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The map label for this gene is sucD [H]

Identifier: 78357377

GI number: 78357377

Start: 2351569

End: 2353671

Strand: Reverse

Name: sucD [H]

Synonym: Dde_2334

Alternate gene names: 78357377

Gene position: 2353671-2351569 (Counterclockwise)

Preceding gene: 78357378

Following gene: 78357376

Centisome position: 63.1

GC content: 60.06

Gene sequence:

>2103_bases
ATGTTTCTGAATGAGCATATGAGCAAGGTGCTGTTTGCCGAAGCCGGAATAGATACCCCTGCGGGCGACTTGCTGACGCC
CGGTCAGCTGGCGGAATATACTCCTGCCGTGTCCGCCCCGTGGTTTCTCAAGGCGCAGGTGCTTACCGGCGGAAGAGGCA
AGGCCGGAGGCATACGCCGTGCCGCCACCCTGAAGGAGCTCAGAGAGACGGCTCAGGACATGTTCACCATGGAAATCAAA
GGACACAGGGTGCCCTTTCTGCGTATCGAATCCGCCACGGACATACGCAGGGAATGCTATCTTTCTTTTGTACTTTCGCG
CGAACGGCGTGACCTGCTGCTTACCACCAGCAGAGCGGGCGGTATTCATGTGGAGAGTTCCACCGGTCAGCAGAAGCCGC
TTGTGCAGCGGGTTCCGCTGGACAGCGGCCTGCGCGAGCATCATCTGCGTGCGGCTTTTTTTGAAATGGGAGTTGAAAAG
GAGCACTGGGCCGGTTTCAAGGCCATGGCGGAAAAACTGTACAGGGCGGTAAGAGAGTACGGTCTGCTGCTGGCCGAGAT
CAACCCTCTGGTGCTTACCTGCGACGGCCGCTGGGTGGCACTGGACGGCAAGGTTGAGCTGGACGACAGTGTGGTGGACC
TGCAGCCCGATCTCGAACGGTTCTATACGCCGGAACATCATTCGCGTGAAGAGAATCTGGCCCGCGAAGCCGGACTCAGC
TATGTGGAGCTTAAAGGCTGGGTGGGGATTCTGGTCAACGGGGCCGGACTGGCCATGGCCACAATGGACCTTCTTAATTT
TTCCGGTCTGTCGGCGGCAAACTTCATGGATCTGGGCGGTGCGGCCGATGCGTCGCGTATGCGCCGCGCACTTGATCTGC
TGTTTGAAAACCGCAATGTGCGCGCGGTGTTCATCAACCTGTTCGGGGGTATTGTTTCGTGCGCCGATGTGGCCCGCGCG
CTTGTGGACGCACTGGAGGGCGGTGATGCGCCAAAGCCCATTGTGGTGCGTATGGCAGGCCACGAATCCGCAGAAGGGCG
GGCGCTGCTGCATGACTTTGCTCATCCTTCGGTAACCATAGCACAGGAAATGCACGAAGCGCTGGACGCGCTGCGGTCCA
TGAAACCCGCAGATGTCCCCCGTATTGAATTTCCGTTGCCGCAGGAACCTGATCCGGTGCCGCAGCATAACGGGCAGGAA
GCTGCCGCCTGTGTGCCGGTGTATAACGGCATGGGGCTGGACAGCAGCTCCGGCGTGCTGGTGCAGGGGCTCACAGGCCG
CGTTGCCCAGCGGCATGCCGCCTTGATGATGGAATACGGCACGCGGGTTGTGGCGGGGGTCACTCCCTTTAAAGGCGGGC
AGGAGGTGATGGGGATTCCGGTGTATGATTCCGTGCATGAGGCGTGCAGGCATCACCGTATTGATGCTTCCATCATTTTT
GTACCGGCCGCATTTGCCCCCGATGCCGTGCTGGAGGCCGCAGCGGAAGAAATTCCGTGGGTTGTGTGCATTACTGAAGG
AATACCTCAGGCGGCCATGCTGTCGGCTCTGAAAAATATCCAGCCGTCGCCCACTTGTGTGGTGGGGCCGAATACTCCGG
GCATAGTGGTTCCGCATCAGCTTAAAATAGGTATCATGCCGGGTTATGTGTTCAGCCCCGGCCCTGTGGCGGTGTTTTCG
CGTTCGGGCACGCTTACCTATGAGGCAGCTTCGCGCCTTTCCGCTGCGGGCATAGGGCAATCCGTATGCGTGGGGGTGGG
CGGAGATTCGTTTGTGGGCACCGGCTTTGTGGACCTGTGCGAAAGAGTGCGCCACGATGCCGCCACCCGTGCGGTGCTGG
TGCTGGGCGAAGTGGGCGGCAGGGCCGAAGAGGAACTGGCAGAATACGTACGCAGGACAGGTTTTTCCAAACCGGTGGTT
TCATTTGTGGCGGCGCGTACTGCTCCTCCCGGCCGCAGGCTGGGGCATGCCGGAGCCATTCTGGACGAAACCACCGGCGG
AGTGGAGGCTAAACTGCAGGCCATGCGCGAGGCCGGTTTTACCATCTGCCCTGATCTGGCAAGTCTGCCGCGCATTATGC
GCGCTGTTCTTGACAGGGCATGA

Upstream 100 bases:

>100_bases
CAGGCCGTGTCCGCCATTGCGGGACGGCCTTTTTTTGCAGCTTCCGGCGGGCCGGATGCTGCCGAATTGCCGCCGCACCG
GCGCCAGTGAAGGAGGATGC

Downstream 100 bases:

>100_bases
CGGTGTGCAGCAGGTGTGCAACCTGTTGACGGCAGGTTGCCGCTCCGCAGGAGCGGAAATGACCGCACCGGATTTTTTGC
GCTGAAAAAAGCACGCCGCA

Product: succinyl-CoA synthetase (ADP-forming) subunit alpha / succinyl-CoA synthetase (ADP-forming) subunit beta

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 700; Mature: 700

Protein sequence:

>700_residues
MFLNEHMSKVLFAEAGIDTPAGDLLTPGQLAEYTPAVSAPWFLKAQVLTGGRGKAGGIRRAATLKELRETAQDMFTMEIK
GHRVPFLRIESATDIRRECYLSFVLSRERRDLLLTTSRAGGIHVESSTGQQKPLVQRVPLDSGLREHHLRAAFFEMGVEK
EHWAGFKAMAEKLYRAVREYGLLLAEINPLVLTCDGRWVALDGKVELDDSVVDLQPDLERFYTPEHHSREENLAREAGLS
YVELKGWVGILVNGAGLAMATMDLLNFSGLSAANFMDLGGAADASRMRRALDLLFENRNVRAVFINLFGGIVSCADVARA
LVDALEGGDAPKPIVVRMAGHESAEGRALLHDFAHPSVTIAQEMHEALDALRSMKPADVPRIEFPLPQEPDPVPQHNGQE
AAACVPVYNGMGLDSSSGVLVQGLTGRVAQRHAALMMEYGTRVVAGVTPFKGGQEVMGIPVYDSVHEACRHHRIDASIIF
VPAAFAPDAVLEAAAEEIPWVVCITEGIPQAAMLSALKNIQPSPTCVVGPNTPGIVVPHQLKIGIMPGYVFSPGPVAVFS
RSGTLTYEAASRLSAAGIGQSVCVGVGGDSFVGTGFVDLCERVRHDAATRAVLVLGEVGGRAEEELAEYVRRTGFSKPVV
SFVAARTAPPGRRLGHAGAILDETTGGVEAKLQAMREAGFTICPDLASLPRIMRAVLDRA

Sequences:

>Translated_700_residues
MFLNEHMSKVLFAEAGIDTPAGDLLTPGQLAEYTPAVSAPWFLKAQVLTGGRGKAGGIRRAATLKELRETAQDMFTMEIK
GHRVPFLRIESATDIRRECYLSFVLSRERRDLLLTTSRAGGIHVESSTGQQKPLVQRVPLDSGLREHHLRAAFFEMGVEK
EHWAGFKAMAEKLYRAVREYGLLLAEINPLVLTCDGRWVALDGKVELDDSVVDLQPDLERFYTPEHHSREENLAREAGLS
YVELKGWVGILVNGAGLAMATMDLLNFSGLSAANFMDLGGAADASRMRRALDLLFENRNVRAVFINLFGGIVSCADVARA
LVDALEGGDAPKPIVVRMAGHESAEGRALLHDFAHPSVTIAQEMHEALDALRSMKPADVPRIEFPLPQEPDPVPQHNGQE
AAACVPVYNGMGLDSSSGVLVQGLTGRVAQRHAALMMEYGTRVVAGVTPFKGGQEVMGIPVYDSVHEACRHHRIDASIIF
VPAAFAPDAVLEAAAEEIPWVVCITEGIPQAAMLSALKNIQPSPTCVVGPNTPGIVVPHQLKIGIMPGYVFSPGPVAVFS
RSGTLTYEAASRLSAAGIGQSVCVGVGGDSFVGTGFVDLCERVRHDAATRAVLVLGEVGGRAEEELAEYVRRTGFSKPVV
SFVAARTAPPGRRLGHAGAILDETTGGVEAKLQAMREAGFTICPDLASLPRIMRAVLDRA
>Mature_700_residues
MFLNEHMSKVLFAEAGIDTPAGDLLTPGQLAEYTPAVSAPWFLKAQVLTGGRGKAGGIRRAATLKELRETAQDMFTMEIK
GHRVPFLRIESATDIRRECYLSFVLSRERRDLLLTTSRAGGIHVESSTGQQKPLVQRVPLDSGLREHHLRAAFFEMGVEK
EHWAGFKAMAEKLYRAVREYGLLLAEINPLVLTCDGRWVALDGKVELDDSVVDLQPDLERFYTPEHHSREENLAREAGLS
YVELKGWVGILVNGAGLAMATMDLLNFSGLSAANFMDLGGAADASRMRRALDLLFENRNVRAVFINLFGGIVSCADVARA
LVDALEGGDAPKPIVVRMAGHESAEGRALLHDFAHPSVTIAQEMHEALDALRSMKPADVPRIEFPLPQEPDPVPQHNGQE
AAACVPVYNGMGLDSSSGVLVQGLTGRVAQRHAALMMEYGTRVVAGVTPFKGGQEVMGIPVYDSVHEACRHHRIDASIIF
VPAAFAPDAVLEAAAEEIPWVVCITEGIPQAAMLSALKNIQPSPTCVVGPNTPGIVVPHQLKIGIMPGYVFSPGPVAVFS
RSGTLTYEAASRLSAAGIGQSVCVGVGGDSFVGTGFVDLCERVRHDAATRAVLVLGEVGGRAEEELAEYVRRTGFSKPVV
SFVAARTAPPGRRLGHAGAILDETTGGVEAKLQAMREAGFTICPDLASLPRIMRAVLDRA

