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The map label for this gene is nadC [H]

Identifier: 78356874

GI number: 78356874

Start: 1880209

End: 1881126

Strand: Reverse

Name: nadC [H]

Synonym: Dde_1831

Alternate gene names: 78356874

Gene position: 1881126-1880209 (Counterclockwise)

Preceding gene: 78356876

Following gene: 78356873

Centisome position: 50.43

GC content: 57.08

Gene sequence:

>918_bases
ATGTACCTTAACAATCCCATGACAACGAGCACTACCCACTTTTTTTTCGCAGGCGAGGCACTGCGGCACACTGTTGCCGC
CATTGATCTGGCGATCACCGAAGATGGTCCCGACCTGACCAGCAACGCGGTTTTCGCCCCTTCTCACCAGCTTGCCGCGC
AGATAATCGCAAAGGAAGACTCCCTTGTGTGCGGGCTGGCATACATACCATACATCATGGACCGCGTCATTGCCTGCGAC
CCGCAGCCGCAGGGATGGGACGACTACACCGTCGACACTCCGTATGCTGACGGTGCGCATGTCACTGCGGGAACCACCGT
CGTCCGGCTTCGGGCTTCCGCCCGCCGCCTGCTCAAGGCGGAAAGAATTATTCTGAATTTCATGACCCATCTTTCCGGAA
TAGCCAATCTGACTGCCCGTTATGTTGACGCACTTTCCGGTACGGGCACCCGCCTTCTTGATACCCGCAAGACATTGCCC
GGATTGAGATATCCGGAAAAGTACGCGGTTGTTATCGGCGGCGGGCTCAACCACCGGCGGAACCTGCAAGAAATGCTGAT
GCTCAAAGACAACCATATTGATCTTGCCGGCAGCATCACCGCCGCAGTGCAGAGGCTCAGGGACACGTATTCCCCCTGCC
CCCCCGTGGAGGTGGAGTGCCGCACGCCGGATGACGTGTGTGAAGCCGTGGCCTGTAACGTTGACAGAATTATGCTGGAC
AACATGGATGCAGACGGGCTTGCAGCCGCTTTACCGCTTATTCCGGATCATATTGAGACTGAAGCAAGCGGCGGAGTGAC
TCTGGAAACCATCCGCGTTCTGGCGCAGGCCTCCTCTCGACGGCTTGATTTTATTTCCGTGGGCAGGCTGACTCATTCCG
CCCCTTCCGCAGATTTCAGCATGCGTATAAGCGAGTAG

Upstream 100 bases:

>100_bases
TGTTCCGCTTGAATGTCGGAGATCCGCTTGACGAAAAAATCTCAGAGTCGTAACACCCCAAAGATCAGTCTCCGAAGGCA
TTGTGCCTCTATCATGTAGC

Downstream 100 bases:

>100_bases
CAAATGAATACACAAAACAGCTATGACACCATTCAGGAGATCAGGTCCCGTATGGGCAGCCGCCTGACCATTATGGGACA
CCACTACCAGCACGAAACCG

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MYLNNPMTTSTTHFFFAGEALRHTVAAIDLAITEDGPDLTSNAVFAPSHQLAAQIIAKEDSLVCGLAYIPYIMDRVIACD
PQPQGWDDYTVDTPYADGAHVTAGTTVVRLRASARRLLKAERIILNFMTHLSGIANLTARYVDALSGTGTRLLDTRKTLP
GLRYPEKYAVVIGGGLNHRRNLQEMLMLKDNHIDLAGSITAAVQRLRDTYSPCPPVEVECRTPDDVCEAVACNVDRIMLD
NMDADGLAAALPLIPDHIETEASGGVTLETIRVLAQASSRRLDFISVGRLTHSAPSADFSMRISE

Sequences:

>Translated_305_residues
MYLNNPMTTSTTHFFFAGEALRHTVAAIDLAITEDGPDLTSNAVFAPSHQLAAQIIAKEDSLVCGLAYIPYIMDRVIACD
PQPQGWDDYTVDTPYADGAHVTAGTTVVRLRASARRLLKAERIILNFMTHLSGIANLTARYVDALSGTGTRLLDTRKTLP
GLRYPEKYAVVIGGGLNHRRNLQEMLMLKDNHIDLAGSITAAVQRLRDTYSPCPPVEVECRTPDDVCEAVACNVDRIMLD
NMDADGLAAALPLIPDHIETEASGGVTLETIRVLAQASSRRLDFISVGRLTHSAPSADFSMRISE
>Mature_305_residues
MYLNNPMTTSTTHFFFAGEALRHTVAAIDLAITEDGPDLTSNAVFAPSHQLAAQIIAKEDSLVCGLAYIPYIMDRVIACD
PQPQGWDDYTVDTPYADGAHVTAGTTVVRLRASARRLLKAERIILNFMTHLSGIANLTARYVDALSGTGTRLLDTRKTLP
GLRYPEKYAVVIGGGLNHRRNLQEMLMLKDNHIDLAGSITAAVQRLRDTYSPCPPVEVECRTPDDVCEAVACNVDRIMLD
NMDADGLAAALPLIPDHIETEASGGVTLETIRVLAQASSRRLDFISVGRLTHSAPSADFSMRISE

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=283, Percent_Identity=31.8021201413428, Blast_Score=122, Evalue=4e-28,
Organism=Escherichia coli, GI1786299, Length=275, Percent_Identity=36.3636363636364, Blast_Score=152, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6321162, Length=287, Percent_Identity=30.6620209059233, Blast_Score=137, Evalue=2e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 33194; Mature: 33194

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLNNPMTTSTTHFFFAGEALRHTVAAIDLAITEDGPDLTSNAVFAPSHQLAAQIIAKED
CCCCCCCCCCCEEEEEECHHHHHHHHHEEEEEECCCCCCCCCCEECCCHHHHHHHHHCCC
SLVCGLAYIPYIMDRVIACDPQPQGWDDYTVDTPYADGAHVTAGTTVVRLRASARRLLKA
CEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEHHHHHHHHHH
ERIILNFMTHLSGIANLTARYVDALSGTGTRLLDTRKTLPGLRYPEKYAVVIGGGLNHRR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCHH
NLQEMLMLKDNHIDLAGSITAAVQRLRDTYSPCPPVEVECRTPDDVCEAVACNVDRIMLD
HHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCCCEEEEC
NMDADGLAAALPLIPDHIETEASGGVTLETIRVLAQASSRRLDFISVGRLTHSAPSADFS
CCCCCHHHHHHCCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCHHCCCCCCCCE
MRISE
EEECC
>Mature Secondary Structure
MYLNNPMTTSTTHFFFAGEALRHTVAAIDLAITEDGPDLTSNAVFAPSHQLAAQIIAKED
CCCCCCCCCCCEEEEEECHHHHHHHHHEEEEEECCCCCCCCCCEECCCHHHHHHHHHCCC
SLVCGLAYIPYIMDRVIACDPQPQGWDDYTVDTPYADGAHVTAGTTVVRLRASARRLLKA
CEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEECCCEEEEEHHHHHHHHHH
ERIILNFMTHLSGIANLTARYVDALSGTGTRLLDTRKTLPGLRYPEKYAVVIGGGLNHRR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCEEEEEEECCCCCHH
NLQEMLMLKDNHIDLAGSITAAVQRLRDTYSPCPPVEVECRTPDDVCEAVACNVDRIMLD
HHHHHHHHCCCCCEEHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHHHCCCCEEEEC
NMDADGLAAALPLIPDHIETEASGGVTLETIRVLAQASSRRLDFISVGRLTHSAPSADFS
CCCCCHHHHHHCCCCCHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCHHCCCCCCCCE
MRISE
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]