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The map label for this gene is mltC [H]

Identifier: 78356829

GI number: 78356829

Start: 1838108

End: 1839274

Strand: Direct

Name: mltC [H]

Synonym: Dde_1786

Alternate gene names: 78356829

Gene position: 1838108-1839274 (Clockwise)

Preceding gene: 78356828

Following gene: 78356830

Centisome position: 49.28

GC content: 56.47

Gene sequence:

>1167_bases
ATGAAAAAAATGGCATTGCCGCTGCTTTGCGCAACGCTGCTTTGCGCATGCTCCCCCGGCGAGGCAGTACGCATGGCCCG
CGTGGCCACATCAGGAGACATGGCCGGCGCCGCGGCACTGGCCCGTGACAAGGGTATCCGCTATGCCATGAATCCGGCAC
AGCTGGAGGCTGACCTCAAACAGCTTGCCCGCCGCCTGCAGGAATTCAGAGACGCCGTGGCAGGCAAATGGGGCAAGGAT
GAAACCAGAGAGGCCGGTCCCAAAGAATATGTCAAATACACACAGAATTATCTGTCGCGTGCCAGCGTTGATTTTGACAA
AGGCGTTGTGACTGTGGAGACTGTTGACGACAAATCACCAGAAAAGAGCCTGCACAGTGCCATTGTAACCACGCTGCTGA
CCCCCGCCGATCCGCGCGCTGTGGATATGTATTCCGCCGGTGAGGTTCGTCTGGGCGAGGAACCTTTTCTATACAATGAG
GTGGTAGACTACCACGGCAAGCCCATACGTTGGGCATGGCGTGCCGAGCGCTACGCCAGCGATCTCATCCGGCGGGCAAG
GACCATGCGGCAGGTCACAGTGGACGGAAAACGGGTTACTGTACACAGTGTCTCGTTTGCCATGGTCAAAGACCATCTGC
ATATCCGGGCGCGCAAGTTTCGTGAGCCTGTCCGGCGGTTTGCCCGTGAGTACGGAATAAGCCCCAATCTGGTATACGCC
GTCATGAAAACGGAAAGTGACTTCAACCCCTTTGCGGTCAGCCATGCTCCCGCTTACGGACTTATGCAGGTTGTGCCTTC
CACCGCGGGAAGCGACGTGTATACAATGCTTAACGGCAGGAAGGGTTCCCCGACGCCGGAGCAGCTTTTTGATCCCGAGA
TCAATATCCGCTACGGCACGGCGTATCTTTTCATTCTCAATAACAGGTACCTTTCCGACATCCGCCATCCGGTATCCCGC
GAATACTGCATGATTGCCGCTTACAACGGCGGCGCAGGAGCCGTGTTGCGCAGCTTCCACGAAAACAGGCGGACTGCCGC
AGAAATCATCAACTCACTTTCGCCCGATGAAGTGTATGACAGGCTGCAAAAGCGGCTTCCGTCCATGGAAACCCGCAGAT
ATCTGTGGAAAGTGGGGCAAGCGCGCAAAGAGTTTGTTGCACTCTGA

Upstream 100 bases:

>100_bases
AAAGGGGCCGCTTATGAAGCAATTCTCAGGCAATACTATCCGCATACCACCGTGAGAGCTTTGTACTGATGACGCAGCTT
CGGCACGACAGGTGAAAATA

Downstream 100 bases:

>100_bases
CAGACAAAGCCATTGCCGCACCGGAACGGAAAATGTAGTGTCGCCAATGTCTGTTTTTGTATACCGGCCTGTGCGCGATT
GCCGCAGGCATCATAATTAT

Product: membrane-bound lytic murein transglycosylase C

Products: N-Acetylmuramic Acid Residues; N-Acetylglucosamine Residues [C]

Alternate protein names: Murein hydrolase C [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MKKMALPLLCATLLCACSPGEAVRMARVATSGDMAGAAALARDKGIRYAMNPAQLEADLKQLARRLQEFRDAVAGKWGKD
ETREAGPKEYVKYTQNYLSRASVDFDKGVVTVETVDDKSPEKSLHSAIVTTLLTPADPRAVDMYSAGEVRLGEEPFLYNE
VVDYHGKPIRWAWRAERYASDLIRRARTMRQVTVDGKRVTVHSVSFAMVKDHLHIRARKFREPVRRFAREYGISPNLVYA
VMKTESDFNPFAVSHAPAYGLMQVVPSTAGSDVYTMLNGRKGSPTPEQLFDPEINIRYGTAYLFILNNRYLSDIRHPVSR
EYCMIAAYNGGAGAVLRSFHENRRTAAEIINSLSPDEVYDRLQKRLPSMETRRYLWKVGQARKEFVAL

Sequences:

>Translated_388_residues
MKKMALPLLCATLLCACSPGEAVRMARVATSGDMAGAAALARDKGIRYAMNPAQLEADLKQLARRLQEFRDAVAGKWGKD
ETREAGPKEYVKYTQNYLSRASVDFDKGVVTVETVDDKSPEKSLHSAIVTTLLTPADPRAVDMYSAGEVRLGEEPFLYNE
VVDYHGKPIRWAWRAERYASDLIRRARTMRQVTVDGKRVTVHSVSFAMVKDHLHIRARKFREPVRRFAREYGISPNLVYA
VMKTESDFNPFAVSHAPAYGLMQVVPSTAGSDVYTMLNGRKGSPTPEQLFDPEINIRYGTAYLFILNNRYLSDIRHPVSR
EYCMIAAYNGGAGAVLRSFHENRRTAAEIINSLSPDEVYDRLQKRLPSMETRRYLWKVGQARKEFVAL
>Mature_388_residues
MKKMALPLLCATLLCACSPGEAVRMARVATSGDMAGAAALARDKGIRYAMNPAQLEADLKQLARRLQEFRDAVAGKWGKD
ETREAGPKEYVKYTQNYLSRASVDFDKGVVTVETVDDKSPEKSLHSAIVTTLLTPADPRAVDMYSAGEVRLGEEPFLYNE
VVDYHGKPIRWAWRAERYASDLIRRARTMRQVTVDGKRVTVHSVSFAMVKDHLHIRARKFREPVRRFAREYGISPNLVYA
VMKTESDFNPFAVSHAPAYGLMQVVPSTAGSDVYTMLNGRKGSPTPEQLFDPEINIRYGTAYLFILNNRYLSDIRHPVSR
EYCMIAAYNGGAGAVLRSFHENRRTAAEIINSLSPDEVYDRLQKRLPSMETRRYLWKVGQARKEFVAL

Specific function: Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division [H]

COG id: COG0741

COG function: function code M; Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains)

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transglycosylase slt family [H]

Homologues:

Organism=Escherichia coli, GI87082191, Length=321, Percent_Identity=46.417445482866, Blast_Score=292, Evalue=2e-80,
Organism=Escherichia coli, GI87081855, Length=166, Percent_Identity=38.5542168674699, Blast_Score=118, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008258
- InterPro:   IPR000189 [H]

Pfam domain/function: PF01464 SLT [H]

EC number: 3.2.1.- [C]

Molecular weight: Translated: 43782; Mature: 43782

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00922 TRANSGLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKMALPLLCATLLCACSPGEAVRMARVATSGDMAGAAALARDKGIRYAMNPAQLEADLK
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCHHHHHHHHH
QLARRLQEFRDAVAGKWGKDETREAGPKEYVKYTQNYLSRASVDFDKGVVTVETVDDKSP
HHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCH
EKSLHSAIVTTLLTPADPRAVDMYSAGEVRLGEEPFLYNEVVDYHGKPIRWAWRAERYAS
HHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCCCCHHHHHHHHCCCCEEEHHHHHHHHH
DLIRRARTMRQVTVDGKRVTVHSVSFAMVKDHLHIRARKFREPVRRFAREYGISPNLVYA
HHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
VMKTESDFNPFAVSHAPAYGLMQVVPSTAGSDVYTMLNGRKGSPTPEQLFDPEINIRYGT
EEECCCCCCCEEECCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHCCCCCEEEEEE
AYLFILNNRYLSDIRHPVSREYCMIAAYNGGAGAVLRSFHENRRTAAEIINSLSPDEVYD
EEEEEECCHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RLQKRLPSMETRRYLWKVGQARKEFVAL
HHHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKKMALPLLCATLLCACSPGEAVRMARVATSGDMAGAAALARDKGIRYAMNPAQLEADLK
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCEEECCHHHHHHHHH
QLARRLQEFRDAVAGKWGKDETREAGPKEYVKYTQNYLSRASVDFDKGVVTVETVDDKSP
HHHHHHHHHHHHHCCCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCH
EKSLHSAIVTTLLTPADPRAVDMYSAGEVRLGEEPFLYNEVVDYHGKPIRWAWRAERYAS
HHHHHHHHHHHHCCCCCCCEEEEECCCCEEECCCCCHHHHHHHHCCCCEEEHHHHHHHHH
DLIRRARTMRQVTVDGKRVTVHSVSFAMVKDHLHIRARKFREPVRRFAREYGISPNLVYA
HHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEE
VMKTESDFNPFAVSHAPAYGLMQVVPSTAGSDVYTMLNGRKGSPTPEQLFDPEINIRYGT
EEECCCCCCCEEECCCCHHHHHHHHCCCCCCCEEEEECCCCCCCCHHHHCCCCCEEEEEE
AYLFILNNRYLSDIRHPVSREYCMIAAYNGGAGAVLRSFHENRRTAAEIINSLSPDEVYD
EEEEEECCHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
RLQKRLPSMETRRYLWKVGQARKEFVAL
HHHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Muramic Acid [C]

Specific reaction: Cleavage Of The Beta-1,4-Glycosidic Bond Between N-Acetylmuramic Acid And N-Acetylglucosamine Residues, Thereby Conserving The Energy In A Newly Synthesized 1,6-Anhydrobond In The Muramic Acid Residue. [C]

General reaction: Cleavage Of The Beta-1,4-Glycosidic Bond [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA