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The map label for this gene is clpA [C]

Identifier: 78357142

GI number: 78357142

Start: 2148490

End: 2150772

Strand: Reverse

Name: clpA [C]

Synonym: Dde_2099

Alternate gene names: 78357142

Gene position: 2150772-2148490 (Counterclockwise)

Preceding gene: 78357143

Following gene: 78357141

Centisome position: 57.66

GC content: 55.98

Gene sequence:

>2283_bases
ATGATCGGCAAGAGGCTTGAAGCCGTTTTATCCGTCGCGGTAAGCGAAGTGAAGGCGAGAAACCATGAGTATCTCACCCT
TGAGCATGTGCTGTATGCCATGACGCTGGAACCGCAGGGCATTTATATACTGGAAGGCTGCGGGGCCGATGCCGAGAATC
TGCGCAAGCGGTTAGAGATTTTTTTTGATTCTCATCTTGAATCGCTTCCGGAAGAGACCCCCACAGAGGTTGTGCAGACG
ATGGGGGTGCAGCGCGTGTTGCAGCGGGCCGTCATGCAGATGCAGTCATCCGGCAAAAATGCGGTGGAGCTGGGCGATGT
GCTGGCCGCCATGTTTGAAGAGGAAGACTCTTATGCGCTGTATTTTTTGAGGGCGCAGGGGGTGGCGCGGCTCGACGTGC
TGGAATTCATTTCGCACGGCATGGGAGACTGGTCCGACGGAGAACCTGAACCGGCAGCGCAGACTGCGGATGGCGGCGAA
CGGCAGGGCAGAGCTTCTGCTCTTGATCAGTTTACCGTCAATCTGACAGCGCGGGCCCGTGACGGGCTCATTGATCCTCT
TATCGGCCGGTCTGCCGAGCTGGAGCGCACAGTGCAGGTGCTTGCCCGCCGCAGAAAGAATAATCCGCTTTTTGTGGGAG
ACCCCGGCGTGGGCAAGACAGCCATAGCCGAGGGGCTGGCTTTGCGCATTGCGGATGGCGATGTGCCCGAAAGCTTTGCC
GATGCCGAAATATTCGCGCTGGATATGGGAACCCTGCTGGCGGGGACAAAATACCGGGGTGATTTCGAGGCCCGGCTTAA
AGCGGTTATCAAGGATTTGTCGGCAATTCCTGAAGCCATTTTGTTTATTGATGAAATACATACCATTGTGGGAGCGGGAG
CCACCAGCGGCGGTTCAATGGATGCTTCGAACATCCTCAAACCGGTGCTGGCATCGGGTGGTATACGCTGTATCGGCTCC
ACGACATACGAGGAATACCGCAACCACTTTGAAAAAGACCGTGCGCTTTCGCGGCGGTTTCAGAAAATCGACGTGCAGGA
ACCTTCGCAGGATGAGTGCCTTGAAATTCTCAAGGGATTGCGTCCGTATTACGAAGAGTTTCACGAAGTGCGTTACACCC
AGCCTGCACTCAAGGCCGCGGTGGAACTTTCCAGCCGGTACCTGCAGGACAGGTTTCTGCCTGATAAAGCCATAGACGTC
ATTGATGAAGCGGGTGCCGTATACAAGCTGGGTGCACACGGGCGCAAGCGCAACACCATTACCGTGAGCGATGTTGAGCG
TGTTATTTCCCGTATGGCGCAGATTCCCGCACAACGGGTCAGTGTTTCGGACAGGGGCAGGCTGGAACGGCTGGAAGAAG
ACCTGCATTCCGTTGTCTTTGGCCAGCAGGCTGCGGTGGACAGTGTTACCAAAGCCATCCTGCGGTCACGCGCAGGTCTT
TCCAGTCCCGAGCGTCCCACCGGCAGTTTCCTTTTTTATGGTCCCACCGGGGTGGGCAAGACAGAGCTTGCCAAACAGCT
GGCTGCTACTCTGGGGGTCAGCTTCATACGCTTTGACATGAGCGAGTATATGGAAAAACACGCCGTGGCCAGGCTTATCG
GGGCTCCTCCGGGCTATGTGGGGTTTGATCAGGGAGGGCTGCTTACAGAAGCCGTGCGCAAGACACCTCATGCCGTGGTG
CTGCTTGACGAGATTGAAAAAGCACACCCCGATATGTTCAACATTTTGCTGCAGGTAATGGATTACGCCAAACTGACGGA
TAATACCGGACGCAAAGCCGATTTCCGCAATGTCATTCTTATTATGACCTCCAATGCCGGAGCACAGGAAATGGCGGCCA
AAACCATCGGCTTCGGCGACAGTGCCGGGCAGGATATGGCGGCAAAGGGGCTGAAGGCCGTGGAAAAGCTGTTCAGCCCT
GAATTCCGTAACCGGCTTGATGCCCTCGTTCCGTTCAGTAATCTTTCCCGCGAAGTGATGCTGAAAATTGTAGAAAAATT
CATAAGTGAGCTGCAAAGACAGATGAAGGACAGGCGGGTGACCATCCATCTTTCGGACAAAGCCCGCGAACGTCTGGCGG
AGAAAGGATATGATTCCGCTTTCGGCGCCCGGCCCATGGGACGCATCATCAGAACAGGCATTGAGGACGTGCTTGCCCGT
GAGGTGCTGTTCGGCAGGCTGCAGAAAGGCGGCACAGTGCGGATTGGAGTCCGCAAGCCGGCAGCGCACGGAGCGGATGA
TGACCTCGGGCTCACGTTCAGATTCGAGACTTCCGCCTTGTAG

Upstream 100 bases:

>100_bases
GTCTACACAGCCGAAGTAGCAGAAACCAAAGTAGCCATGGTACATGCCCGTGCCCGGGCCGAAGGTTTTCCGCTCCGGTG
CAGCATGGAAGAGGTGTAAT

Downstream 100 bases:

>100_bases
CGGTACGGACCCGGGCAGGAGTCTGCATGCACCTTTACGCACTGTCTGAAAAGCTGGAGTTTCCCGACCCGCAGACGGCA
TCGTCGGAAGGGCTGCTGGC

Product: ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 760; Mature: 760

Protein sequence:

>760_residues
MIGKRLEAVLSVAVSEVKARNHEYLTLEHVLYAMTLEPQGIYILEGCGADAENLRKRLEIFFDSHLESLPEETPTEVVQT
MGVQRVLQRAVMQMQSSGKNAVELGDVLAAMFEEEDSYALYFLRAQGVARLDVLEFISHGMGDWSDGEPEPAAQTADGGE
RQGRASALDQFTVNLTARARDGLIDPLIGRSAELERTVQVLARRRKNNPLFVGDPGVGKTAIAEGLALRIADGDVPESFA
DAEIFALDMGTLLAGTKYRGDFEARLKAVIKDLSAIPEAILFIDEIHTIVGAGATSGGSMDASNILKPVLASGGIRCIGS
TTYEEYRNHFEKDRALSRRFQKIDVQEPSQDECLEILKGLRPYYEEFHEVRYTQPALKAAVELSSRYLQDRFLPDKAIDV
IDEAGAVYKLGAHGRKRNTITVSDVERVISRMAQIPAQRVSVSDRGRLERLEEDLHSVVFGQQAAVDSVTKAILRSRAGL
SSPERPTGSFLFYGPTGVGKTELAKQLAATLGVSFIRFDMSEYMEKHAVARLIGAPPGYVGFDQGGLLTEAVRKTPHAVV
LLDEIEKAHPDMFNILLQVMDYAKLTDNTGRKADFRNVILIMTSNAGAQEMAAKTIGFGDSAGQDMAAKGLKAVEKLFSP
EFRNRLDALVPFSNLSREVMLKIVEKFISELQRQMKDRRVTIHLSDKARERLAEKGYDSAFGARPMGRIIRTGIEDVLAR
EVLFGRLQKGGTVRIGVRKPAAHGADDDLGLTFRFETSAL

Sequences:

>Translated_760_residues
MIGKRLEAVLSVAVSEVKARNHEYLTLEHVLYAMTLEPQGIYILEGCGADAENLRKRLEIFFDSHLESLPEETPTEVVQT
MGVQRVLQRAVMQMQSSGKNAVELGDVLAAMFEEEDSYALYFLRAQGVARLDVLEFISHGMGDWSDGEPEPAAQTADGGE
RQGRASALDQFTVNLTARARDGLIDPLIGRSAELERTVQVLARRRKNNPLFVGDPGVGKTAIAEGLALRIADGDVPESFA
DAEIFALDMGTLLAGTKYRGDFEARLKAVIKDLSAIPEAILFIDEIHTIVGAGATSGGSMDASNILKPVLASGGIRCIGS
TTYEEYRNHFEKDRALSRRFQKIDVQEPSQDECLEILKGLRPYYEEFHEVRYTQPALKAAVELSSRYLQDRFLPDKAIDV
IDEAGAVYKLGAHGRKRNTITVSDVERVISRMAQIPAQRVSVSDRGRLERLEEDLHSVVFGQQAAVDSVTKAILRSRAGL
SSPERPTGSFLFYGPTGVGKTELAKQLAATLGVSFIRFDMSEYMEKHAVARLIGAPPGYVGFDQGGLLTEAVRKTPHAVV
LLDEIEKAHPDMFNILLQVMDYAKLTDNTGRKADFRNVILIMTSNAGAQEMAAKTIGFGDSAGQDMAAKGLKAVEKLFSP
EFRNRLDALVPFSNLSREVMLKIVEKFISELQRQMKDRRVTIHLSDKARERLAEKGYDSAFGARPMGRIIRTGIEDVLAR
EVLFGRLQKGGTVRIGVRKPAAHGADDDLGLTFRFETSAL
>Mature_760_residues
MIGKRLEAVLSVAVSEVKARNHEYLTLEHVLYAMTLEPQGIYILEGCGADAENLRKRLEIFFDSHLESLPEETPTEVVQT
MGVQRVLQRAVMQMQSSGKNAVELGDVLAAMFEEEDSYALYFLRAQGVARLDVLEFISHGMGDWSDGEPEPAAQTADGGE
RQGRASALDQFTVNLTARARDGLIDPLIGRSAELERTVQVLARRRKNNPLFVGDPGVGKTAIAEGLALRIADGDVPESFA
DAEIFALDMGTLLAGTKYRGDFEARLKAVIKDLSAIPEAILFIDEIHTIVGAGATSGGSMDASNILKPVLASGGIRCIGS
TTYEEYRNHFEKDRALSRRFQKIDVQEPSQDECLEILKGLRPYYEEFHEVRYTQPALKAAVELSSRYLQDRFLPDKAIDV
IDEAGAVYKLGAHGRKRNTITVSDVERVISRMAQIPAQRVSVSDRGRLERLEEDLHSVVFGQQAAVDSVTKAILRSRAGL
SSPERPTGSFLFYGPTGVGKTELAKQLAATLGVSFIRFDMSEYMEKHAVARLIGAPPGYVGFDQGGLLTEAVRKTPHAVV
LLDEIEKAHPDMFNILLQVMDYAKLTDNTGRKADFRNVILIMTSNAGAQEMAAKTIGFGDSAGQDMAAKGLKAVEKLFSP
EFRNRLDALVPFSNLSREVMLKIVEKFISELQRQMKDRRVTIHLSDKARERLAEKGYDSAFGARPMGRIIRTGIEDVLAR
EVLFGRLQKGGTVRIGVRKPAAHGADDDLGLTFRFETSAL

Specific function: ATP-Dependent Specificity Component Of The Clpp Protease. It Directs The Protease To Specific Substrates. The Primary Function Of The Clpa-Clpp Complex Appears To Be The Degradation Of Unfolded Or Abnormal Proteins. [C]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=316, Percent_Identity=34.1772151898734, Blast_Score=175, Evalue=1e-43,
Organism=Escherichia coli, GI1787109, Length=745, Percent_Identity=54.8993288590604, Blast_Score=820, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=326, Percent_Identity=48.7730061349693, Blast_Score=314, Evalue=1e-86,
Organism=Saccharomyces cerevisiae, GI6320464, Length=326, Percent_Identity=45.7055214723926, Blast_Score=293, Evalue=7e-80,
Organism=Saccharomyces cerevisiae, GI6323002, Length=412, Percent_Identity=36.6504854368932, Blast_Score=235, Evalue=2e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 83666; Mature: 83666

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGKRLEAVLSVAVSEVKARNHEYLTLEHVLYAMTLEPQGIYILEGCGADAENLRKRLEI
CCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHEEECCCCEEEEECCCCCHHHHHHHHHH
FFDSHLESLPEETPTEVVQTMGVQRVLQRAVMQMQSSGKNAVELGDVLAAMFEEEDSYAL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEE
YFLRAQGVARLDVLEFISHGMGDWSDGEPEPAAQTADGGERQGRASALDQFTVNLTARAR
EEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEEHHH
DGLIDPLIGRSAELERTVQVLARRRKNNPLFVGDPGVGKTAIAEGLALRIADGDVPESFA
CCCCCHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCCCEEEEECCCCCCCCC
DAEIFALDMGTLLAGTKYRGDFEARLKAVIKDLSAIPEAILFIDEIHTIVGAGATSGGSM
CCEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DASNILKPVLASGGIRCIGSTTYEEYRNHFEKDRALSRRFQKIDVQEPSQDECLEILKGL
CHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
RPYYEEFHEVRYTQPALKAAVELSSRYLQDRFLPDKAIDVIDEAGAVYKLGAHGRKRNTI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEECCCCCCCCCE
TVSDVERVISRMAQIPAQRVSVSDRGRLERLEEDLHSVVFGQQAAVDSVTKAILRSRAGL
EHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
SSPERPTGSFLFYGPTGVGKTELAKQLAATLGVSFIRFDMSEYMEKHAVARLIGAPPGYV
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GFDQGGLLTEAVRKTPHAVVLLDEIEKAHPDMFNILLQVMDYAKLTDNTGRKADFRNVIL
CCCCCCHHHHHHHCCCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
IMTSNAGAQEMAAKTIGFGDSAGQDMAAKGLKAVEKLFSPEFRNRLDALVPFSNLSREVM
EEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHCCHHHH
LKIVEKFISELQRQMKDRRVTIHLSDKARERLAEKGYDSAFGARPMGRIIRTGIEDVLAR
HHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
EVLFGRLQKGGTVRIGVRKPAAHGADDDLGLTFRFETSAL
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCC
>Mature Secondary Structure
MIGKRLEAVLSVAVSEVKARNHEYLTLEHVLYAMTLEPQGIYILEGCGADAENLRKRLEI
CCCHHHHHHHHHHHHHHHHCCCCEEEHHHHHHHEEECCCCEEEEECCCCCHHHHHHHHHH
FFDSHLESLPEETPTEVVQTMGVQRVLQRAVMQMQSSGKNAVELGDVLAAMFEEEDSYAL
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEE
YFLRAQGVARLDVLEFISHGMGDWSDGEPEPAAQTADGGERQGRASALDQFTVNLTARAR
EEEECCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHEEEEEEHHH
DGLIDPLIGRSAELERTVQVLARRRKNNPLFVGDPGVGKTAIAEGLALRIADGDVPESFA
CCCCCHHHCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHCCCEEEEECCCCCCCCC
DAEIFALDMGTLLAGTKYRGDFEARLKAVIKDLSAIPEAILFIDEIHTIVGAGATSGGSM
CCEEEEEEHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
DASNILKPVLASGGIRCIGSTTYEEYRNHFEKDRALSRRFQKIDVQEPSQDECLEILKGL
CHHHHHHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
RPYYEEFHEVRYTQPALKAAVELSSRYLQDRFLPDKAIDVIDEAGAVYKLGAHGRKRNTI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCEEEECCCCCCCCCE
TVSDVERVISRMAQIPAQRVSVSDRGRLERLEEDLHSVVFGQQAAVDSVTKAILRSRAGL
EHHHHHHHHHHHHHCCHHHCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCC
SSPERPTGSFLFYGPTGVGKTELAKQLAATLGVSFIRFDMSEYMEKHAVARLIGAPPGYV
CCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
GFDQGGLLTEAVRKTPHAVVLLDEIEKAHPDMFNILLQVMDYAKLTDNTGRKADFRNVIL
CCCCCCHHHHHHHCCCCEEEEHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEE
IMTSNAGAQEMAAKTIGFGDSAGQDMAAKGLKAVEKLFSPEFRNRLDALVPFSNLSREVM
EEECCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCHHHHHHHHHHCCHHHCCHHHH
LKIVEKFISELQRQMKDRRVTIHLSDKARERLAEKGYDSAFGARPMGRIIRTGIEDVLAR
HHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
EVLFGRLQKGGTVRIGVRKPAAHGADDDLGLTFRFETSAL
HHHHHHHCCCCEEEEEECCCCCCCCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6209404 [H]