQTGTADDDGMVSAA
EECCCCHHHHHHHHCCCHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHH
QAAVDAASGWERHGDIMSALNHLQLDPYADFSCLSGGMKRRAMLARALVSDPDLLLLDEP
HHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCEEEEECC
TNHLDISSIAWLEDFLLRRARALVFVTHDRAFLRRVAKRIIELDRGRMADWSCDYDTFLE
CCCCCHHHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
RKQAQLEIEEKEWANFDKKLAQEEVWIRQGIKARRTRNMGRVRALQAMRDERRKRRERQG
HHHHHEEECHHHHCCHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
TVTMQMQEAERSGKLVIEADGISYTWPDAPAGTAPVIRDASVLVTRGDKVGIIGPNGAGK
CEEEEEHHHHHCCCEEEEECCCEEECCCCCCCCCCCEECCEEEEECCCEEEEECCCCCCH
TTLLRLLLGDLKPDCGSIRHGTRLEIAYFDQLRNVLDDEASVRESVAGGNDTLEINGVRK
HHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCHHH
HVVGYLKEFLFEPERTMLPVKVLSGGERNRLLLARLFARPSNLLVMDEPTNDLDMETLEL
HHHHHHHHHHHCCCCCEEEHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHH
LEELLGEYSGTVLIVSHDRAFLNNVVTSTLAFEGGGCVNEYVGGYDDWLRQRPQPVQEEK
HHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHCCCCCCCCCC
PAASRQSRTERQQEKPRKLTFNEQRELKQLEEELQELPLRMEALEKEQAAAEAELSDPAL
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEE
YTGNPERFAVLSARLPAIEEELMELLTRWEETEQRAADLRGMPGQ
ECCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
ALISVRDVSLNLYGPQLLDQVTVQIEQGERVCLMGRNGQGKSTFLKLLAGVMQPDSGQI
CEEEEEEEEEEECCHHHHHHHHHEEECCCEEEEECCCCCCHHHHHHHHHHHCCCCCCCE
VRGQGVRTAFLAQDVPQDITGDVYSVVCGGLGEEGRALAAFHGAMRQTGTADDDGMVSAA
EECCCCHHHHHHHHCCCHHCCHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHH
QAAVDAASGWERHGDIMSALNHLQLDPYADFSCLSGGMKRRAMLARALVSDPDLLLLDEP
HHHHHHHCCHHHHHHHHHHHHHCCCCCCCCHHHHHCCHHHHHHHHHHHHCCCCEEEEECC
TNHLDISSIAWLEDFLLRRARALVFVTHDRAFLRRVAKRIIELDRGRMADWSCDYDTFLE
CCCCCHHHHHHHHHHHHHHHCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHH
RKQAQLEIEEKEWANFDKKLAQEEVWIRQGIKARRTRNMGRVRALQAMRDERRKRRERQG
HHHHHEEECHHHHCCHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
TVTMQMQEAERSGKLVIEADGISYTWPDAPAGTAPVIRDASVLVTRGDKVGIIGPNGAGK
CEEEEEHHHHHCCCEEEEECCCEEECCCCCCCCCCCEECCEEEEECCCEEEEECCCCCCH
TTLLRLLLGDLKPDCGSIRHGTRLEIAYFDQLRNVLDDEASVRESVAGGNDTLEINGVRK
HHHHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHHCCHHHHHHHHCCCCCEEEECCHHH
HVVGYLKEFLFEPERTMLPVKVLSGGERNRLLLARLFARPSNLLVMDEPTNDLDMETLEL
HHHHHHHHHHHCCCCCEEEHHHHCCCCCCHHHHHHHHCCCCCEEEEECCCCCCCHHHHHH
LEELLGEYSGTVLIVSHDRAFLNNVVTSTLAFEGGGCVNEYVGGYDDWLRQRPQPVQEEK
HHHHHHHCCCEEEEEECCHHHHHHHHHHHHHCCCCCCHHHHCCCHHHHHHCCCCCCCCCC
PAASRQSRTERQQEKPRKLTFNEQRELKQLEEELQELPLRMEALEKEQAAAEAELSDPAL
CCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCEE
YTGNPERFAVLSARLPAIEEELMELLTRWEETEQRAADLRGMPGQ
ECCCCCCEEEEHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Endonuclease; Excision [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 9139905; 7751275 [H]