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=281, Percent_Identity=46.6192170818505, Blast_Score=219, Evalue=5e-57,
Organism=Homo sapiens, GI11321583, Length=368, Percent_Identity=29.6195652173913, Blast_Score=160, Evalue=6e-39,
Organism=Homo sapiens, GI157779135, Length=384, Percent_Identity=28.3854166666667, Blast_Score=146, Evalue=5e-35,
Organism=Homo sapiens, GI294862256, Length=369, Percent_Identity=28.4552845528455, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI38569421, Length=765, Percent_Identity=23.7908496732026, Blast_Score=119, Evalue=9e-27,
Organism=Homo sapiens, GI38569423, Length=691, Percent_Identity=23.7337192474674, Blast_Score=119, Evalue=1e-26,
Organism=Escherichia coli, GI1786949, Length=285, Percent_Identity=42.4561403508772, Blast_Score=242, Evalue=5e-65,
Organism=Escherichia coli, GI1786948, Length=363, Percent_Identity=34.7107438016529, Blast_Score=198, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17550194, Length=291, Percent_Identity=46.3917525773196, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17553126, Length=294, Percent_Identity=44.8979591836735, Blast_Score=233, Evalue=4e-61,
Organism=Caenorhabditis elegans, GI17539378, Length=324, Percent_Identity=33.0246913580247, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17567829, Length=327, Percent_Identity=29.9694189602446, Blast_Score=153, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17557344, Length=694, Percent_Identity=24.4956772334294, Blast_Score=105, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17551266, Length=278, Percent_Identity=29.136690647482, Blast_Score=99, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6324716, Length=278, Percent_Identity=42.4460431654676, Blast_Score=217, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6321683, Length=370, Percent_Identity=30, Blast_Score=161, Evalue=4e-40,
Organism=Drosophila melanogaster, GI21356559, Length=272, Percent_Identity=45.9558823529412, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI28574296, Length=287, Percent_Identity=45.2961672473868, Blast_Score=221, Evalue=2e-57,
Organism=Drosophila melanogaster, GI21356231, Length=395, Percent_Identity=31.1392405063291, Blast_Score=162, Evalue=7e-40,
Organism=Drosophila melanogaster, GI161078106, Length=367, Percent_Identity=29.700272479564, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI24645208, Length=367, Percent_Identity=29.700272479564, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI281361397, Length=368, Percent_Identity=29.8913043478261, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI281361395, Length=368, Percent_Identity=29.8913043478261, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI281363477, Length=764, Percent_Identity=24.4764397905759, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI281363475, Length=787, Percent_Identity=23.7611181702668, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI281363473, Length=787, Percent_Identity=23.7611181702668, Blast_Score=115, Evalue=7e-26,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 75263; Mature: 75263

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS01216 SUCCINYL_COA_LIG_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLNEHMSKVLFAEAGIDTPAGDLLTPGQLAEYTPAVSAPWFLKAQVLTGGRGKAGGIRR
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEEEEEECCCCCCCCHHH
AATLKELRETAQDMFTMEIKGHRVPFLRIESATDIRRECYLSFVLSRERRDLLLTTSRAG
HHHHHHHHHHHHHHEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCEEEEECCCC
GIHVESSTGQQKPLVQRVPLDSGLREHHLRAAFFEMGVEKEHWAGFKAMAEKLYRAVREY
CEEEECCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHH
GLLLAEINPLVLTCDGRWVALDGKVELDDSVVDLQPDLERFYTPEHHSREENLAREAGLS
CEEEEECCCEEEEECCEEEEECCEEEECCCEECCCCCHHHCCCCCCCCHHHHHHHHHCCC
YVELKGWVGILVNGAGLAMATMDLLNFSGLSAANFMDLGGAADASRMRRALDLLFENRNV
EEEECCCEEEEEECCCHHHHHHHHHCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCE
RAVFINLFGGIVSCADVARALVDALEGGDAPKPIVVRMAGHESAEGRALLHDFAHPSVTI
EEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCHHH
AQEMHEALDALRSMKPADVPRIEFPLPQEPDPVPQHNGQEAAACVPVYNGMGLDSSSGVL
HHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEE
VQGLTGRVAQRHAALMMEYGTRVVAGVTPFKGGQEVMGIPVYDSVHEACRHHRIDASIIF
EECCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHCCCCCEEEE
VPAAFAPDAVLEAAAEEIPWVVCITEGIPQAAMLSALKNIQPSPTCVVGPNTPGIVVPHQ
EECCCCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHCCCCCCCEEECCCCCCEEECCE
LKIGIMPGYVFSPGPVAVFSRSGTLTYEAASRLSAAGIGQSVCVGVGGDSFVGTGFVDLC
EEEEECCCEEECCCCEEEEECCCCEEHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHH
ERVRHDAATRAVLVLGEVGGRAEEELAEYVRRTGFSKPVVSFVAARTAPPGRRLGHAGAI
HHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCC
LDETTGGVEAKLQAMREAGFTICPDLASLPRIMRAVLDRA
CCCCCCCHHHHHHHHHHCCCEECCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFLNEHMSKVLFAEAGIDTPAGDLLTPGQLAEYTPAVSAPWFLKAQVLTGGRGKAGGIRR
CCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHCCCCCCCCCEEEEEEEECCCCCCCCHHH
AATLKELRETAQDMFTMEIKGHRVPFLRIESATDIRRECYLSFVLSRERRDLLLTTSRAG
HHHHHHHHHHHHHHEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCEEEEECCCC
GIHVESSTGQQKPLVQRVPLDSGLREHHLRAAFFEMGVEKEHWAGFKAMAEKLYRAVREY
CEEEECCCCCCCCCHHHCCCCCCHHHHHHHHHHHHHCCCHHHHCCHHHHHHHHHHHHHHH
GLLLAEINPLVLTCDGRWVALDGKVELDDSVVDLQPDLERFYTPEHHSREENLAREAGLS
CEEEEECCCEEEEECCEEEEECCEEEECCCEECCCCCHHHCCCCCCCCHHHHHHHHHCCC
YVELKGWVGILVNGAGLAMATMDLLNFSGLSAANFMDLGGAADASRMRRALDLLFENRNV
EEEECCCEEEEEECCCHHHHHHHHHCCCCCCCCCHHCCCCCCCHHHHHHHHHHHHCCCCE
RAVFINLFGGIVSCADVARALVDALEGGDAPKPIVVRMAGHESAEGRALLHDFAHPSVTI
EEEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCHHHHHHCCCCHHH
AQEMHEALDALRSMKPADVPRIEFPLPQEPDPVPQHNGQEAAACVPVYNGMGLDSSSGVL
HHHHHHHHHHHHCCCCCCCCEEECCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEE
VQGLTGRVAQRHAALMMEYGTRVVAGVTPFKGGQEVMGIPVYDSVHEACRHHRIDASIIF
EECCHHHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEECCCHHHHHHHHHHCCCCCEEEE
VPAAFAPDAVLEAAAEEIPWVVCITEGIPQAAMLSALKNIQPSPTCVVGPNTPGIVVPHQ
EECCCCCHHHHHHHHHHCCEEEEECCCCCHHHHHHHHHCCCCCCCEEECCCCCCEEECCE
LKIGIMPGYVFSPGPVAVFSRSGTLTYEAASRLSAAGIGQSVCVGVGGDSFVGTGFVDLC
EEEEECCCEEECCCCEEEEECCCCEEHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHH
ERVRHDAATRAVLVLGEVGGRAEEELAEYVRRTGFSKPVVSFVAARTAPPGRRLGHAGAI
HHHHHHHHHEEEEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCCCCC
LDETTGGVEAKLQAMREAGFTICPDLASLPRIMRAVLDRA
CCCCCCCHHHHHHHHHHCCCEECCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]