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The map label for this gene is 78357016

Identifier: 78357016

GI number: 78357016

Start: 2018771

End: 2019271

Strand: Direct

Name: 78357016

Synonym: Dde_1973

Alternate gene names: NA

Gene position: 2018771-2019271 (Clockwise)

Preceding gene: 78357015

Following gene: 78357017

Centisome position: 54.12

GC content: 52.1

Gene sequence:

>501_bases
ATGAAAACACTATGGGCACCATGGCGCCTTGAGTACATCCTCGGCCCCAAACCGGACACCTGCGTTTTCTGTCTTCCCGA
ACACACGCAGGAAGATGAGGAAAGGCTTATTCTGTATCGGGGCAAGTTCAACTTTGTCATCATGAATAAATTTCCGTATA
ATAATGGTCACCTCATGGTAACCCCTTATCGCCATGTGATGAATCTGGCGGAACTTTCAGTGGATGAGGCGCATGAGAAC
ATGGATCTGATTCAGGCATGCGTCCGCATCCTCAATGAGCGTTTTTCTCCGCAGGGCATCAACGTGGGGCTGAATCTGGG
AGAAGCTGCCGGGGCCGGAATCCGTGAGCATCTGCATTTCCATCTTGTGCCCCGCTGGAACGGAGACTCTTCGTTCATGG
CGGTGATGGACGAAACGCGCGTCATACCCGAGCATCTTAATGCCACCTATGCCGCACTGAAACCGTATTTTGAAAGGCTG
CCCGCGGGCGAACAACTTTAG

Upstream 100 bases:

>100_bases
ACACCGGTATCATACGGCACAGGCGGCGTTTGCCGCGCTTGCCGCCCGTTTCAGGCGTTTATCATGCAGACGGCCTTGCG
GGAAATCAGACGGAGAAAAT

Downstream 100 bases:

>100_bases
GAGGAGATATATGCGTTTCATTAAAGTATTAGGACTGGTGCTGCTGTTTTTTGTATCCATGCTGTTCTTTGTTCAGAACA
CGCAGGTGCTTTCACAGCCC

Product: HIT family protein

Products: NA

Alternate protein names: ATP adenylyltransferase; Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase; AP,A phosphorylase [H]

Number of amino acids: Translated: 166; Mature: 166

Protein sequence:

>166_residues
MKTLWAPWRLEYILGPKPDTCVFCLPEHTQEDEERLILYRGKFNFVIMNKFPYNNGHLMVTPYRHVMNLAELSVDEAHEN
MDLIQACVRILNERFSPQGINVGLNLGEAAGAGIREHLHFHLVPRWNGDSSFMAVMDETRVIPEHLNATYAALKPYFERL
PAGEQL

Sequences:

>Translated_166_residues
MKTLWAPWRLEYILGPKPDTCVFCLPEHTQEDEERLILYRGKFNFVIMNKFPYNNGHLMVTPYRHVMNLAELSVDEAHEN
MDLIQACVRILNERFSPQGINVGLNLGEAAGAGIREHLHFHLVPRWNGDSSFMAVMDETRVIPEHLNATYAALKPYFERL
PAGEQL
>Mature_166_residues
MKTLWAPWRLEYILGPKPDTCVFCLPEHTQEDEERLILYRGKFNFVIMNKFPYNNGHLMVTPYRHVMNLAELSVDEAHEN
MDLIQACVRILNERFSPQGINVGLNLGEAAGAGIREHLHFHLVPRWNGDSSFMAVMDETRVIPEHLNATYAALKPYFERL
PAGEQL

Specific function: Catabolizes diadenosine 5',5'''-P1,P4-tetraphosphate (Ap4A) into ADP and ATP. It does not catalyze the reverse phosphorolysis reaction. The optimum substrates are dinucleoside polyphosphates containing four or five phosphate residues [H]

COG id: COG0537

COG function: function code FGR; Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HIT domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011146
- InterPro:   IPR011151
- InterPro:   IPR001310 [H]

Pfam domain/function: PF01230 HIT [H]

EC number: =2.7.7.53 [H]

Molecular weight: Translated: 19149; Mature: 19149

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS51084 HIT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTLWAPWRLEYILGPKPDTCVFCLPEHTQEDEERLILYRGKFNFVIMNKFPYNNGHLMV
CCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCEEEEEECCCCEEEEECCCCCCCEEEE
TPYRHVMNLAELSVDEAHENMDLIQACVRILNERFSPQGINVGLNLGEAAGAGIREHLHF
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHCEEE
HLVPRWNGDSSFMAVMDETRVIPEHLNATYAALKPYFERLPAGEQL
EEEEEECCCCCEEEEECCCCCCHHHHCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MKTLWAPWRLEYILGPKPDTCVFCLPEHTQEDEERLILYRGKFNFVIMNKFPYNNGHLMV
CCCCCCCEEEEEEECCCCCEEEEECCCCCCCCCCEEEEEECCCCEEEEECCCCCCCEEEE
TPYRHVMNLAELSVDEAHENMDLIQACVRILNERFSPQGINVGLNLGEAAGAGIREHLHF
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCHHCEEE
HLVPRWNGDSSFMAVMDETRVIPEHLNATYAALKPYFERLPAGEQL
EEEEEECCCCCEEEEECCCCCCHHHHCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12368430; 12218036 [H]