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The map label for this gene is hemA

Identifier: 78357068

GI number: 78357068

Start: 2064540

End: 2065892

Strand: Direct

Name: hemA

Synonym: Dde_2025

Alternate gene names: 78357068

Gene position: 2064540-2065892 (Clockwise)

Preceding gene: 78357067

Following gene: 78357069

Centisome position: 55.35

GC content: 53.88

Gene sequence:

>1353_bases
ATGGATCAGGAAATATTCATCATCGGTTTGAACCACCGTACCGCCGACGTGGAAGTACGCGAAAAGTTTGCGCTTACAGG
CTGTACTTCTCTGGAACCCGCGGTGATACCGCTGGGCAACGGCATAAGTGAAGTCATCATTCTTTCCACATGCAACCGTG
TGGAAATAATGGTCGCCGGACGCGGCGATGACGTGCCGGACACTGTGCTTTCACTGTGGGCCAATGCCAGAGGCCAGCAT
CCGGAAGAACTGCGCCCCTACGTCTACATCCACAGGGGGCTTGCAGCCGTTGAGCACCTGTTCACCGTGGCTTCAAGCCT
CGATTCCATGGTGCTCGGAGAACCGCAGATTCTGGGACAGCTGAAAGATGCTTACCGCGATGCCGTGGCACGCAACACCA
CACGCGTCATTCTGAACAGAATGATGCACAAGGCTTTTTCCGTAGCCAAACGTGTGCGCACAGAAACAGCCGTGGCTTCC
AGTGCGGTTTCCATCAGCTACGCTGCCGTGGAACTGGCCAAACGCATTTTCGGCGAAATGAACGAATACAAAGCCATGCT
CATCGGTGCGGGCGAAATGGCGGAACTGGCCGCAACACACCTGCTGAACTGTGGTGTGAATAAAATCTATGTAGCCAACA
GAACCTTTGAACGCGGGCTTGAGCTGGCAAAACAGTTCGACGGCGAAGCCATTCTTTTTGAAGAGCTGTTCACCCGTCTG
CCCGAAGTTGACATTGTCATCAGTTCCACAGGGGCGCAGCAGGCCGTCATAAGGGCAAAAGACATCCGTGACGTACTCAA
ACGCCGTAAAAACAGGCCCATGTTCTTCATTGACATCGCCGTGCCCCGTGACATTGATCCGGATGTGAACAACCTCGATA
ACGTCTACCTGTACGACATCGACGACTTAAAAGAAGTTGTTGAAGAAAACCTGTCGCACCGGCGCGAAGAGGCCGCCAAG
GCTAAAGCCATTGTCAGATCCGAAACAGAAGTCTTCGGCCGCTGGCTGCGCTCGCTGGATCTGCAGCCAACCATTGTGGA
CATGTATTCCCGGTCCACTGAAATCGCGCAGGAAGAACTGCTGAAGACACTGCGCCGCATAGGGCCTGTGGATGAAAGCA
CTCAGAAAGCCCTTGAGGCAATGCTCAACGCCGTTGTGAAAAAAATTCACCACGAACCCATCTGCTTTCTGAAAAGACGA
TACGAAGAAGAGGATTCCGGCCAGCGCTACATAGACTTTGCGCGGCGCATGTTTAATCTGGATAACGAGCCGGAACAGCC
GGAAGCACATAAAAACCGCAAACGGCCGCAGCCCGACCTGCCTGCGGGCTGTCCGGGGAAAACCATTCTATGA

Upstream 100 bases:

>100_bases
GGCGGCAGTATTGGCCGTCTGGCTCTTTGCCCTAACCGTGTTTTCGCTTGTCGGCGTTAACTATTTCATGCCCACACACC
ACAGCTTTCAGCAGTAAATC

Downstream 100 bases:

>100_bases
AGCTTTACGTCATTGAAGACCTGCAACCGGAAGACATCTCGGTCATAACCGGCCGCCTGAAAGCCATGGAGCTTGAAGCC
GGTCTTGAAGACCTTTACTG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MDQEIFIIGLNHRTADVEVREKFALTGCTSLEPAVIPLGNGISEVIILSTCNRVEIMVAGRGDDVPDTVLSLWANARGQH
PEELRPYVYIHRGLAAVEHLFTVASSLDSMVLGEPQILGQLKDAYRDAVARNTTRVILNRMMHKAFSVAKRVRTETAVAS
SAVSISYAAVELAKRIFGEMNEYKAMLIGAGEMAELAATHLLNCGVNKIYVANRTFERGLELAKQFDGEAILFEELFTRL
PEVDIVISSTGAQQAVIRAKDIRDVLKRRKNRPMFFIDIAVPRDIDPDVNNLDNVYLYDIDDLKEVVEENLSHRREEAAK
AKAIVRSETEVFGRWLRSLDLQPTIVDMYSRSTEIAQEELLKTLRRIGPVDESTQKALEAMLNAVVKKIHHEPICFLKRR
YEEEDSGQRYIDFARRMFNLDNEPEQPEAHKNRKRPQPDLPAGCPGKTIL

Sequences:

>Translated_450_residues
MDQEIFIIGLNHRTADVEVREKFALTGCTSLEPAVIPLGNGISEVIILSTCNRVEIMVAGRGDDVPDTVLSLWANARGQH
PEELRPYVYIHRGLAAVEHLFTVASSLDSMVLGEPQILGQLKDAYRDAVARNTTRVILNRMMHKAFSVAKRVRTETAVAS
SAVSISYAAVELAKRIFGEMNEYKAMLIGAGEMAELAATHLLNCGVNKIYVANRTFERGLELAKQFDGEAILFEELFTRL
PEVDIVISSTGAQQAVIRAKDIRDVLKRRKNRPMFFIDIAVPRDIDPDVNNLDNVYLYDIDDLKEVVEENLSHRREEAAK
AKAIVRSETEVFGRWLRSLDLQPTIVDMYSRSTEIAQEELLKTLRRIGPVDESTQKALEAMLNAVVKKIHHEPICFLKRR
YEEEDSGQRYIDFARRMFNLDNEPEQPEAHKNRKRPQPDLPAGCPGKTIL
>Mature_450_residues
MDQEIFIIGLNHRTADVEVREKFALTGCTSLEPAVIPLGNGISEVIILSTCNRVEIMVAGRGDDVPDTVLSLWANARGQH
PEELRPYVYIHRGLAAVEHLFTVASSLDSMVLGEPQILGQLKDAYRDAVARNTTRVILNRMMHKAFSVAKRVRTETAVAS
SAVSISYAAVELAKRIFGEMNEYKAMLIGAGEMAELAATHLLNCGVNKIYVANRTFERGLELAKQFDGEAILFEELFTRL
PEVDIVISSTGAQQAVIRAKDIRDVLKRRKNRPMFFIDIAVPRDIDPDVNNLDNVYLYDIDDLKEVVEENLSHRREEAAK
AKAIVRSETEVFGRWLRSLDLQPTIVDMYSRSTEIAQEELLKTLRRIGPVDESTQKALEAMLNAVVKKIHHEPICFLKRR
YEEEDSGQRYIDFARRMFNLDNEPEQPEAHKNRKRPQPDLPAGCPGKTIL

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=366, Percent_Identity=40.7103825136612, Blast_Score=248, Evalue=8e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_DESDG (Q30ZS4)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388517.1
- ProteinModelPortal:   Q30ZS4
- SMR:   Q30ZS4
- STRING:   Q30ZS4
- GeneID:   3757033
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_2025
- NMPDR:   fig|207559.3.peg.2308
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- ProtClustDB:   PRK00045
- BioCyc:   DDES207559:DDE_2025-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 50795; Mature: 50795

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 51-51 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQEIFIIGLNHRTADVEVREKFALTGCTSLEPAVIPLGNGISEVIILSTCNRVEIMVAG
CCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCHHHEEEEECCCEEEEEEEC
RGDDVPDTVLSLWANARGQHPEELRPYVYIHRGLAAVEHLFTVASSLDSMVLGEPQILGQ
CCCCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LKDAYRDAVARNTTRVILNRMMHKAFSVAKRVRTETAVASSAVSISYAAVELAKRIFGEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NEYKAMLIGAGEMAELAATHLLNCGVNKIYVANRTFERGLELAKQFDGEAILFEELFTRL
HHHHEEEECCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCEEHHHHHHHHC
PEVDIVISSTGAQQAVIRAKDIRDVLKRRKNRPMFFIDIAVPRDIDPDVNNLDNVYLYDI
CCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEEH
DDLKEVVEENLSHRREEAAKAKAIVRSETEVFGRWLRSLDLQPTIVDMYSRSTEIAQEEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LKTLRRIGPVDESTQKALEAMLNAVVKKIHHEPICFLKRRYEEEDSGQRYIDFARRMFNL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCC
DNEPEQPEAHKNRKRPQPDLPAGCPGKTIL
CCCCCCCHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MDQEIFIIGLNHRTADVEVREKFALTGCTSLEPAVIPLGNGISEVIILSTCNRVEIMVAG
CCCCEEEEECCCCCCCHHHHHHHHHCCCCCCCCCEEECCCCHHHEEEEECCCEEEEEEEC
RGDDVPDTVLSLWANARGQHPEELRPYVYIHRGLAAVEHLFTVASSLDSMVLGEPQILGQ
CCCCCHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
LKDAYRDAVARNTTRVILNRMMHKAFSVAKRVRTETAVASSAVSISYAAVELAKRIFGEM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NEYKAMLIGAGEMAELAATHLLNCGVNKIYVANRTFERGLELAKQFDGEAILFEELFTRL
HHHHEEEECCCHHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHCCCCEEHHHHHHHHC
PEVDIVISSTGAQQAVIRAKDIRDVLKRRKNRPMFFIDIAVPRDIDPDVNNLDNVYLYDI
CCEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCCCCEEEEEH
DDLKEVVEENLSHRREEAAKAKAIVRSETEVFGRWLRSLDLQPTIVDMYSRSTEIAQEEL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
LKTLRRIGPVDESTQKALEAMLNAVVKKIHHEPICFLKRRYEEEDSGQRYIDFARRMFNL
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCC
DNEPEQPEAHKNRKRPQPDLPAGCPGKTIL
CCCCCCCHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA