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The map label for this gene is dapA

Identifier: 78356840

GI number: 78356840

Start: 1847281

End: 1848159

Strand: Reverse

Name: dapA

Synonym: Dde_1797

Alternate gene names: 78356840

Gene position: 1848159-1847281 (Counterclockwise)

Preceding gene: 78356841

Following gene: 78356839

Centisome position: 49.55

GC content: 55.86

Gene sequence:

>879_bases
ATGCAGTTTTCCGGAGCACTGACCGCCATCGTCACCCCCCTCAAAAACGGCCATATTGACGAGGAGGCTTACCGCAACCT
CATTGAATGGCAGATAGAACAGGGCATCAACGGTCTTGTCCCCTGCGGCACAACCGGTGAGTCGGCGACGTTGTCTCATG
AAGAACACCGTGATGTCATCCGTATCTGCATTGATCAGGTCAAGGGCCGTGTTCCCGTGCTGGCCGGTGCCGGCTCCAAC
AGCACCAAAGAAGCCTGCGGGCTGGCCCAGTTTGCCAAAGACGCAGGGGCCGACGGTGCCCTGCTTATCACGCCGTATTA
CAACAAACCCACTCAGGAAGGGCTTTACCAGCACTTCAAGGCTATCGCCGCCGAAGTTTCCATGCCGTATATCATGTATA
ATGTTCCCGGCAGGACAGGCGTGAACATGACGTCGGAAACAGTGGCACGCGTTAAACGCGATGTGCCGGAAGTTGTCGGC
ATCAAAGAGGCTTCAGCCAACCTGAAGCAGGTTTCCGAGATTATCGAGTTCTGCGGCCCTGATTTTCAGGTGTTGTCCGG
CGACGACTTTACAGTGCTGCCTCTGCTTTCCGTGGGGGGATGCGGTGTTATCTCCGTTGTATCGAATATTGTGCCTGCTA
AAATGTCAGGCCTCTGCAAAGCGTTTGCCGGGGGCGACCTTGCCAGAGCTAAAACACTGCATCATGAGCTTTCACCGCTT
TCCCGGGCCATGTTCTGTGAAACAAACCCCATTCCGGTAAAAACGGCACTGTCCATGATGGGCAGGCTTTCCCTTGAACT
GCGCCTGCCGCTGGTGCCCATGCAGCCGCAGAACGAAAAGTACCTGCGCGGCATTCTGTCACTGGCAGGGCTGGTCTGA

Upstream 100 bases:

>100_bases
ACACAGGCGAAATGCAGCCCGAGTCACTGGGTATTTCACTAGATTAGTTTCAACGGCCGGTTTTTCCGGCCATTTGCTTT
TGCAAACACAGGAGAAGCGT

Downstream 100 bases:

>100_bases
TAATGTCCGGCGGGCGTGCACCGGCACGTCCGCCGTCCCGCGCGGAAGGTTCCTTTTCCGCTTGAAGCTGCGGCATGGCT
GCGCTAAGATTGTCAGCCGT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 292; Mature: 292

Protein sequence:

>292_residues
MQFSGALTAIVTPLKNGHIDEEAYRNLIEWQIEQGINGLVPCGTTGESATLSHEEHRDVIRICIDQVKGRVPVLAGAGSN
STKEACGLAQFAKDAGADGALLITPYYNKPTQEGLYQHFKAIAAEVSMPYIMYNVPGRTGVNMTSETVARVKRDVPEVVG
IKEASANLKQVSEIIEFCGPDFQVLSGDDFTVLPLLSVGGCGVISVVSNIVPAKMSGLCKAFAGGDLARAKTLHHELSPL
SRAMFCETNPIPVKTALSMMGRLSLELRLPLVPMQPQNEKYLRGILSLAGLV

Sequences:

>Translated_292_residues
MQFSGALTAIVTPLKNGHIDEEAYRNLIEWQIEQGINGLVPCGTTGESATLSHEEHRDVIRICIDQVKGRVPVLAGAGSN
STKEACGLAQFAKDAGADGALLITPYYNKPTQEGLYQHFKAIAAEVSMPYIMYNVPGRTGVNMTSETVARVKRDVPEVVG
IKEASANLKQVSEIIEFCGPDFQVLSGDDFTVLPLLSVGGCGVISVVSNIVPAKMSGLCKAFAGGDLARAKTLHHELSPL
SRAMFCETNPIPVKTALSMMGRLSLELRLPLVPMQPQNEKYLRGILSLAGLV
>Mature_292_residues
MQFSGALTAIVTPLKNGHIDEEAYRNLIEWQIEQGINGLVPCGTTGESATLSHEEHRDVIRICIDQVKGRVPVLAGAGSN
STKEACGLAQFAKDAGADGALLITPYYNKPTQEGLYQHFKAIAAEVSMPYIMYNVPGRTGVNMTSETVARVKRDVPEVVG
IKEASANLKQVSEIIEFCGPDFQVLSGDDFTVLPLLSVGGCGVISVVSNIVPAKMSGLCKAFAGGDLARAKTLHHELSPL
SRAMFCETNPIPVKTALSMMGRLSLELRLPLVPMQPQNEKYLRGILSLAGLV

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI13540533, Length=236, Percent_Identity=28.8135593220339, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI31543060, Length=252, Percent_Identity=25.7936507936508, Blast_Score=89, Evalue=5e-18,
Organism=Escherichia coli, GI1788823, Length=292, Percent_Identity=45.2054794520548, Blast_Score=270, Evalue=6e-74,
Organism=Escherichia coli, GI1786463, Length=288, Percent_Identity=32.9861111111111, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI87082415, Length=251, Percent_Identity=35.0597609561753, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1789620, Length=288, Percent_Identity=30.9027777777778, Blast_Score=120, Evalue=7e-29,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_DESDG (Q310Q2)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_388289.1
- HSSP:   Q9X1K9
- ProteinModelPortal:   Q310Q2
- SMR:   Q310Q2
- STRING:   Q310Q2
- GeneID:   3756800
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1797
- NMPDR:   fig|207559.3.peg.1108
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   QKGLIEH
- ProtClustDB:   PRK03170
- BioCyc:   DDES207559:DDE_1797-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 31308; Mature: 31308

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 162-162 BINDING 106-106

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQFSGALTAIVTPLKNGHIDEEAYRNLIEWQIEQGINGLVPCGTTGESATLSHEEHRDVI
CCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHH
RICIDQVKGRVPVLAGAGSNSTKEACGLAQFAKDAGADGALLITPYYNKPTQEGLYQHFK
HHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHH
AIAAEVSMPYIMYNVPGRTGVNMTSETVARVKRDVPEVVGIKEASANLKQVSEIIEFCGP
HHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHCC
DFQVLSGDDFTVLPLLSVGGCGVISVVSNIVPAKMSGLCKAFAGGDLARAKTLHHELSPL
CCEEECCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SRAMFCETNPIPVKTALSMMGRLSLELRLPLVPMQPQNEKYLRGILSLAGLV
HHHHHCCCCCCCHHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MQFSGALTAIVTPLKNGHIDEEAYRNLIEWQIEQGINGLVPCGTTGESATLSHEEHRDVI
CCCCCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCHHHHHHH
RICIDQVKGRVPVLAGAGSNSTKEACGLAQFAKDAGADGALLITPYYNKPTQEGLYQHFK
HHHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHH
AIAAEVSMPYIMYNVPGRTGVNMTSETVARVKRDVPEVVGIKEASANLKQVSEIIEFCGP
HHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHCC
DFQVLSGDDFTVLPLLSVGGCGVISVVSNIVPAKMSGLCKAFAGGDLARAKTLHHELSPL
CCEEECCCCEEEEHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHH
SRAMFCETNPIPVKTALSMMGRLSLELRLPLVPMQPQNEKYLRGILSLAGLV
HHHHHCCCCCCCHHHHHHHHHHHCEEEECCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA