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The map label for this gene is ilvC

Identifier: 78357209

GI number: 78357209

Start: 2209163

End: 2210152

Strand: Reverse

Name: ilvC

Synonym: Dde_2166

Alternate gene names: 78357209

Gene position: 2210152-2209163 (Counterclockwise)

Preceding gene: 78357210

Following gene: 78357207

Centisome position: 59.25

GC content: 55.35

Gene sequence:

>990_bases
ATGAAGGTCTATTACGAACAGGATGCAAACCTGGAAGTGCTCAAGGGCAAGACCGTGGCCATCATAGGCTACGGCAGTCA
GGGCCATGCGCATGCGCAGAACCTGCGTGATTCCGGCGTGAACGTGATCGTCGGCCAGCGCCCCGGCGGCCCCAACTTCG
AGCTGGCAAAGGAGCATGGTTTCCAGCCCCTTAGCGCAGCAGAGGCTGCCGCACAAGCCGACCTGATCATGATTCTACTC
CCCGACCAGTATCAGGCTTCTGTGTATGAAAATGATATCAAGCCGCATCTGACCGCCGGTAAATCGCTGGTGTTCGCTCA
TGGCTTTAATATCCATTTCAACCAGATTGTACCGCCCAAGGATGTCGATGTGTTCATGATCGCTCCCAAGGGGCCGGGCC
ATCTTGTCCGCCGTACCTATACCGAAGGTGGCGGCGTTCCCTGTCTTGTGGCCATCCACCAAGATGCCAGCGGACAGGCC
ATGGAGAAAGCCCTTGCCTATGCCATGGGCGTAGGCGGAACACGTTCCGGCGTCATTGAAACCACCTTCCGTGAAGAAAC
GGAAACCGACCTCTTCGGCGAACAGGCGGTTTTGTGCGGTGGTATCAGCGCTCTGATTCAGGCTGGTTTTGAAACTCTGG
TGGAAGCAGGCTATCAGCCTGAAATCGCCTACTTCGAGTGCCTGCACGAGACAAAGCTTATCGTGGATCTTATCTACGAA
GGCGGTCTTGCCAAAATGCGGCATTCCATAAGCGATACGGCAGAATACGGTGACTATGTGACCGGCCGCCGCATTGTGAC
TGAAGAAACCAAAAAAGAAATGAAGGCTGCGCTGAAGGATATTCAGGAAGGCCGTTTTGCACGGGATTTCATCCTTGAGT
GCAAGGCAAACTATCCTACCTTCACGGCCCGCCGGCGCATCGAGGCCGAGCACCCCATTGAAGAAGTGGGGGCGCGCCTG
CGTTCCATGATGCCCTGGCTTAAAAAATAG

Upstream 100 bases:

>100_bases
CGGCAACCCACCTGACGGGCGCTTGAGCCTCTCAGGTGGGTTTTTTTATAGGTAACCACTAACCTTTGGGAAGCTGTACA
AGCTACAGCAGGGAGTAGAA

Downstream 100 bases:

>100_bases
CAGCCGGCATTGTTGTTAAAGGCCGCCCGCAAGGGCGGCCTTGTTTTTCCGGGCGTCAGCTCAGGCACCTTCGGCCACAA
GCCGTGTGAAAAGATACTCG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 329; Mature: 329

Protein sequence:

>329_residues
MKVYYEQDANLEVLKGKTVAIIGYGSQGHAHAQNLRDSGVNVIVGQRPGGPNFELAKEHGFQPLSAAEAAAQADLIMILL
PDQYQASVYENDIKPHLTAGKSLVFAHGFNIHFNQIVPPKDVDVFMIAPKGPGHLVRRTYTEGGGVPCLVAIHQDASGQA
MEKALAYAMGVGGTRSGVIETTFREETETDLFGEQAVLCGGISALIQAGFETLVEAGYQPEIAYFECLHETKLIVDLIYE
GGLAKMRHSISDTAEYGDYVTGRRIVTEETKKEMKAALKDIQEGRFARDFILECKANYPTFTARRRIEAEHPIEEVGARL
RSMMPWLKK

Sequences:

>Translated_329_residues
MKVYYEQDANLEVLKGKTVAIIGYGSQGHAHAQNLRDSGVNVIVGQRPGGPNFELAKEHGFQPLSAAEAAAQADLIMILL
PDQYQASVYENDIKPHLTAGKSLVFAHGFNIHFNQIVPPKDVDVFMIAPKGPGHLVRRTYTEGGGVPCLVAIHQDASGQA
MEKALAYAMGVGGTRSGVIETTFREETETDLFGEQAVLCGGISALIQAGFETLVEAGYQPEIAYFECLHETKLIVDLIYE
GGLAKMRHSISDTAEYGDYVTGRRIVTEETKKEMKAALKDIQEGRFARDFILECKANYPTFTARRRIEAEHPIEEVGARL
RSMMPWLKK
>Mature_329_residues
MKVYYEQDANLEVLKGKTVAIIGYGSQGHAHAQNLRDSGVNVIVGQRPGGPNFELAKEHGFQPLSAAEAAAQADLIMILL
PDQYQASVYENDIKPHLTAGKSLVFAHGFNIHFNQIVPPKDVDVFMIAPKGPGHLVRRTYTEGGGVPCLVAIHQDASGQA
MEKALAYAMGVGGTRSGVIETTFREETETDLFGEQAVLCGGISALIQAGFETLVEAGYQPEIAYFECLHETKLIVDLIYE
GGLAKMRHSISDTAEYGDYVTGRRIVTEETKKEMKAALKDIQEGRFARDFILECKANYPTFTARRRIEAEHPIEEVGARL
RSMMPWLKK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=288, Percent_Identity=35.7638888888889, Blast_Score=147, Evalue=7e-37,
Organism=Saccharomyces cerevisiae, GI6323387, Length=262, Percent_Identity=39.3129770992366, Blast_Score=159, Evalue=4e-40,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_DESDG (Q30ZD3)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388658.1
- ProteinModelPortal:   Q30ZD3
- SMR:   Q30ZD3
- STRING:   Q30ZD3
- GeneID:   3757176
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2166
- NMPDR:   fig|207559.3.peg.2116
- eggNOG:   COG0059
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   DDES207559:DDE_2166-MONOMER
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36187; Mature: 36187

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: ACT_SITE 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVYYEQDANLEVLKGKTVAIIGYGSQGHAHAQNLRDSGVNVIVGQRPGGPNFELAKEHG
CEEEEECCCCEEEECCCEEEEEEECCCCCHHHHHHHCCCCEEEEECCCCCCCCCHHHHCC
FQPLSAAEAAAQADLIMILLPDQYQASVYENDIKPHLTAGKSLVFAHGFNIHFNQIVPPK
CCCCHHHHHHHCCCEEEEEECCCHHHHHHHCCCCCCCCCCCEEEEEECCEEEECCCCCCC
DVDVFMIAPKGPGHLVRRTYTEGGGVPCLVAIHQDASGQAMEKALAYAMGVGGTRSGVIE
CCCEEEECCCCCCHHHEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEEE
TTFREETETDLFGEQAVLCGGISALIQAGFETLVEAGYQPEIAYFECLHETKLIVDLIYE
EHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
GGLAKMRHSISDTAEYGDYVTGRRIVTEETKKEMKAALKDIQEGRFARDFILECKANYPT
CCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHEECCCCCC
FTARRRIEAEHPIEEVGARLRSMMPWLKK
HHHHHCCCCCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKVYYEQDANLEVLKGKTVAIIGYGSQGHAHAQNLRDSGVNVIVGQRPGGPNFELAKEHG
CEEEEECCCCEEEECCCEEEEEEECCCCCHHHHHHHCCCCEEEEECCCCCCCCCHHHHCC
FQPLSAAEAAAQADLIMILLPDQYQASVYENDIKPHLTAGKSLVFAHGFNIHFNQIVPPK
CCCCHHHHHHHCCCEEEEEECCCHHHHHHHCCCCCCCCCCCEEEEEECCEEEECCCCCCC
DVDVFMIAPKGPGHLVRRTYTEGGGVPCLVAIHQDASGQAMEKALAYAMGVGGTRSGVIE
CCCEEEECCCCCCHHHEEEECCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCEEE
TTFREETETDLFGEQAVLCGGISALIQAGFETLVEAGYQPEIAYFECLHETKLIVDLIYE
EHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHC
GGLAKMRHSISDTAEYGDYVTGRRIVTEETKKEMKAALKDIQEGRFARDFILECKANYPT
CCHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHCCCHHHHHHHEECCCCCC
FTARRRIEAEHPIEEVGARLRSMMPWLKK
HHHHHCCCCCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA