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The map label for this gene is guaA

Identifier: 78356515

GI number: 78356515

Start: 1489985

End: 1491535

Strand: Reverse

Name: guaA

Synonym: Dde_1470

Alternate gene names: 78356515

Gene position: 1491535-1489985 (Counterclockwise)

Preceding gene: 78356516

Following gene: 78356514

Centisome position: 39.99

GC content: 58.61

Gene sequence:

>1551_bases
ATGGAAAAGCAGAACAAAGTCATTATCGTGGACTACGGTTCGCAGGTTACGCAGCTGATCGCTCGCCGTATCCGCGAGGC
CGGTGTCTATTCCGAAATTCATCCCTGCATCGTCACTGCCGCAGAAGTAGCCGCCATGTCTCCTTCGGCTGTAGTGCTTT
CCGGCGGACCCGCCAGCGTGCTGGGCGAAGATTCCCCCGCGCTGGACAAAGGCCTGCTGGAACTCGGCGTGCCGGTTCTG
GGCATCTGCTACGGCATGCAGCTGCTTGCGCACAATCTGGGCGGAGAGCTTTCCTGCTCCGAAACCCGCGAATACGGCCC
CGCCGACCTGAAGTTCTGCGCCGGAAGCCCCCTGTGGGACGGCCTGAAAACAGATGAATCATCACGGGTATGGATGTCGC
ACGGTGACAGAGTGAAAAAAGTGCCCGCCGGATTTACGGTGACCGGCAGCACCGAAACACTGGAAGTGGCCGCCATGGCC
GACGACCAGCGCCGCATCTATGCCGTGCAGTTCCACCCCGAAGTCCATCACTCCGAAGACGGCGTGCGCATGCTGCACAA
CTTCCTGTTTAAAATTGCAGGAATCAAGGCTGACTGGTCCATGTCCTCTTTCTGCGAGCGGGTGATAAAAGAAGTCTCCG
AGCAGGTAGGCCCCGACGATCAGGTGGTCTGCGCTCTTTCGGGCGGCATAGACTCCACCGTGGTTGCCGTGCTGCTGCAC
AAGGCCATCGGCCACCGCCTGCACTGCATCTTTGTGGACAACGGAGTGCTGCGCCTGAATGAAGTTGATGAAGTTTCCGG
CTATCTGCGCGAACACTTCGACCTCAACCTGACGGTTGTAGACGCCCGCGAACGCTTTATGAAGCAGTTTGCCGGAGTCG
AAGACCCCGAAAAGAAACGTAAGATCATCGGCTACACCTTCATCGACGTGTTCGATGAAGAGTCGCAGAAAATTCCCAAC
GTGAAGTATCTCGCGCAGGGCACGCTGTACCCCGATGTCATTGAATCCATATCGCACAAGGGCCCTTCGGCCGTCATCAA
AAGCCACCACAACGTGGGCGGCCTGCCCGAAACCATGAAACTCAAGCTCATCGAGCCGCTGCGCGAACTCTTCAAGGACG
AAGTGCGCAAGCTGGCCGTGGAACTCGGCCTGCCCGACTTCATTGTCTGGCGCCATCCCTTCCCCGGTCCCGGCCTTGCC
ATACGCGTCATCGGCGAGGTAACGGAAGAGCGTCTGGACATCCTGCGCAAAGCTGACAAAATCGTTCAGAATGAGTTGAC
GGCGTCTGGCTGGTATCGCAAAGTGTGGCAGGGCTTTGCCGTACTGCTGCCGTTAAAGACGGTCGGTGTCATGGGCGATG
ACCGCACCTACGAGCACGTCATAGCCCTGCGCGTGGTGGACAGTGTCGACGCCATGACCGCAGACTGGGTGCGGCTGCCC
TCCGAAGTGCTGGAGCGCATCTCCAGCCGCATCATCAACGAGGTCAAAGGCGTCAACCGCGTGGTTTACGACATATCCTC
GAAGCCGCCCAGCACCATCGAGTGGGAATAA

Upstream 100 bases:

>100_bases
TGCACGACGTGATCATCACCAAAGAAGCCCCCAACTATAACATGGACAAGTAATCAACCGTCCCAAACGGAGCGCGTAAC
GCACGCCCCGGAGGAATAGA

Downstream 100 bases:

>100_bases
GGGCGGGTAACAAGCTGAAAAGGCGGATACCAGACTATGTTCGGCATCGGAACTACGGAACTCCTTGTTATCCTTGTTGT
TGCTCTTATCGTTCTCGGCC

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 516; Mature: 516

Protein sequence:

>516_residues
MEKQNKVIIVDYGSQVTQLIARRIREAGVYSEIHPCIVTAAEVAAMSPSAVVLSGGPASVLGEDSPALDKGLLELGVPVL
GICYGMQLLAHNLGGELSCSETREYGPADLKFCAGSPLWDGLKTDESSRVWMSHGDRVKKVPAGFTVTGSTETLEVAAMA
DDQRRIYAVQFHPEVHHSEDGVRMLHNFLFKIAGIKADWSMSSFCERVIKEVSEQVGPDDQVVCALSGGIDSTVVAVLLH
KAIGHRLHCIFVDNGVLRLNEVDEVSGYLREHFDLNLTVVDARERFMKQFAGVEDPEKKRKIIGYTFIDVFDEESQKIPN
VKYLAQGTLYPDVIESISHKGPSAVIKSHHNVGGLPETMKLKLIEPLRELFKDEVRKLAVELGLPDFIVWRHPFPGPGLA
IRVIGEVTEERLDILRKADKIVQNELTASGWYRKVWQGFAVLLPLKTVGVMGDDRTYEHVIALRVVDSVDAMTADWVRLP
SEVLERISSRIINEVKGVNRVVYDISSKPPSTIEWE

Sequences:

>Translated_516_residues
MEKQNKVIIVDYGSQVTQLIARRIREAGVYSEIHPCIVTAAEVAAMSPSAVVLSGGPASVLGEDSPALDKGLLELGVPVL
GICYGMQLLAHNLGGELSCSETREYGPADLKFCAGSPLWDGLKTDESSRVWMSHGDRVKKVPAGFTVTGSTETLEVAAMA
DDQRRIYAVQFHPEVHHSEDGVRMLHNFLFKIAGIKADWSMSSFCERVIKEVSEQVGPDDQVVCALSGGIDSTVVAVLLH
KAIGHRLHCIFVDNGVLRLNEVDEVSGYLREHFDLNLTVVDARERFMKQFAGVEDPEKKRKIIGYTFIDVFDEESQKIPN
VKYLAQGTLYPDVIESISHKGPSAVIKSHHNVGGLPETMKLKLIEPLRELFKDEVRKLAVELGLPDFIVWRHPFPGPGLA
IRVIGEVTEERLDILRKADKIVQNELTASGWYRKVWQGFAVLLPLKTVGVMGDDRTYEHVIALRVVDSVDAMTADWVRLP
SEVLERISSRIINEVKGVNRVVYDISSKPPSTIEWE
>Mature_516_residues
MEKQNKVIIVDYGSQVTQLIARRIREAGVYSEIHPCIVTAAEVAAMSPSAVVLSGGPASVLGEDSPALDKGLLELGVPVL
GICYGMQLLAHNLGGELSCSETREYGPADLKFCAGSPLWDGLKTDESSRVWMSHGDRVKKVPAGFTVTGSTETLEVAAMA
DDQRRIYAVQFHPEVHHSEDGVRMLHNFLFKIAGIKADWSMSSFCERVIKEVSEQVGPDDQVVCALSGGIDSTVVAVLLH
KAIGHRLHCIFVDNGVLRLNEVDEVSGYLREHFDLNLTVVDARERFMKQFAGVEDPEKKRKIIGYTFIDVFDEESQKIPN
VKYLAQGTLYPDVIESISHKGPSAVIKSHHNVGGLPETMKLKLIEPLRELFKDEVRKLAVELGLPDFIVWRHPFPGPGLA
IRVIGEVTEERLDILRKADKIVQNELTASGWYRKVWQGFAVLLPLKTVGVMGDDRTYEHVIALRVVDSVDAMTADWVRLP
SEVLERISSRIINEVKGVNRVVYDISSKPPSTIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=553, Percent_Identity=36.7088607594937, Blast_Score=293, Evalue=2e-79,
Organism=Escherichia coli, GI1788854, Length=520, Percent_Identity=52.1153846153846, Blast_Score=557, Evalue=1e-160,
Organism=Escherichia coli, GI1789760, Length=155, Percent_Identity=30.9677419354839, Blast_Score=66, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI71992710, Length=573, Percent_Identity=34.9040139616056, Blast_Score=287, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI71992717, Length=573, Percent_Identity=34.9040139616056, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI133901714, Length=573, Percent_Identity=34.9040139616056, Blast_Score=286, Evalue=2e-77,
Organism=Saccharomyces cerevisiae, GI6323873, Length=518, Percent_Identity=51.9305019305019, Blast_Score=549, Evalue=1e-157,
Organism=Drosophila melanogaster, GI281365319, Length=552, Percent_Identity=35.1449275362319, Blast_Score=284, Evalue=9e-77,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_DESDG (Q311X7)

Other databases:

- EMBL:   CP000112
- RefSeq:   YP_387964.1
- ProteinModelPortal:   Q311X7
- SMR:   Q311X7
- STRING:   Q311X7
- GeneID:   3756062
- GenomeReviews:   CP000112_GR
- KEGG:   dde:Dde_1470
- NMPDR:   fig|207559.3.peg.677
- eggNOG:   COG0519
- HOGENOM:   HBG391775
- OMA:   MKLVEPL
- ProtClustDB:   PRK00074
- BioCyc:   DDES207559:DDE_1470-MONOMER
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001962
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C

EC number: =6.3.5.2

Molecular weight: Translated: 57224; Mature: 57224

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 83-83 ACT_SITE 172-172 ACT_SITE 174-174

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKQNKVIIVDYGSQVTQLIARRIREAGVYSEIHPCIVTAAEVAAMSPSAVVLSGGPASV
CCCCCCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
LGEDSPALDKGLLELGVPVLGICYGMQLLAHNLGGELSCSETREYGPADLKFCAGSPLWD
CCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEECCCCCCC
GLKTDESSRVWMSHGDRVKKVPAGFTVTGSTETLEVAAMADDQRRIYAVQFHPEVHHSED
CCCCCCCCEEECCCCCCEEECCCCEEEECCCCEEEEEEECCCCCEEEEEEECCCCCCCCH
GVRMLHNFLFKIAGIKADWSMSSFCERVIKEVSEQVGPDDQVVCALSGGIDSTVVAVLLH
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHH
KAIGHRLHCIFVDNGVLRLNEVDEVSGYLREHFDLNLTVVDARERFMKQFAGVEDPEKKR
HHHCCEEEEEEECCCEEEECCHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCCCCHHHH
KIIGYTFIDVFDEESQKIPNVKYLAQGTLYPDVIESISHKGPSAVIKSHHNVGGLPETMK
HEEEEHEEEEECCHHHCCCCEEEEECCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCHHHH
LKLIEPLRELFKDEVRKLAVELGLPDFIVWRHPFPGPGLAIRVIGEVTEERLDILRKADK
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
IVQNELTASGWYRKVWQGFAVLLPLKTVGVMGDDRTYEHVIALRVVDSVDAMTADWVRLP
HHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCH
SEVLERISSRIINEVKGVNRVVYDISSKPPSTIEWE
HHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC
>Mature Secondary Structure
MEKQNKVIIVDYGSQVTQLIARRIREAGVYSEIHPCIVTAAEVAAMSPSAVVLSGGPASV
CCCCCCEEEEECCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCC
LGEDSPALDKGLLELGVPVLGICYGMQLLAHNLGGELSCSETREYGPADLKFCAGSPLWD
CCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCEEEECCCCCCC
GLKTDESSRVWMSHGDRVKKVPAGFTVTGSTETLEVAAMADDQRRIYAVQFHPEVHHSED
CCCCCCCCEEECCCCCCEEECCCCEEEECCCCEEEEEEECCCCCEEEEEEECCCCCCCCH
GVRMLHNFLFKIAGIKADWSMSSFCERVIKEVSEQVGPDDQVVCALSGGIDSTVVAVLLH
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHH
KAIGHRLHCIFVDNGVLRLNEVDEVSGYLREHFDLNLTVVDARERFMKQFAGVEDPEKKR
HHHCCEEEEEEECCCEEEECCHHHHHHHHHHHCCCEEEEECHHHHHHHHHCCCCCCHHHH
KIIGYTFIDVFDEESQKIPNVKYLAQGTLYPDVIESISHKGPSAVIKSHHNVGGLPETMK
HEEEEHEEEEECCHHHCCCCEEEEECCCCCHHHHHHHCCCCCHHHHHCCCCCCCCCHHHH
LKLIEPLRELFKDEVRKLAVELGLPDFIVWRHPFPGPGLAIRVIGEVTEERLDILRKADK
HHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEHHHHHHHHHHHHHHHHHH
IVQNELTASGWYRKVWQGFAVLLPLKTVGVMGDDRTYEHVIALRVVDSVDAMTADWVRLP
HHHHHHHHHHHHHHHHCCCEEEEEHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCH
SEVLERISSRIINEVKGVNRVVYDISSKPPSTIEWE
HHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA