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The map label for this gene is dut [H]

Identifier: 78356470

GI number: 78356470

Start: 1451644

End: 1452153

Strand: Direct

Name: dut [H]

Synonym: Dde_1425

Alternate gene names: 78356470

Gene position: 1451644-1452153 (Clockwise)

Preceding gene: 78356466

Following gene: 78356471

Centisome position: 38.92

GC content: 62.35

Gene sequence:

>510_bases
GTGAGCAAAACAGACGATCAGGGCTGTGTCCAGCCCCGTATAGCCGTCCGCTTCAGGTATATGGGCAACGCGCAGGAGTT
GTATGAAAACGGTGAAGCCGGGGATGCGCCGCAGTACGCCACCCCCTGTTCCGCCGGGCTTGACCTGCGGGCCTGTATGG
AAAGCGACGAGGCTGTCATTCCTGCCGGAGGGCGGCTGGCGATACCCGCGGGCATCGCCGTGGAGCCCATGGTGCAGGGC
GTGGCCGGATTTGTGTATTCGCGCAGCGGGCTGGGAACCAAAAAAGGGCTTACTGTCAGTCAGGGCGTGGGGGTCATCGA
TCCGGACTACCGCGGCGAAATCATTGTGTCATTGCTGAACACCTCGGGCGGGGAACAGCGGCTGCGACGAGGCGAGCGTA
TCGCGCAGCTTGTGTTTCAGCCTTTCTTTCAGGCCGAACTGCAGCAGGTTGCAGAGCTGGGCGATACGCAGCGCGGAACC
GGCGGCTTCGGTCATACGGGACGTATCTGA

Upstream 100 bases:

>100_bases
AGATTTTGACTTGCCTTGCCGAGTGTCATAACACTTTCTTTTCCGTGCTGCCTTTCGGGCTGCACGGTAGTGTGCAATTA
CCCTTCATCAGGAGCATTCT

Downstream 100 bases:

>100_bases
TCCCGTCTTTTTCTCAGCTTTTTTCCGGCACAGGAGTGCATTGCAATGACTACGTTCGATGAATTGAAACAGCGTGAAGA
ATCTCTGCTCTGCAGAACAT

Product: deoxyuridine 5'-triphosphate nucleotidohydrolase

Products: NA

Alternate protein names: dUTPase; dUTP pyrophosphatase [H]

Number of amino acids: Translated: 169; Mature: 168

Protein sequence:

>169_residues
MSKTDDQGCVQPRIAVRFRYMGNAQELYENGEAGDAPQYATPCSAGLDLRACMESDEAVIPAGGRLAIPAGIAVEPMVQG
VAGFVYSRSGLGTKKGLTVSQGVGVIDPDYRGEIIVSLLNTSGGEQRLRRGERIAQLVFQPFFQAELQQVAELGDTQRGT
GGFGHTGRI

Sequences:

>Translated_169_residues
MSKTDDQGCVQPRIAVRFRYMGNAQELYENGEAGDAPQYATPCSAGLDLRACMESDEAVIPAGGRLAIPAGIAVEPMVQG
VAGFVYSRSGLGTKKGLTVSQGVGVIDPDYRGEIIVSLLNTSGGEQRLRRGERIAQLVFQPFFQAELQQVAELGDTQRGT
GGFGHTGRI
>Mature_168_residues
SKTDDQGCVQPRIAVRFRYMGNAQELYENGEAGDAPQYATPCSAGLDLRACMESDEAVIPAGGRLAIPAGIAVEPMVQGV
AGFVYSRSGLGTKKGLTVSQGVGVIDPDYRGEIIVSLLNTSGGEQRLRRGERIAQLVFQPFFQAELQQVAELGDTQRGTG
GFGHTGRI

Specific function: This enzyme is involved in nucleotide metabolism:it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA [H]

COG id: COG0756

COG function: function code F; dUTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dUTPase family [H]

Homologues:

Organism=Homo sapiens, GI70906444, Length=142, Percent_Identity=36.6197183098592, Blast_Score=81, Evalue=4e-16,
Organism=Homo sapiens, GI4503423, Length=142, Percent_Identity=36.6197183098592, Blast_Score=81, Evalue=5e-16,
Organism=Homo sapiens, GI70906441, Length=142, Percent_Identity=36.6197183098592, Blast_Score=79, Evalue=2e-15,
Organism=Escherichia coli, GI1790071, Length=132, Percent_Identity=43.1818181818182, Blast_Score=111, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71988561, Length=168, Percent_Identity=36.9047619047619, Blast_Score=91, Evalue=3e-19,
Organism=Saccharomyces cerevisiae, GI6319729, Length=133, Percent_Identity=36.0902255639098, Blast_Score=71, Evalue=7e-14,
Organism=Drosophila melanogaster, GI19921126, Length=131, Percent_Identity=38.1679389312977, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24583610, Length=131, Percent_Identity=38.1679389312977, Blast_Score=80, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008180
- InterPro:   IPR008181 [H]

Pfam domain/function: PF00692 dUTPase [H]

EC number: =3.6.1.23 [H]

Molecular weight: Translated: 17964; Mature: 17832

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTDDQGCVQPRIAVRFRYMGNAQELYENGEAGDAPQYATPCSAGLDLRACMESDEAVI
CCCCCCCCCCCCEEEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEE
PAGGRLAIPAGIAVEPMVQGVAGFVYSRSGLGTKKGLTVSQGVGVIDPDYRGEIIVSLLN
CCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
TSGGEQRLRRGERIAQLVFQPFFQAELQQVAELGDTQRGTGGFGHTGRI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SKTDDQGCVQPRIAVRFRYMGNAQELYENGEAGDAPQYATPCSAGLDLRACMESDEAVI
CCCCCCCCCCCEEEEEEEECCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCEEE
PAGGRLAIPAGIAVEPMVQGVAGFVYSRSGLGTKKGLTVSQGVGVIDPDYRGEIIVSLLN
CCCCCEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECC
TSGGEQRLRRGERIAQLVFQPFFQAELQQVAELGDTQRGTGGFGHTGRI
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA