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The map label for this gene is ddc [H]

Identifier: 78356171

GI number: 78356171

Start: 1154829

End: 1156304

Strand: Reverse

Name: ddc [H]

Synonym: Dde_1124

Alternate gene names: 78356171

Gene position: 1156304-1154829 (Counterclockwise)

Preceding gene: 78356172

Following gene: 78356170

Centisome position: 31.0

GC content: 60.84

Gene sequence:

>1476_bases
ATGACCCGGAAACAATTCGAGACGCTTGATCTCGATAATCTGGAGCAGAATCTCCAGCAGGCCGCGGAACTGATAGCCGG
ACGCATCAGGGCCATTGCCTGCGACCCTGTGAAACAGAATATCAGCTTTGAAGAACTGGCAGCCATCATTCCGTGCGACC
TGCCGGATGAAGGCCATGGCCCTGAAGCCGTCATAGGTGAAGTGGCGCGGCATATCGAGCCATATTCCACCCGCATCGGC
CATCCCCGTTTTCTGGCATGGATAACCACCAGCCCCGGACCGGCAGGAACCATAGGCGACATGCTGTGTACCGGCCTTAA
TCAGGCTCCGCTGAGCTTCAAGGGCGGACCGGCCGCAACCGTGCTGGAAGAGATTGTTCTCGGCTGGTTTGCCGGCATGT
TCGGCATGCCTGAAGGATGGGGCGGCACCATTGTCAGCGGCGGCACCATGGCCAATCTCATGGGGCTTACCGTGGCACGG
CGCGTCCACGCTCCGCAGGTGCATGCCCGCGGCATGCAGGGGCTTGAACGGCCGCTGGTGCTGTATGTTTCCGATCAGGG
GCACATGTCGGTCACCCGCTCGGCCGTGCTGCTGGGCATCGGCGAAGACAACGTGCGCGCCGTTCCCAGTGACAGTGCCT
GCCGCATGATACCGCACGAACTGGAAAAAGCCGTACAGCAGGACCGCAGGGCCGGACGGCTGCCGTTCTGCGTTGTGGCG
CAGGCGGGCAGCGTCACCACGGGTGCCGTGGATCCGTTGCCGGACATTGCCGCCATCTGCCGCCGCGAAAACATGTGGAT
GCACGTGGATGCCGCATACGGCGGTGCCGTGATGCTGGCCGACGAACTGCGCCCGCTGCTGGCCGGCATCGAACTGGCCG
ATTCTGTCTGCGTTGATCCGCACAAATGGTTTTTTGTACCGCTGGAATGCGGCATAACCCTTTTCCGCAGCAGAGAACAA
CAGCTGGAAACATTCCGTGCAAAGGCAGCTTATCTGGGGGCTGAAAATCCCCATGACCTTAAAAACACCACGTTTATCCT
TTCGCGCGCCAACAGGGCCCTGAAAGTCTGGTTCGCCTTCCGCAGCTACGGCCGTCTGCGCATTGCACGCATCATACGCC
GCAATATGGAGCTGGCACGGCAGCTGTACCGGCTGATGTGCGACCATCCGGAGTGGGAACCTCTTGCCCCTGCGCCTCTT
TCCATCGTGTGCGGCCGCTATACCCCTTCGGCTGCTGTGCGCGGGGGCTGGACAGAGCAGCAGATTGATGACCTGCAGCT
GCAGATGATTGAAGAGCTGGAACGCAGCGGCACAGCGCTGCTCACCCCCGCAGCCGTGAACGGGCGGGCCGGCGTGCGCG
TGTGCATAGCAAACCACCGCACCACACCGGAAGACATTACGCTTATTTTCAACACGCTTACTGCCATAGGCACACGGATT
GCCCGGCCGGATGAACATGAAACAGCAGGAGAATGA

Upstream 100 bases:

>100_bases
CATAGACAGTCTGCTGCTTGTGCTGCCGGCATACGCGGGTGCAAGCCGCCTTGTGCCTTTTTTCCAGTAAGACAAGGGTA
TTTTTCAAGGACACACCTTC

Downstream 100 bases:

>100_bases
CGGCGTGAATGGCTATATATCCCCCCTGCCCGACGCCGCGTGGAACAGCCGTTTTCCGCGTTCACTGGTGCTGCTGGGCA
GCACCGGTTCCATAGGCACC

Product: aromatic amino acid decarboxylase

Products: NA

Alternate protein names: DABA decarboxylase; DABA-DC [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MTRKQFETLDLDNLEQNLQQAAELIAGRIRAIACDPVKQNISFEELAAIIPCDLPDEGHGPEAVIGEVARHIEPYSTRIG
HPRFLAWITTSPGPAGTIGDMLCTGLNQAPLSFKGGPAATVLEEIVLGWFAGMFGMPEGWGGTIVSGGTMANLMGLTVAR
RVHAPQVHARGMQGLERPLVLYVSDQGHMSVTRSAVLLGIGEDNVRAVPSDSACRMIPHELEKAVQQDRRAGRLPFCVVA
QAGSVTTGAVDPLPDIAAICRRENMWMHVDAAYGGAVMLADELRPLLAGIELADSVCVDPHKWFFVPLECGITLFRSREQ
QLETFRAKAAYLGAENPHDLKNTTFILSRANRALKVWFAFRSYGRLRIARIIRRNMELARQLYRLMCDHPEWEPLAPAPL
SIVCGRYTPSAAVRGGWTEQQIDDLQLQMIEELERSGTALLTPAAVNGRAGVRVCIANHRTTPEDITLIFNTLTAIGTRI
ARPDEHETAGE

Sequences:

>Translated_491_residues
MTRKQFETLDLDNLEQNLQQAAELIAGRIRAIACDPVKQNISFEELAAIIPCDLPDEGHGPEAVIGEVARHIEPYSTRIG
HPRFLAWITTSPGPAGTIGDMLCTGLNQAPLSFKGGPAATVLEEIVLGWFAGMFGMPEGWGGTIVSGGTMANLMGLTVAR
RVHAPQVHARGMQGLERPLVLYVSDQGHMSVTRSAVLLGIGEDNVRAVPSDSACRMIPHELEKAVQQDRRAGRLPFCVVA
QAGSVTTGAVDPLPDIAAICRRENMWMHVDAAYGGAVMLADELRPLLAGIELADSVCVDPHKWFFVPLECGITLFRSREQ
QLETFRAKAAYLGAENPHDLKNTTFILSRANRALKVWFAFRSYGRLRIARIIRRNMELARQLYRLMCDHPEWEPLAPAPL
SIVCGRYTPSAAVRGGWTEQQIDDLQLQMIEELERSGTALLTPAAVNGRAGVRVCIANHRTTPEDITLIFNTLTAIGTRI
ARPDEHETAGE
>Mature_490_residues
TRKQFETLDLDNLEQNLQQAAELIAGRIRAIACDPVKQNISFEELAAIIPCDLPDEGHGPEAVIGEVARHIEPYSTRIGH
PRFLAWITTSPGPAGTIGDMLCTGLNQAPLSFKGGPAATVLEEIVLGWFAGMFGMPEGWGGTIVSGGTMANLMGLTVARR
VHAPQVHARGMQGLERPLVLYVSDQGHMSVTRSAVLLGIGEDNVRAVPSDSACRMIPHELEKAVQQDRRAGRLPFCVVAQ
AGSVTTGAVDPLPDIAAICRRENMWMHVDAAYGGAVMLADELRPLLAGIELADSVCVDPHKWFFVPLECGITLFRSREQQ
LETFRAKAAYLGAENPHDLKNTTFILSRANRALKVWFAFRSYGRLRIARIIRRNMELARQLYRLMCDHPEWEPLAPAPLS
IVCGRYTPSAAVRGGWTEQQIDDLQLQMIEELERSGTALLTPAAVNGRAGVRVCIANHRTTPEDITLIFNTLTAIGTRIA
RPDEHETAGE

Specific function: Unknown

COG id: COG0076

COG function: function code E; Glutamate decarboxylase and related PLP-dependent proteins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the group II decarboxylase family [H]

Homologues:

Organism=Homo sapiens, GI197383062, Length=483, Percent_Identity=27.536231884058, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI4503281, Length=412, Percent_Identity=30.3398058252427, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI132814448, Length=412, Percent_Identity=30.3398058252427, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI194294551, Length=446, Percent_Identity=29.1479820627803, Blast_Score=201, Evalue=1e-51,
Organism=Homo sapiens, GI197276620, Length=422, Percent_Identity=28.436018957346, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI4503875, Length=422, Percent_Identity=28.436018957346, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI92110055, Length=451, Percent_Identity=27.7161862527716, Blast_Score=185, Evalue=7e-47,
Organism=Homo sapiens, GI58331246, Length=438, Percent_Identity=27.6255707762557, Blast_Score=181, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17534819, Length=507, Percent_Identity=27.810650887574, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17534817, Length=507, Percent_Identity=27.810650887574, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI17555682, Length=414, Percent_Identity=28.743961352657, Blast_Score=177, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71993062, Length=414, Percent_Identity=28.743961352657, Blast_Score=176, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI71993058, Length=314, Percent_Identity=32.484076433121, Blast_Score=168, Evalue=7e-42,
Organism=Caenorhabditis elegans, GI71981211, Length=445, Percent_Identity=25.1685393258427, Blast_Score=154, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71981217, Length=454, Percent_Identity=24.6696035242291, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17551992, Length=468, Percent_Identity=23.0769230769231, Blast_Score=136, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI133931025, Length=480, Percent_Identity=23.3333333333333, Blast_Score=135, Evalue=5e-32,
Organism=Caenorhabditis elegans, GI17543922, Length=307, Percent_Identity=24.7557003257329, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24652373, Length=474, Percent_Identity=29.1139240506329, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24586044, Length=464, Percent_Identity=27.3706896551724, Blast_Score=185, Evalue=6e-47,
Organism=Drosophila melanogaster, GI28573972, Length=462, Percent_Identity=27.2727272727273, Blast_Score=184, Evalue=1e-46,
Organism=Drosophila melanogaster, GI17136190, Length=487, Percent_Identity=26.0780287474333, Blast_Score=182, Evalue=5e-46,
Organism=Drosophila melanogaster, GI17136594, Length=362, Percent_Identity=28.7292817679558, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI221476190, Length=446, Percent_Identity=27.5784753363229, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24585143, Length=446, Percent_Identity=27.5784753363229, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24585139, Length=446, Percent_Identity=27.5784753363229, Blast_Score=172, Evalue=6e-43,
Organism=Drosophila melanogaster, GI24657193, Length=349, Percent_Identity=29.7994269340974, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24657185, Length=349, Percent_Identity=29.7994269340974, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24657188, Length=349, Percent_Identity=29.7994269340974, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21356415, Length=384, Percent_Identity=28.90625, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24585135, Length=446, Percent_Identity=25.7847533632287, Blast_Score=154, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002129
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- InterPro:   IPR021115 [H]

Pfam domain/function: PF00282 Pyridoxal_deC [H]

EC number: =4.1.1.86 [H]

Molecular weight: Translated: 53773; Mature: 53641

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRKQFETLDLDNLEQNLQQAAELIAGRIRAIACDPVKQNISFEELAAIIPCDLPDEGHG
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCHHHCCCHHHHHHHCCCCCCCCCCC
PEAVIGEVARHIEPYSTRIGHPRFLAWITTSPGPAGTIGDMLCTGLNQAPLSFKGGPAAT
HHHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCHHH
VLEEIVLGWFAGMFGMPEGWGGTIVSGGTMANLMGLTVARRVHAPQVHARGMQGLERPLV
HHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEE
LYVSDQGHMSVTRSAVLLGIGEDNVRAVPSDSACRMIPHELEKAVQQDRRAGRLPFCVVA
EEEECCCCCEEECEEEEEEECCCCCEECCCCCCHHCCHHHHHHHHHHHHHCCCCCEEEEE
QAGSVTTGAVDPLPDIAAICRRENMWMHVDAAYGGAVMLADELRPLLAGIELADSVCVDP
CCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCC
HKWFFVPLECGITLFRSREQQLETFRAKAAYLGAENPHDLKNTTFILSRANRALKVWFAF
CCEEEEEHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEHHHH
RSYGRLRIARIIRRNMELARQLYRLMCDHPEWEPLAPAPLSIVCGRYTPSAAVRGGWTEQ
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHCCCCCHH
QIDDLQLQMIEELERSGTALLTPAAVNGRAGVRVCIANHRTTPEDITLIFNTLTAIGTRI
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHC
ARPDEHETAGE
CCCCCCCCCCC
>Mature Secondary Structure 
TRKQFETLDLDNLEQNLQQAAELIAGRIRAIACDPVKQNISFEELAAIIPCDLPDEGHG
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCHHHCCCHHHHHHHCCCCCCCCCCC
PEAVIGEVARHIEPYSTRIGHPRFLAWITTSPGPAGTIGDMLCTGLNQAPLSFKGGPAAT
HHHHHHHHHHHCCCHHHCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCCCCCCCHHH
VLEEIVLGWFAGMFGMPEGWGGTIVSGGTMANLMGLTVARRVHAPQVHARGMQGLERPLV
HHHHHHHHHHHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCEE
LYVSDQGHMSVTRSAVLLGIGEDNVRAVPSDSACRMIPHELEKAVQQDRRAGRLPFCVVA
EEEECCCCCEEECEEEEEEECCCCCEECCCCCCHHCCHHHHHHHHHHHHHCCCCCEEEEE
QAGSVTTGAVDPLPDIAAICRRENMWMHVDAAYGGAVMLADELRPLLAGIELADSVCVDP
CCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCEEEEHHHHHHHHHHHHHHHHHCCCC
HKWFFVPLECGITLFRSREQQLETFRAKAAYLGAENPHDLKNTTFILSRANRALKVWFAF
CCEEEEEHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCEEEHHHH
RSYGRLRIARIIRRNMELARQLYRLMCDHPEWEPLAPAPLSIVCGRYTPSAAVRGGWTEQ
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCCCHHHCCCCCHH
QIDDLQLQMIEELERSGTALLTPAAVNGRAGVRVCIANHRTTPEDITLIFNTLTAIGTRI
HHHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHC
ARPDEHETAGE
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800; 9514614 [H]