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The map label for this gene is cyp18 [H]

Identifier: 78356705

GI number: 78356705

Start: 1715674

End: 1716168

Strand: Direct

Name: cyp18 [H]

Synonym: Dde_1662

Alternate gene names: 78356705

Gene position: 1715674-1716168 (Clockwise)

Preceding gene: 78356704

Following gene: 78356706

Centisome position: 45.99

GC content: 50.51

Gene sequence:

>495_bases
ATGGTTCGTTTTGAGACTAGCATGGGTGACTTTGTTGTGGAACTTGACGCGGAAAAGGCTCCCGCCACCTGCGAAAACTT
TTTGCAGTATGTGCGTGACGGCTTTTACGATGGTACCATTTTTCACCGTGTCATGGACGGCTTCATGGTGCAGGGCGGCG
GTTTCACGGAAAATATGAAGCAGAAGGAAACCCGCGAGCCTGTACAGAACGAAGCCGATAACGGCTTGAAAAATGAAGAA
TATACCGTTGCCATGGCCCGTACGCAGGATCCGCATTCCGCCACAGCGCAGTTTTTCATTAACGTGAAGGACAATGCGTT
TCTGAATCATCGCGGAAAGTCCCTGTCCGGCTGGGGCTATGCAGTTTTCGGCAAGGTGGTTAAAGGCAAAAGCACCATTG
ACGCCATCAAGGGAGTACCTACGGGCAGCTACGGACCTTTTGAAAATGTTCCTCTGGTACCCGTTGTAATCAACAAAGCT
GTGGTCATGGACTGA

Upstream 100 bases:

>100_bases
CAGGTGATTTATGAGCCTAAGACTGTTTTTTTGCTCTTTATTAACGTTAGGCCTGCTTGTAAGCGCGGCGGGTACTGCTT
TTGCCCAAGGGGAGAAATCT

Downstream 100 bases:

>100_bases
TACCGCCCCGGCTTTGCTGCCTTGCGACTTTGCGCCTGCCGGCTTGTTCCGGCAGGCTTTTTTTTTGCGGTTGTCAGATG
TGTTTGTGTTGCAATAAGCT

Product: peptidyl-prolyl cis-trans isomerase B

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MVRFETSMGDFVVELDAEKAPATCENFLQYVRDGFYDGTIFHRVMDGFMVQGGGFTENMKQKETREPVQNEADNGLKNEE
YTVAMARTQDPHSATAQFFINVKDNAFLNHRGKSLSGWGYAVFGKVVKGKSTIDAIKGVPTGSYGPFENVPLVPVVINKA
VVMD

Sequences:

>Translated_164_residues
MVRFETSMGDFVVELDAEKAPATCENFLQYVRDGFYDGTIFHRVMDGFMVQGGGFTENMKQKETREPVQNEADNGLKNEE
YTVAMARTQDPHSATAQFFINVKDNAFLNHRGKSLSGWGYAVFGKVVKGKSTIDAIKGVPTGSYGPFENVPLVPVVINKA
VVMD
>Mature_164_residues
MVRFETSMGDFVVELDAEKAPATCENFLQYVRDGFYDGTIFHRVMDGFMVQGGGFTENMKQKETREPVQNEADNGLKNEE
YTVAMARTQDPHSATAQFFINVKDNAFLNHRGKSLSGWGYAVFGKVVKGKSTIDAIKGVPTGSYGPFENVPLVPVVINKA
VVMD

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=161, Percent_Identity=31.055900621118, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI22547215, Length=140, Percent_Identity=32.1428571428571, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI22547212, Length=140, Percent_Identity=32.1428571428571, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI7657473, Length=140, Percent_Identity=32.1428571428571, Blast_Score=76, Evalue=1e-14,
Organism=Homo sapiens, GI7706339, Length=155, Percent_Identity=29.6774193548387, Blast_Score=74, Evalue=4e-14,
Organism=Homo sapiens, GI24308049, Length=157, Percent_Identity=30.5732484076433, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI64276486, Length=129, Percent_Identity=35.6589147286822, Blast_Score=67, Evalue=5e-12,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=59.8765432098765, Blast_Score=201, Evalue=2e-53,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=57.4074074074074, Blast_Score=189, Evalue=6e-50,
Organism=Caenorhabditis elegans, GI17532641, Length=163, Percent_Identity=30.6748466257669, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71980594, Length=160, Percent_Identity=31.875, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71980590, Length=140, Percent_Identity=33.5714285714286, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=161, Percent_Identity=29.1925465838509, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17506311, Length=159, Percent_Identity=30.188679245283, Blast_Score=64, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17532643, Length=160, Percent_Identity=31.25, Blast_Score=64, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71997782, Length=129, Percent_Identity=33.3333333333333, Blast_Score=63, Evalue=7e-11,
Organism=Drosophila melanogaster, GI17986117, Length=163, Percent_Identity=29.4478527607362, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19922912, Length=160, Percent_Identity=30.625, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24652460, Length=141, Percent_Identity=26.9503546099291, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI19922376, Length=163, Percent_Identity=24.5398773006135, Blast_Score=63, Evalue=1e-10,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 18155; Mature: 18155

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVRFETSMGDFVVELDAEKAPATCENFLQYVRDGFYDGTIFHRVMDGFMVQGGGFTENMK
CEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCEEECCCCCCCHHH
QKETREPVQNEADNGLKNEEYTVAMARTQDPHSATAQFFINVKDNAFLNHRGKSLSGWGY
HHHHHCHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCEEECCCCCCCCCCCH
AVFGKVVKGKSTIDAIKGVPTGSYGPFENVPLVPVVINKAVVMD
HHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCEEHHEECEEEECC
>Mature Secondary Structure
MVRFETSMGDFVVELDAEKAPATCENFLQYVRDGFYDGTIFHRVMDGFMVQGGGFTENMK
CEEEECCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHCEEECCCCCCCHHH
QKETREPVQNEADNGLKNEEYTVAMARTQDPHSATAQFFINVKDNAFLNHRGKSLSGWGY
HHHHHCHHHHHHCCCCCCCCEEEEEECCCCCCCCEEEEEEEECCCEEECCCCCCCCCCCH
AVFGKVVKGKSTIDAIKGVPTGSYGPFENVPLVPVVINKAVVMD
HHHHHHHCCCHHHHHHHCCCCCCCCCCCCCCEEHHEECEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]