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The map label for this gene is barA [H]

Identifier: 78356986

GI number: 78356986

Start: 1991550

End: 1993493

Strand: Reverse

Name: barA [H]

Synonym: Dde_1943

Alternate gene names: 78356986

Gene position: 1993493-1991550 (Counterclockwise)

Preceding gene: 78356987

Following gene: 78356985

Centisome position: 53.44

GC content: 52.67

Gene sequence:

>1944_bases
ATGGGCAAAGACGTCCCCCTTGATCTTGTGGGAGACCCGCTGAGGCTGGGGCAGGTACTGACTAATCTGGTAAGCAATGC
CATCAAATTTACATCCAGTGGAGAGGTCATTGTTTCTGTCAAGCTTGTTAAAGGCTCTGGTGAAAAGTCCCGCATCCGTT
TTGCCGTCAAAGACAGCGGCATAGGCATCAGCAGCTCTGATCTGGCAAAGCTGTTCAACCCGTTTTCTCAGGCCGATGGC
TCGATTACCCGAAAGTACGGCGGAACGGGGCTCGGGCTGAGTATCAGTAACAAGCTTGTCCAGCTGATGGGCGGCGAGAT
GCATGTTGAAAGTGAACCCGGCCGCGGCAGCATTTTTTCTTTTGAGCTGGAGTTTGAACGGCACAGAACAGATTCCGCCG
CAGAGCACCTTTCATTTACCGGTCTTGAAGGCACTCGGGTGCTTGTGGCCGACGACAACTTTACATCGCGCGCCATTCTT
AAAGAGGTTCTGGAGTCCCTCCGTTTTGATGTGACTCTTGCAGAATCAGGTGAAGAGGCGGTCGATCTTGTTCAGAAAAC
AGCCGAACCCTTCAAGGTAGTGCTGCTTGACTGGCGGATGCCCGGTCTGGACGGTCTGGCGTGTGCACGGCATATCAGGC
AGCTTGATCTGCCGGTGCGCCCCACCATTCTTATTATTACCGCTTACGGACGTGAAGAGGTTCTGGGTGAAATTCCTTCA
GAGATTATTGACGGGGTGTTGCTCAAGCCTGTTGCCAGATCTCTGCTGTTGAATACCATCCTTGATGCCCTTCCGGAATA
CAGCAGCCGCCCCGAGCAGGAAAGCCGCATTATTCAGATAGATACGGCTCAGTTACGGCAGGAGCTGGCAGATACCAGCG
TGCTGGTTGTTGAGGACAATAAAATCAACAGACAGATCGCCAAGGAACTGCTGGAAGGTGTCGGTGTGCGCGTCACACTG
GCGGGTGATGGGCTTGAGGCTTTGGCTCTTGTGGAAAACTATGACTTTGACCTGATTTTTATGGATATTCAGATGCCCAG
AATGGACGGGCTTGAAGCCTGCCGGCGTATCAGGCAGTTGCAGCATAAAAAGCAGCCCCCGGTCGTAGCCATGACGGCGC
ATGCTCTGGCCGGCGACAGAGAGACCAGCCTGCGTGCAGGTATGAATGATCATATAACCAAGCCGATAGACCCTGATGAG
CTGTATGCTGCGCTGGCAAACTGGATAAAACGGAACCATGCGCCAGAAGGTCCGGACGGCATTGCGTCTTCTGCCGAGAT
GGAACTGCCGCAGCCTGATGACGCTGGTGATGATGCGGATCAGCCGTATTCTTCAAGGTATGCAGATGCCCCCCTGCTCG
ATTTTGAATCGGGGCTGAAGCGGATCAAAGGGAACAGAAAGCTGTACAACGGGCTGTTGCGAGAATTTGCGGATGAGTTT
GCAACATATCCGCAAACCATAAGGCAGTATATCGGGCAGGATATGCCAGATGAGGCAAGACGGGTTAATCATGCCCTGCG
CGGTGTTGCCGGTAATATCGGCGCCAAGCGCCTGTACAATATCTCAATTGAAATCAGTGACTGCCTTAAAGAGCAGCTGC
TTGAGTGCGCGCCTCTGGTGACGGAACTGGGCAGCAGCATGCTTATGACGCTCCGCGAGATAGAGCATTATCTGGAAACA
CTTGAAGCGGAACATGCCCCTGAATCCGGTCATGTATCTTCAGAAGGGCTTGCGGAACAGGTTGAAAAGCTGCGTGCACT
TCTTAAAGTGCATGATACGCGTGCACTTGAATCTGTTGAAGGCTTGAAAAGCGTTCTGCAGGGCAGTCAGCCGGATATAT
ACGATGATCTTGTCCGCGCGCTGAATAAGTTCGACTTTAAGGCTGCGCTGAAGCTTCTTGACCGTATACATCTGCAAACC
GAAGAGAACGGGATGGTGCAATGA

Upstream 100 bases:

>100_bases
ACATTTTTATTGTCCCAAACCGTCCCAAAAAGGTGACATTTTCATTGGCTGTTTACATTCCATTGCGGCATCAGATAAAG
GTCTGGAGTTTCTGCTTGAT

Downstream 100 bases:

>100_bases
TGAAAAGAACCAACCGGATTCTCATAGTTGATGACAACCATGTGAATATTCTTATCCTTAAGCAGATTCTGGAACAGGAG
CATCAGGTGTTTGCTGCTGT

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 647; Mature: 646

Protein sequence:

>647_residues
MGKDVPLDLVGDPLRLGQVLTNLVSNAIKFTSSGEVIVSVKLVKGSGEKSRIRFAVKDSGIGISSSDLAKLFNPFSQADG
SITRKYGGTGLGLSISNKLVQLMGGEMHVESEPGRGSIFSFELEFERHRTDSAAEHLSFTGLEGTRVLVADDNFTSRAIL
KEVLESLRFDVTLAESGEEAVDLVQKTAEPFKVVLLDWRMPGLDGLACARHIRQLDLPVRPTILIITAYGREEVLGEIPS
EIIDGVLLKPVARSLLLNTILDALPEYSSRPEQESRIIQIDTAQLRQELADTSVLVVEDNKINRQIAKELLEGVGVRVTL
AGDGLEALALVENYDFDLIFMDIQMPRMDGLEACRRIRQLQHKKQPPVVAMTAHALAGDRETSLRAGMNDHITKPIDPDE
LYAALANWIKRNHAPEGPDGIASSAEMELPQPDDAGDDADQPYSSRYADAPLLDFESGLKRIKGNRKLYNGLLREFADEF
ATYPQTIRQYIGQDMPDEARRVNHALRGVAGNIGAKRLYNISIEISDCLKEQLLECAPLVTELGSSMLMTLREIEHYLET
LEAEHAPESGHVSSEGLAEQVEKLRALLKVHDTRALESVEGLKSVLQGSQPDIYDDLVRALNKFDFKAALKLLDRIHLQT
EENGMVQ

Sequences:

>Translated_647_residues
MGKDVPLDLVGDPLRLGQVLTNLVSNAIKFTSSGEVIVSVKLVKGSGEKSRIRFAVKDSGIGISSSDLAKLFNPFSQADG
SITRKYGGTGLGLSISNKLVQLMGGEMHVESEPGRGSIFSFELEFERHRTDSAAEHLSFTGLEGTRVLVADDNFTSRAIL
KEVLESLRFDVTLAESGEEAVDLVQKTAEPFKVVLLDWRMPGLDGLACARHIRQLDLPVRPTILIITAYGREEVLGEIPS
EIIDGVLLKPVARSLLLNTILDALPEYSSRPEQESRIIQIDTAQLRQELADTSVLVVEDNKINRQIAKELLEGVGVRVTL
AGDGLEALALVENYDFDLIFMDIQMPRMDGLEACRRIRQLQHKKQPPVVAMTAHALAGDRETSLRAGMNDHITKPIDPDE
LYAALANWIKRNHAPEGPDGIASSAEMELPQPDDAGDDADQPYSSRYADAPLLDFESGLKRIKGNRKLYNGLLREFADEF
ATYPQTIRQYIGQDMPDEARRVNHALRGVAGNIGAKRLYNISIEISDCLKEQLLECAPLVTELGSSMLMTLREIEHYLET
LEAEHAPESGHVSSEGLAEQVEKLRALLKVHDTRALESVEGLKSVLQGSQPDIYDDLVRALNKFDFKAALKLLDRIHLQT
EENGMVQ
>Mature_646_residues
GKDVPLDLVGDPLRLGQVLTNLVSNAIKFTSSGEVIVSVKLVKGSGEKSRIRFAVKDSGIGISSSDLAKLFNPFSQADGS
ITRKYGGTGLGLSISNKLVQLMGGEMHVESEPGRGSIFSFELEFERHRTDSAAEHLSFTGLEGTRVLVADDNFTSRAILK
EVLESLRFDVTLAESGEEAVDLVQKTAEPFKVVLLDWRMPGLDGLACARHIRQLDLPVRPTILIITAYGREEVLGEIPSE
IIDGVLLKPVARSLLLNTILDALPEYSSRPEQESRIIQIDTAQLRQELADTSVLVVEDNKINRQIAKELLEGVGVRVTLA
GDGLEALALVENYDFDLIFMDIQMPRMDGLEACRRIRQLQHKKQPPVVAMTAHALAGDRETSLRAGMNDHITKPIDPDEL
YAALANWIKRNHAPEGPDGIASSAEMELPQPDDAGDDADQPYSSRYADAPLLDFESGLKRIKGNRKLYNGLLREFADEFA
TYPQTIRQYIGQDMPDEARRVNHALRGVAGNIGAKRLYNISIEISDCLKEQLLECAPLVTELGSSMLMTLREIEHYLETL
EAEHAPESGHVSSEGLAEQVEKLRALLKVHDTRALESVEGLKSVLQGSQPDIYDDLVRALNKFDFKAALKLLDRIHLQTE
ENGMVQ

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. Phosphorylates UvrY, probably via a four-step phosphorelay [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=523, Percent_Identity=31.5487571701721, Blast_Score=222, Evalue=7e-59,
Organism=Escherichia coli, GI145693157, Length=413, Percent_Identity=31.4769975786925, Blast_Score=175, Evalue=7e-45,
Organism=Escherichia coli, GI87081816, Length=258, Percent_Identity=34.8837209302326, Blast_Score=145, Evalue=9e-36,
Organism=Escherichia coli, GI48994928, Length=215, Percent_Identity=34.8837209302326, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1788713, Length=213, Percent_Identity=34.2723004694836, Blast_Score=106, Evalue=5e-24,
Organism=Escherichia coli, GI1790436, Length=124, Percent_Identity=36.2903225806452, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1790437, Length=139, Percent_Identity=33.8129496402878, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87082012, Length=121, Percent_Identity=32.2314049586777, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788393, Length=121, Percent_Identity=34.7107438016529, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1787487, Length=112, Percent_Identity=33.9285714285714, Blast_Score=70, Evalue=6e-13,
Organism=Escherichia coli, GI1788550, Length=112, Percent_Identity=34.8214285714286, Blast_Score=69, Evalue=1e-12,
Organism=Escherichia coli, GI1786911, Length=136, Percent_Identity=32.3529411764706, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=115, Percent_Identity=35.6521739130435, Blast_Score=67, Evalue=4e-12,
Organism=Escherichia coli, GI1790863, Length=118, Percent_Identity=32.2033898305085, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6322000, Length=142, Percent_Identity=35.2112676056338, Blast_Score=91, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6322044, Length=123, Percent_Identity=38.2113821138211, Blast_Score=77, Evalue=9e-15,
Organism=Saccharomyces cerevisiae, GI6323034, Length=142, Percent_Identity=30.9859154929577, Blast_Score=71, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR019247
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF09984 DUF2222; PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 71399; Mature: 71268

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS50894 HPT ; PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKDVPLDLVGDPLRLGQVLTNLVSNAIKFTSSGEVIVSVKLVKGSGEKSRIRFAVKDSG
CCCCCCHHHCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCCCCEEEEEEECCC
IGISSSDLAKLFNPFSQADGSITRKYGGTGLGLSISNKLVQLMGGEMHVESEPGRGSIFS
CCCCHHHHHHHHCHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEE
FELEFERHRTDSAAEHLSFTGLEGTRVLVADDNFTSRAILKEVLESLRFDVTLAESGEEA
EEEEHHHHCCHHHHHHCEEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCHHH
VDLVQKTAEPFKVVLLDWRMPGLDGLACARHIRQLDLPVRPTILIITAYGREEVLGEIPS
HHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHCHH
EIIDGVLLKPVARSLLLNTILDALPEYSSRPEQESRIIQIDTAQLRQELADTSVLVVEDN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHCCCEEEEEECC
KINRQIAKELLEGVGVRVTLAGDGLEALALVENYDFDLIFMDIQMPRMDGLEACRRIRQL
CHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHH
QHKKQPPVVAMTAHALAGDRETSLRAGMNDHITKPIDPDELYAALANWIKRNHAPEGPDG
HHCCCCCEEEEEHHHHCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
IASSAEMELPQPDDAGDDADQPYSSRYADAPLLDFESGLKRIKGNRKLYNGLLREFADEF
CCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ATYPQTIRQYIGQDMPDEARRVNHALRGVAGNIGAKRLYNISIEISDCLKEQLLECAPLV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHHHHHH
TELGSSMLMTLREIEHYLETLEAEHAPESGHVSSEGLAEQVEKLRALLKVHDTRALESVE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLKSVLQGSQPDIYDDLVRALNKFDFKAALKLLDRIHLQTEENGMVQ
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
GKDVPLDLVGDPLRLGQVLTNLVSNAIKFTSSGEVIVSVKLVKGSGEKSRIRFAVKDSG
CCCCCHHHCCCHHHHHHHHHHHHHHHHEECCCCCEEEEEEEEECCCCCCEEEEEEECCC
IGISSSDLAKLFNPFSQADGSITRKYGGTGLGLSISNKLVQLMGGEMHVESEPGRGSIFS
CCCCHHHHHHHHCHHHHCCCCEEECCCCCCCCHHHHHHHHHHHCCCEEEECCCCCCCEEE
FELEFERHRTDSAAEHLSFTGLEGTRVLVADDNFTSRAILKEVLESLRFDVTLAESGEEA
EEEEHHHHCCHHHHHHCEEECCCCCEEEEECCCCHHHHHHHHHHHHHCCCEEECCCCHHH
VDLVQKTAEPFKVVLLDWRMPGLDGLACARHIRQLDLPVRPTILIITAYGREEVLGEIPS
HHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHCHH
EIIDGVLLKPVARSLLLNTILDALPEYSSRPEQESRIIQIDTAQLRQELADTSVLVVEDN
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHHHHCCCEEEEEECC
KINRQIAKELLEGVGVRVTLAGDGLEALALVENYDFDLIFMDIQMPRMDGLEACRRIRQL
CHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHH
QHKKQPPVVAMTAHALAGDRETSLRAGMNDHITKPIDPDELYAALANWIKRNHAPEGPDG
HHCCCCCEEEEEHHHHCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCC
IASSAEMELPQPDDAGDDADQPYSSRYADAPLLDFESGLKRIKGNRKLYNGLLREFADEF
CCCCCCCCCCCCCCCCCCCCCCCHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHH
ATYPQTIRQYIGQDMPDEARRVNHALRGVAGNIGAKRLYNISIEISDCLKEQLLECAPLV
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEEEHHHHHHHHHHHHHHHH
TELGSSMLMTLREIEHYLETLEAEHAPESGHVSSEGLAEQVEKLRALLKVHDTRALESVE
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLKSVLQGSQPDIYDDLVRALNKFDFKAALKLLDRIHLQTEENGMVQ
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]