Click here to switch to the map view.

The map label for this gene is rpfC [H]

Identifier: 78356984

GI number: 78356984

Start: 1989255

End: 1990442

Strand: Reverse

Name: rpfC [H]

Synonym: Dde_1941

Alternate gene names: 78356984

Gene position: 1990442-1989255 (Counterclockwise)

Preceding gene: 78356985

Following gene: 78356983

Centisome position: 53.36

GC content: 53.03

Gene sequence:

>1188_bases
ATGATACATACCGCAGAACGCTTTTCCGTGCTTTGTGTGGATGATATGCCAGCCAATCTTGCCGTTCTTGATGGTATCCT
GCGCGACGAATACATTGTGCTTACGGCTACCAACGGGCACGATGCACTGGAAATCGCAACGGGAGACTCTCCGCCGGATC
TTATCCTGCTGGATGTGGTGATGCCTGGTATGGACGGGTATCAGGTTTGCCGGACGTTAAAAAAAATACCGGCTACTGCG
GCCATTCCGGTTATATTCGTGACATCACTGGATGATGAGGGCAATGAGGAAAAAGGGTTCAGCCTGGGGGCTGTGGATTA
CGTCCAGAAGCCTTTTTCTCAGCTTGTCATCCGTGCACGGGTAAGAGCGCATCTGGTGATATACCGCACTCAGCGCATTC
TTGAAAAGACAGTCAGAGAGCGGACAAGAGCTCTGGAACGTGCAAAAGAAAAAGCTGAAGAAGCCAACAGAGCCAAAACC
GTTTTTCTGGCTAACGTCAGCCATGAACTACGCACTCCGCTTAACGGAGTGCTGGGGATGGCACAACTGCTCTCCTCCAC
TTCCATGAGCGGTGAACAGCGGTACCTTCTTGCCAGCCTGAAGCAGTCGGCGGGCAGGCTGGGGTCGCTGGTTTCCGACA
TCCTTGAACACTCGAGCCTTGAAGCAGGAATGCTTCGTCCTTCCCAAGATAATTTTGTTCTGAAGGAAGCTCTGGCTCCG
CTGATAAGGCACTTTGGTGCTGTGGCGGATAAAAAAAATATTCTGTTCACGCACACAGTGCAGGATGGTGTTCCCCGCAC
GCTTGCCGGAGACCGCGGGGCTTTGATCCAGATTCTGCACAATCTGCTTGATAACGCATGCAACTACACCTCTGTCGGGA
CTGTGGATCTGCATGTTGCTCTCTGGACGTGCGAAAATATCTGCACAGCCGACAACCGGAAAGCTGTCTGGTTGCGTTTT
GATGTGCGTGATACAGGCAGCGGTATTCCGGAAGCCAAAGGGGGGGATATCTTTGCTCCTTTTTCCATAGCGGAGCATTT
TCTTACAAAGCGTTTGGGCGGGGCCGGTCTGGGGCTGGCTGTGGCCAGGCAGCTGGCAGAGCGTGATGGCGGGGAAATCA
GCTTTGTCAGCAAAGAAGGTGTGGGCAGCACCTTCAGCGTGGTTCTTCCCTTTTTGCTTCCCTGCTGA

Upstream 100 bases:

>100_bases
GAACGACATCAGGAAGAAATCCGCGCCATAGCCATCGCAGACGCAGATCTGGAAGAAGAGCGTGAGGCATTGAGGAGATG
ACCGTTCAGGGCGGTGCCAT

Downstream 100 bases:

>100_bases
ATGCCTGTTCTGGCATCCATTTTGCTAATTCCCTGCGGAATGCCCTGAGGGGGAAATACATGCAGTGTCGGTCAGGAGGT
AGCTTCCGTGCCTATAGATG

Product: response regulator receiver sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 395; Mature: 395

Protein sequence:

>395_residues
MIHTAERFSVLCVDDMPANLAVLDGILRDEYIVLTATNGHDALEIATGDSPPDLILLDVVMPGMDGYQVCRTLKKIPATA
AIPVIFVTSLDDEGNEEKGFSLGAVDYVQKPFSQLVIRARVRAHLVIYRTQRILEKTVRERTRALERAKEKAEEANRAKT
VFLANVSHELRTPLNGVLGMAQLLSSTSMSGEQRYLLASLKQSAGRLGSLVSDILEHSSLEAGMLRPSQDNFVLKEALAP
LIRHFGAVADKKNILFTHTVQDGVPRTLAGDRGALIQILHNLLDNACNYTSVGTVDLHVALWTCENICTADNRKAVWLRF
DVRDTGSGIPEAKGGDIFAPFSIAEHFLTKRLGGAGLGLAVARQLAERDGGEISFVSKEGVGSTFSVVLPFLLPC

Sequences:

>Translated_395_residues
MIHTAERFSVLCVDDMPANLAVLDGILRDEYIVLTATNGHDALEIATGDSPPDLILLDVVMPGMDGYQVCRTLKKIPATA
AIPVIFVTSLDDEGNEEKGFSLGAVDYVQKPFSQLVIRARVRAHLVIYRTQRILEKTVRERTRALERAKEKAEEANRAKT
VFLANVSHELRTPLNGVLGMAQLLSSTSMSGEQRYLLASLKQSAGRLGSLVSDILEHSSLEAGMLRPSQDNFVLKEALAP
LIRHFGAVADKKNILFTHTVQDGVPRTLAGDRGALIQILHNLLDNACNYTSVGTVDLHVALWTCENICTADNRKAVWLRF
DVRDTGSGIPEAKGGDIFAPFSIAEHFLTKRLGGAGLGLAVARQLAERDGGEISFVSKEGVGSTFSVVLPFLLPC
>Mature_395_residues
MIHTAERFSVLCVDDMPANLAVLDGILRDEYIVLTATNGHDALEIATGDSPPDLILLDVVMPGMDGYQVCRTLKKIPATA
AIPVIFVTSLDDEGNEEKGFSLGAVDYVQKPFSQLVIRARVRAHLVIYRTQRILEKTVRERTRALERAKEKAEEANRAKT
VFLANVSHELRTPLNGVLGMAQLLSSTSMSGEQRYLLASLKQSAGRLGSLVSDILEHSSLEAGMLRPSQDNFVLKEALAP
LIRHFGAVADKKNILFTHTVQDGVPRTLAGDRGALIQILHNLLDNACNYTSVGTVDLHVALWTCENICTADNRKAVWLRF
DVRDTGSGIPEAKGGDIFAPFSIAEHFLTKRLGGAGLGLAVARQLAERDGGEISFVSKEGVGSTFSVVLPFLLPC

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789149, Length=241, Percent_Identity=37.7593360995851, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI145693157, Length=248, Percent_Identity=33.0645161290323, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI48994928, Length=245, Percent_Identity=32.6530612244898, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI87081816, Length=274, Percent_Identity=33.5766423357664, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI1788713, Length=253, Percent_Identity=30.8300395256917, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1790436, Length=256, Percent_Identity=29.6875, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1786600, Length=234, Percent_Identity=27.3504273504274, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786912, Length=297, Percent_Identity=27.2727272727273, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI87082128, Length=266, Percent_Identity=27.8195488721804, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788549, Length=251, Percent_Identity=27.4900398406374, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87082012, Length=116, Percent_Identity=37.0689655172414, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1788394, Length=166, Percent_Identity=30.1204819277108, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI1790300, Length=277, Percent_Identity=26.3537906137184, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1788393, Length=247, Percent_Identity=27.5303643724696, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1786783, Length=242, Percent_Identity=24.3801652892562, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1786599, Length=105, Percent_Identity=35.2380952380952, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1789809, Length=121, Percent_Identity=33.0578512396694, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322044, Length=179, Percent_Identity=36.3128491620112, Blast_Score=75, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 42941; Mature: 42941

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHTAERFSVLCVDDMPANLAVLDGILRDEYIVLTATNGHDALEIATGDSPPDLILLDVV
CCCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCCCEEEEEEC
MPGMDGYQVCRTLKKIPATAAIPVIFVTSLDDEGNEEKGFSLGAVDYVQKPFSQLVIRAR
CCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
VRAHLVIYRTQRILEKTVRERTRALERAKEKAEEANRAKTVFLANVSHELRTPLNGVLGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHCCHHHHHHH
AQLLSSTSMSGEQRYLLASLKQSAGRLGSLVSDILEHSSLEAGMLRPSQDNFVLKEALAP
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
LIRHFGAVADKKNILFTHTVQDGVPRTLAGDRGALIQILHNLLDNACNYTSVGTVDLHVA
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEE
LWTCENICTADNRKAVWLRFDVRDTGSGIPEAKGGDIFAPFSIAEHFLTKRLGGAGLGLA
EEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHH
VARQLAERDGGEISFVSKEGVGSTFSVVLPFLLPC
HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCC
>Mature Secondary Structure
MIHTAERFSVLCVDDMPANLAVLDGILRDEYIVLTATNGHDALEIATGDSPPDLILLDVV
CCCCCCCCEEEEECCCCCCHHHHHHHHCCCEEEEEECCCCCEEEEECCCCCCCEEEEEEC
MPGMDGYQVCRTLKKIPATAAIPVIFVTSLDDEGNEEKGFSLGAVDYVQKPFSQLVIRAR
CCCCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
VRAHLVIYRTQRILEKTVRERTRALERAKEKAEEANRAKTVFLANVSHELRTPLNGVLGM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCHHHHCCHHHHHHH
AQLLSSTSMSGEQRYLLASLKQSAGRLGSLVSDILEHSSLEAGMLRPSQDNFVLKEALAP
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHH
LIRHFGAVADKKNILFTHTVQDGVPRTLAGDRGALIQILHNLLDNACNYTSVGTVDLHVA
HHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEEEEE
LWTCENICTADNRKAVWLRFDVRDTGSGIPEAKGGDIFAPFSIAEHFLTKRLGGAGLGLA
EEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCEEEHHHHHHHHHHHHCCCCCHHHH
VARQLAERDGGEISFVSKEGVGSTFSVVLPFLLPC
HHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]