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The map label for this gene is tmk

Identifier: 78357381

GI number: 78357381

Start: 2357184

End: 2357822

Strand: Reverse

Name: tmk

Synonym: Dde_2338

Alternate gene names: 78357381

Gene position: 2357822-2357184 (Counterclockwise)

Preceding gene: 78357382

Following gene: 78357380

Centisome position: 63.21

GC content: 58.84

Gene sequence:

>639_bases
ATGTTCATTACTTTCGAAGGGATAGAAGGTTCAGGCAAAAGTACGGCTCTTGCCCGCCTGAAGGACTGGCTGCAGGAGCA
CGGCCACGGTGCGACGCTGACCCGCGAGCCGGGAGGCAGCCGTCTGGGTGGTATTCTGCGTTCCATTCTGCTGGATATAG
GCAATGACGATCTGACAGGGGAAACCGAGCTTTTTCTGTATCTTGCCGACAGGTCGCAGCATGTGCATCAGGTCATCCGG
CCGGCGCTGGCAGAAGGTGTTGCTGTGATAAGCGACAGATACGCCGATTCCACCGTGGTCTATCAGGGCTACGGCAGAGG
GCTGGACCCTGCTTTGCTGCACCGGCTCAACGACGTGGCCGTGCGCGGGCTGTGGCCTGATTTGACGCTGCTGTTTGATC
TGGAGCCGGAAATCGGTCTCAAGCGGGCCACCACCCGCAATCTGCGGGAAGGCACAGGCGCAACAGAAGGCCGTTTCGAG
GCGGAGAGTCTGGCCTTTCACACCAGAGTGCGCGAAGGATATCTGACGTGGGCGGCTCTGAATAAGGAACGATTCAGAAT
CATTGATGCGGCCGCTTCGCCCGATGAGGTTTTTGAACAGGTCCGCAGCGCCGTGGCCGATGTGTTTACCATCGGCTGA

Upstream 100 bases:

>100_bases
CGTTTCAGCCCACATTGCAGCGCTTTTTGTACAACCCTGTGCGCACTCCGGAAACGGAAACCGTCAGACGGAAGCGTCCT
GAAACTCCACGGGAAGAACA

Downstream 100 bases:

>100_bases
ACTGCTTACCGCCACAGGGAGAGTACCCATGCTTGAAGCCGCCAATAAACTGGGCATCATCTTTTTTCCCGCGTATGACT
GGGCCATCAGCCCCACGCAT

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MFITFEGIEGSGKSTALARLKDWLQEHGHGATLTREPGGSRLGGILRSILLDIGNDDLTGETELFLYLADRSQHVHQVIR
PALAEGVAVISDRYADSTVVYQGYGRGLDPALLHRLNDVAVRGLWPDLTLLFDLEPEIGLKRATTRNLREGTGATEGRFE
AESLAFHTRVREGYLTWAALNKERFRIIDAAASPDEVFEQVRSAVADVFTIG

Sequences:

>Translated_212_residues
MFITFEGIEGSGKSTALARLKDWLQEHGHGATLTREPGGSRLGGILRSILLDIGNDDLTGETELFLYLADRSQHVHQVIR
PALAEGVAVISDRYADSTVVYQGYGRGLDPALLHRLNDVAVRGLWPDLTLLFDLEPEIGLKRATTRNLREGTGATEGRFE
AESLAFHTRVREGYLTWAALNKERFRIIDAAASPDEVFEQVRSAVADVFTIG
>Mature_212_residues
MFITFEGIEGSGKSTALARLKDWLQEHGHGATLTREPGGSRLGGILRSILLDIGNDDLTGETELFLYLADRSQHVHQVIR
PALAEGVAVISDRYADSTVVYQGYGRGLDPALLHRLNDVAVRGLWPDLTLLFDLEPEIGLKRATTRNLREGTGATEGRFE
AESLAFHTRVREGYLTWAALNKERFRIIDAAASPDEVFEQVRSAVADVFTIG

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=208, Percent_Identity=41.3461538461538, Blast_Score=137, Evalue=5e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_DESDG (Q30YW1)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388830.1
- HSSP:   P65248
- ProteinModelPortal:   Q30YW1
- SMR:   Q30YW1
- STRING:   Q30YW1
- GeneID:   3757349
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2338
- NMPDR:   fig|207559.3.peg.2696
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   CLSK926754
- BioCyc:   DDES207559:DDE_2338-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23362; Mature: 23362

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
0.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFITFEGIEGSGKSTALARLKDWLQEHGHGATLTREPGGSRLGGILRSILLDIGNDDLTG
CEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCC
ETELFLYLADRSQHVHQVIRPALAEGVAVISDRYADSTVVYQGYGRGLDPALLHRLNDVA
CEEEEEEEECCCHHHHHHHHHHHHCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHH
VRGLWPDLTLLFDLEPEIGLKRATTRNLREGTGATEGRFEAESLAFHTRVREGYLTWAAL
HHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCEEEEEEC
NKERFRIIDAAASPDEVFEQVRSAVADVFTIG
CCCCEEEEECCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFITFEGIEGSGKSTALARLKDWLQEHGHGATLTREPGGSRLGGILRSILLDIGNDDLTG
CEEEEECCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCC
ETELFLYLADRSQHVHQVIRPALAEGVAVISDRYADSTVVYQGYGRGLDPALLHRLNDVA
CEEEEEEEECCCHHHHHHHHHHHHCCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHH
VRGLWPDLTLLFDLEPEIGLKRATTRNLREGTGATEGRFEAESLAFHTRVREGYLTWAAL
HHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCEEEEEEC
NKERFRIIDAAASPDEVFEQVRSAVADVFTIG
CCCCEEEEECCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA