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The map label for this gene is guaB [H]

Identifier: 78356516

GI number: 78356516

Start: 1491583

End: 1493040

Strand: Reverse

Name: guaB [H]

Synonym: Dde_1471

Alternate gene names: 78356516

Gene position: 1493040-1491583 (Counterclockwise)

Preceding gene: 78356518

Following gene: 78356515

Centisome position: 40.03

GC content: 57.61

Gene sequence:

>1458_bases
ATGGGCACGATTCTTGGCAAAGCTCTGACATTTGACGATGTGCTGCTTGTCCCCGGCTACTCCGAGATCACGCCGGATCA
GGTGGACGTTTCCACCATGCTGACCGCGCAGATCAAGCTGAACATCCCGCTTATCAGCGCCGCCATGGACACCGTTACAG
AGTCTGCCATGGCCATCTCCATGGCGCGTAACGGCGGTGTGGGCGTCATCCACAAAAACATGACCATCGACGAGCAGCGG
CTTGAAATCGAAAAGGTCAAAAAATCGGAAAGCGGCATGATCATCGATCCGGTGACCATAGCCCCCGACTACACTGTGGC
GCAGGCGCTGCAGATCATGCGCGAATACCGCGTTTCCGGTCTGCCCGTTGTTAAAGACGCCGAACTGGTGGGCATACTGA
CCAACCGCGATGTGCGTTTTGTCACCGATCTTGAAGGCACCAGAGTGCACGAAGTGATGACCAGCGAAGAACTGGTAACC
GTGCCGGTGGGAACCACCCTGGATGAAGCCCGCCATCACCTGCATGAACACCGCATCGAAAAATTGCTTGTGGTTGATGA
GAACAACAGACTCAAGGGTCTCATCACCATGAAAGACATCGACAAGGTGCAGAAATACCCGCAGGCATGCAAAGACGACA
AAGGCCGTCTGCGTGTCGGTGCCGCCATCGGTGTGGGCGGCGAATGCGAAGCCCGCGCACAGGCCCTGCTCGGGGCCGGA
GCCGACTTCCTCGTTCTTGATTCTGCCCACGGGCATTCGCAGAACATCCTCAAAACCGTGGAAATGGTGAAAAACACCTT
CCCCGATTGCCAGCTTATCGCAGGTAACGTGGCTTCCTACGAAGGCGCCAAGGCGCTTTTCAAGGCAGGAGCCGACACTG
TGAAAGTAGGCATCGGCCCCGGTTCCATCTGCACCACGCGTATCGTGGCCGGTGTGGGCGTGCCCCAGATCACGGCCATC
ATGGAAGCCGTGCGTGCCGCCAGAGAATTCGGCCGCCACATCATTGCGGACGGCGGCATCAAATACTCCGGCGACATTGT
CAAAGCCCTTGCCGTGGGTGCCAACACCGTCATGCTGGGTTCGCTGCTGGCAGGCACCGAGGAAAGCCCGGGTGAAACCG
TGCTCTATCAGGGCCGCACCTACAAAATCTACCGCGGCATGGGATCCATCGACGCCATGAAGGACGGCAGCTCCGACCGC
TACTTCCAGGAAAAGACCAAAAAACTGGTTCCCGAAGGCATCGTGGGACGTGTGCCCTACCGCGGACATGTGGGCGACAC
GGTCTTTCAGCTGGTGGGCGGACTGCGTTCCGGTATGGGATACACCGGCGCGGCCACCATTGCAGAACTGGATGAAAAAG
CACAGATGGTGCAGATTTCCGTTGCGGGTCTTCGTGAATCACACGTGCACGACGTGATCATCACCAAAGAAGCCCCCAAC
TATAACATGGACAAGTAA

Upstream 100 bases:

>100_bases
GATTTTAGACCGTTTCTTCCTCCACGGAAGCACGGCTCAGCGCAGACGGCGGCCTGCTTAAGGGCCGGCCGTCTGACGGA
AACCTGTTTGGAGAAATATC

Downstream 100 bases:

>100_bases
TCAACCGTCCCAAACGGAGCGCGTAACGCACGCCCCGGAGGAATAGAATGGAAAAGCAGAACAAAGTCATTATCGTGGAC
TACGGTTCGCAGGTTACGCA

Product: inosine-5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 485; Mature: 484

Protein sequence:

>485_residues
MGTILGKALTFDDVLLVPGYSEITPDQVDVSTMLTAQIKLNIPLISAAMDTVTESAMAISMARNGGVGVIHKNMTIDEQR
LEIEKVKKSESGMIIDPVTIAPDYTVAQALQIMREYRVSGLPVVKDAELVGILTNRDVRFVTDLEGTRVHEVMTSEELVT
VPVGTTLDEARHHLHEHRIEKLLVVDENNRLKGLITMKDIDKVQKYPQACKDDKGRLRVGAAIGVGGECEARAQALLGAG
ADFLVLDSAHGHSQNILKTVEMVKNTFPDCQLIAGNVASYEGAKALFKAGADTVKVGIGPGSICTTRIVAGVGVPQITAI
MEAVRAAREFGRHIIADGGIKYSGDIVKALAVGANTVMLGSLLAGTEESPGETVLYQGRTYKIYRGMGSIDAMKDGSSDR
YFQEKTKKLVPEGIVGRVPYRGHVGDTVFQLVGGLRSGMGYTGAATIAELDEKAQMVQISVAGLRESHVHDVIITKEAPN
YNMDK

Sequences:

>Translated_485_residues
MGTILGKALTFDDVLLVPGYSEITPDQVDVSTMLTAQIKLNIPLISAAMDTVTESAMAISMARNGGVGVIHKNMTIDEQR
LEIEKVKKSESGMIIDPVTIAPDYTVAQALQIMREYRVSGLPVVKDAELVGILTNRDVRFVTDLEGTRVHEVMTSEELVT
VPVGTTLDEARHHLHEHRIEKLLVVDENNRLKGLITMKDIDKVQKYPQACKDDKGRLRVGAAIGVGGECEARAQALLGAG
ADFLVLDSAHGHSQNILKTVEMVKNTFPDCQLIAGNVASYEGAKALFKAGADTVKVGIGPGSICTTRIVAGVGVPQITAI
MEAVRAAREFGRHIIADGGIKYSGDIVKALAVGANTVMLGSLLAGTEESPGETVLYQGRTYKIYRGMGSIDAMKDGSSDR
YFQEKTKKLVPEGIVGRVPYRGHVGDTVFQLVGGLRSGMGYTGAATIAELDEKAQMVQISVAGLRESHVHDVIITKEAPN
YNMDK
>Mature_484_residues
GTILGKALTFDDVLLVPGYSEITPDQVDVSTMLTAQIKLNIPLISAAMDTVTESAMAISMARNGGVGVIHKNMTIDEQRL
EIEKVKKSESGMIIDPVTIAPDYTVAQALQIMREYRVSGLPVVKDAELVGILTNRDVRFVTDLEGTRVHEVMTSEELVTV
PVGTTLDEARHHLHEHRIEKLLVVDENNRLKGLITMKDIDKVQKYPQACKDDKGRLRVGAAIGVGGECEARAQALLGAGA
DFLVLDSAHGHSQNILKTVEMVKNTFPDCQLIAGNVASYEGAKALFKAGADTVKVGIGPGSICTTRIVAGVGVPQITAIM
EAVRAAREFGRHIIADGGIKYSGDIVKALAVGANTVMLGSLLAGTEESPGETVLYQGRTYKIYRGMGSIDAMKDGSSDRY
FQEKTKKLVPEGIVGRVPYRGHVGDTVFQLVGGLRSGMGYTGAATIAELDEKAQMVQISVAGLRESHVHDVIITKEAPNY
NMDK

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=453, Percent_Identity=42.1633554083885, Blast_Score=338, Evalue=6e-93,
Organism=Homo sapiens, GI217035146, Length=450, Percent_Identity=42.8888888888889, Blast_Score=338, Evalue=7e-93,
Organism=Homo sapiens, GI156616279, Length=450, Percent_Identity=42.8888888888889, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI34328930, Length=450, Percent_Identity=42.8888888888889, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI34328928, Length=450, Percent_Identity=42.8888888888889, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI217035152, Length=446, Percent_Identity=42.8251121076233, Blast_Score=331, Evalue=7e-91,
Organism=Homo sapiens, GI217035148, Length=450, Percent_Identity=42, Blast_Score=325, Evalue=4e-89,
Organism=Homo sapiens, GI217035150, Length=450, Percent_Identity=40.2222222222222, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI50541954, Length=218, Percent_Identity=41.2844036697248, Blast_Score=170, Evalue=4e-42,
Organism=Homo sapiens, GI50541952, Length=218, Percent_Identity=41.2844036697248, Blast_Score=170, Evalue=4e-42,
Organism=Homo sapiens, GI50541948, Length=218, Percent_Identity=41.2844036697248, Blast_Score=170, Evalue=4e-42,
Organism=Homo sapiens, GI50541956, Length=218, Percent_Identity=41.2844036697248, Blast_Score=169, Evalue=4e-42,
Organism=Homo sapiens, GI156104880, Length=218, Percent_Identity=39.4495412844037, Blast_Score=169, Evalue=5e-42,
Organism=Escherichia coli, GI1788855, Length=486, Percent_Identity=55.9670781893004, Blast_Score=491, Evalue=1e-140,
Organism=Escherichia coli, GI1786293, Length=223, Percent_Identity=39.0134529147982, Blast_Score=161, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI71994385, Length=471, Percent_Identity=36.3057324840764, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71994389, Length=419, Percent_Identity=38.1861575178998, Blast_Score=268, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI17560440, Length=237, Percent_Identity=37.1308016877637, Blast_Score=171, Evalue=1e-42,
Organism=Saccharomyces cerevisiae, GI6323585, Length=458, Percent_Identity=41.2663755458515, Blast_Score=328, Evalue=1e-90,
Organism=Saccharomyces cerevisiae, GI6322012, Length=458, Percent_Identity=41.0480349344978, Blast_Score=322, Evalue=1e-88,
Organism=Saccharomyces cerevisiae, GI6323464, Length=458, Percent_Identity=41.4847161572052, Blast_Score=318, Evalue=2e-87,
Organism=Saccharomyces cerevisiae, GI6319352, Length=338, Percent_Identity=41.1242603550296, Blast_Score=242, Evalue=1e-64,
Organism=Saccharomyces cerevisiae, GI6319353, Length=116, Percent_Identity=42.2413793103448, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24641071, Length=455, Percent_Identity=41.0989010989011, Blast_Score=332, Evalue=5e-91,
Organism=Drosophila melanogaster, GI24641073, Length=455, Percent_Identity=41.0989010989011, Blast_Score=332, Evalue=5e-91,
Organism=Drosophila melanogaster, GI28571163, Length=412, Percent_Identity=41.0194174757282, Blast_Score=290, Evalue=2e-78,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52097; Mature: 51966

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGTILGKALTFDDVLLVPGYSEITPDQVDVSTMLTAQIKLNIPLISAAMDTVTESAMAIS
CCCCCCCEECCCCEEEECCCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHEEE
MARNGGVGVIHKNMTIDEQRLEIEKVKKSESGMIIDPVTIAPDYTVAQALQIMREYRVSG
EECCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEECEEECCCHHHHHHHHHHHHHCCCC
LPVVKDAELVGILTNRDVRFVTDLEGTRVHEVMTSEELVTVPVGTTLDEARHHLHEHRIE
CCEEECCEEEEEEECCCEEEEECCCCCCHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHH
KLLVVDENNRLKGLITMKDIDKVQKYPQACKDDKGRLRVGAAIGVGGECEARAQALLGAG
EEEEEECCCCEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHCCC
ADFLVLDSAHGHSQNILKTVEMVKNTFPDCQLIAGNVASYEGAKALFKAGADTVKVGIGP
CCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHCCCCEEEEECCC
GSICTTRIVAGVGVPQITAIMEAVRAAREFGRHIIADGGIKYSGDIVKALAVGANTVMLG
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEECCCEEECCHHHHHHHHCCCHHHHH
SLLAGTEESPGETVLYQGRTYKIYRGMGSIDAMKDGSSDRYFQEKTKKLVPEGIVGRVPY
HHHCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
RGHVGDTVFQLVGGLRSGMGYTGAATIAELDEKAQMVQISVAGLRESHVHDVIITKEAPN
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEECCCC
YNMDK
CCCCC
>Mature Secondary Structure 
GTILGKALTFDDVLLVPGYSEITPDQVDVSTMLTAQIKLNIPLISAAMDTVTESAMAIS
CCCCCCEECCCCEEEECCCCCCCCCCCCCEEEEEEEEEECCCHHHHHHHHHHHHHHEEE
MARNGGVGVIHKNMTIDEQRLEIEKVKKSESGMIIDPVTIAPDYTVAQALQIMREYRVSG
EECCCCEEEEECCCCCCHHHHHHHHHHCCCCCEEEECEEECCCHHHHHHHHHHHHHCCCC
LPVVKDAELVGILTNRDVRFVTDLEGTRVHEVMTSEELVTVPVGTTLDEARHHLHEHRIE
CCEEECCEEEEEEECCCEEEEECCCCCCHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHH
KLLVVDENNRLKGLITMKDIDKVQKYPQACKDDKGRLRVGAAIGVGGECEARAQALLGAG
EEEEEECCCCEEEEEEHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHCCC
ADFLVLDSAHGHSQNILKTVEMVKNTFPDCQLIAGNVASYEGAKALFKAGADTVKVGIGP
CCEEEEECCCCCHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHCCCCEEEEECCC
GSICTTRIVAGVGVPQITAIMEAVRAAREFGRHIIADGGIKYSGDIVKALAVGANTVMLG
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCEEEECCCEEECCHHHHHHHHCCCHHHHH
SLLAGTEESPGETVLYQGRTYKIYRGMGSIDAMKDGSSDRYFQEKTKKLVPEGIVGRVPY
HHHCCCCCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCC
RGHVGDTVFQLVGGLRSGMGYTGAATIAELDEKAQMVQISVAGLRESHVHDVIITKEAPN
CCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCEEEEEEECCCC
YNMDK
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]