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The map label for this gene is atoC [H]

Identifier: 78357398

GI number: 78357398

Start: 2377725

End: 2379122

Strand: Direct

Name: atoC [H]

Synonym: Dde_2355

Alternate gene names: 78357398

Gene position: 2377725-2379122 (Clockwise)

Preceding gene: 78357397

Following gene: 78357400

Centisome position: 63.74

GC content: 59.66

Gene sequence:

>1398_bases
ATGAGCGAACACATCCTGCTTATCGAAGATGACAACGCCTTTCAGGAGATGCTTTCCGAGGCGTTACGAAGCCGCGGGTA
CGCCGTGAGCTCGGCCTCCAGAGCGGAGGAAGGCATCAGCATGGCGCGTCAGCATGATTTCGATCTTATCCTGACCGATG
TCATGCTGCCCGGCATGTCGGGTGTGGAGGCCATTCCTCAGCTGCGTGAAGCCGCCCCCGGTTCCGATATCATCGTCATG
ACCGCCTACTCCACCAGAGAACTGGCGCTTGAAGCCATCCGTCTGGGAGCCTACGATTTTTTTTCAAAACCATTCAGCCT
GAAAGAACTGGATATCGTGGTGCGCAGGGCGCTGGAAAAACGCCGTCTGCAAAAAGAGGTGACCACTCTGCGCGAAACGC
TGCGCCATGACAGCCCGGTACAACGCATCATCGGCGACAGCGCCCCCATGCGCGCCGTAAAAACGCTGGTCGAAAAAGTA
GCCCCGCTCGATTCGACAGTGCTTATCACCGGCGAATCCGGCACCGGCAAAGAACTGGTCTCCGACACCCTGCGCGCGCT
TTCCGGCCGGGCAGGAGCACCTTTTGTCAAGGTAAACTGCGCCGCCATTCCTGAACATCTGTTTGAAAACGAACTGTTCG
GTCACGAGAAAGGTGCCTTTACCGGTGCCACATCTGCACAGCCCGGCAAATTTGAACTGGCGCACGGCGGCACCCTGCTG
CTGGACGAAATCGGCGACATGCCCGCAGCCATTCAGCCCAAACTGCTGCGGGCCGTGGAAGAAAAACAGATCGAACGGCT
GGGCGGGCGCAGACCGGTTGCAGTCAACGTACGCATTATCGCCGCCACCAACCAGAACCTGCGTGAACTTGTGGCCCGCA
AAGCGTTTCGCGAAGACCTGTATTACAGGCTGGGCGTAGCCGTAATCATGCTGCCTCCCCTGCGCGACCGCAAAGAAGAC
ATACCCCGGCTGGCGGAGCATATTCTCCGCAAACTGGGGCTGACGCTGGGCATACCGGTGCACGGCATCACTGCCGCAGC
CGTACAGGCGCTTATGAACCACCACTGGCCCGGCAATGTCCGGCAGCTGGCCAACCTGCTGGAAAGAGCGGCCATCAGCG
CACAGGGACGCATTACAGCCCAAGACATAGCCGCTGCACTTGCCGTGCAGAACGGTACATCGCCGCAGCCCTGCACCGCA
CAGTCTCCGCATGACGCCCCCGCGGCAGAAGACTGCCTGCGTATGCCCCTGCGCGAAACCCTGCACCAGATGGAACGCAA
CCTGCTGCTGGAAGCGCTGCGCAGGGCGGAAGGCAGCCAGAAAAACGCTGCGGCCCTGCTGGGTCTTACTCCCAAAAACA
TGTGGGCAAAACTGCAGAAGCATCAGATACGCATCTGA

Upstream 100 bases:

>100_bases
ACGACTCGTTTTTATTTGACTTTTAAAAAGAACCCATCTAATAGAACTGCACGGCGTGTCATGGTATGATCGGAGTGCAA
CCCCAACCCCCCCATGCGGC

Downstream 100 bases:

>100_bases
GTGCCGTCGCGTATCTATTTTTTTTAGACCCGACGGAATATCTCATCCCGCCGGCAAGCTGCTGTTCATCCATCATTCCC
GACGACATCCCCCGCAGGAC

Product: two component Fis family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 465; Mature: 464

Protein sequence:

>465_residues
MSEHILLIEDDNAFQEMLSEALRSRGYAVSSASRAEEGISMARQHDFDLILTDVMLPGMSGVEAIPQLREAAPGSDIIVM
TAYSTRELALEAIRLGAYDFFSKPFSLKELDIVVRRALEKRRLQKEVTTLRETLRHDSPVQRIIGDSAPMRAVKTLVEKV
APLDSTVLITGESGTGKELVSDTLRALSGRAGAPFVKVNCAAIPEHLFENELFGHEKGAFTGATSAQPGKFELAHGGTLL
LDEIGDMPAAIQPKLLRAVEEKQIERLGGRRPVAVNVRIIAATNQNLRELVARKAFREDLYYRLGVAVIMLPPLRDRKED
IPRLAEHILRKLGLTLGIPVHGITAAAVQALMNHHWPGNVRQLANLLERAAISAQGRITAQDIAAALAVQNGTSPQPCTA
QSPHDAPAAEDCLRMPLRETLHQMERNLLLEALRRAEGSQKNAAALLGLTPKNMWAKLQKHQIRI

Sequences:

>Translated_465_residues
MSEHILLIEDDNAFQEMLSEALRSRGYAVSSASRAEEGISMARQHDFDLILTDVMLPGMSGVEAIPQLREAAPGSDIIVM
TAYSTRELALEAIRLGAYDFFSKPFSLKELDIVVRRALEKRRLQKEVTTLRETLRHDSPVQRIIGDSAPMRAVKTLVEKV
APLDSTVLITGESGTGKELVSDTLRALSGRAGAPFVKVNCAAIPEHLFENELFGHEKGAFTGATSAQPGKFELAHGGTLL
LDEIGDMPAAIQPKLLRAVEEKQIERLGGRRPVAVNVRIIAATNQNLRELVARKAFREDLYYRLGVAVIMLPPLRDRKED
IPRLAEHILRKLGLTLGIPVHGITAAAVQALMNHHWPGNVRQLANLLERAAISAQGRITAQDIAAALAVQNGTSPQPCTA
QSPHDAPAAEDCLRMPLRETLHQMERNLLLEALRRAEGSQKNAAALLGLTPKNMWAKLQKHQIRI
>Mature_464_residues
SEHILLIEDDNAFQEMLSEALRSRGYAVSSASRAEEGISMARQHDFDLILTDVMLPGMSGVEAIPQLREAAPGSDIIVMT
AYSTRELALEAIRLGAYDFFSKPFSLKELDIVVRRALEKRRLQKEVTTLRETLRHDSPVQRIIGDSAPMRAVKTLVEKVA
PLDSTVLITGESGTGKELVSDTLRALSGRAGAPFVKVNCAAIPEHLFENELFGHEKGAFTGATSAQPGKFELAHGGTLLL
DEIGDMPAAIQPKLLRAVEEKQIERLGGRRPVAVNVRIIAATNQNLRELVARKAFREDLYYRLGVAVIMLPPLRDRKEDI
PRLAEHILRKLGLTLGIPVHGITAAAVQALMNHHWPGNVRQLANLLERAAISAQGRITAQDIAAALAVQNGTSPQPCTAQ
SPHDAPAAEDCLRMPLRETLHQMERNLLLEALRRAEGSQKNAAALLGLTPKNMWAKLQKHQIRI

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=461, Percent_Identity=40.1301518438178, Blast_Score=349, Evalue=2e-97,
Organism=Escherichia coli, GI1790299, Length=464, Percent_Identity=39.4396551724138, Blast_Score=311, Evalue=6e-86,
Organism=Escherichia coli, GI1790437, Length=457, Percent_Identity=38.2932166301969, Blast_Score=303, Evalue=2e-83,
Organism=Escherichia coli, GI1788905, Length=461, Percent_Identity=35.5748373101952, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI87082117, Length=254, Percent_Identity=51.5748031496063, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1789233, Length=330, Percent_Identity=41.8181818181818, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1789087, Length=260, Percent_Identity=50.7692307692308, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI87081872, Length=328, Percent_Identity=42.0731707317073, Blast_Score=247, Evalue=1e-66,
Organism=Escherichia coli, GI87082152, Length=316, Percent_Identity=39.5569620253165, Blast_Score=208, Evalue=8e-55,
Organism=Escherichia coli, GI1786524, Length=255, Percent_Identity=44.3137254901961, Blast_Score=206, Evalue=3e-54,
Organism=Escherichia coli, GI1787583, Length=353, Percent_Identity=36.8271954674221, Blast_Score=192, Evalue=4e-50,
Organism=Escherichia coli, GI87081858, Length=298, Percent_Identity=31.2080536912752, Blast_Score=139, Evalue=5e-34,
Organism=Escherichia coli, GI1789828, Length=234, Percent_Identity=39.3162393162393, Blast_Score=136, Evalue=3e-33,
Organism=Escherichia coli, GI87082012, Length=116, Percent_Identity=36.2068965517241, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786784, Length=116, Percent_Identity=35.3448275862069, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786599, Length=112, Percent_Identity=33.9285714285714, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1789402, Length=106, Percent_Identity=31.1320754716981, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1788394, Length=128, Percent_Identity=33.59375, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790860, Length=141, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=4e-11,
Organism=Escherichia coli, GI1786911, Length=119, Percent_Identity=35.2941176470588, Blast_Score=62, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 51032; Mature: 50901

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEHILLIEDDNAFQEMLSEALRSRGYAVSSASRAEEGISMARQHDFDLILTDVMLPGMS
CCCCEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
GVEAIPQLREAAPGSDIIVMTAYSTRELALEAIRLGAYDFFSKPFSLKELDIVVRRALEK
CHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
RRLQKEVTTLRETLRHDSPVQRIIGDSAPMRAVKTLVEKVAPLDSTVLITGESGTGKELV
HHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHH
SDTLRALSGRAGAPFVKVNCAAIPEHLFENELFGHEKGAFTGATSAQPGKFELAHGGTLL
HHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCEEE
LDEIGDMPAAIQPKLLRAVEEKQIERLGGRRPVAVNVRIIAATNQNLRELVARKAFREDL
EHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHH
YYRLGVAVIMLPPLRDRKEDIPRLAEHILRKLGLTLGIPVHGITAAAVQALMNHHWPGNV
HHHHCCHHEEECCCCCHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHCCCCCCH
RQLANLLERAAISAQGRITAQDIAAALAVQNGTSPQPCTAQSPHDAPAAEDCLRMPLRET
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LHQMERNLLLEALRRAEGSQKNAAALLGLTPKNMWAKLQKHQIRI
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
SEHILLIEDDNAFQEMLSEALRSRGYAVSSASRAEEGISMARQHDFDLILTDVMLPGMS
CCCEEEEECCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCC
GVEAIPQLREAAPGSDIIVMTAYSTRELALEAIRLGAYDFFSKPFSLKELDIVVRRALEK
CHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
RRLQKEVTTLRETLRHDSPVQRIIGDSAPMRAVKTLVEKVAPLDSTVLITGESGTGKELV
HHHHHHHHHHHHHHHCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHH
SDTLRALSGRAGAPFVKVNCAAIPEHLFENELFGHEKGAFTGATSAQPGKFELAHGGTLL
HHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCEEE
LDEIGDMPAAIQPKLLRAVEEKQIERLGGRRPVAVNVRIIAATNQNLRELVARKAFREDL
EHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEEEEEEEEECCHHHHHHHHHHHHHHHH
YYRLGVAVIMLPPLRDRKEDIPRLAEHILRKLGLTLGIPVHGITAAAVQALMNHHWPGNV
HHHHCCHHEEECCCCCHHHHHHHHHHHHHHHCCCEECCCHHHHHHHHHHHHHHCCCCCCH
RQLANLLERAAISAQGRITAQDIAAALAVQNGTSPQPCTAQSPHDAPAAEDCLRMPLRET
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHH
LHQMERNLLLEALRRAEGSQKNAAALLGLTPKNMWAKLQKHQIRI
HHHHHHHHHHHHHHHHCCCCCCCEEEEECCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]