Click here to switch to the map view.

The map label for this gene is folK [H]

Identifier: 78357012

GI number: 78357012

Start: 2013035

End: 2013508

Strand: Reverse

Name: folK [H]

Synonym: Dde_1969

Alternate gene names: 78357012

Gene position: 2013508-2013035 (Counterclockwise)

Preceding gene: 78357013

Following gene: 78357011

Centisome position: 53.98

GC content: 54.85

Gene sequence:

>474_bases
GTGGCTGCCATTGCAGCCCTGTCCGGCCTTACGGTGGAAAAGAGGTCTTCTGTTTACCGCACAGAGCCGCAGGAAAAAAA
GAATCAGCCGTGGTTTGCCAATCAGGTGCTGAGGTGCCGTTGTTCCGGATGGACTCCGGCAGCACTTATGCAGTCTTTGC
TGGACTGCGAGACGGCTTTGGGCCGGGTGCGTGATGTGGCGGACCCGGCTGACAGATTTGGTCCGCGGGTGATAGATATT
GATCTGCTGCTGTTTGCAGATGTGGAAAGCTCTTCTTCTCTGGTGACGCTTCCCCATCCGCGTATGTGGCAGAGAGCGTT
TGTTCTGGTTCCGCTTCTTGAGGTTTATGAGGAACCGGAAGATGTTACATCGGTCTCGGCAGACAGGCAAAACAGCCTGT
TTTCTGCCGGAGCTATCCGCAGCCGTCTTGCTCAGCTGCAGTTCCGCGTAGAAAGAGACTGTATCTGGCAATAA

Upstream 100 bases:

>100_bases
AGCGACTTGAGGAGGCCGTATCCCGAATCGCCAGCCTGTAACCGTTTATATCTGCCTTGGCTCCAATCAAGGCGATACAG
ATGCAAATCTGGAAAGGGCA

Downstream 100 bases:

>100_bases
ACTGCACAAGGAGAGGGATCGTTCATGCTCAAGTGGTTGATTATCGCTGTCGCCGGCTACCTGCTTTTCCGTATGCTGAC
CAATGACCAGAAGCGTAAAT

Product: 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase

Products: NA

Alternate protein names: 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase; PPPK; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase; HPPK [H]

Number of amino acids: Translated: 157; Mature: 156

Protein sequence:

>157_residues
MAAIAALSGLTVEKRSSVYRTEPQEKKNQPWFANQVLRCRCSGWTPAALMQSLLDCETALGRVRDVADPADRFGPRVIDI
DLLLFADVESSSSLVTLPHPRMWQRAFVLVPLLEVYEEPEDVTSVSADRQNSLFSAGAIRSRLAQLQFRVERDCIWQ

Sequences:

>Translated_157_residues
MAAIAALSGLTVEKRSSVYRTEPQEKKNQPWFANQVLRCRCSGWTPAALMQSLLDCETALGRVRDVADPADRFGPRVIDI
DLLLFADVESSSSLVTLPHPRMWQRAFVLVPLLEVYEEPEDVTSVSADRQNSLFSAGAIRSRLAQLQFRVERDCIWQ
>Mature_156_residues
AAIAALSGLTVEKRSSVYRTEPQEKKNQPWFANQVLRCRCSGWTPAALMQSLLDCETALGRVRDVADPADRFGPRVIDID
LLLFADVESSSSLVTLPHPRMWQRAFVLVPLLEVYEEPEDVTSVSADRQNSLFSAGAIRSRLAQLQFRVERDCIWQ

Specific function: Dihydrofolate biosynthesis; first step. [C]

COG id: COG0801

COG function: function code H; 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HPPK family [H]

Homologues:

Organism=Escherichia coli, GI1786335, Length=103, Percent_Identity=35.9223300970874, Blast_Score=64, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000550 [H]

Pfam domain/function: PF01288 HPPK [H]

EC number: =2.7.6.3 [H]

Molecular weight: Translated: 17693; Mature: 17562

Theoretical pI: Translated: 5.27; Mature: 5.27

Prosite motif: PS00579 RIBOSOMAL_L29 ; PS00794 HPPK

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAIAALSGLTVEKRSSVYRTEPQEKKNQPWFANQVLRCRCSGWTPAALMQSLLDCETAL
CCHHHHHCCCCHHHHCCHHCCCCHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GRVRDVADPADRFGPRVIDIDLLLFADVESSSSLVTLPHPRMWQRAFVLVPLLEVYEEPE
HHHHHHCCHHHHHCCEEEEEEEEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCH
DVTSVSADRQNSLFSAGAIRSRLAQLQFRVERDCIWQ
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AAIAALSGLTVEKRSSVYRTEPQEKKNQPWFANQVLRCRCSGWTPAALMQSLLDCETAL
CHHHHHCCCCHHHHCCHHCCCCHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
GRVRDVADPADRFGPRVIDIDLLLFADVESSSSLVTLPHPRMWQRAFVLVPLLEVYEEPE
HHHHHHCCHHHHHCCEEEEEEEEEEEECCCCCCEEECCCCHHHHHHHHHHHHHHHHCCCH
DVTSVSADRQNSLFSAGAIRSRLAQLQFRVERDCIWQ
HHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9168622 [H]